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M. gilvum PYR-GCK Mflv_4521 (-)

annotation: putative GAF sensor protein
coordinates: 4815211 - 4817766
length: 851

ADDRNLPAFRRHGRQEGDRTDAEFDELIAARNQMDHLVRAIVAIGSDLDFSVTLERIVTAARELSGARYA
GLGIRAAGGNLVSFVESGDEFDVAALAGLPIDGGLRIDDLRDHPEITDLQALNRPIRALLAIPVTVRGAD
FGSLYLADDRPGRVFSDAQESAVRALATAAAAAIDNARLFEREREAARWTKASREITTALLSGDPQTGPL
QLIVNRALELAGAEQAILLVPLEPDVPAEDVDTLIVAATAGRYSSEVIGRQVPMAGSTTGGVARRGLPMI
TDSFQYPIEGFTDVGERSAIVMPLIVDDAVLGVIAVARRPNQPAFDEDYLELVSDFARHASIALALAAGR
EHALNRQLAQADSVSEAMAGAAEELRRLWRARRVLAVTFPTRSEAADVEPVVVSAGEHTTWRELPDGIRQ
ILLSMRRGDLLTPNAAEPGTAGIAVQHPEGILVVWIELAEHRSFTLEDQTLLTVLAGRLSAGLQRVHQVD
QQRETALALQHAILGPAHLPPGFTVRYQAASRPLQVGGDWYDVVDLDDGRIALIVGDCVGHGLAAATVMG
QVRSACRALLLENPSPGAALSGMDRFAARLPGAQCTTAVVMVLDPASGEIAYSSAGHPPPLVVHADGEVE
TFDDAHTIALGLRLNWVRPETRRTLEVGSTLVLYTDGLVERRRIPLEEGISRATDVVVEHRAAPLDDLAN
AIMSELAPSVGYQDDVALLLYRHPAPLELTFPAHADHLAPTRTALRRWLSGAKVEQGRVMEVLVAAGEAV
ANAIEHGHRHGPPGTVRLRATALVDLVELIITDSGSWKPPSAIPDTYRGRGIGIMRGLMQDVTIAHDSDG
TTIHLYARIS*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. gilvum PYR-GCKMflv_4521--100% (851)putative GAF sensor protein
M. gilvum PYR-GCKMflv_4423-e-17060.60% (500) multi-sensor signal transduction histidine kinase
M. gilvum PYR-GCKMflv_3844-5e-4435.42% (336) GAF sensor signal transduction histidine kinase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2052c-1e-4933.90% (354) histidine kinase response regulator
M. tuberculosis H37RvRv2027c-1e-4933.90% (354) histidine kinase response regulator
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_3890c-2e-4334.10% (349) histidine kinase response regulator
M. marinum MMMAR_5186-1e-9540.08% (514) sensor-component of a two-component regulator
M. avium 104MAV_2108-0.070.72% (830) stage II sporulation protein E (SpoIIE)
M. smegmatis MC2 155MSMEG_3941-8e-5742.48% (339) GAF family protein
M. thermoresistible (build 8)TH_2781-3e-9539.42% (515) PUTATIVE stage II sporulation protein E (SpoIIE)
M. ulcerans Agy99MUL_3853rsbU8e-5233.25% (400) regulator of sigma subunit, anti-anti-sigma factor RsbU
M. vanbaalenii PYR-1Mvan_3797-0.074.58% (826) putative GAF sensor protein

CLUSTAL 2.0.9 multiple sequence alignment


Mb2052c|M.bovis_AF2122/97           MTHPDRANVNPGSPPVRETLSQLRLRELLLEVQDRIEQIVEG-RDRLDGL
Rv2027c|M.tuberculosis_H37Rv        MTHPDRANVNPGSPPLRETLSQLRLRELLLEVQDRIEQIVEG-RDRLDGL
MAB_3890c|M.abscessus_ATCC_199      MVEDVGAQPNR----VTAELAHLQLRELLAEVQGRIEQIVDGTRGRMDAL
MSMEG_3941|M.smegmatis_MC2_155      ------------------------------MGQSHTDDSPEAVEVRMAAL
MAV_2108|M.avium_104                --------------------------------MHTRLDELMAARDQLEQL
Mvan_3797|M.vanbaalenii_PYR-1       ------------------------------------MDELVAARDQMERL
Mflv_4521|M.gilvum_PYR-GCK          ------------MADDRNLPAFRRHGRQEGDRTDAEFDELIAARNQMDHL
MMAR_5186|M.marinum_M               ----------------------------------MTETGDFGAVDAFQTQ
TH_2781|M.thermoresistible__bu      ------------------------------------MSPDFGAR------
MUL_3853|M.ulcerans_Agy99           --------------------------MLLLDLLRQRTYSFVRSVHRRDGY
                                                                                      

Mb2052c|M.bovis_AF2122/97           IDAILAITSGLKLDATLRAIVHTAAELVDARYGALGVRGYDHRLVEFVYE
Rv2027c|M.tuberculosis_H37Rv        IDAILAITSGLKLDATLRAIVHTAAELVDARYGALGVRGYDHRLVEFVYE
MAB_3890c|M.abscessus_ATCC_199      LDAVMAVSSGLELDATLREIVCAASELVSARYGALGVVGSDEKLAEFVYE
MSMEG_3941|M.smegmatis_MC2_155      LQDMASLDAGLEPESTLHGILDAIMRVSGACYGAAGLCAPDGTPATFLQA
MAV_2108|M.avium_104                VRVIAEIGSDLDLDVTLRRVLKAAMELTGARYAVLSSRASDGGLLSFVHA
Mvan_3797|M.vanbaalenii_PYR-1       VRVIVAIGADLDLDVTLRRIVTGARELSGARYGALGIRGADGTWASFVCD
Mflv_4521|M.gilvum_PYR-GCK          VRAIVAIGSDLDFSVTLERIVTAARELSGARYAGLGIRAAGGNLVSFVES
MMAR_5186|M.marinum_M               YADALRAYLDTRDENSLAVGHEFGRRALQEQISILDIIENHFRLLDEISP
TH_2781|M.thermoresistible__bu      YAAALAAYLEDSSERRLAVAHDLGRQALLGRISVLQIVEDHVRLVDELSR
MUL_3853|M.ulcerans_Agy99           MAAEMDWDKNVGTANTVRRIFENVPTMLVGLEGPEHRFVAANAAYRRFSP
                                                    :               .              .  

Mb2052c|M.bovis_AF2122/97           GIDEETRHLIGSLPEGRGVLGALIEEPKPIRLDDISRHPASVGFPLHHPP
Rv2027c|M.tuberculosis_H37Rv        GIDEETRHLIGSLPEGRGVLGALIEEPKPIRLDDISRHPASVGFPLHHPP
MAB_3890c|M.abscessus_ATCC_199      GIDEATRDLIGPLPTGHGVLGVVIDEAKPLRLRDIAAHPASVGFPANHPP
MSMEG_3941|M.smegmatis_MC2_155      G---ALAQAVPDSPD-RDMLGFLRNRTGPLRIDGLARSAAEVGLPELLPP
MAV_2108|M.avium_104                GLDADTARQLGELAVGDGLR-----------IDDVSVDPRSAHLSAHDPP
Mvan_3797|M.vanbaalenii_PYR-1       GMEEDAARALGGLAAGEGIR-----------IDDLTGYSGVAGLRSQKTP
Mflv_4521|M.gilvum_PYR-GCK          GDEFDVA-ALAGLPIDGGLR-----------IDDLRDHPEITDLQALNRP
MMAR_5186|M.marinum_M               NPGSDRSVALEFLLQTLAAL-----------------DVATRGFLDGTKR
TH_2781|M.thermoresistible__bu      RQPVDTDTALQFLLQALAAV-----------------DVAVRGYLEGTRR
MUL_3853|M.ulcerans_Agy99           TFTAVGQPAREVYPELESQQ-----------IYHMLDRVYETGEPQSGAE
                                                                                      

Mb2052c|M.bovis_AF2122/97           MRTFLGVPVRIRDEVFGNLYLTEKADGQPFSDDDEVLVQALAAAAGIAVD
Rv2027c|M.tuberculosis_H37Rv        MRTFLGVPVRIRDEVFGNLYLTEKADGQPFSDDDEVLVQALAAAAGIAVD
MAB_3890c|M.abscessus_ATCC_199      MRTFLGVPVQVRGEVFGRLYLTEKLDGQEFTEDDEVVVRALAGAAGIAIE
MSMEG_3941|M.smegmatis_MC2_155      MRAVLGVPLVSHGEVLGSLYVADSRAGFEFSDAHVGVVEVLATVAADVVH
MAV_2108|M.avium_104                LRALLGIPITVRAANFGNLYLADDRQGRVFTDSQEGAVRAMATAAAAAID
Mvan_3797|M.vanbaalenii_PYR-1       MRALLGVPITVRGADFGALYLADDQPDRVFSDSQEGAVRALATAAAAAID
Mflv_4521|M.gilvum_PYR-GCK          IRALLAIPVTVRGADFGSLYLADDRPGRVFSDAQESAVRALATAAAAAID
MMAR_5186|M.marinum_M               YEEQRARAEDLAHRDKFRSALVNSLQEGFFVADDEGAVIDMNSAFAEILG
TH_2781|M.thermoresistible__bu      YEQQRARAEGLAGRDTFRSALVNAMQEAFFVMDRTGSVIDINEAFAEITG
MUL_3853|M.ulcerans_Agy99           WRLQADFDGSGIDERYFDFLVTPRRREDGSIEGVQILFDDVTTRVRARLA
                                     .                  :.               .  :         

Mb2052c|M.bovis_AF2122/97           NARLFEESRTREAWIEATRDIGTQMLAGAD--PAMVFRLIAEEALTLMAG
Rv2027c|M.tuberculosis_H37Rv        NARLFEESRTREAWIEATRDIGTQMLAGAD--PAMVFRLIAEEALTLMAG
MAB_3890c|M.abscessus_ATCC_199      NARLYQHARRREQWQRATADITAELLGGVD--PGKALHLVASSAALLAEA
MSMEG_3941|M.smegmatis_MC2_155      SVWHLAKVRTVARWVSASREITMALLGMSGG-EDAPLRLIVGRAAELTVA
MAV_2108|M.avium_104                NARLFERERESAKWTKASREITTALLSGDP--QTGPLQLIVNRALELAGA
Mvan_3797|M.vanbaalenii_PYR-1       NARLFERERESAKWTKASREITTALLSGDP--QTGPLQLIVNLALELADA
Mflv_4521|M.gilvum_PYR-GCK          NARLFEREREAARWTKASREITTALLSGDP--QTGPLQLIVNRALELAGA
MMAR_5186|M.marinum_M               YPPEGLPYRWPHPWLVDRKSAAQQQERVRHEGSADYETPVRHQDGHLSWV
TH_2781|M.thermoresistible__bu      YDGHDLPYRWPHPWVVDEPRADEDLLELLQHGRVQLERQIRHRSGHLAWV
MUL_3853|M.ulcerans_Agy99           AEARVEELSERYRHLRDSAIVMQQALLAPS-------VPVVSGPDIAAQY
                                                                           :          

Mb2052c|M.bovis_AF2122/97           AATLVAVPLDDEAPACEVDDLVIVEVAGEISPAVKQMTVAVSGTSIGGVF
Rv2027c|M.tuberculosis_H37Rv        AATLVAVPLDDEAPACEVDDLVIVEVAGEISPAVKQMTVAVSGTSIGGVF
MAB_3890c|M.abscessus_ATCC_199      DFAFIALPAGDEE---DTAELVVAVCEGKGAEVLNDKLIPIDGSTSGSTF
MSMEG_3941|M.smegmatis_MC2_155      SQAAILVPSEADRAPEEVRSLTVAVAAGARADEVEGQQVPVSGSTSGRVF
MAV_2108|M.avium_104                EQAILLVPREPESPGREADTLVVSATAGRYASQVIGRQVPMDGSTTGGVA
Mvan_3797|M.vanbaalenii_PYR-1       EQAILLVPGEPDLPGDEADTLVVAATAGRYASEVIGRQVPMDGSTTGGVA
Mflv_4521|M.gilvum_PYR-GCK          EQAILLVPLEPDVPAEDVDTLIVAATAGRYSSEVIGRQVPMAGSTTGGVA
MMAR_5186|M.marinum_M               AVSINAVRGSGSDRDVYVGTVRDITAERAFAARESAVLRLATSVSVAKSV
TH_2781|M.thermoresistible__bu      AISVNVVNPNGT---AFVGTMRDITAAHKAAARESALTRLATAAGVATSV
MUL_3853|M.ulcerans_Agy99           LVAAQDTAAGGDWFDAVALGDRLVLIVGDVVGHGVEAAAVMSQLRTALRL
                                      :              .                            .   

Mb2052c|M.bovis_AF2122/97           HDRTPRRFDRLDLAVDG--PVEPGPALVLPLRAADTVAGVLVALRSADEQ
Rv2027c|M.tuberculosis_H37Rv        HDRTPRRFDRLDLAVDG--PVEPGPALVLPLRAADTVAGVLVALRSADEQ
MAB_3890c|M.abscessus_ATCC_199      IDHEPRNVGRLAVNLAEGTDLAFGPALVLPLGGGESTAGVLILLRTVGAI
MSMEG_3941|M.smegmatis_MC2_155      RTGESTMTDGFRYPITSFTDQGRRPAIVVPLRSATNNLGVIAVARDADDP
MAV_2108|M.avium_104                RRGLPLITDSFQYPIEGFTDVGERSAIVIPLIADGAVLGVIAVARDPQQP
Mvan_3797|M.vanbaalenii_PYR-1       RRGLPLITDSFQYPIEGFTDAGERSAIVMPLIADEAVLGVIAVARRPHQP
Mflv_4521|M.gilvum_PYR-GCK          RRGLPMITDSFQYPIEGFTDVGERSAIVMPLIVDDAVLGVIAVARRPNQP
MMAR_5186|M.marinum_M               SEVLSITLEECRTAVDV-------QRVVAVMWPPSDGEPTVQVAGEPAES
TH_2781|M.thermoresistible__bu      SEVLSIMLDECRPAIDS-------RRVIAVTWAREDAEPTIQVVGDPPAS
MUL_3853|M.ulcerans_Agy99           QIAAGRSIGEALEALDAFHEHVPGSNSATLCVGSLDFTTGEFQYCTAGHP
                                                  :                                   

Mb2052c|M.bovis_AF2122/97           PFSDKQLDMMAAFADQAALAWRLATAQRQMR-EVEILTDRDRIARDLHDH
Rv2027c|M.tuberculosis_H37Rv        PFSDKQLDMMAAFADQAALAWRLATAQRQMR-EVEILTDRDRIARDLHDH
MAB_3890c|M.abscessus_ATCC_199      AFDEEQLDMAASFAGQAALALEQAEVRLAKH-ELDVLADRDRIARDLHDH
MSMEG_3941|M.smegmatis_MC2_155      PFDVDEMAIMEDFAHHAAVALTLCRANEQAR-QLTVLSDRERIARDLHDH
MAV_2108|M.avium_104                PFGNDYLDLVSDFARHAAIALALAAGRQHALNQELAQADTVDEAVRAAAE
Mvan_3797|M.vanbaalenii_PYR-1       PFDNDYLELVSDFARHAAIALALAAGREHALNQELAQADSVDAALHAAAE
Mflv_4521|M.gilvum_PYR-GCK          AFDEDYLELVSDFARHASIALALAAGREHALNRQLAQADSVSEAMAGAAE
MMAR_5186|M.marinum_M               SWRALDPQLRETFLGARAQLPLTARPIEWPDSPGRAQG-LVAVLSGTADV
TH_2781|M.thermoresistible__bu      TWADLDESLRTTLLAARDWPPLTVQPVSDAG-QNTSRG-IVAVLSGTPAT
MUL_3853|M.ulcerans_Agy99           PPLVVTAEAKARYLEPSGAGPLGSDTGFPVRTELIGVGDVVLLYTDGLIE
                                    .                                                 

Mb2052c|M.bovis_AF2122/97           VIQRLFAVGLTLQGAAP---------------------------------
Rv2027c|M.tuberculosis_H37Rv        VIQRLFAVGLTLQGAAP---------------------------------
MAB_3890c|M.abscessus_ATCC_199      VIQRLFAVGLAMQSTHR---------------------------------
MSMEG_3941|M.smegmatis_MC2_155      VIQRLFLAGMDLQGTIA---------------------------------
MAV_2108|M.avium_104                ELRRLWRARRVLAVTFPSHTSATETAFGPPEVVSVGEPTQWADLPSHMHQ
Mvan_3797|M.vanbaalenii_PYR-1       ELRRLWRARRVLAVTFPTHGDSVESA---PKVVAVGEDTHWADLSAPTRL
Mflv_4521|M.gilvum_PYR-GCK          ELRRLWRARRVLAVTFPTRSEAADVE---PVVVSAGEHTTWRELPDGIRQ
MMAR_5186|M.marinum_M               ALWLELGAPRWVT--AE---------------------------------
TH_2781|M.thermoresistible__bu      VLWLEHRVPRPVG--ID---------------------------------
MUL_3853|M.ulcerans_Agy99           RPGRPLGASTAEFADLA---------------------------------
                                           .                                          

Mb2052c|M.bovis_AF2122/97           ------------------------------------------------RA
Rv2027c|M.tuberculosis_H37Rv        ------------------------------------------------RA
MAB_3890c|M.abscessus_ATCC_199      ------------------------------------------------RS
MSMEG_3941|M.smegmatis_MC2_155      ------------------------------------------------RT
MAV_2108|M.avium_104                ALGSLRDGDLLTPNTTQPGTAGIALQHPDGVLVVWIDLTDERSFTLEDQT
Mvan_3797|M.vanbaalenii_PYR-1       TLSALRDGDLLTPNTAQPGTAGIAMQHPEGILVVWLDLTDQRSFTLEDQT
Mflv_4521|M.gilvum_PYR-GCK          ILLSMRRGDLLTPNAAEPGTAGIAVQHPEGILVVWIELAEHRSFTLEDQT
MMAR_5186|M.marinum_M               -----------------------------------------------DRL
TH_2781|M.thermoresistible__bu      -----------------------------------------------GRR
MUL_3853|M.ulcerans_Agy99           --------------------------------------------------
                                                                                      

Mb2052c|M.bovis_AF2122/97           RVPAVRESIYSSIDDLQEIIQEIRSAIFDLHAGP---SRATGLRHRLDKV
Rv2027c|M.tuberculosis_H37Rv        RVPAVRESIYSSIDDLQEIIQEIRSAIFDLHAGP---SRATGLRHRLDKV
MAB_3890c|M.abscessus_ATCC_199      VDPTVAARLADHIDQLHEVIQEIRTAIFDLHTN------DESLRATLRST
MSMEG_3941|M.smegmatis_MC2_155      KSDLLKERLSRTVDDLQSIIDEIRTAIFDLQSPA---ASAMSFRQRIQAA
MAV_2108|M.avium_104                LLTVLAGRLGQGLQRVHQVDQQRETALALQHAILGPADLPNGFAVRYQAA
Mvan_3797|M.vanbaalenii_PYR-1       LLTVLAGRLSQGLQRVHRVDQQRETALALQHAILGPADLPHGFAVRYQAA
Mflv_4521|M.gilvum_PYR-GCK          LLTVLAGRLSAGLQRVHQVDQQRETALALQHAILGPAHLPPGFTVRYQAA
MMAR_5186|M.marinum_M               LVTVLVGHLSLAIGHVRQFESARETSLTLQRAMLPPVKPPPGFAVRYEPA
TH_2781|M.thermoresistible__bu      LINALVGHVSLAVQHVRRFEIARESSLTLQRAMLPDIVPPPGFAVRYEPA
MUL_3853|M.ulcerans_Agy99           -ANITSGGGFVIDAQSRPIDRLCSETLELLLRSTGYNDDITLLAVQRRAP
                                                    : .      ::               :       

Mb2052c|M.bovis_AF2122/97           IDQLAIP-ALHTTVQYTG---PLSVVDTVLANHAEAVLREAVSNAVRHAN
Rv2027c|M.tuberculosis_H37Rv        IDQLAIP-ALHTTVQYTG---PLSVVDTVLANHAEAVLREAVSNAVRHAN
MAB_3890c|M.abscessus_ATCC_199      INELTAETGLRVSVRMSG---PLDVVPASTSGDAEAVVREAVSNVVRHAR
MSMEG_3941|M.smegmatis_MC2_155      VAAVTDNSPLATTVRISG---PIVAVDPALADDAEAVIVEAISNAVRHSG
MAV_2108|M.avium_104                TRPLQVGGDWFDIVDLEDGRVALVVGDCVGHGLASATVMGQVRSACRALL
Mvan_3797|M.vanbaalenii_PYR-1       SRPLQVGGDWYDVVDLDDGRIAMIVGDCVGHGLPAATVMGQVRSACRALL
Mflv_4521|M.gilvum_PYR-GCK          SRPLQVGGDWYDVVDLDDGRIALIVGDCVGHGLAAATVMGQVRSACRALL
MMAR_5186|M.marinum_M               VPPLEIGGDWYDVLPIGEHRIGIVVGDCVGRGLPAAAIMGQLRSSARALL
TH_2781|M.thermoresistible__bu      VRPLEIGGDWYDVLPLDDHQIGIIVGDCVGRGLPAAAVMGQLRSSARALL
MUL_3853|M.ulcerans_Agy99           TPPLNITEDATIHAARAIRSRLRQWLSEIGADSGDISDIVHAISEFVENA
                                       :                           .           .      

Mb2052c|M.bovis_AF2122/97           ATSLAINVSVEDDVRVEVVDDGVGISGDITES-GLRNLRQRADDAGGEFT
Rv2027c|M.tuberculosis_H37Rv        ATSLAINVSVEDDVRVEVVDDGVGISGDITES-GLRNLRQRADDAGGEFT
MAB_3890c|M.abscessus_ATCC_199      ARELSVTVSVDDELVIEVVDDGIGIPDVVARS-GLSGLANRAAQSGGTFS
MSMEG_3941|M.smegmatis_MC2_155      ATSVTISIEVSDRLDIEVVDNGRGIPANTARCSGLANLKARAQQAGGSCQ
MAV_2108|M.avium_104                IENPSPAAALAGLDRFAARLPGAQCTTAVCAVLTPDTGELVYSSAGHPPP
Mvan_3797|M.vanbaalenii_PYR-1       FDNPSPAAALAGMDRFAARLPGAQCATAVCAVLDPATGELVYSSAGHPPP
Mflv_4521|M.gilvum_PYR-GCK          LENPSPGAALSGMDRFAARLPGAQCTTAVVMVLDPASGEIAYSSAGHPPP
MMAR_5186|M.marinum_M               LTGAQPALLLEQLDAAASLIPDAYCTTVFLAILDTESGILDYSNAGHMPA
TH_2781|M.thermoresistible__bu      LSGAEPARLLENLDAVAALIPDAYCATVLLAVLDTESGTLRYSNAGHVPA
MUL_3853|M.ulcerans_Agy99           VEHGYSTDVSDGLAVAAALGGDGKLRVAVIDHGTWKHHREGERGRGRGLA
                                                         .                       *    

Mb2052c|M.bovis_AF2122/97           VENMPTG-------------GTLLRWSAPLR-------------------
Rv2027c|M.tuberculosis_H37Rv        VENMPTG-------------GTLLRWSAPLR-------------------
MAB_3890c|M.abscessus_ATCC_199      VSAMDTG-------------GTRLVWSAPLP-------------------
MSMEG_3941|M.smegmatis_MC2_155      ITSSAGS-------------GTHVRWSAPLSGA-----------------
MAV_2108|M.avium_104                IVVHGDGSTQILDEGHTIALGIRRDWPRPEARVTIPARATLLLYTDGLVE
Mvan_3797|M.vanbaalenii_PYR-1       ILMHADGSARLLEGAHTIALGLRVGWSRPEGRLSIPAGATLMLYTDGLVE
Mflv_4521|M.gilvum_PYR-GCK          LVVHADGEVETFDDAHTIALGLRLNWVRPETRRTLEVGSTLVLYTDGLVE
MMAR_5186|M.marinum_M               VLAEPKSGPVLLTDARSVPLAVRRVEPRPEATQVLPPGSTLLLFTDGLVE
TH_2781|M.thermoresistible__bu      LLAGPGPHATVLTDGASVPLGVQQNRPRPQVSRQLTPGSTLMLYTDGLVE
MUL_3853|M.ulcerans_Agy99           MAEALVS-----------ETHVSHDGAGTTATVVHRLSRPAQFVTDPVVS
                                    :                           .                     

Mb2052c|M.bovis_AF2122/97           --------------------------------------------------
Rv2027c|M.tuberculosis_H37Rv        --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199      --------------------------------------------------
MSMEG_3941|M.smegmatis_MC2_155      --------------------------------------------------
MAV_2108|M.avium_104                RRRSPLDRGIYRVATVAQDARGSSLDELATRIMSAVAPSGGYQDDVVLLL
Mvan_3797|M.vanbaalenii_PYR-1       RRRTLLEDGISRAAELLEGHRTSDLEDLADQIMSGLAPSVGYQDDVALLL
Mflv_4521|M.gilvum_PYR-GCK          RRRIPLEEGISRATDVVVEHRAAPLDDLANAIMSELAPSVGYQDDVALLL
MMAR_5186|M.marinum_M               RRYESIDEGLGRVADVVADSVMLPIDAVADAVLSQLAPTGGYDDDVAMVA
TH_2781|M.thermoresistible__bu      RRDSPIDTGMDRACQVLTAMLDAEPEAVADAMLDTLAPADGYDDDVAIVV
MUL_3853|M.ulcerans_Agy99           RAPNRPAIDSEFASTVTESGHIVVRGDVDSNTAPTLDRQIAVESRSGIAS
                                                                                      

Mb2052c|M.bovis_AF2122/97           --------------------------------------------------
Rv2027c|M.tuberculosis_H37Rv        --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199      --------------------------------------------------
MSMEG_3941|M.smegmatis_MC2_155      --------------------------------------------------
MAV_2108|M.avium_104                YRHPAP-LELNFPADVNQLAPARTALRNWLRRVRLDPEQTLNVLVAAGEA
Mvan_3797|M.vanbaalenii_PYR-1       YRHPAP-LQLNFPADANHLAPARAALRSWLTSARVEPARVMDVLVAAGEA
Mflv_4521|M.gilvum_PYR-GCK          YRHPAP-LELTFPAHADHLAPTRTALRRWLSGAKVEQGRVMEVLVAAGEA
MMAR_5186|M.marinum_M               YRYQHGPLRIETSATPDQLVIVRRQLLSWLQAAEVPDEQAGDIVLVVSEA
TH_2781|M.thermoresistible__bu      YRHTFAPLRIELPATPDRLSEVRARLTGWLTAAGAPELLISDIVLAVNEA
MUL_3853|M.ulcerans_Agy99           LTIDLSAVTHLGSAGVSALVTARDRAR-----------------------
                                                                                      

Mb2052c|M.bovis_AF2122/97           --------------------------------------------------
Rv2027c|M.tuberculosis_H37Rv        --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199      --------------------------------------------------
MSMEG_3941|M.smegmatis_MC2_155      --------------------------------------------------
MAV_2108|M.avium_104                VANAIEHGHRHSPQGTIRLGATALGDQVRLTITDTGTWKVPQATSYPHRG
Mvan_3797|M.vanbaalenii_PYR-1       LANAIEHGHRHTPDGTVSLRATALVDRVRLTVADTGSWKVPQPGRDSRRG
Mflv_4521|M.gilvum_PYR-GCK          VANAIEHGHRHGPPGTVRLRATALVDLVELIITDSGSWKPPSAIPDTYRG
MMAR_5186|M.marinum_M               CTNCIEHAYRGQSVGTMLLDVEAADWAIHARVVDSGSWKKPAADP-GNGG
TH_2781|M.thermoresistible__bu      CTNSVEHAYRDREPGPMQVYADLRDGQIMLQVRDFGTWKTPEPNP-RIRG
MUL_3853|M.ulcerans_Agy99           -----KQGGRCVLMAPPGSPAHHVLSLVQIPVISGETENVFAED------
                                                                                      

Mb2052c|M.bovis_AF2122/97           -------------------------------------
Rv2027c|M.tuberculosis_H37Rv        -------------------------------------
MAB_3890c|M.abscessus_ATCC_199      -------------------------------------
MSMEG_3941|M.smegmatis_MC2_155      -------------------------------------
MAV_2108|M.avium_104                RGIPLMKSLMNDVDIRSDTGGTTVQLSARIT------
Mvan_3797|M.vanbaalenii_PYR-1       RGIALMRALMHDVEIDIGRSGTSVHLDTRID------
Mflv_4521|M.gilvum_PYR-GCK          RGIGIMRGLMQDVTIAHDSDGTTIHLYARIS------
MMAR_5186|M.marinum_M               RGMTLIRAISDEVEIDNSPGGTAIDMTFRLPSED---
TH_2781|M.thermoresistible__bu      RGLPMMRAISADVQVDNTRSGTVVELTFTLSGQPALT
MUL_3853|M.ulcerans_Agy99           -------------------------------------