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RGLRPTVPGLSGGNIVRDLVGELIASIDPQSLLQRIVEQVCVRMPTASGASVALKTPGDFLEVLATYGAT GTLKGRVVPIDDTFQVYPLGSGRPEIVDDTATDARITPQVRELSQQLGVRSCLSIPLISEGSAIGTLSVV AHEPYAFGASDVAPVSAVAEFLGVLISASTQLAALLKDLLGAGSIRVDSRAAADLLASVLLPELSERDEL RRVIDDVVMAGEIVPVFQPIFDLITGEVIGFEGLSRFRCEPTRSPDKWIALAHNVRRGIDVELKALRALL KGALSIPDKYLVSVNLSPLALADPIIQQELLSYPRGVVVELTEREPAPELLGESVEPLRQSGIRLAIDDA GSGFAGLTTILRLRPDIIKLDRELTVGIDTDPSRRALATALTHFAREIDAYTVAEGIETEVQMQLLRDIG IRYGQGYFLGRPQPVDVFEESLFSRA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4571 | - | - | 100% (447) | diguanylate phosphodiesterase |
| M. gilvum PYR-GCK | Mflv_5174 | - | 6e-43 | 31.50% (381) | diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF |
| M. gilvum PYR-GCK | Mflv_2073 | - | 3e-20 | 34.57% (243) | diguanylate cyclase/phosphodiesterase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1389c | - | 9e-15 | 25.46% (271) | hypothetical protein Mb1389c |
| M. tuberculosis H37Rv | Rv1354c | - | 9e-15 | 25.46% (271) | hypothetical protein Rv1354c |
| M. leprae Br4923 | MLBr_01750 | - | 2e-18 | 29.31% (232) | hypothetical protein MLBr_01750 |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | - | - | - | - | - |
| M. avium 104 | MAV_3132 | - | 2e-19 | 26.22% (267) | GGDEF domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_2196 | - | 4e-17 | 26.27% (255) | sensory box/response regulator |
| M. thermoresistible (build 8) | TH_0811 | - | 1e-15 | 26.74% (258) | sensory box/response regulator |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_1152 | - | 7e-40 | 29.92% (371) | diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_2196|M.smegmatis_MC2_155 ---------------------------------------MSESLDVLVTS
TH_0811|M.thermoresistible__bu ---------------------------------------VSTELDLLVTG
Mb1389c|M.bovis_AF2122/97 ----------------------------------MCNDTATPQLEELVTT
Rv1354c|M.tuberculosis_H37Rv ----------------------------------MCNDTATPQLEELVTT
MLBr_01750|M.leprae_Br4923 ---------------------------------------MTRSLDELVTR
MAV_3132|M.avium_104 ---------------------------------------MSGTLDHLVTA
Mflv_4571|M.gilvum_PYR-GCK ------------------------------------MRGLRPTVPGLSGG
Mvan_1152|M.vanbaalenii_PYR-1 MTGDQPELPVDLVRTLLGVLRQRLGLDAAWLSSFDDGMQVIEVLDGNADG
:
MSMEG_2196|M.smegmatis_MC2_155 V---ATQLMAVEAATSVSVSQQVLAELVSFFDVDVSFLRHNDHRAHATRL
TH_0811|M.thermoresistible__bu V---ATKLMAADAATARDVSRRVLADLVRAFELDFSFLRHNDHEIRASKL
Mb1389c|M.bovis_AF2122/97 V---ANQLMTVDAATSAEVSQRVLAYLVEQLGVDVSFLRHNDRDRRATRL
Rv1354c|M.tuberculosis_H37Rv V---ANQLMTVDAATSAEVSQRVLAYLVEQLGVDVSFLRHNDRDRRATRL
MLBr_01750|M.leprae_Br4923 V---ASKLMAATAATAVTISEGVLAILVEHFGVDVSFLRHNNHDIHETKL
MAV_3132|M.avium_104 A---AAELMAATAADAAQISERVLADLVSHFGVNFGFLRHNDHSIRATVL
Mflv_4571|M.gilvum_PYR-GCK N---IVRDLVGELIASIDP-QSLLQRIVEQVCVRMPTASGASVALKTPGD
Mvan_1152|M.vanbaalenii_PYR-1 LGVSPGQRIGLPESYCVRVIDGRLPAVIPDTSADQTTAALPITRESGVGA
. : . * ::
MSMEG_2196|M.smegmatis_MC2_155 VAEWPPRPVDAATDPIAVVHFADADP----------VFAMAEHLKEPAVF
TH_0811|M.thermoresistible__bu IAEWPVRENVPDPDPIGVVHFEGADP----------VFALAEHAKEIHIF
Mb1389c|M.bovis_AF2122/97 VAEWPPRLNIPDPDPLRLIYFADADP----------VFALCEHAKEPLVF
Rv1354c|M.tuberculosis_H37Rv VAEWPPRLNIPDPDPLRLIYFADADP----------VFALCEHAKEPLVF
MLBr_01750|M.leprae_Br4923 IVEWPPRDYVPDPDPIGVVYFADADP----------VFAMAEYLKEPAVL
MAV_3132|M.avium_104 VAEWPPRN--VDPDPLGVIYFADADS----------VFARVETMKEPDVL
Mflv_4571|M.gilvum_PYR-GCK FLEVLATYGATGTLKGRVVPIDDTFQ----------VYPLGSGRPE-IVD
Mvan_1152|M.vanbaalenii_PYR-1 YVGVPVPVPGHGDATAGMVCVVSREPKPDLTDEDLQIVKQVADLIGTLID
:: . . : :
MSMEG_2196|M.smegmatis_MC2_155 RPEPLYDDYQRTIEAGRHIPAT-----SMACVPLLSGDVTTGVLGFVKFG
TH_0811|M.thermoresistible__bu RPEPATDEFQRLIEESSGVPAS-----TVAAVPLVSGEITTGVLGFVKYG
Mb1389c|M.bovis_AF2122/97 RPEPATEDYQRLIEEARGVPVT-----SAAAVPLVSGEITTGLLGFIKFG
Rv1354c|M.tuberculosis_H37Rv RPEPATEDYQRLIEEARGVPVT-----SAAAVPLVSGEITTGLLGFIKFG
MLBr_01750|M.leprae_Br4923 RPEPANADYQRRIEEGASVPAV-----SLACVPLLSGEITTGVLGFVKYG
MAV_3132|M.avium_104 RPEPANADYQRNIEDGTGIPEV-----SLAAVPLLSGDVTTGTLGFVKFG
Mflv_4571|M.gilvum_PYR-GCK DTATDARITPQVRELSQQLGVR-----SCLSIPLISEGSAIGTLSVVAHE
Mvan_1152|M.vanbaalenii_PYR-1 SPAPGADPTADQRKAIRRVLAERDFEVVFQAVHDAATGKVVGVEALARFP
. . : : .: : . * .. .
MSMEG_2196|M.smegmatis_MC2_155 DREWLPAELNALKAIASLFAQVQARIEAEERLRYLADHDHLTGLYNRRAL
TH_0811|M.thermoresistible__bu DRQWHPDELNALKAIASLFAQVQARVEAEERLRYLAEHDDLTGLHNRRAL
Mb1389c|M.bovis_AF2122/97 DRKWHEAELNALMTIATLFAQVQARVAAEARLRYLADHDDLTGLHNRRAL
Rv1354c|M.tuberculosis_H37Rv DRKWHEAELNALMTIATLFAQVQARVAAEARLRYLADHDDLTGLHNRRAL
MLBr_01750|M.leprae_Br4923 DREWHDDELRALQAIATLFAQLQARIVAEEQLRYLAEHDDLTGLLNRRAL
MAV_3132|M.avium_104 DREWLSEELNALQAIAALFAQLQARVVAEEQIHYLAEHDELTGLLNRRAL
Mflv_4571|M.gilvum_PYR-GCK PYAFGASDVAPVSAVAEFLGVLIS---------------------ASTQL
Mvan_1152|M.vanbaalenii_PYR-1 CEPFRPDAFFQQAAQLGLDIELETAIVRRVLSMIPQLPDDVFVAMNISPA
: . : : : :
MSMEG_2196|M.smegmatis_MC2_155 MAHLEARLAPGQPGPVAVMFFDLDRLKAINDYLGHTAGDAFISILAQRLQ
TH_0811|M.thermoresistible__bu LAHLDARLAAGQPGPVSALYFDLDRLKAVNDYLGHTVGDWFIRVLAERLR
Mb1389c|M.bovis_AF2122/97 LQHLDQRLAPGQPGPVAALFLDLDRLKAINDYLGHAAGDQFIHVFAQRIG
Rv1354c|M.tuberculosis_H37Rv LQHLDQRLAPGQPGPVAALFLDLDRLKAINDYLGHAAGDQFIHVFAQRIG
MLBr_01750|M.leprae_Br4923 IAHLDERLADGQRGPVTLLFLGLDRLKAVNDYLGHNAGDRLIEVFADRLR
MAV_3132|M.avium_104 IAHLDKRLAPGQPGPVPVVFLAIDRFKVINGRLGQDAGDRFIDAFAALLR
Mflv_4571|M.gilvum_PYR-GCK AALLKDLLGAGS--------IRVD---------SRAAADLLASVLLPELS
Mvan_1152|M.vanbaalenii_PYR-1 AALAAPWHELLVDVDPSRIVLEITEHVAVGNYGALDDALESCRARGMRIA
: : . . :
MSMEG_2196|M.smegmatis_MC2_155 RGDDAPKLIARLGGDEFVVVPDDPMSLDEATALAYRLQSVLRERVTVDG-
TH_0811|M.thermoresistible__bu EGAGPDDLIARLGGDEFVVVPSGPVDADAALELANRLRSRLQQQVCVDG-
Mb1389c|M.bovis_AF2122/97 DALVGESLIARLGGDEFVLIPASPMSADAAQPLAERLRDQLKDHVAIGG-
Rv1354c|M.tuberculosis_H37Rv DALVGESLIARLGGDEFVLIPASPMSADAAQPLAERLRDQLKDHVAIGG-
MLBr_01750|M.leprae_Br4923 EAAESLTVIARFGGDEFVVVPAESVSVDVAESFAHRLQTRLQKQVVIDG-
MAV_3132|M.avium_104 EATEIPSVIARFGGDEFGVVPAAPMDVEAAESFAHSLHERLHHPIAIDD-
Mflv_4571|M.gilvum_PYR-GCK ERDE---------------------------------LRRVIDDVVMAG-
Mvan_1152|M.vanbaalenii_PYR-1 VDDVGAGFASFSHVLELTPEFVKIDQSITRHIDVDDARRRLAQAIAEFAG
: . :
MSMEG_2196|M.smegmatis_MC2_155 EMLTRTVSIGIAQGIPGKDSTSDVLNRADHAVLTAKGSGGNRVAVFSDAM
TH_0811|M.thermoresistible__bu EMLTRTASIGVAQGTPGRDTTSDLLRRADQAVLTAKSAGGNQITVFTDDM
Mb1389c|M.bovis_AF2122/97 EVLTRTVSIGVASGTPGQHTPSDLLRRADQAALAAKHAGGDSVAIFTADM
Rv1354c|M.tuberculosis_H37Rv EVLTRTVSIGVASGTPGQHTPSDLLRRADQAALAAKHAGGDSVAIFTADM
MLBr_01750|M.leprae_Br4923 EILTRTVSIGVATGLPGRDTTSDLLRWADHAALSAKSDG-SKVVVLDHGI
MAV_3132|M.avium_104 EMLSRTVSIGVAAGIPGDESTSDLLRRVDQATRSAKAAGGNNVATFRPEM
Mflv_4571|M.gilvum_PYR-GCK EIVP----------------------------------------------
Mvan_1152|M.vanbaalenii_PYR-1 QIGATVIAEGVESQGELDAVVAAGITWAQGFCLSRPKPHAHGFPPSFATA
:: .
MSMEG_2196|M.smegmatis_MC2_155 AMEIDFRNDIELHLQSVIEG--GALVLHYLPEIDMRTGEVLAAEALVRWE
TH_0811|M.thermoresistible__bu SLEAEFRNDIELHLQSVIQD--EALLLHFLPEVDMRTGEILATEALVRWH
Mb1389c|M.bovis_AF2122/97 SVSGELRNDIELHLRRGIES--DALRLVYLPEVDLRTGDIVGTEALVRWQ
Rv1354c|M.tuberculosis_H37Rv SVSGELRNDIELHLRRGIES--DALRLVYLPEVDLRTGDIVGTEALVRWQ
MLBr_01750|M.leprae_Br4923 SAQHTLRTEVELHLAGMIDT---DLVLHYLPEVDMSTGKVLGTEALVRWQ
MAV_3132|M.avium_104 STIDTIRNDIELYLEGMIDGGSGALVLHYLPEFDMRTGEILGTEALTRWQ
Mflv_4571|M.gilvum_PYR-GCK ---------------------------VFQPIFDLITGEVIGFEGLSRFR
Mvan_1152|M.vanbaalenii_PYR-1 ASTERVLAPVDLLGDRPFELA-LTHSPIGMAVVGLDGGFLRTNRALRAML
. ..: * : ..*
MSMEG_2196|M.smegmatis_MC2_155 HPTRGLLSPDSFIGVAESINLAGELGR--WVLRTACAEFSRWRANGVGRN
TH_0811|M.thermoresistible__bu HPTRGLLAPDTFIGVAESVNLAGELGR--WVMRTACGEFAKWRAEGIGLD
Mb1389c|M.bovis_AF2122/97 HPTRGLLAPGCFIPVAESINLAGELDR--WVLRRACNEFSEWQSAGLGHD
Rv1354c|M.tuberculosis_H37Rv HPTRGLLAPGCFIPVAESINLAGELDR--WVLRRACNEFSEWQSAGLGHD
MLBr_01750|M.leprae_Br4923 HPTRGLLFPDSFIPVAESINLAGKLGR--MVMHSACAEFSRWRSAGVGLD
MAV_3132|M.avium_104 HPTLGLLMPDSFIQVAESINLGAKLGR--LVMRSACAQFGQWRSRGVGQG
Mflv_4571|M.gilvum_PYR-GCK CEPT--RSPDKWIALAHNVRRGIDVEL--KALRALLKG-----ALSIPDK
Mvan_1152|M.vanbaalenii_PYR-1 GYSRGTLADMTFQQITHPDDLDADLAMVAECLEGRRRSYRIDKRYIAADG
. : ::. .: :.
MSMEG_2196|M.smegmatis_MC2_155 IVLRINVSPVQLVTDGFVESVAGIMKEFGLPRGSVCLEITESVVVQDIET
TH_0811|M.thermoresistible__bu AVLRINVSPVQLVTDGFVASVADIIDEFGLDGSSVCLEITESVVVQDIKT
Mb1389c|M.bovis_AF2122/97 ALLRINVSAGQLVTGGFVDFVADTIGQHGLDASSVCLEITENVVVQDLHT
Rv1354c|M.tuberculosis_H37Rv ALLRINVSAGQLVTGGFVDFVADTIGQHGLDASSVCLEITENVVVQDLHT
MLBr_01750|M.leprae_Br4923 ALLRINVSPVQLVAEGFVDNVAGTLDEFGLDGSMVCLEITENVVVQNIDA
MAV_3132|M.avium_104 TVLRINVSPVQLVTAGIVDTVAATLDEFGLDPSTVCLEITESVVVQDIDA
Mflv_4571|M.gilvum_PYR-GCK YLVSVNLSPLALADP-------IIQQELLSYPRGVVVELTEREPAPELLG
Mvan_1152|M.vanbaalenii_PYR-1 HIVWCALTVVLVHAPRDQPRCFVSQIVDVTADRAREAELARQAATDPLTA
:: :: : *::. . :
MSMEG_2196|M.smegmatis_MC2_155 TRTTLTGLH-----------------NVGVQVAIDDFGTGYSVLSLLKSL
TH_0811|M.thermoresistible__bu TRITLEGLN-----------------EVGVQVAIDDFGTGYSVLSHLKTL
Mb1389c|M.bovis_AF2122/97 ARATLARLK-----------------EVGVHIAIDDFGTGYSAISLLQTL
Rv1354c|M.tuberculosis_H37Rv ARATLARLK-----------------EVGVHIAIDDFGTGYSAISLLQTL
MLBr_01750|M.leprae_Br4923 TRKTLAGLK-----------------EVGVHLAIDDFGTGYSVLTHLKSL
MAV_3132|M.avium_104 TRQTLFGLK-----------------DIGVQIAIDDFGTGYSVLTYLKSL
Mflv_4571|M.gilvum_PYR-GCK --ESVEPLR-----------------QSGIRLAIDDAGSGFAGLTTILRL
Mvan_1152|M.vanbaalenii_PYR-1 IANRSAAFRRLEQLDAGHDGYGVLFCDIERFKSVNDWCGHHAGDQLLVEV
:. : :::* .: : :
MSMEG_2196|M.smegmatis_MC2_155 PVDTLKIDRS--FVAELGSNPGDLPIVRAVIALAGAFGLQLVAEGVETER
TH_0811|M.thermoresistible__bu PVDTLKIDKG--FVQDLGNSPGDLAIVRAIIALAEAFGLQLVAEGVETEA
Mb1389c|M.bovis_AF2122/97 PIDTLKIDKT--FVRQLGTNTSDLVIVRGIMTLAEGFQLDVVAEGVETEA
Rv1354c|M.tuberculosis_H37Rv PIDTLKIDKT--FVRQLGTNTSDLVIVRGIMTLAEGFQLDVVAEGVETEA
MLBr_01750|M.leprae_Br4923 PVDTIKIDKS--FVAELGSNASDLAIVRAIMALAKEFELEVVAEGVETAV
MAV_3132|M.avium_104 PVDSLKIDKG--FVQSLDTNPGDLAIVRSTLALADAFGLDVVAEGVETVA
Mflv_4571|M.gilvum_PYR-GCK RPDIIKLDRE--LTVGIDTDPSRRALATALTHFAREIDAYTVAEGIETEV
Mvan_1152|M.vanbaalenii_PYR-1 AARLLAAVDEGALVARWGGDEFLVVTDTVEEHELARLATRITEEVDRTPV
: :. . . : . * .*
MSMEG_2196|M.smegmatis_MC2_155 AALTLLRHGCYRAQGFLLSKPILGSEMQTLLAKGRVPVHFSAAPRM----
TH_0811|M.thermoresistible__bu AALTLLRHGCHRAQGFLLSRPIPSNEMRELLARGRIPMRFSATP------
Mb1389c|M.bovis_AF2122/97 AARILLDQRCYRAQGFLFSRPVPGEAMRHMLSARRLPPTCIPATDPALS-
Rv1354c|M.tuberculosis_H37Rv AARILLDQRCYRAQGFLFSRPVPGEAMRHMLSARRLPPTCIPATDPALS-
MLBr_01750|M.leprae_Br4923 AAQVLLELGCNRAQGFLLSRPVDGAAMESLLAKGVIPMALGTCQSPEPSE
MAV_3132|M.avium_104 AAETLLSLGCHRAQGFLLSRPLDSAGMEALLIKGAIPMRFSDGGAPE-NQ
Mflv_4571|M.gilvum_PYR-GCK QMQLLRDIGIRYGQGYFLGRPQPVDVFEESLFSRA---------------
Mvan_1152|M.vanbaalenii_PYR-1 TLADGTQMPVAMTIGFAAHRPGDGRSIDAVLDCADQAMYEQRRQRRNTVL
*: :* : *
MSMEG_2196|M.smegmatis_MC2_155 -----------
TH_0811|M.thermoresistible__bu -----------
Mb1389c|M.bovis_AF2122/97 -----------
Rv1354c|M.tuberculosis_H37Rv -----------
MLBr_01750|M.leprae_Br4923 HQIHRS-----
MAV_3132|M.avium_104 HVV--------
Mflv_4571|M.gilvum_PYR-GCK -----------
Mvan_1152|M.vanbaalenii_PYR-1 HKGNEAIGLVE