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MAERLAAGRHRLSRDEVAAHQKQRLFKALAVVMGTRGYNKTSVDDLIKHAGVSRATFYELFDSKQDCFMA GFAGMQGHVIDAILAAPAGATPLERFGVMLDRYLGFMALDPPTARLYLVEVYSAGPDAMHRRAELQQQFV DGVAKIFKARSKADKFACKALVAAISALVTTALIDGDPAAILALKAPVLTFAERALRAGPS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_5172 | - | - | 100% (201) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_1674 | - | 1e-08 | 28.57% (126) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_1103 | - | 2e-08 | 31.25% (112) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1561 | - | 2e-10 | 27.84% (176) | transcriptional regulator |
| M. tuberculosis H37Rv | Rv1534 | - | 2e-10 | 27.84% (176) | transcriptional regulator |
| M. leprae Br4923 | MLBr_00717 | - | 7e-07 | 30.43% (115) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_2061c | - | 3e-07 | 25.41% (185) | TetR family transcriptional regulator |
| M. marinum M | MMAR_0345 | - | 3e-09 | 45.83% (48) | transcriptional regulatory protein |
| M. avium 104 | MAV_0586 | - | 6e-08 | 36.11% (72) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_2557 | - | 6e-07 | 36.00% (75) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_0083 | - | 2e-09 | 25.54% (184) | POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN |
| M. ulcerans Agy99 | MUL_4775 | - | 2e-09 | 45.83% (48) | transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_1169 | - | 6e-71 | 65.99% (197) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_5172|M.gilvum_PYR-GCK MAERLAAGRHRLSRDEVAAHQKQRLFKALAVVMGTRGYNKTSVDDLIKHA
Mvan_1169|M.vanbaalenii_PYR-1 MPDRLASGRHHLSREQVAANQKQRLFKALAAVMAEKGYSDTTVHDLTTAA
Mb1561|M.bovis_AF2122/97 -MSRASARRRRAVSDEDKSQRRDEILAAAKIVFAHKGFHATTVADIAKQA
Rv1534|M.tuberculosis_H37Rv -MSRASARRRRAVSDEDKSQRRDEILAAAKIVFAHKGFHATTVADIAKQA
MMAR_0345|M.marinum_M -----MTAAASSPAALDSDPFRQRLLEGLVASIGERGYHATTVADIVRHA
MUL_4775|M.ulcerans_Agy99 -----MTAAASSPAALDSDPFRQRLLEGLVASIGERGYHATTVADIVRHA
TH_0083|M.thermoresistible__bu ----MTTAVQPADVGAGDDAFRGRLLSGLAASIAERGYRETTVADIVRHA
MAB_2061c|M.abscessus_ATCC_199 ----------------MAGLRRKLLLEAAADLFARQGFHAVGIDDIGAAA
MAV_0586|M.avium_104 -------------MARWEPDARARLVAAALDLFNERGYDQTTVAEIAERA
MLBr_00717|M.leprae_Br4923 --------MTTARRRLSPEDRRAELLALGAEVFGKRPYDEVRIDEIAERA
MSMEG_2557|M.smegmatis_MC2_155 ----MAGTDAGTDAGTEASSTRERILAATAKVLGSNGTTKLSLSDVASQA
: :. : . : :: *
Mflv_5172|M.gilvum_PYR-GCK GVSRATFYELFDSKQDCFMAGFAG----MQGHVIDAILAAPAGATPLER-
Mvan_1169|M.vanbaalenii_PYR-1 GVSKATFYQHFTSKQDCFMSAYAR----MQQFVIDAIQAAPAAGTPMQR-
Mb1561|M.bovis_AF2122/97 GLAYGLIYWYFDSKDDLFHALMAGEEEALRAHVAAELARVGGSTEAPLRA
Rv1534|M.tuberculosis_H37Rv GLAYGLIYWYFDSKDDLFHALMAGEEEALRAHVAAELARVGGSTEAPLRA
MMAR_0345|M.marinum_M RTSKRTFYDRFESKEQCFLDLLRADNERLAKRIRAAVDPEADWQAQIRQ-
MUL_4775|M.ulcerans_Agy99 RTSKRTFYDRFESKEQCFLDLLRADNERLAKRIRAAVDPEADWQAQIRQ-
TH_0083|M.thermoresistible__bu RTSKRTFYDQFGSKEECFQELLWANNIDMIGAIRAAVDPEADWSEQIRQ-
MAB_2061c|M.abscessus_ATCC_199 GVSGPAVYRHFQNKDAILRELCDAAMTELLAGARRATT--AGTPTEVLH-
MAV_0586|M.avium_104 GLTKSTFFRHFPDKRDVLAAGQDAIAQLLREGIAAAPADATPLALVCSG-
MLBr_00717|M.leprae_Br4923 GVSRALMYHYFPDKRAFFAAVVKDEADRLYAATNIPPPAGLTMFEEVRVG
MSMEG_2557|M.smegmatis_MC2_155 GVSRPTLYRWFSSKQDLLDAFVVWERRGYEQAVAQATGALPASERLDAA-
: .: * .* :
Mflv_5172|M.gilvum_PYR-GCK -FGVMLDRYLGFMALDPPTARLYLVEVYSAGPDAM-----------HRRA
Mvan_1169|M.vanbaalenii_PYR-1 -FAALLDRYLGFLALDPTTARLFLVEVNAAGPEAM-----------RQRA
Mb1561|M.bovis_AF2122/97 LLQAAVQATFEFFETDKATVKLLFRDAYALGGRFE-----------EHLG
Rv1534|M.tuberculosis_H37Rv LLQAAVQATFEFFETDKATVKLLFRDAYALGGRFE-----------EHLG
MMAR_0345|M.marinum_M ----AVEAYVSHIESRLAVTLSWIREFPSLGPISY-----------PVQR
MUL_4775|M.ulcerans_Agy99 ----AVEAYLSHIESRLAVTLSWIREFPSLGPISY-----------PVQR
TH_0083|M.thermoresistible__bu ----AVVAYVDHIESRPAITLAWIRELPAIGASVR-----------PIQR
MAB_2061c|M.abscessus_ATCC_199 ---ALVDLHAAFGARRRGLLAVYAREHRSLSPLAT-----------RALR
MAV_0586|M.avium_104 -----LKSAAAAFTPFNKELAPRLRAAIAASAELQ-----------ERNA
MLBr_00717|M.leprae_Br4923 -----VLAYMAYHKQNPEAAWAAYVGLGRSDPVLLGIDDEAKNRQMEHIM
MSMEG_2557|M.smegmatis_MC2_155 -----LRVIAEYQRSYPGLRMVDIEPEHVIR----------------RLS
:
Mflv_5172|M.gilvum_PYR-GCK ELQQQFVDGVAKIFKARSK-------ADKFACKALVAAISALVTTALIDG
Mvan_1169|M.vanbaalenii_PYR-1 QLQQEFVSGVAKVFKARSK-------ADRFACQMLVAGISTLVTNALADA
Mb1561|M.bovis_AF2122/97 GIYERFIDDIEAVVVAAQRRGEVVEAPSRMAAYTLAALVGQLAHRRLNTD
Rv1534|M.tuberculosis_H37Rv GIYERFIDDIEAVVVAAQRRGEVVEAPSRMAAYTLAALVGQLAHRRLNTD
MMAR_0345|M.marinum_M HGMNLLTSLLVELSASPGFRRAGLPAVPGALAVILLGGLRELTALTVEDG
MUL_4775|M.ulcerans_Agy99 HGMNLLTSLLVELSASPGFRRAGLPAVPGALAVILLGGLRELTALTVEDG
TH_0083|M.thermoresistible__bu AMMHELTELLIELSRSPGFARAQMPPLTRQLAVFLLGGLRELTALFVEDG
MAB_2061c|M.abscessus_ATCC_199 RRQHSYESFWVEALVRARGDLDRERAQGLVAAVLSLLNASAYMPASLDDA
MAV_0586|M.avium_104 LKQIGLALAVSEALQARGVP----EPAAALAAELGALAFKTAYARWAEPD
MLBr_00717|M.leprae_Br4923 SRIGDVVSVVPESKLHPDIERDLRVIVHGWLAFTFEVCRQRIMDPSTDAD
MSMEG_2557|M.smegmatis_MC2_155 QIMPLLRERLQRLTTGPDS--------DVAAATAVRVAISHYLVRSDDAD
.
Mflv_5172|M.gilvum_PYR-GCK D-----PAAILALKAPVLTFAERALRAGPS-------
Mvan_1169|M.vanbaalenii_PYR-1 D-----GDAVTALKTPILGFTERVMKVPAGG------
Mb1561|M.bovis_AF2122/97 DNVTAAQVADFVVSLVLDGLRPRALAVGARGGRAART
Rv1534|M.tuberculosis_H37Rv DNVTAAQVADFVVSLVLDGLRPRALAVGARGGRAART
MMAR_0345|M.marinum_M R-------DIREIVEPAVDASIALVGPRH--------
MUL_4775|M.ulcerans_Agy99 R-------DIREIVEPAVDASIALVGPRH--------
TH_0083|M.thermoresistible__bu R-------DVRGLIAPAVSASKALLSAGASE------
MAB_2061c|M.abscessus_ATCC_199 T------IEAMLAAAAVAALFSRAVTQQVDGAPHRI-
MAV_0586|M.avium_104 E-------SGDLGDMACQALRELHAAAADLG------
MLBr_00717|M.leprae_Br4923 RLADSCAHALLDAIARVPEISKELADAMAIARQPPQ-
MSMEG_2557|M.smegmatis_MC2_155 D--------FLAQLRHVARPRRRE-------------