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GQSHTDDSPEAVEVRMAALLQDMASLDAGLEPESTLHGILDAIMRVSGACYGAAGLCAPDGTPATFLQAG ALAQAVPDSPDRDMLGFLRNRTGPLRIDGLARSAAEVGLPELLPPMRAVLGVPLVSHGEVLGSLYVADSR AGFEFSDAHVGVVEVLATVAADVVHSVWHLAKVRTVARWVSASREITMALLGMSGGEDAPLRLIVGRAAE LTVASQAAILVPSEADRAPEEVRSLTVAVAAGARADEVEGQQVPVSGSTSGRVFRTGESTMTDGFRYPIT SFTDQGRRPAIVVPLRSATNNLGVIAVARDADDPPFDVDEMAIMEDFAHHAAVALTLCRANEQARQLTVL SDRERIARDLHDHVIQRLFLAGMDLQGTIARTKSDLLKERLSRTVDDLQSIIDEIRTAIFDLQSPAASAM SFRQRIQAAVAAVTDNSPLATTVRISGPIVAVDPALADDAEAVIVEAISNAVRHSGATSVTISIEVSDRL DIEVVDNGRGIPANTARCSGLANLKARAQQAGGSCQITSSAGSGTHVRWSAPLSGA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3941 | - | - | 100% (547) | GAF family protein |
| M. smegmatis MC2 155 | MSMEG_4614 | - | e-104 | 82.57% (241) | GAF family protein |
| M. smegmatis MC2 155 | MSMEG_5241 | - | 4e-89 | 38.01% (534) | GAF family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3156c | devS | 1e-89 | 38.92% (537) | two component sensor histidine kinase DEVS |
| M. gilvum PYR-GCK | Mflv_3844 | - | 3e-92 | 39.70% (534) | GAF sensor signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv3132c | devS | 5e-90 | 38.92% (537) | two component sensor histidine kinase DEVS |
| M. leprae Br4923 | MLBr_02124 | - | 1e-05 | 29.20% (250) | sensor histidine kinase |
| M. abscessus ATCC 19977 | MAB_3890c | - | 2e-82 | 36.23% (552) | histidine kinase response regulator |
| M. marinum M | MMAR_3479 | - | 1e-128 | 46.83% (536) | two-component sensor histidine kinase |
| M. avium 104 | MAV_4108 | - | 1e-132 | 48.34% (542) | GAF family protein |
| M. thermoresistible (build 8) | TH_0388 | - | 3e-58 | 47.72% (241) | TWO COMPONENT SENSOR HISTIDINE KINASE DEVS |
| M. ulcerans Agy99 | MUL_2422 | devS | 7e-89 | 38.43% (536) | two component sensor histidine kinase DevS |
| M. vanbaalenii PYR-1 | Mvan_1413 | - | 1e-129 | 46.63% (534) | GAF sensor signal transduction histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3156c|M.bovis_AF2122/97 -------MTTGGLVDENDG---AAMRPLRHTLSQLRLHELLVEVQDRVEQ
Rv3132c|M.tuberculosis_H37Rv -------MTTGGLVDENDG---AAMRPLRHTLSQLRLHELLVEVQDRVEQ
MUL_2422|M.ulcerans_Agy99 MTDEPHPQDAGPSLGVPSG---DGLRPLRLTLSQLRLRELLVEVQERVEQ
Mflv_3844|M.gilvum_PYR-GCK -------MHDGAVADADDHRARDGARPVRTTLSQLRLRELLTEVQDRVEQ
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199 -------------MVEDVG---AQPNRVTAELAHLQLRELLAEVQGRIEQ
MMAR_3479|M.marinum_M -------------------------------------------MHAQLDE
MAV_4108|M.avium_104 ------------------------------------------MTGNRFDE
Mvan_1413|M.vanbaalenii_PYR-1 ------------------------MSNRQQRAFGRRHPADLRRIHEQLDE
MSMEG_3941|M.smegmatis_MC2_155 -----------------------------------------MGQSHTDDS
MLBr_02124|M.leprae_Br4923 --------------------------------------------------
Mb3156c|M.bovis_AF2122/97 IVEG-RDRLDGLVEAMLVVTAGLDLEATLRAIVHSATSLVDARYGAMEVH
Rv3132c|M.tuberculosis_H37Rv IVEG-RDRLDGLVEAMLVVTAGLDLEATLRAIVHSATSLVDARYGAMEVH
MUL_2422|M.ulcerans_Agy99 IVEG-RDRLDGLVEAMLVVTSGLELDATLRTIVHSATNLVDARYCALEVH
Mflv_3844|M.gilvum_PYR-GCK IIRG-RDRLDGLVEAMLAVTSGLELDETLRTIVHTAIELVDAQYGALGVR
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199 IVDGTRGRMDALLDAVMAVSSGLELDATLREIVCAASELVSARYGALGVV
MMAR_3479|M.marinum_M LLAA-RDQMEQLLRVIVEIGSDLDLDATLRRIVLAARELTSAPYGALAVR
MAV_4108|M.avium_104 LAAA-RDQTEKLLRVIAEIGAGLDLDATLHRIISAARELTSAPYGALAVR
Mvan_1413|M.vanbaalenii_PYR-1 LAAD-RDQMGQLLQVAVEIGSDLELNATLQRIVRAARGMTAARYGAIGVW
MSMEG_3941|M.smegmatis_MC2_155 PEAV-EVRMAALLQDMASLDAGLEPESTLHGILDAIMRVSGACYGAAGLC
MLBr_02124|M.leprae_Br4923 --------------------------------------------------
Mb3156c|M.bovis_AF2122/97 DRQHRVLHFVYEGIDEETVRRIGHLPKGLGVIGLLIEDPKPLRLDDVSAH
Rv3132c|M.tuberculosis_H37Rv DRQHRVLHFVYEGIDEETVRRIGHLPKGLGVIGLLIEDPKPLRLDDVSAH
MUL_2422|M.ulcerans_Agy99 DRDKRVLQFVYEGIDEDTVARIGHLPEGLGIIGLLIDEPKPLRLEDISQH
Mflv_3844|M.gilvum_PYR-GCK GHDQELVEFIYEGIDEPMRERIGHLPEGRGVLGVLINDPKPIRLEDISRH
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199 GSDEKLAEFVYEGIDEATRDLIGPLPTGHGVLGVVIDEAKPLRLRDIAAH
MMAR_3479|M.marinum_M DPEGTLIRFIHAGMDDDVARRIGHLPVGKGVLGVSLVETPALRLDDLTMH
MAV_4108|M.avium_104 DWHANLISFVHEGMDAETVRRIGHHPVGKGLLSLSLLDTPALRMDDLTAH
Mvan_1413|M.vanbaalenii_PYR-1 GTDDLLSDFVHDGMDEGTVQAVGHPPVGKGLLGFLRQGTDPVRLDNAAEH
MSMEG_3941|M.smegmatis_MC2_155 APDGTPATFLQAG---ALAQAVPDSPD-RDMLGFLRNRTGPLRIDGLARS
MLBr_02124|M.leprae_Br4923 ----------------------------MNILSRIFARTPSLRTRVVVAT
Mb3156c|M.bovis_AF2122/97 PASIGFPPYHPPMRTFLGVPVRVRDESFGTLYLTDKTNGQPFSDDDEVLV
Rv3132c|M.tuberculosis_H37Rv PASIGFPPYHPPMRTFLGVPVRVRDESFGTLYLTDKTNGQPFSDDDEVLV
MUL_2422|M.ulcerans_Agy99 PASIGFPSHHPPMRTFLGVPVRVRDVSLGTLYLTDKTNGQPFSDDDELLV
Mflv_3844|M.gilvum_PYR-GCK ADSVGFPPNHPPMRTFLGVPVRIRDEVFGNLYLTEKSDGQPFSEDDEVLV
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199 PASVGFPANHPPMRTFLGVPVQVRGEVFGRLYLTEKLDGQEFTEDDEVVV
MMAR_3479|M.marinum_M PAACGFPEHHPPMRAFLAVPITIRGTVFGSLYLTHVDPGRKFSESDEFAA
MAV_4108|M.avium_104 PAAAGFPEHHPAMRAFLAVPITIRGAVFGNLYLTHVDEARVFSDADEMAA
Mvan_1413|M.vanbaalenii_PYR-1 PSAVGFPQHHPAMRAFIGVPIVIRGEPFGSLYLADDRPDFAFAEADEMTV
MSMEG_3941|M.smegmatis_MC2_155 AAEVGLPELLPPMRAVLGVPLVSHGEVLGSLYVADSRAGFEFSDAHVGVV
MLBr_02124|M.leprae_Br4923 AIGAAIPVLIVGTVVWVGITNDRKERLDRKLDEAAGFAIPFVPRGLDEIP
Mb3156c|M.bovis_AF2122/97 QALAAAAGIAVANARLYQQAKARQSWIEATRDIATELLSGTEP-ATVFRL
Rv3132c|M.tuberculosis_H37Rv QALAAAAGIAVANARLYQQAKARQSWIEATRDIATELLSGTEP-ATVFRL
MUL_2422|M.ulcerans_Agy99 QALAAAAGIAIANARLYEQAKARQAWIGATRDIATELLSGTEP-ASVFRL
Mflv_3844|M.gilvum_PYR-GCK QALAAAAGIAIDNARLYAQSQARQSWIEATRDIGTELLSGIDP-AGVFRR
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199 RALAGAAGIAIENARLYQHARRREQWQRATADITAELLGGVDP-GKALHL
MMAR_3479|M.marinum_M RALAFAAGVAIDNAQVFERERTAVKWMEASREITTALMSSTESRREPLQL
MAV_4108|M.avium_104 RALAFAAAVAIDNAQVFERERMSVKWIEASREITTALLSRTEPHRRPMQL
Mvan_1413|M.vanbaalenii_PYR-1 RALASIAAVAIDNARLLDHARATVRWTDAGREITAAVLGGDDPYLRPLQL
MSMEG_3941|M.smegmatis_MC2_155 EVLATVAADVVHSVWHLAKVRTVARWVSASREITMALLGMSGGEDAPLRL
MLBr_02124|M.leprae_Br4923 RSPNDQDAIITVRRGNLVKSNFDITLPKLTNDYADTYLRGVRYRVRTVEI
Mb3156c|M.bovis_AF2122/97 VAAEALKLTAADAALVAVPVDEDMPAA-DVGELLVIETVGSAVASTVGRT
Rv3132c|M.tuberculosis_H37Rv VAAEALKLTAADAALVAVPVDEDMPAA-DVGELLVIETVGSAVASIVGRT
MUL_2422|M.ulcerans_Agy99 VAEEALKLTSADAALVAIPVDEDVPAS-EVAQLLVIETVGNAVAAAEGCT
Mflv_3844|M.gilvum_PYR-GCK VADRAQKLSGAAATLVAVPDDPDLPVG-EVAELTVAASAGETIAAAHD-P
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199 VASSAALLAEADFAFIALPAGDEE----DTAELVVAVCEGKGAEVLNDKL
MMAR_3479|M.marinum_M IAQRACTLTDAEQAIVLVPVESDLATD-EIDTLVVSAAVGLHAEEVVGQQ
MAV_4108|M.avium_104 IAERACALTDAEQAIVLVPADPEQPGNPEVDTLVVSAAVGLPAADVLGQR
Mvan_1413|M.vanbaalenii_PYR-1 IVGRACELTGAEQGIVLVASDPEQPVD-EVDTLVVSTAAGRYADDVLGQR
MSMEG_3941|M.smegmatis_MC2_155 IVGRAAELTVASQAAILVPSEADRAPE-EVRSLTVAVAAGARADEVEGQQ
MLBr_02124|M.leprae_Br4923 PAPEPTSIAVGATYDATVAETNNLHRR-----VLLICGFAIAAAAVFAWL
Mb3156c|M.bovis_AF2122/97 IPVAGAVLREVFVNGIPRRVDRVDLEGLD-ELADAGPALLLPLRARGTVA
Rv3132c|M.tuberculosis_H37Rv IPVAGAVLREVFVNGIPRRVDRVDLEGLD-ELADAGPALLLPLRARGTVA
MUL_2422|M.ulcerans_Agy99 IAVAGTALAEVLLDSAPRQVDKIAVEDVD-ELGDMGPALVLPLRATDAVA
Mflv_3844|M.gilvum_PYR-GCK IPVAGTAIGDAFVHRTPGMTDRADIG----IGATVGPALLLPLRAPDAVP
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199 IPIDGSTSGSTFIDHEPRNVGRLAVNLAEGTDLAFGPALVLPLGGGESTA
MMAR_3479|M.marinum_M VPVRGSTCGDVFRSGEPLISEAFSYPIEAFTDVAQRSAIVMPLSAHEKVA
MAV_4108|M.avium_104 VPVRGSTSGAVFKSGEPLITDEFRYPIQAFTDAGRRPAIVMPLRARDEVV
Mvan_1413|M.vanbaalenii_PYR-1 VPVHGSTTGAVFQSGRPVITEAFGHSIPFFTDVGERPVVVVPLRSERQNL
MSMEG_3941|M.smegmatis_MC2_155 VPVSGSTSGRVFRTGESTMTDGFRYPITSFTDQGRRPAIVVPLRSATNNL
MLBr_02124|M.leprae_Br4923 LAAFAVRPFKQLAQQTRSVDAGGEAPRVEVHGATEAVEIAEAMRG-----
Mb3156c|M.bovis_AF2122/97 GVVVVLSQGGPGAFTDEQLEMMAAFADQAALAWQLATSQRRMRELDVLTD
Rv3132c|M.tuberculosis_H37Rv GVVVVLSQGGPGAFTDEQLEMMAAFADQAALAWQLATSQRRMRELDVLTD
MUL_2422|M.ulcerans_Agy99 GVVVLLHPSSPESVTEEQLEMMAAFADQAALALQLATSQRRMRELDVVTE
Mflv_3844|M.gilvum_PYR-GCK GVLIVLRSVGAQPFRSDELDMLAAFADQAAQAWQLASTQHRLRELGILTD
TH_0388|M.thermoresistible__bu -VLVVCRAEEGRPFTDEQLEILVTFADQAALAWQLAATQRRMRELDVLSD
MAB_3890c|M.abscessus_ATCC_199 GVLILLRTVGAIAFDEEQLDMAASFAGQAALALEQAEVRLAKHELDVLAD
MMAR_3479|M.marinum_M GVIAVARGADQPPFDARCLDLVSQFATHAAIALLLASGREDARQLTILAE
MAV_4108|M.avium_104 GVIAIARGTEQPPFDESYLDLVRDFATHAAIALVLAAAREDARQLAVLAE
Mvan_1413|M.vanbaalenii_PYR-1 GVLALARNASAPRFQAGDLDLVRDYAYHTAIAIVIARARGTANELAMFTD
MSMEG_3941|M.smegmatis_MC2_155 GVIAVARDADDPPFDVDEMAIMEDFAHHAAVALTLCRANEQARQLTVLSD
MLBr_02124|M.leprae_Br4923 ---MLQRIWNEQNRTKEALASARDFAAVSSHELRTPLTAMRT-NLEVLAT
: : :* :: :* :.:
Mb3156c|M.bovis_AF2122/97 RDRIARDLHDHVIQRLFAIGLALQGAVPHERNPEVQQRLSDVVDDLQDVI
Rv3132c|M.tuberculosis_H37Rv RDRIARDLHDHVIQRLFAIGLALQGAVPHERNPEVQQRLSDVVDDLQDVI
MUL_2422|M.ulcerans_Agy99 RDRIARDLHDHVIQRLFAIGLALQGSVPRTREPKVQQRLSEVIDDLQGVI
Mflv_3844|M.gilvum_PYR-GCK RDRIARDLHDHVIQRLFAVGLSLQGSIARARSEEVQQRLSANVDDLQSVI
TH_0388|M.thermoresistible__bu RDRIARDLHDHVIQRLFAVGLTLQGTIPRARSTEVQQRLSECIDDLQAVI
MAB_3890c|M.abscessus_ATCC_199 RDRIARDLHDHVIQRLFAVGLAMQSTHRRSVDPTVAARLADHIDQLHEVI
MMAR_3479|M.marinum_M RERIAHDLHDHVIQRLFASGMDLQGTLARARSPEVIDRLNRTVDDLQTII
MAV_4108|M.avium_104 RERIAHDLHDHVIQRLFAAGMDLQGTLARARSPEVADRLNRTLDDLQTII
Mvan_1413|M.vanbaalenii_PYR-1 RERIAHDLHDQVIQRVFAVGMDLQGVVARVRSPALNERLSNSVDELQAVI
MSMEG_3941|M.smegmatis_MC2_155 RERIARDLHDHVIQRLFLAGMDLQGTIARTKSDLLKERLSRTVDDLQSII
MLBr_02124|M.leprae_Br4923 LD-LADDQRKEVLGDVIRTQSRIEATLS-ALERLAQGELSTSDDHVPVDI
: :* * :..*: :: ::. . .* *.: *
Mb3156c|M.bovis_AF2122/97 QEIRTTIYDLHGASQGITRLRQRIDAAVAQFA-DSGLRTSVQFVGPLSVV
Rv3132c|M.tuberculosis_H37Rv QEIRTTIYDLHGASQGITRLRQRIDAAVAQFA-DSGLRTSVQFVGPLSVV
MUL_2422|M.ulcerans_Agy99 QEIRTTIFDLHGSSQGVTRLRQRIDAAVAAFG-SSGLRTTVQFIGPLSVV
Mflv_3844|M.gilvum_PYR-GCK QEIRTAIFDLHGGSSAVTRLRQRLDAAVAAFP-ESGVRTSMQCAGPLSVV
TH_0388|M.thermoresistible__bu GEIRTTIFDLHGGPATGSQIRQRIGEAANQFS-DAGVRTRVQFAGPLSVI
MAB_3890c|M.abscessus_ATCC_199 QEIRTAIFDLHTNDE---SLRATLRSTINELTAETGLRVSVRMSGPLDVV
MMAR_3479|M.marinum_M EEIRSTIFQLKSPSGRDGGFRQRIQQVVADLTEHRDVVTTIHMHGPMSAV
MAV_4108|M.avium_104 EEIRTTIFALRSPAAVAGDFRHRIQRVIAELTENRDLVTTVRMDGPMTAV
Mvan_1413|M.vanbaalenii_PYR-1 TEIRSTIFNLQKPAEAHGAFAKRIRHAFQRLTEDREMAATLTVSGPMEVV
MSMEG_3941|M.smegmatis_MC2_155 DEIRTAIFDLQSPAASAMSFRQRIQAAVAAVTDNSPLATTVRISGPIVAV
MLBr_02124|M.leprae_Br4923 TEL----LDRAAHDATRSYPELKVSLVPSPTCIIVGLPAGLRLAVDNAVA
*: : . : . : .
Mb3156c|M.bovis_AF2122/97 DSALADQAEAVVREAVSNAVRHAKASTLTVRVKVDDDLCIEVTDNGRG-L
Rv3132c|M.tuberculosis_H37Rv DSALADQAEAVVREAVSNAVRHAKASTLTVRVKVDDDLCIEVTDNGRG-L
MUL_2422|M.ulcerans_Agy99 DNVLADHAEAVVREAVSNAVRHAQATTLTVRVKVDDDLCIEVSDNGRG-M
Mflv_3844|M.gilvum_PYR-GCK DAGLADHAEAVVREAVSNAVRHAEASTVAVTVTVEDDLAITVTDDGRG-I
TH_0388|M.thermoresistible__bu SAVLADHAEAVVREAVSNAVRHGGATDLSVDVSVDDDLTIEVTDNGRG-F
MAB_3890c|M.abscessus_ATCC_199 PASTSGDAEAVVREAVSNVVRHARARELSVTVSVDDELVIEVVDDGIG-I
MMAR_3479|M.marinum_M QGELADHAEAVATEAISNAVRHSGAGRVTLDVSVGDMFSLEVVDDGCG-I
MAV_4108|M.avium_104 GAELAEHAEAVTAEAVSNAVRHSGASRLTVQIGVADMFTLDVIDNGRG-I
Mvan_1413|M.vanbaalenii_PYR-1 APSLVDDAEAVVLEGLSNAVRHSGAAAVAVEIAVGDDLVVEVCDDGQG-I
MSMEG_3941|M.smegmatis_MC2_155 DPALADDAEAVIVEAISNAVRHSGATSVTISIEVSDRLDIEVVDNGRG-I
MLBr_02124|M.leprae_Br4923 NAVKHGGATRVQLSAVSSRAGVEIAVDDNGSGVPEDERQVVFERFSRGST
* * ..:*. . * * : . . *
Mb3156c|M.bovis_AF2122/97 PD-EFTGSGLTNLRQRAEQAGGEFTLASVPGASGTVLRWSAPLSQ-
Rv3132c|M.tuberculosis_H37Rv PD-EFTGSGLTNLRQRAEQAGGEFTLASVPGASGTVLRWSAPLSQ-
MUL_2422|M.ulcerans_Agy99 PK-TYTSSGLTNLRRRAQEAGGQFTIESPAAGGGTLLRWSAPLIQ-
Mflv_3844|M.gilvum_PYR-GCK AA-DVTGSGLANLARRAQDVGGSFSVR-RGAQVGTTLTWRAPLP--
TH_0388|M.thermoresistible__bu PEGEVTESGLANLRHRARHAGGTLEVHNRPDG-GARLHWSVPLT--
MAB_3890c|M.abscessus_ATCC_199 PD-VVARSGLSGLANRAAQSGGTFSVSAMDTG-GTRLVWSAPLP--
MMAR_3479|M.marinum_M SPDVSRRSGLANMRSRAEKLGGTCGITTPTEG-GTRISWTVPFGDL
MAV_4108|M.avium_104 AAGNTRRSGLANMTRRAEQLGGSCEISSPPGG-GTRVHWTAPLLDH
Mvan_1413|M.vanbaalenii_PYR-1 PAESRRRSGLANLAARARAAGGELVIDTPPSG-GTRLIWSVPLART
MSMEG_3941|M.smegmatis_MC2_155 PANTARCSGLANLKARAQQAGGSCQITSSAGS-GTHVRWSAPLSGA
MLBr_02124|M.leprae_Br4923 ASHSGSGLGLALVAQQAQLHGGTASLETSPLG-GARLLLRISAPS-
. **: : :* ** : *: : .