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M. marinum M MMAR_5186 (-)

annotation: sensor-component of a two-component regulator
coordinates: 6265076 - 6267304
length: 742

MTETGDFGAVDAFQTQYADALRAYLDTRDENSLAVGHEFGRRALQEQISILDIIENHFRLLDEISPNPGS
DRSVALEFLLQTLAALDVATRGFLDGTKRYEEQRARAEDLAHRDKFRSALVNSLQEGFFVADDEGAVIDM
NSAFAEILGYPPEGLPYRWPHPWLVDRKSAAQQQERVRHEGSADYETPVRHQDGHLSWVAVSINAVRGSG
SDRDVYVGTVRDITAERAFAARESAVLRLATSVSVAKSVSEVLSITLEECRTAVDVQRVVAVMWPPSDGE
PTVQVAGEPAESSWRALDPQLRETFLGARAQLPLTARPIEWPDSPGRAQGLVAVLSGTADVALWLELGAP
RWVTAEDRLLVTVLVGHLSLAIGHVRQFESARETSLTLQRAMLPPVKPPPGFAVRYEPAVPPLEIGGDWY
DVLPIGEHRIGIVVGDCVGRGLPAAAIMGQLRSSARALLLTGAQPALLLEQLDAAASLIPDAYCTTVFLA
ILDTESGILDYSNAGHMPAVLAEPKSGPVLLTDARSVPLAVRRVEPRPEATQVLPPGSTLLLFTDGLVER
RYESIDEGLGRVADVVADSVMLPIDAVADAVLSQLAPTGGYDDDVAMVAYRYQHGPLRIETSATPDQLVI
VRRQLLSWLQAAEVPDEQAGDIVLVVSEACTNCIEHAYRGQSVGTMLLDVEAADWAIHARVVDSGSWKKP
AADPGNGGRGMTLIRAISDEVEIDNSPGGTAIDMTFRLPSED
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. marinum MMMAR_5186--100% (742)sensor-component of a two-component regulator
M. marinum MMMAR_0738-2e-5532.73% (440) two-component sensor and regulator
M. marinum MMMAR_3991rsbU3e-4129.10% (378) regulator of sigma subunit, anti-anti-sigma factor RsbU

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1399c-8e-4531.93% (379) hypothetical protein Mb1399c
M. gilvum PYR-GCKMflv_4423-1e-12639.66% (696) multi-sensor signal transduction histidine kinase
M. tuberculosis H37RvRv1364c-2e-4431.66% (379) hypothetical protein Rv1364c
M. leprae Br4923-----
M. abscessus ATCC 19977-----
M. avium 104MAV_0430-0.072.33% (730) stage II sporulation protein E (SpoIIE)
M. smegmatis MC2 155MSMEG_6131-1e-1127.86% (262) magnesium or manganese-dependent protein phosphatase
M. thermoresistible (build 8)TH_2781-0.057.20% (736) PUTATIVE stage II sporulation protein E (SpoIIE)
M. ulcerans Agy99MUL_3853rsbU4e-4229.37% (378) regulator of sigma subunit, anti-anti-sigma factor RsbU
M. vanbaalenii PYR-1Mvan_1931-1e-12841.14% (683) multi-sensor signal transduction histidine kinase

CLUSTAL 2.0.9 multiple sequence alignment


Mb1399c|M.bovis_AF2122/97           --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv        --------------------------------------------------
MUL_3853|M.ulcerans_Agy99           --------------------------------------------------
MMAR_5186|M.marinum_M               --------------------------------------------------
MAV_0430|M.avium_104                --------------------------------------------------
TH_2781|M.thermoresistible__bu      --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK          ----------------------------MNWAQTPLGPTSEWPQSLQTAA
Mvan_1931|M.vanbaalenii_PYR-1       MTGDGRGESFSPAGIFADGGEVGRDHARVDWAATPLGPPSRWPQSLLTAA
MSMEG_6131|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

Mb1399c|M.bovis_AF2122/97           --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv        --------------------------------------------------
MUL_3853|M.ulcerans_Agy99           --------------------------------------------------
MMAR_5186|M.marinum_M               --------------------------------------------------
MAV_0430|M.avium_104                --------------------------------------------------
TH_2781|M.thermoresistible__bu      --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK          NILLSSRFPMWMAWGPDLTFFCNDAYRNVTLGRKYPWALGRPASEVWAEI
Mvan_1931|M.vanbaalenii_PYR-1       SILLSSRFPMWMAWGPELTFFCNDAYRRDTLGRKYPWALGRPASEVWAEI
MSMEG_6131|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

Mb1399c|M.bovis_AF2122/97           --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv        --------------------------------------------------
MUL_3853|M.ulcerans_Agy99           --------------------------------------------------
MMAR_5186|M.marinum_M               --------------------------------------------------
MAV_0430|M.avium_104                --------------------------------------------------
TH_2781|M.thermoresistible__bu      --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK          WDDIGPRIERVLSTGVATWDTSLLLFLERSGYTEESYHTFSYSPLRDDDG
Mvan_1931|M.vanbaalenii_PYR-1       WDDIGPRIERVLSTGQATWDTALLLFLERSGYPEETYHTFSYSPLRDDDG
MSMEG_6131|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

Mb1399c|M.bovis_AF2122/97           --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv        --------------------------------------------------
MUL_3853|M.ulcerans_Agy99           --------------------------------------------------
MMAR_5186|M.marinum_M               --------------------------------------------------
MAV_0430|M.avium_104                --------------------------------------------------
TH_2781|M.thermoresistible__bu      --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK          AVVGMLCVVSEDTLQVIGERRMATLRDLGSDPSVVRTEGEILSFVDRQLA
Mvan_1931|M.vanbaalenii_PYR-1       RVVGMLCVVSEDTVRVIGERRMATLRDLGSDLSLVRSEVDILRFADEQLG
MSMEG_6131|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

Mb1399c|M.bovis_AF2122/97           --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv        --------------------------------------------------
MUL_3853|M.ulcerans_Agy99           --------------------------------------------------
MMAR_5186|M.marinum_M               --------------------------------------------------
MAV_0430|M.avium_104                --------------------------------------------------
TH_2781|M.thermoresistible__bu      --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK          QNLRDLPFTLTYLFDDDGSAHLAGMSGITGDHPAAPDVLTGADGELWPVG
Mvan_1931|M.vanbaalenii_PYR-1       HNLRDLPFTLTYLFDGDGSARLAGTSGIAPEHPAVPTRLSADGGGIWPVA
MSMEG_6131|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

Mb1399c|M.bovis_AF2122/97           --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv        --------------------------------------------------
MUL_3853|M.ulcerans_Agy99           --------------------------------------------------
MMAR_5186|M.marinum_M               --------------------------------------------------
MAV_0430|M.avium_104                --------------------------------------------------
TH_2781|M.thermoresistible__bu      --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK          PPAGGETVLLEVDTAPYPAMPTGDWREPPRQVLIVPLLQQGAAPTGFLVA
Mvan_1931|M.vanbaalenii_PYR-1       EPARSESVLVDLDGDSYPSLPTGDWREPPAQALVVPLLHQGGSPSGFLVV
MSMEG_6131|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

Mb1399c|M.bovis_AF2122/97           --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv        --------------------------------------------------
MUL_3853|M.ulcerans_Agy99           --------------------------------------------------
MMAR_5186|M.marinum_M               --------------------------------------------------
MAV_0430|M.avium_104                --------------------------------------------------
TH_2781|M.thermoresistible__bu      --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK          GLNRYRVLDDAYRGFVALVAGHIAAGIGLSRSYRTQQMRAEELAELDRAK
Mvan_1931|M.vanbaalenii_PYR-1       GLNRYRLLDDGYRGFLTLVAGHIAAGIGLARSYRAQQRRAEELAELDRVK
MSMEG_6131|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

Mb1399c|M.bovis_AF2122/97           --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv        --------------------------------------------------
MUL_3853|M.ulcerans_Agy99           --------------------------------------------------
MMAR_5186|M.marinum_M               --------------------------------------------------
MAV_0430|M.avium_104                --------------------------------------------------
TH_2781|M.thermoresistible__bu      --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK          TTFFSNISHEFRTPLTLILDPVSELRRADTLGDAARQELDVVWRNGLRLN
Mvan_1931|M.vanbaalenii_PYR-1       TTFFSNISHEFRTPLTLILDPVSELRRAESIDEPVRRELDVVWRNGLRLT
MSMEG_6131|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

Mb1399c|M.bovis_AF2122/97           --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv        --------------------------------------------------
MUL_3853|M.ulcerans_Agy99           --------------------------------------------------
MMAR_5186|M.marinum_M               --------------------------------------------------
MAV_0430|M.avium_104                --------------------------------------------------
TH_2781|M.thermoresistible__bu      --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK          KLVNTLLDFSRIEAGRTQAHYQPVDLGAVTAELASVFRSAIERAGLVFDV
Mvan_1931|M.vanbaalenii_PYR-1       KLVNTLLDFSRIEAGRTQARYQPVDLGALTAELASMFRSAVERAGLTFDI
MSMEG_6131|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

Mb1399c|M.bovis_AF2122/97           --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv        --------------------------------------------------
MUL_3853|M.ulcerans_Agy99           --------------------------------------------------
MMAR_5186|M.marinum_M               --------------------------------------------------
MAV_0430|M.avium_104                --------------------------------------------------
TH_2781|M.thermoresistible__bu      --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK          DCPPLGEEAYVDLDMWEKVIFNLLSNALKFTFEGSVSVTARRDGRGAVIT
Mvan_1931|M.vanbaalenii_PYR-1       DCDPLDEVVYVDRDMWEKVIFNLLSNALKFTFEGAVSVRVRRDGHQAVVV
MSMEG_6131|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

Mb1399c|M.bovis_AF2122/97           --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv        --------------------------------------------------
MUL_3853|M.ulcerans_Agy99           --------------------------------------------------
MMAR_5186|M.marinum_M               --------------------------------------------------
MAV_0430|M.avium_104                --------------------------------------------------
TH_2781|M.thermoresistible__bu      --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK          VSDTGTGVPADEMPRLFERFHRIENTRARSNEGSGIGLALVKELVGLHGG
Mvan_1931|M.vanbaalenii_PYR-1       VADTGTGVPADEMPRLFERFHRIENAKARSNEGSGIGLALVKELIGLHGG
MSMEG_6131|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

Mb1399c|M.bovis_AF2122/97           --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv        --------------------------------------------------
MUL_3853|M.ulcerans_Agy99           --------------------------------------------------
MMAR_5186|M.marinum_M               -MTETGDFGAVDAFQTQY---------------------ADALRAYLDTR
MAV_0430|M.avium_104                -MSDD------NDFHDQY---------------------ARALRAYLASR
TH_2781|M.thermoresistible__bu      -MSPD--------FGARY---------------------AAALAAYLEDS
Mflv_4423|M.gilvum_PYR-GCK          TIEADSAESRGTTFTIRLPWGAGHLPADAVASQPRERRPGNTVDAYVEEA
Mvan_1931|M.vanbaalenii_PYR-1       TIVADSAEGQGTAFTIRMPFGAAHLPDDALAPVGDGREAAGGADAYVEEA
MSMEG_6131|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

Mb1399c|M.bovis_AF2122/97           --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv        --------------------------------------------------
MUL_3853|M.ulcerans_Agy99           ---------------------------------MLLLDLLRQRTYSFVRS
MMAR_5186|M.marinum_M               D------------------------------ENSLAVGHEFGRRALQEQI
MAV_0430|M.avium_104                D------------------------------EASLAVGHELGRRALQEQI
TH_2781|M.thermoresistible__bu      S------------------------------ERRLAVAHDLGRQALLGRI
Mflv_4423|M.gilvum_PYR-GCK          LRWTPDGVREYVAESAQPTTGPEKPIGTGTLARVLVADDNADMREYLGRL
Mvan_1931|M.vanbaalenii_PYR-1       LRWIPADT-EADDESAHAPTGS----VTAASARVLVADDNADMREYLTRL
MSMEG_6131|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

Mb1399c|M.bovis_AF2122/97           -------MAAEMDWDKTVGAAEDVR-------------------------
Rv1364c|M.tuberculosis_H37Rv        -------MAAEMDWDKTVGAAEDVR-------------------------
MUL_3853|M.ulcerans_Agy99           VHRRDGYMAAEMDWDKNVGTANTVR-------------------------
MMAR_5186|M.marinum_M               S-----ILDIIENHFRLLDEISPN-----------PGSD-----------
MAV_0430|M.avium_104                S-----LLEIIEQHVRLVFEISQD-----------VRID-----------
TH_2781|M.thermoresistible__bu      S-----VLQIVEDHVRLVDELSRR-----------QPVD-----------
Mflv_4423|M.gilvum_PYR-GCK          LRSDGYAVEAVVDGWQALEAIRAEPPDLVISDVMMPRLDGLGLVAELRAD
Mvan_1931|M.vanbaalenii_PYR-1       LRSDGYRVDAVADGLEALEAIRAGAPDIVVSDVMMPRLDGLGLVAELRAD
MSMEG_6131|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

Mb1399c|M.bovis_AF2122/97           ----RIFEHIPAILVGLEGPDHRFVAVNAAYRGFSPLLDTVGQPAR----
Rv1364c|M.tuberculosis_H37Rv        ----RIFEHIPAILVGLEGPDHRFVAVNAAYRGFSPLLDTVGQPAR----
MUL_3853|M.ulcerans_Agy99           ----RIFENVPTMLVGLEGPEHRFVAANAAYRRFSPTFTAVGQPAR----
MMAR_5186|M.marinum_M               --RSVALEFLLQTLAALDVATRGFLDGTKRYEEQRARAEDLAHRD-----
MAV_0430|M.avium_104                --APIALEFLLQLLVPLDVATRGFIDGNRRYAEQRARAEGLADRD-----
TH_2781|M.thermoresistible__bu      --TDTALQFLLQALAAVDVAVRGYLEGTRRYEQQRARAEGLAGRD-----
Mflv_4423|M.gilvum_PYR-GCK          RRTAAVPVLLLSARAGQEASISGLQAGADDYLVKPFAAAELLARVRANIQ
Mvan_1931|M.vanbaalenii_PYR-1       RRTAATPVLLLSARAGQQESISGLRAGADDYLVKPFAAAELLARVRTNVE
MSMEG_6131|M.smegmatis_MC2_155      ----------------MRAPFDRVIASPVDLTGPGQRRLSLLLVE-----
                                                       .                    :         

Mb1399c|M.bovis_AF2122/97           ---------EVYPELEGQQIYEMLDRVYQTGEPQSGSEWRLQTDYDGSGV
Rv1364c|M.tuberculosis_H37Rv        ---------EVYPELEGQQIYEMLDRVYQTGEPQSGSEWRLQTDYDGSGV
MUL_3853|M.ulcerans_Agy99           ---------EVYPELESQQIYHMLDRVYETGEPQSGAEWRLQADFDGSGI
MMAR_5186|M.marinum_M               ---------KFRSALVNSLQEGFFVADDEGAVIDMNSAFAEILGYPPEGL
MAV_0430|M.avium_104                ---------KFRNALVNSLQEGFFVADHEGSVIEVNNAFIEILGFPAEGL
TH_2781|M.thermoresistible__bu      ---------TFRSALVNAMQEAFFVMDRTGSVIDINEAFAEITGYDGHDL
Mflv_4423|M.gilvum_PYR-GCK          LARLREGHARWRTALVDSLQEAFFVCDEHGAVVEINPAFTEILGYDSTGL
Mvan_1931|M.vanbaalenii_PYR-1       LARLRHHHAQWRTALVDSLQEAFFVCDADGAVIEINPAFTEILGYDRAGL
MSMEG_6131|M.smegmatis_MC2_155      ----------------DDRADAILVEELIADAPDIDFVWAKSMSDAERTL
                                                    .     ::         : .  :    .     :

Mb1399c|M.bovis_AF2122/97           EERYFDFVVTPRRRADGSIEGVQLIVDDVTSRVRARQAAEARVEELSERY
Rv1364c|M.tuberculosis_H37Rv        EERYFDFVVTPRRRADGSIEGVQLIVDDVTSRVRARQAAEARVEELSERY
MUL_3853|M.ulcerans_Agy99           DERYFDFLVTPRRREDGSIEGVQILFDDVTTRVRARLAAEARVEELSERY
MMAR_5186|M.marinum_M               PYRWPHPWLVDR-------KSAAQQQERVR-HEG-SADYETPVRHQDGHL
MAV_0430|M.avium_104                PYRWPHPWLVDP-------KTASEQIGVVL-RTG-SAEYETPIRHADGHL
TH_2781|M.thermoresistible__bu      PYRWPHPWVVDE-------PRADEDLLELL-QHG-RVQLERQIRHRSGHL
Mflv_4423|M.gilvum_PYR-GCK          PYPLMHPWWPLKGSDAEANRRVEEAFGSFM-RDPHGTLTEVPVTHRDGHR
Mvan_1931|M.vanbaalenii_PYR-1       PYRPMHPWWPSADNDPDAHRQVAEAFDSLL-GNRRGTITAVPVTHRDGHR
MSMEG_6131|M.smegmatis_MC2_155      ADHRPDCVLLDLN------------------------------------L
                                         .                                            

Mb1399c|M.bovis_AF2122/97           RNVRDSATVMQQALLAASVPVVPGADIAAEYLVAAEDTAAG--GDWFDAL
Rv1364c|M.tuberculosis_H37Rv        RNVRDSATVMQQALLAASVPVVPGADIAAEYLVAAEDTAAG--GDWFDAL
MUL_3853|M.ulcerans_Agy99           RHLRDSAIVMQQALLAPSVPVVSGPDIAAQYLVAAQDTAAG--GDWFDAV
MMAR_5186|M.marinum_M               SWVAVSINAVRGSGSDRDVYVGTVRDITAERAFAARESAVLRLATSVSVA
MAV_0430|M.avium_104                AWVKVSINAVKDSGSDRDAYVGTIRDVTAERAFAARESAVLRLATAVAVA
TH_2781|M.thermoresistible__bu      AWVAISVNVVNPNGT---AFVGTMRDITAAHKAAARESALTRLATAAGVA
Mflv_4423|M.gilvum_PYR-GCK          LYVTVTFSHADDPETGRDVIVGTLRDVTAERYIVQRESALASLNEKLAQA
Mvan_1931|M.vanbaalenii_PYR-1       LWVTATFAHAEDPETGGDVVVGTVRDVSAEHFVVQRETALASLNESLAQA
MSMEG_6131|M.smegmatis_MC2_155      PDAAGIDALHHLGKLDARIPIIVLTGLNDEHFGVS-------------AV
                                                        :    .:      .                

Mb1399c|M.bovis_AF2122/97           ALGDRLVLVVGDVVGHGVEAAAVMSQLRTA----------LRMQISTGYT
Rv1364c|M.tuberculosis_H37Rv        ALGDRLVLVVGDVVGHGVEAAAVMSQLRTA----------LRMQISAGYT
MUL_3853|M.ulcerans_Agy99           ALGDRLVLIVGDVVGHGVEAAAVMSQLRTA----------LRLQIAAGRS
MMAR_5186|M.marinum_M               KSVSEVLSITLEECRTAVDVQRVVAVMWPP-------SDGEPTVQVAGEP
MAV_0430|M.avium_104                KSVDELLSITLDECSTAIDVQRVVAVSWPS-------GDGDPAVQVAGRP
TH_2781|M.thermoresistible__bu      TSVSEVLSIMLDECRPAIDSRRVIAVTWAR-------EDAEPTIQVVGDP
Mflv_4423|M.gilvum_PYR-GCK          DTLDDAVLAAAEEFSSIWSARRVVAATWPD-EPDGEHESDAPSLTVVGAP
Mvan_1931|M.vanbaalenii_PYR-1       DTLGDAVRAATAEFAAVWRARRVLAVTWPDGYPVDTETPVDPHLVCAGEP
MSMEG_6131|M.smegmatis_MC2_155      ASGAQDYLVKGRVEPEMLRRAVLYAIERKR--------------------
                                                          : :                         

Mb1399c|M.bovis_AF2122/97           VVEALEAVDRFHKQVPGSKSATMCVGSLDFTSGEFQYCTAGHPPPLLVTA
Rv1364c|M.tuberculosis_H37Rv        VVEALEAVDRFHKQVPGSKSATMCVGSLDFTSGEFQYCTAGHPPPLLVTA
MUL_3853|M.ulcerans_Agy99           IGEALEALDAFHEHVPGSNSATLCVGSLDFTTGEFQYCTAGHPPPLVVTA
MMAR_5186|M.marinum_M               AESSWRALDPQLRETFLGARAQLPLTARPIEWPDSPGRAQG-LVAVLSGT
MAV_0430|M.avium_104                AASSWRELDPWLRDTFAEARHQLPLTAKTVDHPDNPGKSRG-LVAVLSGA
TH_2781|M.thermoresistible__bu      PASTWADLDESLRTTLLAARDWPPLTVQPVSDAG-QNTSRG-IVAVLSGT
Mflv_4423|M.gilvum_PYR-GCK          --ATWDGLPGSARELILTLRRDH------LLAPHTSDAGAA-GVALRHPR
Mvan_1931|M.vanbaalenii_PYR-1       --ARWSDLPAHTRERITALRDDD------LLDPDTSTAGAA-GVALQHPQ
MSMEG_6131|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

Mb1399c|M.bovis_AF2122/97           DASARYVEPTGAGPLGSGTGFPVRSEVLNIGDAILFYTDGLIERPG----
Rv1364c|M.tuberculosis_H37Rv        DASARYVEPTGAGPLGSGTGFPVRSEVLNIGDAILFYTDGLIERPG----
MUL_3853|M.ulcerans_Agy99           EAKARYLEPSGAGPLGSDTGFPVRTELIGVGDVVLLYTDGLIERPG----
MMAR_5186|M.marinum_M               ADVALWLELGAPRWVTAEDRLLVTVLVGHLSLAIGHVRQFESARETSLTL
MAV_0430|M.avium_104                GDLALWLELRTPRWVSGEDRLLVTVLIGHLSLALQHVRQFENARETSLTL
TH_2781|M.thermoresistible__bu      PATVLWLEHRVPRPVGIDGRRLINALVGHVSLAVQHVRRFEIARESSLTL
Mflv_4423|M.gilvum_PYR-GCK          GVLVLYVELPEQRLFTAEDDTLLTVLAGRLGQGLQRVHQIDQQRETALAL
Mvan_1931|M.vanbaalenii_PYR-1       GVLVIYVELFERRRFTAEDHTLLTVLAGRLGQGLQRVQQIDQQRETALAL
MSMEG_6131|M.smegmatis_MC2_155      -AELTSVDLHASQLRAQENARLERGLLPSP--------------------
                                          ::                                          

Mb1399c|M.bovis_AF2122/97           -RPLEASTAEFADLAASIASGSGGFVLDAPARPIDRLCSDTLELLLRSTG
Rv1364c|M.tuberculosis_H37Rv        -RPLEASTAEFADLAASIASGSGGFVLDAPARPIDRLCSDTLELLLRSTG
MUL_3853|M.ulcerans_Agy99           -RPLGASTAEFADLAANITSG-GGFVIDAQSRPIDRLCSETLELLLRSTG
MMAR_5186|M.marinum_M               QRAMLPPVKPPPGFAVRYEPAVPPLEIGGDWYDVLPIGEHRIGIVVGDCV
MAV_0430|M.avium_104                QRAMLPPVQPPPGFAVRYEPAVPPLEIGGDWYDVLPIGDHRIGIVVGDCV
TH_2781|M.thermoresistible__bu      QRAMLPDIVPPPGFAVRYEPAVRPLEIGGDWYDVLPLDDHQIGIIVGDCV
Mflv_4423|M.gilvum_PYR-GCK          QHAILGPSLSS-AFAVRYQPATRPLQVGGDWYDVVDLEDGRIGLIVGDCV
Mvan_1931|M.vanbaalenii_PYR-1       QHAILGPALSG-GFAVRYQPATRPLQVGGDWYDVVDLDDGRIALIVGDCV
MSMEG_6131|M.smegmatis_MC2_155      ----LLMEGSGVDIVVEARPSRQHALIGGDFYDVVQTPDRTVHVMIGDVA
                                                 :..   ..     :..    :    .  : ::: .  

Mb1399c|M.bovis_AF2122/97           YNDDVTLLAMQRRAPTPPLHITLDATINAARTVRAQLREWLAEIGADHSD
Rv1364c|M.tuberculosis_H37Rv        YNDDVTLLAMQRRAPTPPLHITLDATINAARTVRAQLREWLAEIGADHSD
MUL_3853|M.ulcerans_Agy99           YNDDITLLAVQRRAPTPPLNITEDATIHAARAIRSRLRQWLSEIGADSGD
MMAR_5186|M.marinum_M               GRGLPAAAIMGQLRSSARALLLTGAQPALLLEQLDAAASLIPDAYCTTVF
MAV_0430|M.avium_104                GRGLPAAAIMGQLRSSARALLINGAEPAVLLDQLDSAASLIPNAYCTTVF
TH_2781|M.thermoresistible__bu      GRGLPAAAVMGQLRSSARALLLSGAEPARLLENLDAVAALIPDAYCATVL
Mflv_4423|M.gilvum_PYR-GCK          GHGLAAATVMGQLRSACRALLLEHPSPAAALSALDRFAARLPGARCTTAF
Mvan_1931|M.vanbaalenii_PYR-1       GHGLAAAAIMGQLRSACRALLLEHPSPAAALSGLDRFAARLPGARCTTAF
MSMEG_6131|M.smegmatis_MC2_155      GHGPDEAALGVALRIGWRALTFAGLRGNERMRQLDRILTTERPGKGIFAT
                                     ..                                               

Mb1399c|M.bovis_AF2122/97           IADIVHAISEFVENAVEHGYATDVSKGIVVEAALAGDGNVRASVIDRGQW
Rv1364c|M.tuberculosis_H37Rv        IADIVHAISEFVENAVEHGYATDVSKGIVVAAALAGDGNVRASVIDRGQW
MUL_3853|M.ulcerans_Agy99           ISDIVHAISEFVENAVEHGYSTDVSDGLAVAAALGGDGKLRVAVIDHGTW
MMAR_5186|M.marinum_M               LAILDTESGILDYSNAGHMPAVLAEPKSGP-VLLTDARSVPLAVRRVEPR
MAV_0430|M.avium_104                LAILDTETGVLQYSNAGHMPAVLAGPEPGTTTLLTDAASVPLAVRREDPR
TH_2781|M.thermoresistible__bu      LAVLDTESGTLRYSNAGHVPALLAGPGPHA-TVLTDGASVPLGVQQNRPR
Mflv_4423|M.gilvum_PYR-GCK          CAVLDPRIGEVVYSCAGHPPPIMVTADRTT-ELLEGARATPLGLKNPPHR
Mvan_1931|M.vanbaalenii_PYR-1       CAVLDPETGEVVYSCAGHPPPILIGADRST-RLLEEARATPLGLKNPPHR
MSMEG_6131|M.smegmatis_MC2_155      LCSVALEPDSGRFTVVRAGHPGLLVHGNGTVDWLEPRPGAALGLG-AREW
                                     . :    .    . .    .            *        .:      

Mb1399c|M.bovis_AF2122/97           KDHRDGARGRGRGLAMAEALVSEAR--IMHGAGGTTATLTHRLSRPARFV
Rv1364c|M.tuberculosis_H37Rv        KDHRDGARGRGRGLAMAEALVSEAR--IMHGAGGTTATLTHRLSRPARFV
MUL_3853|M.ulcerans_Agy99           KHHREGERGRGRGLAMAEALVSETH--VSHDGAGTTATVVHRLSRPAQFV
MMAR_5186|M.marinum_M               PEATQVLPPGSTLLLFTDGLVERRYESIDEGLGRVADVVADSVMLPIDAV
MAV_0430|M.avium_104                PQATRLLPPGSTLMLFTDGLVERKHEPIDDGIGRAAEVLAQTMTLPLDTV
TH_2781|M.thermoresistible__bu      PQVSRQLTPGSTLMLYTDGLVERRDSPIDTGMDRACQVLTAMLDAEPEAV
Mflv_4423|M.gilvum_PYR-GCK          TEARVTMPARATLLLYTDGLVERRRESIDDGIARATDVVQGNRATDLDQL
Mvan_1931|M.vanbaalenii_PYR-1       TEARETMAPRATLLLYTDGLVERRRESIDDGIARAAGVVEDNRATALDEL
MSMEG_6131|M.smegmatis_MC2_155      PVNHYELPEGHGLLLLTDGLFEGHAGRGDERLGESGLLAVAR--------
                                                 :  ::.*..                            

Mb1399c|M.bovis_AF2122/97           TDTMVRRAAFQQTIDSEFVS-LVESGRIVVRGDVDSTTAATLDRQIAVES
Rv1364c|M.tuberculosis_H37Rv        TDTMVRRAAFQQTIDSEFVS-LVESGRIVVRGDVDSTTAATLDRQIAVES
MUL_3853|M.ulcerans_Agy99           TDPVVSRAPNRPAIDSEFASTVTESGHIVVRGDVDSNTAPTLDRQIAVES
MMAR_5186|M.marinum_M               ADAVLSQLAPTGGYDDDVAMVAYRYQHGPLRIETSATPDQLVIVRRQLLS
MAV_0430|M.avium_104                ADEVLRELAPAAGYDDDVAMVIYRHQQSPLRIETAATADQLVRIRHRLAD
TH_2781|M.thermoresistible__bu      ADAMLDTLAPADGYDDDVAIVVYRHTFAPLRIELPATPDRLSEVRARLTG
Mflv_4423|M.gilvum_PYR-GCK          ANVIMARLAPADGYHDDVALLLYRQP-EPLDLDFPADVAELAGSRTVLRG
Mvan_1931|M.vanbaalenii_PYR-1       ANAVMAGLAPADGYHDDVALLLYRQP-APLDLEFAADVAELAVGREALRG
MSMEG_6131|M.smegmatis_MC2_155      ------ALAATPGRDFVTSLINEAESRAQTHGGLSDDIAVIRVERSRR--
                                            .     .                             :     

Mb1399c|M.bovis_AF2122/97           RSGIAPVTIDLSAVTHLGSAGVGALAAACDRARKQGTECVLVAPPGSPAH
Rv1364c|M.tuberculosis_H37Rv        RSGIAPVTIDLSAVTHLGSAGVGALAAACDRARKQGTECVLVAPPGSPAH
MUL_3853|M.ulcerans_Agy99           RSGIASLTIDLSAVTHLGSAGVSALVTARDRARKQGGRCVLMAPPGSPAH
MMAR_5186|M.marinum_M               WLQAAEVPDEQAGDIVLVVSEACTNCIEHAYRGQSVGTMLLDVEAADWAI
MAV_0430|M.avium_104                WLGAAGITGELAADIVLVVNEACTNCVEHAYRGFVAGTMVLDARLGEGEV
TH_2781|M.thermoresistible__bu      WLTAAGAPELLISDIVLAVNEACTNSVEHAYRDREPGPMQVYADLRDGQI
Mflv_4423|M.gilvum_PYR-GCK          WLDSAGVPQDQALDVLIAVGEALANAIEHGHRDDPGGRVRLRAVALPDRV
Mvan_1931|M.vanbaalenii_PYR-1       WLDRAGVGAEQSLDVLIATGEALANAIEHGHREQPRGPVRLRAIALPDRV
MSMEG_6131|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

Mb1399c|M.bovis_AF2122/97           HVLSLVQ-----------------LPVVGADTEDIFAQE-----------
Rv1364c|M.tuberculosis_H37Rv        HVLSLVQ-----------------LPVVGADTEDIFAQE-----------
MUL_3853|M.ulcerans_Agy99           HVLSLVQ-----------------IPVISGETENVFAED-----------
MMAR_5186|M.marinum_M               HARVVDSGSWKKPAADPGNG-GRGMTLIRAISDEVEIDNSPGGTAIDMTF
MAV_0430|M.avium_104                HTRITDYGSWKTPAANPVNS-GRGLPLMKALSQAMELRTSATGTVADITF
TH_2781|M.thermoresistible__bu      MLQVRDFGTWKTPEPNPRIR-GRGLPMMRAISADVQVDNTRSGTVVELTF
Mflv_4423|M.gilvum_PYR-GCK          QLTIIDTGSWKAPDDVPALHRGRGIALMKALMQDVTIDSQTTGTTVHMNT
Mvan_1931|M.vanbaalenii_PYR-1       HVTVVDSGTWKPPATVPALHRGRGIALMRALMHDVTIDSQTTGTTVHMNA
MSMEG_6131|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

Mb1399c|M.bovis_AF2122/97           ---------
Rv1364c|M.tuberculosis_H37Rv        ---------
MUL_3853|M.ulcerans_Agy99           ---------
MMAR_5186|M.marinum_M               RLPSED---
MAV_0430|M.avium_104                RRPAE----
TH_2781|M.thermoresistible__bu      TLSGQPALT
Mflv_4423|M.gilvum_PYR-GCK          RIA------
Mvan_1931|M.vanbaalenii_PYR-1       RIV------
MSMEG_6131|M.smegmatis_MC2_155      ---------