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SSPSRWAGVPLKDRRAERRALLVEAAYRLFGSEGEAAVSVRSVCRECGLNTRYFYESFRDTDDLLGAVYD RVSEQLEEVIAAAIEQAGDSLRARTRAGIAAVLGFSSADPRRGRVLFTDARTNPVLAARRRATQDMLRQG VLSEGWRLNPRSDPVAAEVAAAMYTGAMAELAQQWLAGHLGGDLDAVVDYASKLVLR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3986 | - | - | 100% (198) | transcriptional regulator, TetR family protein |
| M. avium 104 | MAV_4882 | - | 1e-21 | 35.38% (195) | FadD27 protein |
| M. avium 104 | MAV_0773 | - | 7e-19 | 31.02% (187) | hypothetical protein MAV_0773 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0848c | - | 7e-22 | 33.33% (192) | hypothetical protein Mb0848c |
| M. gilvum PYR-GCK | Mflv_5109 | - | 2e-82 | 77.84% (194) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0825c | - | 7e-22 | 33.33% (192) | hypothetical protein Rv0825c |
| M. leprae Br4923 | MLBr_01733 | - | 2e-08 | 29.53% (193) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_3300c | - | 4e-25 | 38.00% (200) | TetR family transcriptional regulator |
| M. marinum M | MMAR_3144 | - | 4e-24 | 32.82% (195) | AcrR family transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_1355 | - | 2e-85 | 79.70% (197) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_4000 | - | 2e-84 | 77.56% (205) | PUTATIVE transcriptional regulator, TetR family |
| M. ulcerans Agy99 | MUL_0446 | - | 5e-24 | 34.90% (192) | hypothetical protein MUL_0446 |
| M. vanbaalenii PYR-1 | Mvan_1244 | - | 4e-83 | 78.17% (197) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0848c|M.bovis_AF2122/97 --------------------------MQTGQ-----NRGRWSGVPLESR-
Rv0825c|M.tuberculosis_H37Rv --------------------------MQTGQ-----NRGRWSGVPLESR-
MUL_0446|M.ulcerans_Agy99 --------------------------MQAGQ-----RRGRWTGVPLEDR-
MMAR_3144|M.marinum_M --------------------------MSPAR-----VYG---GLSATQR-
MSMEG_1355|M.smegmatis_MC2_155 --------------------------MT--------TPTRWAGVPLTDR-
TH_4000|M.thermoresistible__bu --------------------------MT--------SPTRWAGVPLTDR-
Mflv_5109|M.gilvum_PYR-GCK --------------------------MSGAP-----HATRWAGVPLTDR-
Mvan_1244|M.vanbaalenii_PYR-1 --------------------------MSSAASRPAATPTRWAGVPLTDR-
MAV_3986|M.avium_104 --------------------------MS--------SPSRWAGVPLKDR-
MAB_3300c|M.abscessus_ATCC_199 -----------------------------------MPSRTYGGATSGER-
MLBr_01733|M.leprae_Br4923 MTRRSIHTRKPLKWSGCAGQHVRSGKVFDVGRISLSYPSMKPGVKIDARS
* *
Mb0848c|M.bovis_AF2122/97 ------HALRRDNLVAAGVQLLGGAGGPALTVRAVCRHAGLTERYFYESF
Rv0825c|M.tuberculosis_H37Rv ------HALRRDNLVAAGVQLLGGAGGPALTVRAVCRHAGLTERYFYESF
MUL_0446|M.ulcerans_Agy99 ------HAVRRDTLIAAGVQLLGEEAGPALTVRAVCRQAALTERYFYESF
MMAR_3144|M.marinum_M ------DAQRRALLIDAAVALMGKQGAAACTVTAVCTESGVTSRYFYQQF
MSMEG_1355|M.smegmatis_MC2_155 ------RAERRALLVDAAFRLFGDGGETALSVRSVCRECGLNTRYFYESF
TH_4000|M.thermoresistible__bu ------RAERRALLIAAAYRLFGEGGEAALSVRSVCRESELNSRYFYESF
Mflv_5109|M.gilvum_PYR-GCK ------RAERRALLVDAAFRLFGDGGESAVSVRSVSRECGLNTRYFYESF
Mvan_1244|M.vanbaalenii_PYR-1 ------RAERRALLVDAAFRLFGDGGEQALSVRSVSREAGLNTRYFYESF
MAV_3986|M.avium_104 ------RAERRALLVEAAYRLFGSEGEAAVSVRSVCRECGLNTRYFYESF
MAB_3300c|M.abscessus_ATCC_199 ------RARRRAALLDAALDLVAGSGVKGLTVRGVCAEARLNDRYFYESF
MLBr_01733|M.leprae_Br4923 ERWREHRKKVRGEIVDAAFRALDRLG-PEVSVREIAEEAGTAKPKIYRHF
* :: *. . . :* :. .. :*. *
Mb0848c|M.bovis_AF2122/97 ADREHFVRAVYDDVCTRAMATLTSAQ--------TPR---------EAVE
Rv0825c|M.tuberculosis_H37Rv ADREHFVRAVYDDVCTRAMATLTSAQ--------TPR---------EAVE
MUL_0446|M.ulcerans_Agy99 SDRDHFVRAVYDDVCTRAMATLMSAN--------TPR---------DAVE
MMAR_3144|M.marinum_M RDRDALLRAMFTKISTTFQAVITKAI--------PDDTVAPQELAYAPIK
MSMEG_1355|M.smegmatis_MC2_155 ADTDDLIGAVYDEVSALLAADVEAAM--------EGAGNSLRARTRAGIA
TH_4000|M.thermoresistible__bu ADVDELLGAVYDEVSAQLAAEVETAMAAAVEGAGEGAGDSLRARTRAGIV
Mflv_5109|M.gilvum_PYR-GCK GGTDDLLGAVYDRVSAELSVAVADAM--------DHAEDSLRARTRAGMA
Mvan_1244|M.vanbaalenii_PYR-1 TDTDDLLGAVYDRVSAELAEVVEAAM--------SGAGASLPARTRAGMT
MAV_3986|M.avium_104 RDTDDLLGAVYDRVSEQLEEVIAAAI--------EQAGDSLRARTRAGIA
MAB_3300c|M.abscessus_ATCC_199 RSTDELVLAMLDEQMLAGSATIIEAIAK------SSTSKDPVVRTRAAVG
MLBr_01733|M.leprae_Br4923 TDKSDLFEAIGIRLRDMLWAAIFPAI--------DLATDSAREIIRRSVD
. . :. *: : * :
Mb0848c|M.bovis_AF2122/97 QFVELMVDDPVRGRVLLLAPAVEPALTRSGAEWMPNFIELLQRKLSRIVD
Rv0825c|M.tuberculosis_H37Rv QFVELMVDDPVRGRVLLLAPAVEPALTRSGAEWMPNFIELLQRKLSRIVD
MUL_0446|M.ulcerans_Agy99 RFVALMVDDPVRGRVLLLAPAVEPVLTRSGADWMPNFIDLLQRKLSQIAD
MMAR_3144|M.marinum_M ALVQMIENDPSMARILFVESGAEPLLRQLRSELMSEFAELVLREARLHLD
MSMEG_1355|M.smegmatis_MC2_155 AVLGFSSADPRRGRVLFTDARANPVLAQRRAVTQDLLREAVLSEGGRLNP
TH_4000|M.thermoresistible__bu AVLGFSSADPRRGRILFTDARANPVLAARRAATQDQLREAVLTEGWRLHP
Mflv_5109|M.gilvum_PYR-GCK AVLHFSSADPRRGRVLFTDARSNPVLTARRAATQDLLREAVLTEGWRLHP
Mvan_1244|M.vanbaalenii_PYR-1 AVLHFSSADPRRGRVLFTDARANPVLTQRRAATQDLLREAVLTEGWRLHP
MAV_3986|M.avium_104 AVLGFSSADPRRGRVLFTDARTNPVLAARRRATQDMLRQGVLSEGWRLNP
MAB_3300c|M.abscessus_ATCC_199 SGLRFLTADPRRGR-LLVESQATEGLAARRRDLVKTLAQVMADQGRVLLP
MLBr_01733|M.leprae_Br4923 EYVSLVDKHPNVLRVFIQGRFSAQSEATVRTLDEGREITLTMAEMFNNEL
: : .* * :: :
Mb0848c|M.bovis_AF2122/97 P------VLQKLVATSLIGALTGLFTAYLNGRLG----ATRKQFIDYCVN
Rv0825c|M.tuberculosis_H37Rv P------VLQKLVATSLIGALTGLFTAYLNGRLG----ATRKQFIDYCVN
MUL_0446|M.ulcerans_Agy99 P------VLQKLVATSLIGALTGLFTAYLNGQLG----ATRQQFIDYCVD
MMAR_3144|M.marinum_M IPSEV-IQVADLAATYGVGGLFEILRRWIDGQLN----LSTEVLIEHCAG
MSMEG_1355|M.smegmatis_MC2_155 GSDP---VAAQVGAAMYTGAMAELAQQWLAGNLG----DDLDAVVDHALR
TH_4000|M.thermoresistible__bu KSDP---VAAQVGAAMYTGAMAELAQQWLAGNLG----DDLDRVVDYALR
Mflv_5109|M.gilvum_PYR-GCK DTDP---VAAATGAAMYTGAMAELAQQWLSGNLG----DDLDVVVDHALR
Mvan_1244|M.vanbaalenii_PYR-1 DSDP---TAAMVGAAMYTGAMAELAQQWLAGHLG----DDLDAVVGYALR
MAV_3986|M.avium_104 RSDP---VAAEVAAAMYTGAMAELAQQWLAGHLG----GDLDAVVDYASK
MAB_3300c|M.abscessus_ATCC_199 ADDAL-DPDLDLATFTLVSGGLDLVTTWFRGELD----ITRDRLEDFLVA
MLBr_01733|M.leprae_Br4923 REMELNRAASELAAFAAFGSVASATEWWLGPEPDSPRRMPREQFVAHLTI
: .. :: . . . . .
Mb0848c|M.bovis_AF2122/97 MLLST-----AATYAPHRERGESEHSIPAGPHN-
Rv0825c|M.tuberculosis_H37Rv MLLST-----AATYAPHRERGESEHSIPAGPHN-
MUL_0446|M.ulcerans_Agy99 LLLGT-----AAAYAPHRDRGEAEHPVAARQHD-
MMAR_3144|M.marinum_M FLGSLGLYTLGQKPDPAASHIQVDINSPAGHNR-
MSMEG_1355|M.smegmatis_MC2_155 LVLGR-----------------------------
TH_4000|M.thermoresistible__bu LVLGR-----------------------------
Mflv_5109|M.gilvum_PYR-GCK LVLR------------------------------
Mvan_1244|M.vanbaalenii_PYR-1 LVLR------------------------------
MAV_3986|M.avium_104 LVLR------------------------------
MAB_3300c|M.abscessus_ATCC_199 LVTRAN-----IRADQHEDSGEAAKPGN------
MLBr_01733|M.leprae_Br4923 IMMAVIVGTAETLGISMNPDRPIHDAVPLDRSAS
::