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MLLLDLLRQRTYSFVRSVHRRDGYMAAEMDWDKNVGTANTVRRIFENVPTMLVGLEGPEHRFVAANAAYR RFSPTFTAVGQPAREVYPELESQQIYHMLDRVYETGEPQSGAEWRLQADFDGSGIDERYFDFLVTPRRRE DGSIEGVQILFDDVTTRVRARLAAEARVEELSERYRHLRDSAIVMQQALLAPSVPVVSGPDIAAQYLVAA QDTAAGGDWFDAVALGDRLVLIVGDVVGHGVEAAAVMSQLRTALRLQIAAGRSIGEALEALDAFHEHVPG SNSATLCVGSLDFTTGEFQYCTAGHPPPLVVTAEAKARYLEPSGAGPLGSDTGFPVRTELIGVGDVVLLY TDGLIERPGRPLGASTAEFADLAANITSGGGFVIDAQSRPIDRLCSETLELLLRSTGYNDDITLLAVQRR APTPPLNITEDATIHAARAIRSRLRQWLSEIGADSGDISDIVHAISEFVENAVEHGYSTDVSDGLAVAAA LGGDGKLRVAVIDHGTWKHHREGERGRGRGLAMAEALVSETHVSHDGAGTTATVVHRLSRPAQFVTDPVV SRAPNRPAIDSEFASTVTESGHIVVRGDVDSNTAPTLDRQIAVESRSGIASLTIDLSAVTHLGSAGVSAL VTARDRARKQGGRCVLMAPPGSPAHHVLSLVQIPVISGETENVFAED
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_3853 | rsbU | - | 100% (677) | regulator of sigma subunit, anti-anti-sigma factor RsbU |
| M. ulcerans Agy99 | MUL_2625 | - | 2e-13 | 27.53% (316) | hypothetical protein MUL_2625 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1399c | - | 0.0 | 77.52% (654) | hypothetical protein Mb1399c |
| M. gilvum PYR-GCK | Mflv_4521 | - | 8e-52 | 33.25% (400) | putative GAF sensor protein |
| M. tuberculosis H37Rv | Rv1364c | - | 0.0 | 77.83% (654) | hypothetical protein Rv1364c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_3991 | rsbU | 0.0 | 99.23% (653) | regulator of sigma subunit, anti-anti-sigma factor RsbU |
| M. avium 104 | MAV_1619 | - | 0.0 | 75.99% (654) | anti-anti-sigma factor |
| M. smegmatis MC2 155 | MSMEG_6131 | - | 1e-16 | 31.09% (267) | magnesium or manganese-dependent protein phosphatase |
| M. thermoresistible (build 8) | TH_2781 | - | 9e-48 | 34.04% (379) | PUTATIVE stage II sporulation protein E (SpoIIE) |
| M. vanbaalenii PYR-1 | Mvan_1931 | - | 1e-49 | 34.63% (387) | multi-sensor signal transduction histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4521|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1931|M.vanbaalenii_PYR-1 MTGDGRGESFSPAGIFADGGEVGRDHARVDWAATPLGPPSRWPQSLLTAA
TH_2781|M.thermoresistible__bu --------------------------------------------------
MUL_3853|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3991|M.marinum_M --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1619|M.avium_104 --------------------------------------------------
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4521|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1931|M.vanbaalenii_PYR-1 SILLSSRFPMWMAWGPELTFFCNDAYRRDTLGRKYPWALGRPASEVWAEI
TH_2781|M.thermoresistible__bu --------------------------------------------------
MUL_3853|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3991|M.marinum_M --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1619|M.avium_104 --------------------------------------------------
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4521|M.gilvum_PYR-GCK -----------------MADDRNLPAFRRHGRQEGDRTDAEFDELIAARN
Mvan_1931|M.vanbaalenii_PYR-1 WDDIGPRIERVLSTGQATWDTALLLFLERSGYPEETYHTFSYSPLRDDDG
TH_2781|M.thermoresistible__bu -----------------------------MSPDFGARYAAALAAYLEDSS
MUL_3853|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3991|M.marinum_M --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1619|M.avium_104 --------------------------------------------------
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4521|M.gilvum_PYR-GCK --------QMDHLVRAIVA--------IGSDLDFSVTLERIVTAARELSG
Mvan_1931|M.vanbaalenii_PYR-1 RVVGMLCVVSEDTVRVIGERRMATLRDLGSDLSLVRSEVDILRFADEQLG
TH_2781|M.thermoresistible__bu -------------ERRLAVAHDLGRQALLGRISVLQIVEDHVRLVDELSR
MUL_3853|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3991|M.marinum_M --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1619|M.avium_104 --------------------------------------------------
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4521|M.gilvum_PYR-GCK -------------------ARYAGLG------------IRAAGGNLVSFV
Mvan_1931|M.vanbaalenii_PYR-1 HNLRDLPFTLTYLFDGDGSARLAGTSGIAPEHPAVPTRLSADGGGIWPVA
TH_2781|M.thermoresistible__bu --------------------------------------------------
MUL_3853|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3991|M.marinum_M --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1619|M.avium_104 --------------------------------------------------
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4521|M.gilvum_PYR-GCK ESGD------EFDVAALAGLP-----------------------------
Mvan_1931|M.vanbaalenii_PYR-1 EPARSESVLVDLDGDSYPSLPTGDWREPPAQALVVPLLHQGGSPSGFLVV
TH_2781|M.thermoresistible__bu --------------------------------------------------
MUL_3853|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3991|M.marinum_M --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1619|M.avium_104 --------------------------------------------------
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4521|M.gilvum_PYR-GCK -------IDGGLR-------------------------------------
Mvan_1931|M.vanbaalenii_PYR-1 GLNRYRLLDDGYRGFLTLVAGHIAAGIGLARSYRAQQRRAEELAELDRVK
TH_2781|M.thermoresistible__bu --------------------------------------------------
MUL_3853|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3991|M.marinum_M --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1619|M.avium_104 --------------------------------------------------
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4521|M.gilvum_PYR-GCK ---------------------IDDLR-----DHPEITDLQALNRP-----
Mvan_1931|M.vanbaalenii_PYR-1 TTFFSNISHEFRTPLTLILDPVSELRRAESIDEPVRRELDVVWRNGLRLT
TH_2781|M.thermoresistible__bu -------------------------------RQPVDTDTALQFLL-----
MUL_3853|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3991|M.marinum_M --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1619|M.avium_104 --------------------------------------------------
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4521|M.gilvum_PYR-GCK --IRALLAIPVTVRG---------------ADFGSLYLADDRPG------
Mvan_1931|M.vanbaalenii_PYR-1 KLVNTLLDFSRIEAGRTQARYQPVDLGALTAELASMFRSAVERAGLTFDI
TH_2781|M.thermoresistible__bu ---QALAAVDVAVRG--------------YLEGTRRYEQQRARAEG----
MUL_3853|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3991|M.marinum_M --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1619|M.avium_104 --------------------------------------------------
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4521|M.gilvum_PYR-GCK --------------------------------------RVFSDAQESAVR
Mvan_1931|M.vanbaalenii_PYR-1 DCDPLDEVVYVDRDMWEKVIFNLLSNALKFTFEGAVSVRVRRDGHQAVVV
TH_2781|M.thermoresistible__bu --------------------------------------LAGRDTFRSALV
MUL_3853|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3991|M.marinum_M --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1619|M.avium_104 --------------------------------------------------
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4521|M.gilvum_PYR-GCK ALATAAAAAIDNA-RLFER----EREAARWTKAS-------REIT---TA
Mvan_1931|M.vanbaalenii_PYR-1 VADTGTGVPADEMPRLFERFHRIENAKARSNEGSGIGLALVKELIGLHGG
TH_2781|M.thermoresistible__bu NAMQEAFFVMDRTGSVIDINEAFAEITGYDG-------------------
MUL_3853|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3991|M.marinum_M --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1619|M.avium_104 --------------------------------------------------
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4521|M.gilvum_PYR-GCK LLSGDPQTG------------------PLQLIVNRALELAG-----AEQA
Mvan_1931|M.vanbaalenii_PYR-1 TIVADSAEGQGTAFTIRMPFGAAHLPDDALAPVGDGREAAGGADAYVEEA
TH_2781|M.thermoresistible__bu ----------------------------------------------HDLP
MUL_3853|M.ulcerans_Agy99 ---------------------------------------MLLLDLLRQRT
MMAR_3991|M.marinum_M --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1619|M.avium_104 --------------------------------------------------
MSMEG_6131|M.smegmatis_MC2_155 ----------------------------------------------MRAP
Mflv_4521|M.gilvum_PYR-GCK ILLVPLEPDVPAEDVDTLIVAATAG----------RYSSEVIGRQVPMAG
Mvan_1931|M.vanbaalenii_PYR-1 LRWIPADTEADDESAHAPTGSVTAASARVLVADDNADMREYLTRLLRSDG
TH_2781|M.thermoresistible__bu YRWPHPWVVDEPRADEDLLELLQHG-------------RVQLERQIRHRS
MUL_3853|M.ulcerans_Agy99 YSFVRSVHRRDGYMAAEMDWDKNVG------------TANTVRRIFENVP
MMAR_3991|M.marinum_M -------------MAAEMDWDKSVG------------TANTVRRIFENVP
Mb1399c|M.bovis_AF2122/97 -------------MAAEMDWDKTVG------------AAEDVRRIFEHIP
Rv1364c|M.tuberculosis_H37Rv -------------MAAEMDWDKTVG------------AAEDVRRIFEHIP
MAV_1619|M.avium_104 -------------MVAEKDWDRIVG------------AADDVRRVFDNVP
MSMEG_6131|M.smegmatis_MC2_155 FDRVIASPVDLTGPGQRRLSLLLVE--------DDRADAILVEELIADAP
: . .
Mflv_4521|M.gilvum_PYR-GCK STTGGVAR---------RGLP--MITDSFQYPIEGFTDVGE----RSAIV
Mvan_1931|M.vanbaalenii_PYR-1 YRVDAVADGLEALEAIRAGAPDIVVSDVMMPRLDGLGLVAELRADRRTAA
TH_2781|M.thermoresistible__bu GHLAWVAIS------------------VNVVNPNGTAFVGTMR-------
MUL_3853|M.ulcerans_Agy99 TMLVGLEGP-----------------------------------------
MMAR_3991|M.marinum_M TMLVGLEGP-----------------------------------------
Mb1399c|M.bovis_AF2122/97 AILVGLEGP-----------------------------------------
Rv1364c|M.tuberculosis_H37Rv AILVGLEGP-----------------------------------------
MAV_1619|M.avium_104 ALLVGLEGP-----------------------------------------
MSMEG_6131|M.smegmatis_MC2_155 DIDFVWAKS-----------------------------------------
Mflv_4521|M.gilvum_PYR-GCK MPLIVDDAVLG------------------------VIAVARR--------
Mvan_1931|M.vanbaalenii_PYR-1 TPVLLLSARAGQQESISGLRAGADDYLVKPFAAAELLARVRTNVELARLR
TH_2781|M.thermoresistible__bu --------------------------------------------------
MUL_3853|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3991|M.marinum_M --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1619|M.avium_104 --------------------------------------------------
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4521|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1931|M.vanbaalenii_PYR-1 HHHAQWRTALVDSLQEAFFVCDADGAVIEINPAFTEILGYDRAGLPYRPM
TH_2781|M.thermoresistible__bu --------------------------------------------------
MUL_3853|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3991|M.marinum_M --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1619|M.avium_104 --------------------------------------------------
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4521|M.gilvum_PYR-GCK -PNQPAFDED---------------------------------YLELVSD
Mvan_1931|M.vanbaalenii_PYR-1 HPWWPSADNDPDAHRQVAEAFDSLLGNRRGTITAVPVTHRDGHRLWVTAT
TH_2781|M.thermoresistible__bu --------------------------------------------------
MUL_3853|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3991|M.marinum_M --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1619|M.avium_104 --------------------------------------------------
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4521|M.gilvum_PYR-GCK FARHAS---------------IALALAAGREHALN---RQLAQADSVSEA
Mvan_1931|M.vanbaalenii_PYR-1 FAHAEDPETGGDVVVGTVRDVSAEHFVVQRETALASLNESLAQADTLGDA
TH_2781|M.thermoresistible__bu -------------------DITAAHKAAARESALTRLATAAGVATSVSEV
MUL_3853|M.ulcerans_Agy99 -----------------------EHRFVAANAAYRRFSPTFTAVGQPARE
MMAR_3991|M.marinum_M -----------------------EHRFVAANAAYRRFSPTFTAVGQPARE
Mb1399c|M.bovis_AF2122/97 -----------------------DHRFVAVNAAYRGFSPLLDTVGQPARE
Rv1364c|M.tuberculosis_H37Rv -----------------------DHRFVAVNAAYRGFSPLLDTVGQPARE
MAV_1619|M.avium_104 -----------------------DHRFVAVNAAYRALSPPVDPIGLLARE
MSMEG_6131|M.smegmatis_MC2_155 ------------------------MSDAERTLADHRPDCVLLDLNLPDAA
. *
Mflv_4521|M.gilvum_PYR-GCK MAGAAEELRRLWRARRVLAVTFPT---RSEAADVEPVVVSAGEHTTWREL
Mvan_1931|M.vanbaalenii_PYR-1 VRAATAEFAAVWRARRVLAVTWPDGYPVDTETPVDPHLVCAGEPARWSDL
TH_2781|M.thermoresistible__bu LSIMLDECRPAIDSRRVIAVTWAR-----EDAEPTIQVVGDPPASTWADL
MUL_3853|M.ulcerans_Agy99 VYPELESQQIYHMLDRVYETGEPQ------------------SGAEWRLQ
MMAR_3991|M.marinum_M VYPELESQQIYHMLDRVYETGEPQ------------------SGAEWRLQ
Mb1399c|M.bovis_AF2122/97 VYPELEGQQIYEMLDRVYQTGEPQ------------------SGSEWRLQ
Rv1364c|M.tuberculosis_H37Rv VYPELEGQQIYEMLDRVYQTGEPQ------------------SGSEWRLQ
MAV_1619|M.avium_104 VYPELESQQIFQMFDRVYQTGEPQ------------------SGTEWRVQ
MSMEG_6131|M.smegmatis_MC2_155 GIDALHHLGKLDARIPIIVLTGLN--------------------------
:
Mflv_4521|M.gilvum_PYR-GCK PDGIRQILLSMRRGDLLTPNAAEPG-----TAGIAVQHPEGILVVWIELA
Mvan_1931|M.vanbaalenii_PYR-1 PAHTRERITALRDDDLLDPDTSTAG-----AAGVALQHPQGVLVIYVELF
TH_2781|M.thermoresistible__bu DESLRTTLLAARDWPPLTVQPVSDAGQNTSRGIVAVLSGTPATVLWLEHR
MUL_3853|M.ulcerans_Agy99 ADFDGSG-IDERYFDFLVTPRRREDG-----------SIEGVQILFDDVT
MMAR_3991|M.marinum_M ADFDGSG-IDERYFDFLVTPRRREDG-----------SIEGVQILFDDVT
Mb1399c|M.bovis_AF2122/97 TDYDGSG-VEERYFDFVVTPRRRADG-----------SIEGVQLIVDDVT
Rv1364c|M.tuberculosis_H37Rv TDYDGSG-VEERYFDFVVTPRRRADG-----------SIEGVQLIVDDVT
MAV_1619|M.avium_104 ADFEGVGKAQEHFFDFIVTPRRGDDG-----------SIEGVQLAFVDVT
MSMEG_6131|M.smegmatis_MC2_155 DEHFGVSAVASGAQDYLVKGRVEPEMLR--------------RAVLYAIE
:
Mflv_4521|M.gilvum_PYR-GCK EHRSFTLEDQTLLTVLAGRLSAGLQRVHQVDQQRETALALQHAILGPAH-
Mvan_1931|M.vanbaalenii_PYR-1 ERRRFTAEDHTLLTVLAGRLGQGLQRVQQIDQQRETALALQHAILGPA--
TH_2781|M.thermoresistible__bu VPRPVGIDGRRLINALVGHVSLAVQHVRRFEIARESSLTLQRAMLPDIV-
MUL_3853|M.ulcerans_Agy99 TRVRARLAAEARVEELS----------ERYRHLRDSAIVMQQALLAPSVP
MMAR_3991|M.marinum_M TRVRARLAAEARVEELS----------ERYRHLRDSAIVMQQALLAPSVP
Mb1399c|M.bovis_AF2122/97 SRVRARQAAEARVEELS----------ERYRNVRDSATVMQQALLAASVP
Rv1364c|M.tuberculosis_H37Rv SRVRARQAAEARVEELS----------ERYRNVRDSATVMQQALLAASVP
MAV_1619|M.avium_104 DRVRNRMAAEARLEELS----------ERYRNVRDSATVMQQALLAPSVP
MSMEG_6131|M.smegmatis_MC2_155 RKRAELTSVDLHASQLR---------------AQENARLERGLLPSPLLM
* ::.: : :
Mflv_4521|M.gilvum_PYR-GCK --LPPGFTVRYQAASRPLQVGGDWYDVVDLDDGRIALIVGDCVGHGLAAA
Mvan_1931|M.vanbaalenii_PYR-1 --LSGGFAVRYQPATRPLQVGGDWYDVVDLDDGRIALIVGDCVGHGLAAA
TH_2781|M.thermoresistible__bu --PPPGFAVRYEPAVRPLEIGGDWYDVLPLDDHQIGIIVGDCVGRGLPAA
MUL_3853|M.ulcerans_Agy99 VVSGPDIAAQYLVAAQDTAAGGDWFDAVALGD-RLVLIVGDVVGHGVEAA
MMAR_3991|M.marinum_M VVSGADIAAQYLVAAQDTAAGGDWFDAVALGD-RLVLIVGDVVGHGVEAA
Mb1399c|M.bovis_AF2122/97 VVPGADIAAEYLVAAEDTAAGGDWFDALALGD-RLVLVVGDVVGHGVEAA
Rv1364c|M.tuberculosis_H37Rv VVPGADIAAEYLVAAEDTAAGGDWFDALALGD-RLVLVVGDVVGHGVEAA
MAV_1619|M.avium_104 VTPGADVTAEYLVAAQDTAAGGDWFDAIPLGD-RLVLIVGDVVGHGVEAA
MSMEG_6131|M.smegmatis_MC2_155 EGSGVDIVVEARPSRQHALIGGDFYDVVQTPDRTVHVMIGDVAGHGPDEA
..... : . ***::*.: * : :::** .*:* *
Mflv_4521|M.gilvum_PYR-GCK TVMGQVRSACRALLLENPSPGAALSGMDRFAARLPGAQ--CTTAVVMVLD
Mvan_1931|M.vanbaalenii_PYR-1 AIMGQLRSACRALLLEHPSPAAALSGLDRFAARLPGAR--CTTAFCAVLD
TH_2781|M.thermoresistible__bu AVMGQLRSSARALLLSGAEPARLLENLDAVAALIPDAY--CATVLLAVLD
MUL_3853|M.ulcerans_Agy99 AVMSQLRTALRLQIAAGRSIGEALEALDAFHEHVPGSN--SATLCVGSLD
MMAR_3991|M.marinum_M AVMSQLRTALRLQIAAGRSIGEALEALDAFHEHVPGSN--SATLCVGSLD
Mb1399c|M.bovis_AF2122/97 AVMSQLRTALRMQISTGYTVVEALEAVDRFHKQVPGSK--SATMCVGSLD
Rv1364c|M.tuberculosis_H37Rv AVMSQLRTALRMQISAGYTVVEALEAVDRFHKQVPGSK--SATMCVGSLD
MAV_1619|M.avium_104 AVMSQLRTALRMQILAGYPIAEALEAVDRFHKHVPGSS--SATMCVGSLD
MSMEG_6131|M.smegmatis_MC2_155 ALGVALRIGWRALTFAGLRGNERMRQLDRILTTERPGKGIFATLCSVALE
:: :* . * : :* . . :* *:
Mflv_4521|M.gilvum_PYR-GCK PASGEIAYSSAGHPPPLVVHADGEVETFDDAHTIALGLRLNWVRPETRRT
Mvan_1931|M.vanbaalenii_PYR-1 PETGEVVYSCAGHPPPILIGADRSTRLLEEARATPLGLKNPPHRTEARET
TH_2781|M.thermoresistible__bu TESGTLRYSNAGHVPALLAGPGPHATVLTDGASVPLGVQQNRPRPQVSRQ
MUL_3853|M.ulcerans_Agy99 FTTGEFQYCTAGHPPPLVVTAEAKARYLEPSGAGPLGSDTG--FPVRTEL
MMAR_3991|M.marinum_M FTTGEFQYCTAGHPPPLVVTAEAKSRYLEPSGAGPLGSDTG--FPVRTEL
Mb1399c|M.bovis_AF2122/97 FTSGEFQYCTAGHPPPLLVTADASARYVEPTGAGPLGSGTG--FPVRSEV
Rv1364c|M.tuberculosis_H37Rv FTSGEFQYCTAGHPPPLLVTADASARYVEPTGAGPLGSGTG--FPVRSEV
MAV_1619|M.avium_104 FGSGEFSYCTAGHPPPLLVTADATARYVEPSGAGPLGSGTG--FPVRTEF
MSMEG_6131|M.smegmatis_MC2_155 PDSGRFTVVRAGHPG-LLVHGNGTVDWLEPRPGAALGLGAR-EWPVNHYE
:* . *** :: . .** .
Mflv_4521|M.gilvum_PYR-GCK LEVGSTLVLYTDGLVERRRIPLEEGISRATDVVV-----------EHRAA
Mvan_1931|M.vanbaalenii_PYR-1 MAPRATLLLYTDGLVERRRESIDDGIARAAGVVE-----------DNRAT
TH_2781|M.thermoresistible__bu LTPGSTLMLYTDGLVERRDSPIDTGMDRACQVLT-----------AMLDA
MUL_3853|M.ulcerans_Agy99 IGVGDVVLLYTDGLIERPGRPLGASTAEFADLAANITSG-GGFVIDAQSR
MMAR_3991|M.marinum_M IGVGDVVLLYTDGLIERPGRPLGASTAEFADLAANITSG-GGFVIDAQSR
Mb1399c|M.bovis_AF2122/97 LNIGDAILFYTDGLIERPGRPLEASTAEFADLAASIASGSGGFVLDAPAR
Rv1364c|M.tuberculosis_H37Rv LNIGDAILFYTDGLIERPGRPLEASTAEFADLAASIASGSGGFVLDAPAR
MAV_1619|M.avium_104 LDVGDSILLYTDGLIERPGRPLGASTAEFADLAANIVSGQGGFVIESSVR
MSMEG_6131|M.smegmatis_MC2_155 LPEGHGLLLLTDGLFEGHAGRGDERLGESG--------------------
: ::: ****.* .
Mflv_4521|M.gilvum_PYR-GCK PLDDLANAIMSELAPSVGYQDDVALLLYRHP---APLELTFPAHADHLAP
Mvan_1931|M.vanbaalenii_PYR-1 ALDELANAVMAGLAPADGYHDDVALLLYRQP---APLDLEFAADVAELAV
TH_2781|M.thermoresistible__bu EPEAVADAMLDTLAPADGYDDDVAIVVYRHTF--APLRIELPATPDRLSE
MUL_3853|M.ulcerans_Agy99 PIDRLCSETLELLLRSTGYNDDITLLAVQRRAPTPPLNITEDATIHAARA
MMAR_3991|M.marinum_M PIDRLCSETLELLLRSTGYNDDITLLAVQRRAPTPPLNITEDATIHAARA
Mb1399c|M.bovis_AF2122/97 PIDRLCSDTLELLLRSTGYNDDVTLLAMQRRAPTPPLHITLDATINAART
Rv1364c|M.tuberculosis_H37Rv PIDRLCSDTLELLLRSTGYNDDVTLLAMQRRAPTPPLHITLDATINAART
MAV_1619|M.avium_104 TVDRLCAETLELLLRSTGYSDDVTLLAAQRRTPPPPLNLTLDATIHAART
MSMEG_6131|M.smegmatis_MC2_155 -----LLAVARALAATPGRD------------------------------
* : *
Mflv_4521|M.gilvum_PYR-GCK TRTALRRWLSGAKVEQGRVMEVLVAAGEAVANAIEHGHRHGPPGTVRLRA
Mvan_1931|M.vanbaalenii_PYR-1 GREALRGWLDRAGVGAEQSLDVLIATGEALANAIEHGHREQPRGPVRLRA
TH_2781|M.thermoresistible__bu VRARLTGWLTAAGAPELLISDIVLAVNEACTNSVEHAYRDREPGPMQVYA
MUL_3853|M.ulcerans_Agy99 IRSRLRQWLSEIGADSGDISDIVHAISEFVENAVEHGYSTDVSDGLAVAA
MMAR_3991|M.marinum_M IRSRLRQWLSEIGADSSDISDIVHAISEFVENAVEHGYSTDVSDGLAVAA
Mb1399c|M.bovis_AF2122/97 VRAQLREWLAEIGADHSDIADIVHAISEFVENAVEHGYATDVSKGIVVEA
Rv1364c|M.tuberculosis_H37Rv VRAQLREWLAEIGADHSDIADIVHAISEFVENAVEHGYATDVSKGIVVAA
MAV_1619|M.avium_104 VRTRLRQWLSDVGADADDISDIVHAISEFVENAVEHGYATEVPDGVVVEA
MSMEG_6131|M.smegmatis_MC2_155 --------------------FVTSLINEAESRAQTHGGLSDDIAVIRVER
: .* .: *. : :
Mflv_4521|M.gilvum_PYR-GCK TAL-VDLVELIITDSGSWKPPSAIPDTYRGRGIGIMRGLMQDVTIAHDSD
Mvan_1931|M.vanbaalenii_PYR-1 IAL-PDRVHVTVVDSGTWKPPATVPALHRGRGIALMRALMHDVTIDSQTT
TH_2781|M.thermoresistible__bu DLR-DGQIMLQVRDFGTWKTPEPNPRIR-GRGLPMMRAISADVQVDNTRS
MUL_3853|M.ulcerans_Agy99 ALGGDGKLRVAVIDHGTWKHHRE-GERGRGRGLAMAEALVSETHVSHDGA
MMAR_3991|M.marinum_M ALGGDGKLRVAVIDHGTWKHHRE-GERGRGRGLAMAEALVSETHVSHDGA
Mb1399c|M.bovis_AF2122/97 ALAGDGNVRASVIDRGQWKDHRD-GARGRGRGLAMAEALVSEARIMHGAG
Rv1364c|M.tuberculosis_H37Rv ALAGDGNVRASVIDRGQWKDHRD-GARGRGRGLAMAEALVSEARIMHGAG
MAV_1619|M.avium_104 MLAGDGNLHASVIDRGRWKDHRE-GETGRGRGLAMAEALVSEAHVSHGPE
MSMEG_6131|M.smegmatis_MC2_155 SRR-----------------------------------------------
Mflv_4521|M.gilvum_PYR-GCK GTTIHLYARIS---------------------------------------
Mvan_1931|M.vanbaalenii_PYR-1 GTTVHMNARIV---------------------------------------
TH_2781|M.thermoresistible__bu GTVVELTFTLSGQPALT---------------------------------
MUL_3853|M.ulcerans_Agy99 GTTATVVHRLSRPAQFVTDPVVSRAPNRPAIDSEFASTVTESGHIVVRGD
MMAR_3991|M.marinum_M GTTATVVHRLSRPAQFVTDPVVSRAPNRPTIDSEFASTVTESGHIVVRGD
Mb1399c|M.bovis_AF2122/97 GTTATLTHRLSRPARFVTDTMVRRAAFQQTIDSEFVS-LVESGRIVVRGD
Rv1364c|M.tuberculosis_H37Rv GTTATLTHRLSRPARFVTDTMVRRAAFQQTIDSEFVS-LVESGRIVVRGD
MAV_1619|M.avium_104 GTTASVTHRLSRPANFVADSLVSRAGDHGVRSAEFVSTVTEPGRIVVSGD
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4521|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1931|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2781|M.thermoresistible__bu --------------------------------------------------
MUL_3853|M.ulcerans_Agy99 VDSNTAPTLDRQIAVESRSGIASLTIDLSAVTHLGSAGVSALVTARDRAR
MMAR_3991|M.marinum_M VDSNTAPTLDRQIAVESRSGIASLTIDLSAVTHLGSAGVSALVTARDRAR
Mb1399c|M.bovis_AF2122/97 VDSTTAATLDRQIAVESRSGIAPVTIDLSAVTHLGSAGVGALAAACDRAR
Rv1364c|M.tuberculosis_H37Rv VDSTTAATLDRQIAVESRSGIAPVTIDLSAVTHLGSAGVGALAAACDRAR
MAV_1619|M.avium_104 VDSNTASTLDRQIAVESRSGVAPLTVDLSAVTHLGSAGVSALAAARERAL
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4521|M.gilvum_PYR-GCK ---------------------------------------
Mvan_1931|M.vanbaalenii_PYR-1 ---------------------------------------
TH_2781|M.thermoresistible__bu ---------------------------------------
MUL_3853|M.ulcerans_Agy99 KQGGRCVLMAPPGSPAHHVLSLVQIPVISGETENVFAED
MMAR_3991|M.marinum_M KQGGRCVLMAPPGSPAHHVLSLVQIPVISGETENVFAED
Mb1399c|M.bovis_AF2122/97 KQGTECVLVAPPGSPAHHVLSLVQLPVVGADTEDIFAQE
Rv1364c|M.tuberculosis_H37Rv KQGTECVLVAPPGSPAHHVLSLVQLPVVGADTEDIFAQE
MAV_1619|M.avium_104 RQGSDYVLVAPPGSPAHHVLSLVQIPVVSGLAENVVAEG
MSMEG_6131|M.smegmatis_MC2_155 ---------------------------------------