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FDNLVPEPAALAGLSDAELVDAAGAAARAENAVCARKLAVMAELFTRRVDLAPEDRLNWWVDPDAAVAAE IAAAVTITQGLATHQTYRAVVLRDRLPKVGALFLAGLLSELLVRAIITRTDLITDPELIAAVDADLAADI LRWGPQSAKKTEAAIDHIVERHDPDAVRQSRAGDLDRAIEIGNPGDAPGYTTVWARMFAGDAAAGQRTLT AMAYSVCDNDPRTLDERRNDALTALFHGITTLACRCGHTDCDAATNPRPPRELTVYALTDQTTADSASEE PRGDATDADASAGDAQPATPTAPKPRRSKPTLLPGRSGYLFGSGFMSAPLFDALLDGAKIREIIHPGQAG PEPRYTPSTALADFIRCRDLTCRFPGCDTPATEADIDHTVAHPVGPTHASNLKCLCRFHHLLKTFWTGPG GWHDRQHPDGTITWTSPTGHTYITHPGSRLLFPTLCKPTATLWTGNPPQNPTNNNRGSMMPRRTRTRAQN RATYITAERTRNAAHRTDSPRGNDPPPF*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. gilvum PYR-GCK | Mflv_1180 | - | - | 100% (519) | hypothetical protein Mflv_1180 |
M. gilvum PYR-GCK | Mflv_4099 | - | 0.0 | 93.23% (517) | hypothetical protein Mflv_4099 |
M. gilvum PYR-GCK | Mflv_0179 | - | 0.0 | 88.78% (526) | hypothetical protein Mflv_0179 |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2126 | - | 1e-111 | 44.30% (535) | hypothetical protein Mb2126 |
M. tuberculosis H37Rv | Rv2100 | - | 1e-111 | 44.30% (535) | hypothetical protein Rv2100 |
M. leprae Br4923 | - | - | - | - | - |
M. abscessus ATCC 19977 | MAB_4752 | - | 5e-71 | 36.22% (508) | hypothetical protein MAB_4752 |
M. marinum M | MMAR_5187 | - | 1e-102 | 42.97% (498) | 13e12 repeat-containing protein |
M. avium 104 | MAV_4456 | - | 1e-101 | 41.12% (535) | 13e12 repeat-containing protein |
M. smegmatis MC2 155 | MSMEG_0144 | - | 1e-117 | 41.83% (600) | HNH endonuclease |
M. thermoresistible (build 8) | TH_0334 | - | 7e-67 | 37.63% (396) | HNH endonuclease |
M. ulcerans Agy99 | MUL_2679 | - | 1e-81 | 39.92% (471) | 13e12 repeat-containing protein |
M. vanbaalenii PYR-1 | Mvan_0728 | - | 0.0 | 75.48% (518) | hypothetical protein Mvan_0728 |
CLUSTAL 2.0.9 multiple sequence alignment MMAR_5187|M.marinum_M ------------------------MFESMGVAAGVDHPCDALAERRQLRT MAV_4456|M.avium_104 ------------------------------MCEDATAWFDELMER-CYPS MUL_2679|M.ulcerans_Agy99 --------------------------------------MDQHIIEYVFDT TH_0334|M.thermoresistible__bu ----------------------------------------------MFES MAB_4752|M.abscessus_ATCC_1997 ----------------------------------------------MFDE Mflv_1180|M.gilvum_PYR-GCK --------------------------------------MFDNLVPEPAAL Mvan_0728|M.vanbaalenii_PYR-1 --------------------------------------MFDVLVPDPADL MSMEG_0144|M.smegmatis_MC2_155 ---MSWGYPQTRVHPQIAVLRCRG-----GFTVGRFERMYEGLLVQIAEF Mb2126|M.bovis_AF2122/97 MAGALFEPSFAAAHPAGLLRRPVTRTVVLSVAATSIAHMFEISLPDPTEL Rv2100|M.tuberculosis_H37Rv MAGALFEPSFAAAHPAGLLRRPVTRTVVLSVAATSIAHMFEISLPDPTEL MMAR_5187|M.marinum_M PTAESARWVQRIGAAARAENRAAAAQLIEIGQLFAYRLSR--CSETEDWA MAV_4456|M.avium_104 ATPESAALVQRIGVFARVENRAAAEQLAAIGELFAYRLSR--CSECEDWA MUL_2679|M.ulcerans_Agy99 ---DDSAPLTRITAAARAEARAAAERLAAIGDLFRLRLSQ--HGNREDWV TH_0334|M.thermoresistible__bu --LDDGAVVDSIAAASREQSAACGREMLAIGELYARRAPED-DTERANWA MAB_4752|M.abscessus_ATCC_1997 --LGDVELIDLIASAQRAEAQACARKLDAIGVLVDRHADLGKPDERDHHA Mflv_1180|M.gilvum_PYR-GCK AGLSDAELVDAAGAAARAENAVCARKLAVMAELFTRRVDLAPED-RLNWW Mvan_0728|M.vanbaalenii_PYR-1 AALSDAELLDAATATTRAENAVCARKLAVMAELFIRRTTLAPQD-RLDWW MSMEG_0144|M.smegmatis_MC2_155 SALSDLELEGQARGWAQAEASASAHKHAAMAELFIRATSTPSADERRWWF Mb2126|M.bovis_AF2122/97 CRSDDGALVAAIEDCARVEAAASARRLSAIAELTGRRTG---ADQRADWA Rv2100|M.tuberculosis_H37Rv CRSDDGALVAAIEDCARVEAAASARRLSAIAELTGRRTG---ADQRADWA . : : ... . :. * MMAR_5187|M.marinum_M VDTMEAVAAEVAAGLRISQGLAASRLRYARALRERLPKTGAVFAAGQIDL MAV_4456|M.avium_104 VDTEAAVSAEVAAQLRIGQGLAAAKVRYARAMRERLPRVGEVFRAGEIDF MUL_2679|M.ulcerans_Agy99 ADTCDAVAAEVAAALNTSVAMGHSNLRYARAMRERLPQLGAEFRAGGIDF TH_0334|M.thermoresistible__bu IDGHANVVAEISAALNISRGRAAGRLQLAIDLRERLPRVAAVFAAGDIDF MAB_4752|M.abscessus_ATCC_1997 LDRWDRVASEVAAAQGITHALASSQMRYAQVLRHRLRAVAERFAAGDLDF Mflv_1180|M.gilvum_PYR-GCK VDPDAAVAAEIAAAVTITQGLATHQTYRAVVLRDRLPKVGALFLAGLLSE Mvan_0728|M.vanbaalenii_PYR-1 VDPEAAVTAELAAAHHITQGLATHQAYRAVVLRDRLPKIGALFLQGLLSE MSMEG_0144|M.smegmatis_MC2_155 VDPDAAVGAQLGAAQGITAWAALHQAQRGVALRDRLPKVNEVFAAGLVSE Mb2126|M.bovis_AF2122/97 CDFWDCAAAEVAAALTISHGKASGQMHLSLALN-RLPQVAALFLAGHLGA Rv2100|M.tuberculosis_H37Rv CDFWDCAAAEVAAALTISHGKASGQMHLSLALN-RLPQVAALFLAGHLGA * . :::.* . . . :. ** * * :. MMAR_5187|M.marinum_M RAFQTIVFRTDLIVDPQVMAAVDALVALNVGRWPSMTKARLSGQIDAIVA MAV_4456|M.avium_104 RLFATIVYRTDLITDRRVLAAVDAELAATAARWPSMTRARLAARVDAVVA MUL_2679|M.ulcerans_Agy99 RLFRTIVFRTDLITESDALAAVDARLAIKAPRWPSMTSWKLATEVDRVVA TH_0334|M.thermoresistible__bu RMVSALVNRSRNVVDPDLLARLDAALAAWSPKWMKLSGPTLNERIDMWVE MAB_4752|M.abscessus_ATCC_1997 RTVALIINRTELVDDEAVVARVDAAIVRALPRWARWSHKRITAALDALVL Mflv_1180|M.gilvum_PYR-GCK LLVRAIITRTDLITDPELIAAVDADLAADILRWGPQSAKKTEAAIDHIVE Mvan_0728|M.vanbaalenii_PYR-1 LLVRAIITRTGLITDPDLIAAVDADLATDILDWGPLSVKATEAEIDAIID MSMEG_0144|M.smegmatis_MC2_155 MIVRNICWSTALMLEPDKLALIDAELAAQISGWGKLTLKEIDNTIDDLIL Mb2126|M.bovis_AF2122/97 RLFSIIAWRTYLVRDPHALSLLDAALAEHAGAWGPLSAPKLEKAIDSWID Rv2100|M.tuberculosis_H37Rv RLFSIIAWRTYLVRDPHALSLLDAALAEHAGAWGPLSAPKLEKAIDSWID . : : : : :: :** :. * : :* : MMAR_5187|M.marinum_M RADADAVRRRKERHADREIWIGQDADG--ISRIDGSMFTIDAHALDRRLS MAV_4456|M.avium_104 KADADAVRRTEKQAASRHVWIAEMGEG--LSHLEGTVSSPDAHALDKRLD MUL_2679|M.ulcerans_Agy99 KFDRDAVRRSRRDAADRYVDCAPLEPG--MALVNRQVFSATAEALARRLD TH_0334|M.thermoresistible__bu RFDPTGVREPRSPGEDRYVVVTPAGQG--MVDVSARLTFEAGFAFXTRLD MAB_4752|M.abscessus_ATCC_1997 HFDQDAVRRNRSATDKRHLEIRPLGNGEPVAEVWGTLQAVHAVALDKRLD Mflv_1180|M.gilvum_PYR-GCK RHDPDAVRQSRAGDLDRAIEIGNPGDAPGYTTVWARMFAGDAAAGQRTLT Mvan_0728|M.vanbaalenii_PYR-1 RHDPDAVRKSRAPETGRTVQFGNPGDAPGYTSMWARMYASDAAAADRTLT MSMEG_0144|M.smegmatis_MC2_155 KHDPGSFRRGRASRRGRYFDIGSPTDAPGVLTVTGRLQAHLGNAYDARIA Mb2126|M.bovis_AF2122/97 RYDPGALRRSRISARTRDLCIGDPDEDAGTAALWGRLYATDAAMLDRRLT Rv2100|M.tuberculosis_H37Rv RYDPGALRRSRISARTRDLCIGDPDEDAGTAALWGRLYATDAAMLDRRLT : * ..*. . * . : : . : MMAR_5187|M.marinum_M ALAATVCAQDPRSREQRRADALGVLAAGGDRLGCRCGLPDC-AAGARPAA MAV_4456|M.avium_104 ALAATVCEHDPRTGEQRRADALGALAAGADRLGCRCGRADC-AAGTRPAA MUL_2679|M.ulcerans_Agy99 ELAKTVCADDPRTVVQRRADALGTLAAGQDRLICDCGRTDCPAAGAPQQP TH_0334|M.thermoresistible__bu QIAATVCRDDPRTADQRRADAMAAMSEGQNRLVCGCGSEDCPADPADTAA MAB_4752|M.abscessus_ATCC_1997 LLAGTVCPADPRSKTQRRADAVGALTQGLNRMRCACGHPDC--SGRDTAD Mflv_1180|M.gilvum_PYR-GCK AMAYSVCDNDPRTLDERRNDALTALFHGITTLACRCGHTDCDAAT-NPRP Mvan_0728|M.vanbaalenii_PYR-1 ALAYSVCDNDPRTLDERRNDAHTALLTGITTLACQCGNPDCHAST-NPRP MSMEG_0144|M.smegmatis_MC2_155 ELIEGVCPDDPRTLNELRHDALGAILD-HTTLACECEDPDCVRGR-EQSP Mb2126|M.bovis_AF2122/97 EMAHGVCEDDPRTLAQRRADALGALAAGADHLACGCGKPDCPSGAGNDER Rv2100|M.tuberculosis_H37Rv EMAHGVCEDDPRTLAQRRADALGALAAGADHLACGCGKPDCPSGAGNDER : ** ***: : * ** .: : * * ** MMAR_5187|M.marinum_M QP-VVIHVIAERATLDGDGG------------------------------ MAV_4456|M.avium_104 GP-VVIHLIAERASVEGTGG------------------------------ MUL_2679|M.ulcerans_Agy99 SR-VVIHVVAGCQTVDGAGE------------------------------ TH_0334|M.thermoresistible__bu TR-LVINVIAEQATVEGRSD------------------------------ MAB_4752|M.abscessus_ATCC_1997 VP-VVVNVVINQSTLAGSDD------------------------------ Mflv_1180|M.gilvum_PYR-GCK PRELTVYALTDQTTADSASEEPRG----DATDADASAGDAQPATPTAPKP Mvan_0728|M.vanbaalenii_PYR-1 PRDITVYALTDHTTTT------------DTGDADTTT-DTKPPTPPAPQP MSMEG_0144|M.smegmatis_MC2_155 RGHLVVHVIAREDTVTAAQHAATTTNTPDDAPADTPAADTEPAEPAEPAE Mb2126|M.bovis_AF2122/97 AAGVVIHVVADASALDAQPDPHLSG---DEPPSRPLTPETTLFEALTPDP Rv2100|M.tuberculosis_H37Rv AAGVVIHVVADASALDAQPDPHLSG---DEPPSRPLTPETTLFEALTPDP :.: : : MMAR_5187|M.marinum_M ---------------------APAWEVGA--------------------- MAV_4456|M.avium_104 ---------------------GPAVEVGA--------------------- MUL_2679|M.ulcerans_Agy99 ---------------------APGVLPG---------------------- TH_0334|M.thermoresistible__bu ---------------------NPGYLPG---------------------- MAB_4752|M.abscessus_ATCC_1997 ---------------------CPAHVPG---------------------- Mflv_1180|M.gilvum_PYR-GCK RRS------------------KPTLLPGR--------------------- Mvan_0728|M.vanbaalenii_PYR-1 RRS------------------KPILIPGR--------------------- MSMEG_0144|M.smegmatis_MC2_155 PAEPAEPAEPAEPAEPVEPVDDPDIAPAASATETATDTTASPTGTDCDPE Mb2126|M.bovis_AF2122/97 EPDP-----------------PATHAPAE--------------------- Rv2100|M.tuberculosis_H37Rv EPDP-----------------PATHAPAE--------------------- . . MMAR_5187|M.marinum_M ------------------------------------DGLVTPELVAELAK MAV_4456|M.avium_104 ------------------------------------EGLLPAQLVAELAA MUL_2679|M.ulcerans_Agy99 ------------------------------------DGIIPAEIVRELAK TH_0334|M.thermoresistible__bu ------------------------------------YGAVPASILRAKAA MAB_4752|M.abscessus_ATCC_1997 ------------------------------------FGVLAAESARAAVA Mflv_1180|M.gilvum_PYR-GCK ------------------------------SGYLFGSGFMSAPLFDALLD Mvan_0728|M.vanbaalenii_PYR-1 ------------------------------PAYLFGAGFMPAPLFDALLA MSMEG_0144|M.smegmatis_MC2_155 SVSVTEFTDNSSDTPSAFLDPDEHPLDRVPPAVLFGGGVLPAYALAEIIN Mb2126|M.bovis_AF2122/97 -------------------------------LITTGGGVVPAPLLAELIR Rv2100|M.tuberculosis_H37Rv -------------------------------LITTGGGVVPAPLLAELIR * :.. MMAR_5187|M.marinum_M S-AKLVPLRHPG-DVPPEPGYVPSKALADFVRCRDLTCRWPGCDHPALNC MAV_4456|M.avium_104 S-ARLMPLVHPA-DAPPENRYTPSAALADFVRCRDLTCRWPGCDRPATEC MUL_2679|M.ulcerans_Agy99 S-AKLQPMSTP---ILAETGYVPSPALMDFVRARDLTCRAPGCDRPATQC TH_0334|M.thermoresistible__bu T-ATLRPVALP--QPCAEAGYRPSAALTRFIRCRDLTCRFPGCDAPAAVC MAB_4752|M.abscessus_ATCC_1997 G-TPTRNLTDS-----RSTGYRPSAKLAAFVRSRDQLCRFPGCEAVADRA Mflv_1180|M.gilvum_PYR-GCK G-AKIREIIHPG-QAGPEPRYTPSTALADFIRCRDLTCRFPGCDTPATEA Mvan_0728|M.vanbaalenii_PYR-1 E-ATIREIIHPGNRSAPEPRYTPSQALAEFIRCRDLTCRFPGCDKPATEA MSMEG_0144|M.smegmatis_MC2_155 N-ATIRPLKHPG-DTAPEDRYIPSRALADYVRCRDLTCRFPGCDKPADRC Mb2126|M.bovis_AF2122/97 GGATISQVRHPG-DLAAEPHYRPSAKLAEFVRMRDLTCRFPGCDVPAEFC Rv2100|M.tuberculosis_H37Rv GGATISQVRHPG-DLAAEPHYRPSAKLAEFVRMRDLTCRFPGCDVPAEFC : : . . * ** * ::* ** ** ***: * . MMAR_5187|M.marinum_M DLDHTIPYAQGGPTHASNLKCYCRTHHLVKTFWG----WHDQQLPDGTLI MAV_4456|M.avium_104 DLDHTIPYAEGGPTHASNLKCYCRTHHLVKTFWG----WREQQLPDATLI MUL_2679|M.ulcerans_Agy99 DVDHTIPYSDGGATHPSNLKCLCRKHHLLKTFWG----WHDEQLPDATVI TH_0334|M.thermoresistible__bu QIDHTIPYPAG-PTHPSNLKLLCVFHCRQAELRF----THDQHKHQSSCL MAB_4752|M.abscessus_ATCC_1997 DIDHTVPWATGGPTTGANLKALCRKHHLLKTFGQ----WTELQEPDGTVI Mflv_1180|M.gilvum_PYR-GCK DIDHTVAHPVG-PTHASNLKCLCRFHHLLKTFWTGPGGWHDRQHPDGTIT Mvan_0728|M.vanbaalenii_PYR-1 DIDHTVPYPIG-PTHPSNLKCLCRFHHLLKTFWLGATGWHDRQHPDGTIT MSMEG_0144|M.smegmatis_MC2_155 DLDHTVPYPAG-PTHASNLKCLCRFHHLLKTFWTGPRGWTDRQHPDGTIV Mb2126|M.bovis_AF2122/97 DIDHSAPWPLG-PTHPSNLKCACRKHHLLKTFWTG---WRDVQLPDGTVI Rv2100|M.tuberculosis_H37Rv DIDHSAPWPLG-PTHPSNLKCACRKHHLLKTFWTG---WRDVQLPDGTVI ::**: . . * .* :*** * * : : : :.: MMAR_5187|M.marinum_M LTSPAGHTYVTTPGSA--LLFPSLCHSTGGLPAAEADPPSDHCDQRSAMM MAV_4456|M.avium_104 LTSPAGRTYVTTPGSA--LLFPSLCVPTG-EPARPVAAGSQPCGERTAMM MUL_2679|M.ulcerans_Agy99 WSLPDGQTYVTTPGSA--WLLPGLFAPSPELPPP---------------- TH_0334|M.thermoresistible__bu P------AYFQRPHG----------------------------------- MAB_4752|M.abscessus_ATCC_1997 WKSPTGHRYATTPVSW--FLFPAL-------------------------- Mflv_1180|M.gilvum_PYR-GCK WTSPTGHTYITHPGS--RLLFPTLCKPTATL-WTGNPPQNPTNNNRGSMM Mvan_0728|M.vanbaalenii_PYR-1 WTAPTGHTYTTHPGS--RLLFPTLCQPTATL-WTGEPPQVPQSQQRGAMM MSMEG_0144|M.smegmatis_MC2_155 WTSPSGRQYTTVPGSHRRLSITELAAPTGALDLPATPIPTADPDLRGVKM Mb2126|M.bovis_AF2122/97 WTAPNGHTYTTHPGS--RIFFPTWHTTTAEL--PQTSTAAVNVDARGLMM Rv2100|M.tuberculosis_H37Rv WTAPNGHTYTTHPGS--RIFFPTWHTTTAEL--PQTSTAAVNVDARGLMM * * . MMAR_5187|M.marinum_M PRRQRTRAQDRARRVATERRQNHHARSTQPGGQPR--------------- MAV_4456|M.avium_104 PTRRRTRGQNRAARVAAERRANRAARLARATRPAP--------------- MUL_2679|M.ulcerans_Agy99 PRSEATGSLRKPRRDDAQTRPNSRPKLGR--------------------- TH_0334|M.thermoresistible__bu PATRRPPSARGLREAVPRQGVDPRRVSGQ--------------------- MAB_4752|M.abscessus_ATCC_1997 -TRHHTRQQARDRRRRTERNLNREQRLQREAALAA--------------- Mflv_1180|M.gilvum_PYR-GCK PRRTRTRAQNRATYITAERTRNAAHRTDS--------PR----------- Mvan_0728|M.vanbaalenii_PYR-1 PRRRNTRAHNHAAYITAERRRNAQTRYATTGNTPPYLPRDHIPYQSSTGW MSMEG_0144|M.smegmatis_MC2_155 PKRRRTRAQNTARTIAAERKLNDDLVAEH--------------------- Mb2126|M.bovis_AF2122/97 PRRRRTRAAELAHRINAERALNDAYMAER--------------------- Rv2100|M.tuberculosis_H37Rv PRRRRTRAAELAHRINAERALNDAYMAER--------------------- . .. : MMAR_5187|M.marinum_M ---SAAPPTPPQSEPQSHPPPF MAV_4456|M.avium_104 ---AASQSWPAGHGPDADPPPF MUL_2679|M.ulcerans_Agy99 ---THCDRTQPQHD-------- TH_0334|M.thermoresistible__bu ---------------------- MAB_4752|M.abscessus_ATCC_1997 ---LAAKDPPPF---------- Mflv_1180|M.gilvum_PYR-GCK -----GNDPPPF---------- Mvan_0728|M.vanbaalenii_PYR-1 REPDYGNDPPPF---------- MSMEG_0144|M.smegmatis_MC2_155 ------NKPPPF---------- Mb2126|M.bovis_AF2122/97 ------NKPPSF---------- Rv2100|M.tuberculosis_H37Rv ------NKPPSF----------