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LSPTIGSIERMFGAMFAGLDQPTLIAAIEQSAREEAVAGARKLAAIAQLVHSAVTFDDECDRWAYDSWAE AACELGAVLNMGQMRASAQMRIAVALRDRLPKVAELFLAGRLSARLVAEITWRTCLVDDEQVLAVLDGAL AQRALRWGPLSQDRLRCAIDALIERYDPDAVIRAREVINGRDFRIGAHEDPDELVTVWGKVLGCDAVVLA ARIAALLKGICADDPRSEGERRSCAVGAIIQGQDHLPCRCGSPDCTASAPPASSNVVISVIADHAAVAAA RQLIATEDREQQQKHAQNQAKTEPAPEAEAEPTPEPDAEPAGDPVESAPLPVGEDESPEPGPAAGPEVAN PVRCLRDSGVALLPGVKVLPIVALAEAIRAGAAIKSLWLPGPDPEPHYRPSAKLAAFVRARDLFCRYPGC DVPAEHCDIDHVVPYPFGPTHASNLNCTCRTHHLGKTFAEGWQVEQLPDGTVTWTTPAGQHHTTMPGSRL LFPGWDTTTAALPPMAQPPPDPDRVAKMPKRRRTRAAEEAARIKAERECNAVQRALERQRALDQQAAEHN RQAGLPPPAPPPPDYGDDPPPF
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1291 | - | - | 100% (582) | hypothetical protein Mvan_1291 |
| M. vanbaalenii PYR-1 | Mvan_3176 | - | 0.0 | 72.71% (601) | hypothetical protein Mvan_3176 |
| M. vanbaalenii PYR-1 | Mvan_2714 | - | 0.0 | 68.94% (602) | hypothetical protein Mvan_2714 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3805 | - | 1e-118 | 45.86% (556) | hypothetical protein Mb3805 |
| M. gilvum PYR-GCK | Mflv_1272 | - | 0.0 | 69.46% (573) | HNH endonuclease |
| M. tuberculosis H37Rv | Rv3776 | - | 1e-118 | 45.86% (556) | hypothetical protein Rv3776 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4752 | - | 4e-42 | 40.30% (268) | hypothetical protein MAB_4752 |
| M. marinum M | MMAR_5187 | - | 8e-76 | 36.48% (562) | 13e12 repeat-containing protein |
| M. avium 104 | MAV_4456 | - | 2e-61 | 33.57% (566) | 13e12 repeat-containing protein |
| M. smegmatis MC2 155 | MSMEG_5583 | - | 1e-114 | 41.09% (606) | HNH endonuclease |
| M. thermoresistible (build 8) | TH_0334 | - | 6e-37 | 35.09% (265) | HNH endonuclease |
| M. ulcerans Agy99 | MUL_1813 | - | 5e-37 | 35.08% (248) | 13e12 repeat-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1291|M.vanbaalenii_PYR-1 ----------MSPTIGSIERMFGAMFAGLDQPTLIAAIEQSAREEAVAGA
Mflv_1272|M.gilvum_PYR-GCK --------------------MFDSGLAGLDKPALISAIEQAACEEVRAGA
Mb3805|M.bovis_AF2122/97 --------------MFEISLSDPVELRDADDAALLAAIEDCARAEVAAGA
Rv3776|M.tuberculosis_H37Rv --------------MFEISLSDPVELRDADDAALLAAIEDCARAEVAAGA
MSMEG_5583|M.smegmatis_MC2_155 ------MCLLVVPVCDTGCMPFEHTFDDLDDAALVAGIEGCERAQNAAAA
MMAR_5187|M.marinum_M MFESMGVAAGVDHPCDALAERRQLRTPTAESARWVQRIGAAARAENRAAA
MAV_4456|M.avium_104 ------MCEDATAWFDELMER-CYPSATPESAALVQRIGVFARVENRAAA
MUL_1813|M.ulcerans_Agy99 ----------------------------------MERAREASRREAAAAA
MAB_4752|M.abscessus_ATCC_1997 ------------------------MFDELGDVELIDLIASAQRAEAQACA
TH_0334|M.thermoresistible__bu ------------------------MFESLDDGAVVDSIAAASREQSAACG
: : * .
Mvan_1291|M.vanbaalenii_PYR-1 RKLAAIAQLVHSAVTF--DDECDRWAYDSWAEAACELGAVLNMGQMRASA
Mflv_1272|M.gilvum_PYR-GCK RKTAAIAALVHDHVTY--DDVRDEWVWDSWIETACELGAVLNTSHRRASA
Mb3805|M.bovis_AF2122/97 RRLSAIAELT-SRRTG--NDQRADWACDGWDCAAAEVAAALTVSHRKASG
Rv3776|M.tuberculosis_H37Rv RRLSAIAELT-SRRTG--NDQRADWACDGWDCAAAEVAAALTVSHRKASG
MSMEG_5583|M.smegmatis_MC2_155 RKLALVARFTARRAADS-EDEVLRWAGDDWAATAAEVGAALNVGPAVASK
MMAR_5187|M.marinum_M AQLIEIGQLFAYR--LSRCSETEDWAVDTMEAVAAEVAAGLRISQGLAAS
MAV_4456|M.avium_104 EQLAAIGELFAYR--LSRCSECEDWAVDTEAAVSAEVAAQLRIGQGLAAA
MUL_1813|M.ulcerans_Agy99 ERLDVVGALFVLR--CRESGDRAEWATDTWEAVGAQVAAALRTSVAMGSS
MAB_4752|M.abscessus_ATCC_1997 RKLDAIGVLVDRHADLGKPDERDHHALDRWDRVASEVAAAQGITHALASS
TH_0334|M.thermoresistible__bu REMLAIGELYARR-APEDDTERANWAIDGHANVVAEISAALNISRGRAAG
. :. : . * . .::.* .:
Mvan_1291|M.vanbaalenii_PYR-1 QMRIAVALRDRLPKVAELFLAGRLSARLVAEITWRTCLVDDEQVLAVLDG
Mflv_1272|M.gilvum_PYR-GCK QMRIAVALRDRLPGVAALHAQGRLSARLIGQITWRTRLVQDPQALALIDA
Mb3805|M.bovis_AF2122/97 QMHLSLTLN-RLPQVAALFLAGQLSARLVSIIAWRTYLVRDPEALSLLDA
Rv3776|M.tuberculosis_H37Rv QMHLSLTLN-RLPQVAALFLAGQLSARLVSIIAWRTYLVRDPEALSLLDA
MSMEG_5583|M.smegmatis_MC2_155 WMRVAQEVGERLPRVQEMFAAGWLSAQVVATLTWATHLVGDEQVLAIVDA
MMAR_5187|M.marinum_M RLRYARALRERLPKTGAVFAAGQIDLRAFQTIVFRTDLIVDPQVMAAVDA
MAV_4456|M.avium_104 KVRYARAMRERLPRVGEVFRAGEIDFRLFATIVYRTDLITDRRVLAAVDA
MUL_1813|M.ulcerans_Agy99 YLRYAMAMRNRLPKVGQAFRAEDIDYRAFQTIVFRTDLITDAEVLAKVDA
MAB_4752|M.abscessus_ATCC_1997 QMRYAQVLRHRLRAVAERFAAGDLDFRTVALIINRTELVDDEAVVARVDA
TH_0334|M.thermoresistible__bu RLQLAIDLRERLPRVAAVFAAGDIDFRMVSALVNRSRNVVDPDLLARLDA
:: : : ** . . :. : . : : : * :: :*.
Mvan_1291|M.vanbaalenii_PYR-1 ALAQRALRWGPLSQDRLRCAIDALIERYDPDAVIRAREVINGRDFRIGAH
Mflv_1272|M.gilvum_PYR-GCK AIAEKATRWEPLSEDNLTAALDAVIERFDPDAVIRTREQLKGVDFRIGAS
Mb3805|M.bovis_AF2122/97 ALAKHATAWGPLSAPKLEKAIDSWIDRYDPAALRRTRISARSRDLCIGDP
Rv3776|M.tuberculosis_H37Rv ALAKHATAWGPLSAPKLEKAIDSWIDRYDPAALRRTRISARSRDLCIGDP
MSMEG_5583|M.smegmatis_MC2_155 QLAARAREFGPMTVDGVKAAVASLLEKYDPAAVRRSREASRDRDVRFGKP
MMAR_5187|M.marinum_M LVALNVGRWPSMTKARLSGQIDAIVARADADAVRRRKERHADREIWIGQD
MAV_4456|M.avium_104 ELAATAARWPSMTRARLAARVDAVVAKADADAVRRTEKQAASRHVWIAEM
MUL_1813|M.ulcerans_Agy99 QLAALLARCPAVTRGRLSVAVDQVVADVDRDVVRRVAEAADGRFVDVDVI
MAB_4752|M.abscessus_ATCC_1997 AIVRALPRWARWSHKRITAALDALVLHFDQDAVRRNRSATDKRHLEIRPL
TH_0334|M.thermoresistible__bu ALAAWSPKWMKLSGPTLNERIDMWVERFDPTGVREPRSPGEDRYVVVTPA
:. : : : : * : . . .
Mvan_1291|M.vanbaalenii_PYR-1 EDPDELVTVWGKVLGCDAVVLAARIAALLKGICADDPRSEGERRSCAVGA
Mflv_1272|M.gilvum_PYR-GCK DDPDALVTVWGKILGCDAVVLAARIAELLKGLCDADPRGIGERRSCAVGA
Mb3805|M.bovis_AF2122/97 DEDAGTAALWGRLFATDAAMLDKRLTQLAHGVCDDDPRTIAQRRADALGA
Rv3776|M.tuberculosis_H37Rv DEDAGTAALWGRLFATDAAMLDKRLTQLAHGVCDDDPRTIAQRRADALGA
MSMEG_5583|M.smegmatis_MC2_155 DDVTGTVSISGRVNTADAVAYQKRSAHLTGGVCGDDPRTAGQRRADAFGV
MMAR_5187|M.marinum_M ADG--ISRIDGSMFTIDAHALDRRLSALAATVCAQDPRSREQRRADALGV
MAV_4456|M.avium_104 GEG--LSHLEGTVSSPDAHALDKRLDALAATVCEHDPRTGEQRRADALGA
MUL_1813|M.ulcerans_Agy99 ADGSGLAALAGSVLATAGRAFDRRLDELANTVCAADPRTREQRRADAVGA
MAB_4752|M.abscessus_ATCC_1997 GNGEPVAEVWGTLQAVHAVALDKRLDLLAGTVCPADPRSKTQRRADAVGA
TH_0334|M.thermoresistible__bu GQG--MVDVSARLTFEAGFAFXTRLDQIAATVCRDDPRTADQRRADAMAA
: : . : . * : :* *** :**: *...
Mvan_1291|M.vanbaalenii_PYR-1 IIQGQDHLPCRCGSPDCTAS--APPASSNVVISVIADHAAVAAARQLIAT
Mflv_1272|M.gilvum_PYR-GCK IVRGQDHLPCRCGSPDCAAAP-VVPGSSNVVISVLADPAALEAVRSLIAD
Mb3805|M.bovis_AF2122/97 LAAGADRLTCGCGNSDCPSSAGNHRQATGVVIHVVADAAALGAAPDPRLS
Rv3776|M.tuberculosis_H37Rv LAAGADRLTCGCGNSDCPSSAGNHRQATGVVIHVVADAAALGAAPDPRLS
MSMEG_5583|M.smegmatis_MC2_155 IAVQGDRLVCLCGDPQCPWAG-VDPRAANTMVHIFAEPSVVDAKPDPYVH
MMAR_5187|M.marinum_M LAAGGDRLGCRCGLPDC-AAG-ARPAAQPVVIHVIAERATLDGDGGA---
MAV_4456|M.avium_104 LAAGADRLGCRCGRADC-AAG-TRPAAGPVVIHLIAERASVEGTGGG---
MUL_1813|M.ulcerans_Agy99 LVAGSDRLACGCTSADC-TAA-ARSAPSKVVIHVVADQSTVDGTGHT---
MAB_4752|M.abscessus_ATCC_1997 LTQGLNRMRCACGHPDC-SGR-D-TADVPVVVNVVINQSTLAGSDDC---
TH_0334|M.thermoresistible__bu MSEGQNRLVCGCGSEDCPADP-ADTAATRLVINVIAEQATVEGRSDN---
: ::: * * :* :: :. : : : .
Mvan_1291|M.vanbaalenii_PYR-1 EDREQQQKHAQNQAKTEPAPEAEAEPTPEPDAEP----------------
Mflv_1272|M.gilvum_PYR-GCK EDRHQQDALAEKQ-------------------------------------
Mb3805|M.bovis_AF2122/97 G-------------------------------------------------
Rv3776|M.tuberculosis_H37Rv G-------------------------------------------------
MSMEG_5583|M.smegmatis_MC2_155 GDYASNPVPFVDPEFDPWPVYPERDSTPPPEPPSEPQWAPQWWSEIPLPP
MMAR_5187|M.marinum_M --------------------------------------------------
MAV_4456|M.avium_104 --------------------------------------------------
MUL_1813|M.ulcerans_Agy99 --------------------------------------------------
MAB_4752|M.abscessus_ATCC_1997 --------------------------------------------------
TH_0334|M.thermoresistible__bu --------------------------------------------------
Mvan_1291|M.vanbaalenii_PYR-1 -------------------------AGDPVESAPLPVGEDES--------
Mflv_1272|M.gilvum_PYR-GCK ---------------------------------PHAVKAKEQ--------
Mb3805|M.bovis_AF2122/97 ---------------------------------PEPALAPEA--------
Rv3776|M.tuberculosis_H37Rv ---------------------------------PEPALAPEA--------
MSMEG_5583|M.smegmatis_MC2_155 EPEPEPEPEPEPEPEPEPEPELRFESEPQTASAPQPEPEPEARPEPQPKT
MMAR_5187|M.marinum_M --------------------------------------------------
MAV_4456|M.avium_104 --------------------------------------------------
MUL_1813|M.ulcerans_Agy99 --------------------------------------------------
MAB_4752|M.abscessus_ATCC_1997 --------------------------------------------------
TH_0334|M.thermoresistible__bu --------------------------------------------------
Mvan_1291|M.vanbaalenii_PYR-1 ---PEPGPAAGPEVANPVRCLRDSG--------------------VALLP
Mflv_1272|M.gilvum_PYR-GCK ---GEP---AAPAPSNRGRCVRDSG--------------------TALLP
Mb3805|M.bovis_AF2122/97 ---PAT-----PAVKPP----------------------------AALIS
Rv3776|M.tuberculosis_H37Rv ---PAT-----PAVKPP----------------------------AALIS
MSMEG_5583|M.smegmatis_MC2_155 GPEPEPVSTPKPQPQDPPAAAESWGGGGVNPLVVAPAPVVSPQRATAVIV
MMAR_5187|M.marinum_M ---------------------------------------------PAWEV
MAV_4456|M.avium_104 ---------------------------------------------PAVEV
MUL_1813|M.ulcerans_Agy99 ---------------------------------------------PAVLL
MAB_4752|M.abscessus_ATCC_1997 ---------------------------------------------PAHVP
TH_0334|M.thermoresistible__bu ---------------------------------------------PGYLP
.
Mvan_1291|M.vanbaalenii_PYR-1 GVKVLPIVALAEAIRAGAAIKSLWLPG-PDPEPHYRPSAKLAAFVRARDL
Mflv_1272|M.gilvum_PYR-GCK GVKILPIVALAEAIRAGAAIKQLWLPG-PDPEPHYRPSAKLAAFVRARDL
Mb3805|M.bovis_AF2122/97 GGGVVPAPLLAELIRGGAALSRVRHPGDLRSEPHYRPSAKLAEFVRIRDM
Rv3776|M.tuberculosis_H37Rv GGGVVPAPLLAELIRGGAALSRMRHPGDLRSEPHYRPSAKLAEFVRIRDM
MSMEG_5583|M.smegmatis_MC2_155 GGGLVPASYVAQMIASGAKVKQGRVPL-EDPESGYRPSVGLAEFVRMRDL
MMAR_5187|M.marinum_M GADGLVTPELVAELAKSAKLVPLRHPGDVPPEPGYVPSKALADFVRCRDL
MAV_4456|M.avium_104 GAEGLLPAQLVAELAASARLMPLVHPADAPPENRYTPSAALADFVRCRDL
MUL_1813|M.ulcerans_Agy99 GAEGLIPASLIAELAKVATLRPLMRPSGRP-ESGYAPSAGLAEFVRCRDL
MAB_4752|M.abscessus_ATCC_1997 GFG-----VLAAESARAAVAGTPTRNLTDSRSTGYRPSAKLAAFVRSRDQ
TH_0334|M.thermoresistible__bu GYG-AVPASILRAKAATATLRPVALP-QPCAEAGYRPSAALTRFIRCRDL
* : * . * ** *: *:* **
Mvan_1291|M.vanbaalenii_PYR-1 FCRYPGCDVPAEHCDIDHVVPYPFG-PTHASNLNCTCRTHHLGKTFAEGW
Mflv_1272|M.gilvum_PYR-GCK FCRYPGCNVPAEQCDIDHVVPWPYG-PTHPSNLNCKCRTHHLGKTFAEGW
Mb3805|M.bovis_AF2122/97 TCRFPGCDQPTEFCDIDHTLPYPLG-PTHPSNLKCLCRKHHLLKTFWTGW
Rv3776|M.tuberculosis_H37Rv TCRFPGCDQPTEFCDIDHTLPYPLG-PTHPSNLKCLCRKHHLLKTFWTGW
MSMEG_5583|M.smegmatis_MC2_155 TCRFPGCGRPAECCDIDHTEPFPGG-VTHASNIKCLCRFHHLIKTFWAGF
MMAR_5187|M.marinum_M TCRWPGCDHPALNCDLDHTIPYAQGGPTHASNLKCYCRTHHLVKTFWG-W
MAV_4456|M.avium_104 TCRWPGCDRPATECDLDHTIPYAEGGPTHASNLKCYCRTHHLVKTFWG-W
MUL_1813|M.ulcerans_Agy99 TCRARGCDQPAVCCDLDHTVAYGDGGHTHASNLKCLCRKHHLLKTFWG-W
MAB_4752|M.abscessus_ATCC_1997 LCRFPGCEAVADRADIDHTVPWATGGPTTGANLKALCRKHHLLKTFGQ-W
TH_0334|M.thermoresistible__bu TCRFPGCDAPAAVCQIDHTIPYPAG-PTHPSNLKLLCVFHCRQAELRF-T
** ** : .::**. .: * * :*:: * * :
Mvan_1291|M.vanbaalenii_PYR-1 QVEQLPDGTVTWTTPAGQHHTTMPGSRLLFPGWDTTTAALPPMAQPPPD-
Mflv_1272|M.gilvum_PYR-GCK HEEQLPDGTVIWTTPAGQRYSTVPGSRLFFPGWDTTTAELPPMAQPPPD-
Mb3805|M.bovis_AF2122/97 RDVQLPDGTIIWTAPNGHTYTTHPDSRIFLPSWHTTTAALPPAPSPPAIG
Rv3776|M.tuberculosis_H37Rv RDVQLPDGTIIWTAPNGHTYTTHPDSRIFLPSWHTTTAALPPAPSPPAIG
MSMEG_5583|M.smegmatis_MC2_155 VDTQLPDGQVVWTMPSGRTYTTVPGSRWVFPQWDTTTTTLPPPP-PRATS
MMAR_5187|M.marinum_M HDQQLPDGTLILTSPAGHTYVTTPGSALLFPSLCHSTGGLPAAEADPP--
MAV_4456|M.avium_104 REQQLPDATLILTSPAGRTYVTTPGSALLFPSLCVPTG-EPARPVAAG--
MUL_1813|M.ulcerans_Agy99 RDLQLPDGTVIWLLPDGHTYVTTPGSALLFPNLCVPTGELPPIVGTAGKP
MAB_4752|M.abscessus_ATCC_1997 TELQEPDGTVIWKSPTGHRYATTPVSWFLFPALT----------------
TH_0334|M.thermoresistible__bu HDQHKHQSSCLPAYFQRPHGPAT---------------------------
: :. :
Mvan_1291|M.vanbaalenii_PYR-1 -----------------------PDRVAKMP-----KRRRTR-------A
Mflv_1272|M.gilvum_PYR-GCK -----------------------PDRLAKMP-----KRRRTR-------A
Mb3805|M.bovis_AF2122/97 -----------------------PTHTLLMP-----RRRRTR-------A
Rv3776|M.tuberculosis_H37Rv -----------------------PTHTLLMP-----RRRRTR-------A
MSMEG_5583|M.smegmatis_MC2_155 -----------------------PARGVMMP-----QRKLTR-------A
MMAR_5187|M.marinum_M --------SDHCD-----------QRSAMMP-----RRQRTR-------A
MAV_4456|M.avium_104 --------SQPCG-----------ERTAMMP-----TRRRTR-------G
MUL_1813|M.ulcerans_Agy99 PRWPSGEDADPCPNPRTKPGESHRHRAPMQSQGTGSRRRRPRRPVRHPGA
MAB_4752|M.abscessus_ATCC_1997 -------------------------------------RHHTR-------Q
TH_0334|M.thermoresistible__bu -------------------------------------RRPPS--------
*: .
Mvan_1291|M.vanbaalenii_PYR-1 AEEAARIKAERECNAVQRALERQRALDQQAAEHNRQAGLPPPAPPPPDYG
Mflv_1272|M.gilvum_PYR-GCK ADHAARIKAEREDNAHQRALETERAA-------ARRSGLPPPAP--PDYG
Mb3805|M.bovis_AF2122/97 AELAHRIKRER-AHVTQRNKPPPSGGD-----TAVAEGFEPPDG-VSRLS
Rv3776|M.tuberculosis_H37Rv AELAHRIKRER-AHVTQRNKPPPSGGD-----TAVAEGFEPPDG-VSRLS
MSMEG_5583|M.smegmatis_MC2_155 EQRARQIRAERARNEKYLS----------------ERNKPPPQ-------
MMAR_5187|M.marinum_M QDRARRVATERRQNHHARSTQPGGQPR--------SAAPPTPPQSEPQS-
MAV_4456|M.avium_104 QNRAARVAAERRANRAARLARATRPAP--------AASQSWPAGHGPDA-
MUL_1813|M.ulcerans_Agy99 GNRSRRAAALLAATSLGTCQIPRRIAP--------RPGPSRSSRGCTDSG
MAB_4752|M.abscessus_ATCC_1997 QARDRRRRTERNLNREQRLQREAALAA--------LAAK-----------
TH_0334|M.thermoresistible__bu -ARGLREAVPRQGVDPRRVSGQ----------------------------
:
Mvan_1291|M.vanbaalenii_PYR-1 D---------DPPPF---
Mflv_1272|M.gilvum_PYR-GCK D---------DPPPF---
Mb3805|M.bovis_AF2122/97 L---------SRRVH---
Rv3776|M.tuberculosis_H37Rv L---------SRRVH---
MSMEG_5583|M.smegmatis_MC2_155 ------------------
MMAR_5187|M.marinum_M ----------HPPPF---
MAV_4456|M.avium_104 ----------DPPPF---
MUL_1813|M.ulcerans_Agy99 TRMGESSMSARPRACVAG
MAB_4752|M.abscessus_ATCC_1997 ----------DPPPF---
TH_0334|M.thermoresistible__bu ------------------