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VGHLPPPAEVRHPVYATRVLCEVANERGVPTADVLAGTAIEPADLDDPDAVVGALDEITAVRRLLARLPD DAGIGIDVGSRFALTHFGLFGFAVMSCGTLRELLTIAMRYFALTTMHVDITLFETADDCLVELDASHLPA DVRGFFIERDIAGIIATTTSFALPLAAKYADQVSAELAVDAELLRPLLELVPVHDVAFGRAHNRVHFPRA MFDEPLPQADRHTLEMCIAQCDVLMQRNERRRGITALVRSKLFRDSGLFPTFTDVAGELDMHPRTLRRRL AEEGTSFRALLGEARSTVAVDLLRNVGLTVQQVSTRLGYTEVSTFSHAFKRWYGVAPSEYSRRG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1395 | - | - | 100% (344) | PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN |
| M. tuberculosis H37Rv | Rv3736 | - | 4e-13 | 41.25% (80) | transcriptional regulatory protein AraC/XylS-family |
| M. tuberculosis H37Rv | Rv3082c | virS | 4e-13 | 41.25% (80) | virulence-regulating transcriptional regulator VirS |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1430 | - | 0.0 | 100.00% (344) | transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_4594 | - | 5e-18 | 27.64% (275) | helix-turn-helix domain-containing protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2050 | - | 7e-16 | 25.63% (277) | putative HTH-type transcriptional regulator AraC |
| M. marinum M | MMAR_3156 | - | 2e-14 | 25.44% (342) | AraC/XylS family transcriptional regulator |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_6546 | - | 7e-07 | 35.71% (84) | transcriptional regulatory protein |
| M. thermoresistible (build 8) | TH_3718 | - | 7e-51 | 35.91% (323) | PUTATIVE putative aldehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_4350 | - | 4e-14 | 40.00% (80) | AraC/XylS family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_4276 | - | 1e-06 | 36.90% (84) | AraC family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1395|M.tuberculosis_H37Rv --MGHLPPPAEVRHPVYATRVLCEVANERGVPTADVLAGTAIEPADLDDP
Mb1430|M.bovis_AF2122/97 --MGHLPPPAEVRHPVYATRVLCEVANERGVPTADVLAGTAIEPADLDDP
TH_3718|M.thermoresistible__bu ----------------VAAADLIDTAVEAGIPADRCLRGTWLTRSDLAAA
Mflv_4594|M.gilvum_PYR-GCK MDWAQGARSVKFSNAGVPPVAFVQMLESQALDPDAVARLRTIMAREGTDE
MMAR_3156|M.marinum_M ---------MNPNDAGVPPLAFVQMLESPAFDPDAVARLRNIMAREGTDE
MAB_2050|M.abscessus_ATCC_1997 ---------MKLDDSGMPALAFLQMLDSEALGHDASIALRSIMVREHVTE
MSMEG_6546|M.smegmatis_MC2_155 ---------------------MTETANL----TRPVIELR----------
Mvan_4276|M.vanbaalenii_PYR-1 -----------MTVSASSDRILSEAANLGAGPPRRVIDLR----------
MUL_4350|M.ulcerans_Agy99 ----------MSVVRGTGLSNYPNLVSELGGDPAALLRAAGVREQDVGNY
:
Rv1395|M.tuberculosis_H37Rv DAVVG--ALDEITAVRRLLARLPDDAG--IGIDVGSRFALTHFGLFGFAV
Mb1430|M.bovis_AF2122/97 DAVVG--ALDEITAVRRLLARLPDDAG--IGIDVGSRFALTHFGLFGFAV
TH_3718|M.thermoresistible__bu DRLIT--AEQELRIVRNVLAATEHPTA--LAGSAGARYQLPRAGFLGFAL
Mflv_4594|M.gilvum_PYR-GCK ATLMQHDVQAPLRWFRDLYPDLDVDRATLLGFSFAGQAQLTSFGPLSVPL
MMAR_3156|M.marinum_M ATLIQRDIQAPLRWFREAYPGLDIDQATLLGFALAEQAQLTSFGPLSVPL
MAB_2050|M.abscessus_ATCC_1997 SMLVGRDAQVPLRWFREIYSDFDCDQGTRLGFAFAEHAKLTSFGALSVPL
MSMEG_6546|M.smegmatis_MC2_155 ------------RGGRALAGSYLYEGEGLITGWHSHEVHQIEYALHGVVE
Mvan_4276|M.vanbaalenii_PYR-1 ------------RGGRALGGSYLYEGDALITGWHSHDVHQIEYALHGVVE
MUL_4350|M.ulcerans_Agy99 DAFIP-----VRAVIRAIETAAAATGTHDFGRQLAQRQGIEILGPVGVAA
* : . . ..
Rv1395|M.tuberculosis_H37Rv MSCGTLRELLTIAMRYFALTTMHVDITLFETADDCLVELDASHLPADVRG
Mb1430|M.bovis_AF2122/97 MSCGTLRELLTIAMRYFALTTMHVDITLFETADDCLVELDASHLPADVRG
TH_3718|M.thermoresistible__bu LSSNTLGDAIRVGIRFWRLTSVFERVTLEVNRQTTAIVLDDRDVPADVRQ
Mflv_4594|M.gilvum_PYR-GCK VSAGSVAEIVEL-LTYLPLITTAINAQFRPNDQGLTVGLWGHTGDRALDC
MMAR_3156|M.marinum_M VSAGSVAEIVEL-LTYLPLITTAVKAQFHPDDQGLTVGLWGHTSDRALDC
MAB_2050|M.abscessus_ATCC_1997 VSAGSVAEVVEL-LAYLPVITTALSPSFHSTERGLTIGLTGRTGDAGLNC
MSMEG_6546|M.smegmatis_MC2_155 VETDAAHYLLPPQQAAWIPAGLQHQAVMNPDVKTVAVMFDPQMIPDGG--
Mvan_4276|M.vanbaalenii_PYR-1 VETDSAHYLLPPQQAAWIPAGLEHQAVMNPDVKTVAVMFDPTLIPDGG--
MUL_4350|M.ulcerans_Agy99 RTAATVADALMIFHTFMAAYSPAIHIEITPLARTQRSVVAIEIVPDDPIP
: : : .
Rv1395|M.tuberculosis_H37Rv FFIERDIAGIIATTTSFALPLAAKYADQVSAELAVDAELLRPLLELVPVH
Mb1430|M.bovis_AF2122/97 FFIERDIAGIIATTTSFALPLAAKYADQVSAELAVDAELLRPLLELVPVH
TH_3718|M.thermoresistible__bu FLVERDAATMVGVTP--AL-LGGPLPDGVRMSLRRRPNGDAAVEELV---
Mflv_4594|M.gilvum_PYR-GCK LAVTYTGSALLRLLD---MLVSDALTVTLHLSWSAPVSLNKLAAEMVLAG
MMAR_3156|M.marinum_M LAVTYAGLALLRLLD---MLVRAAPTLTLHLSWPAPAALKDREDDLT-AG
MAB_2050|M.abscessus_ATCC_1997 LAVTYGGLALLRLLD---MLAGAVPNIELHLSHSAPESW--VLHDEVLAG
MSMEG_6546|M.smegmatis_MC2_155 -----TRARIIAVSP----LIREMMIYGLRWPIDR-----------ADGD
Mvan_4276|M.vanbaalenii_PYR-1 -----DRARILAVSP----LIREMMIYALRWHIERGPGA-------GDDD
MUL_4350|M.ulcerans_Agy99 CPHTLELALGVSLGVFRLLMGADYTPLAVHLPHDPLTPP----TTYVRYF
: :
Rv1395|M.tuberculosis_H37Rv DVAFGRAHNRVHFPRAMFDEPLPQADRHTLEMCIAQCDVLMQRNERRRGI
Mb1430|M.bovis_AF2122/97 DVAFGRAHNRVHFPRAMFDEPLPQADRHTLEMCIAQCDVLMQRNERRRGI
TH_3718|M.thermoresistible__bu DVSYGADRNAITFPTALLDRPLAAANPAVAAQCIAQCDELLARHQDEPTV
Mflv_4594|M.gilvum_PYR-GCK RLFFDAPMSYLHVPVNALNEVCRFSDPLAYRLAVAELRRTLDEQSGATSF
MMAR_3156|M.marinum_M RLFFDAPMSFLHVPADTLNEVCRFSDPVAYRLAIVDLQRTLDQRSETTSF
MAB_2050|M.abscessus_ATCC_1997 RIFFDAPSSFVHVPAATLEEVCRFSDPVAYRIAVTDLQRTLDQRR-DTSV
MSMEG_6546|M.smegmatis_MC2_155 EISDGFFQTLANLVAEALDHEAPLSLPTSDNPIVAAALAYTKEHLDSVTA
Mvan_4276|M.vanbaalenii_PYR-1 GVADGFFRTLAALVCEALDHEAPLSLPTSDNPIVAAAMAYTKQHLDTVTC
MUL_4350|M.ulcerans_Agy99 ECTPHFAERRSGFTVRSTDLVRPLHRDELAHRAVVDYLSSITPLGAGIVE
. : :.
Rv1395|M.tuberculosis_H37Rv TALVRSKLFRDSGLFPTFTDVAGELDMHPRTLRRRLAE-EGTSFRALLGE
Mb1430|M.bovis_AF2122/97 TALVRSKLFRDSGLFPTFTDVAGELDMHPRTLRRRLAE-EGTSFRALLGE
TH_3718|M.thermoresistible__bu ASRVRRRLARDPGAVPLMRTLATEMGFTERTLRRRLAR-EGTGYRSLIDE
Mflv_4594|M.gilvum_PYR-GCK SKKVRRLLDEDPGQR-SCQRVADELSVSTSTLKRRLAE-EGTTFRELRQS
MMAR_3156|M.marinum_M SEKVRRLLQKEPGRR-SKHWFAHELSMSTSTLKRRLSE-EETTFRELRQA
MAB_2050|M.abscessus_ATCC_1997 SEKVRDLLEKDPGKT-NISRTAGELSISPSTLKRRLRE-EGTTFRELRQS
MSMEG_6546|M.smegmatis_MC2_155 EQVSR------------------AVSVSERTLRRLFADTIGMSWRTYLLH
Mvan_4276|M.vanbaalenii_PYR-1 EEVSR------------------AVSVSERTLRRLFAETLGLPWRTYLLH
MUL_4350|M.ulcerans_Agy99 SVRTMARQLLPTGAT-TLEVVAAQFHLHPKTLQRRLAD-ESTTFAALIDE
. . **:* : :
Rv1395|M.tuberculosis_H37Rv ARSTVAVDLLRNVGLTVQQVSTRLGYTEVSTFSHAFKRWYGVAPSEYSRR
Mb1430|M.bovis_AF2122/97 ARSTVAVDLLRNVGLTVQQVSTRLGYTEVSTFSHAFKRWYGVAPSEYSRR
TH_3718|M.thermoresistible__bu VRGARAADLLS-GGATVKQVAQQLGYSEPAAFHHAFVRWHALPPARFRRA
Mflv_4594|M.gilvum_PYR-GCK CLRESAMMLLITRSMSASQIATELGYGDLANFSHAFKRWTGRSPSEYRRS
MMAR_3156|M.marinum_M FLRERAMLQLLDRSLSVSEIATDLGYSDLANFSHAFKRWTGRSPSEFRLS
MAB_2050|M.abscessus_ATCC_1997 FLQERAILRILDRSVSVSEIAAELGYADLTNFTHAFKRWTGRSPRHFRKT
MSMEG_6546|M.smegmatis_MC2_155 ARMLRAMALLADQDQSVQATATAVGFENLSSFTRCFAQFCGETPSNYRRR
Mvan_4276|M.vanbaalenii_PYR-1 ARMLRAMALLTAPTQSVQGTATAVGFDSVSSFTRAFTQFCGETPSAYRKR
MUL_4350|M.ulcerans_Agy99 VRKETADRYLRTTAMSLSHLARELGYAEQSVLTRSCKRWFGIGPAAYRAK
* : : . : :*: . : : :. :: . * :
Rv1395|M.tuberculosis_H37Rv G---------
Mb1430|M.bovis_AF2122/97 G---------
TH_3718|M.thermoresistible__bu DVR-------
Mflv_4594|M.gilvum_PYR-GCK QR--------
MMAR_3156|M.marinum_M PH--------
MAB_2050|M.abscessus_ATCC_1997 RD--------
MSMEG_6546|M.smegmatis_MC2_155 ATGS------
Mvan_4276|M.vanbaalenii_PYR-1 VADASD----
MUL_4350|M.ulcerans_Agy99 TRVRATPRRR