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PLELASFFRTTLPLDLKGLDAADDGRYHSLWMPDHLVSFWPDSIWTPEFTDLAEVSPSPHRYLDTIALAG AVAARTTRTRLATSVLDTVRRHPVMLAQSALTLSHLSDGRFILGLGAGERENLAPYGFDPRGTVSRFAEA LQLIRLLWNADGPIDFTGRYFTLEHARLDTEVHRSGPPPIWIGANGPRMLHLVGEYGDGWWPTGSAGPET YARQLTRIREAAERAGRDPQAITPAKMVVCLIGEPDELREILQRPLVKSLVLQLTADALADTGHRHPMGQ RWRGIQDIDPRVLTRDRLLRLFEQVDPAAILSVVPHGTPTQVAAQVAEFGEAGARVVSVLDYSGMAGQAY AAESARKVREVEMQLTGSGA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4402 | - | - | 100% (371) | luciferase family protein |
| M. gilvum PYR-GCK | Mflv_2493 | - | e-131 | 60.77% (362) | luciferase family protein |
| M. gilvum PYR-GCK | Mflv_3380 | - | 2e-55 | 39.50% (319) | luciferase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2975c | - | 8e-54 | 39.50% (319) | oxidoreductase |
| M. tuberculosis H37Rv | Rv2951c | - | 8e-54 | 39.50% (319) | oxidoreductase |
| M. leprae Br4923 | MLBr_00131 | - | 4e-51 | 36.88% (320) | putative oxidoreductase |
| M. abscessus ATCC 19977 | MAB_0968c | - | 1e-25 | 36.29% (259) | luciferase-like hypothetical protein |
| M. marinum M | MMAR_1758 | - | 8e-55 | 39.38% (320) | ketoreductase |
| M. avium 104 | MAV_0066 | - | 1e-128 | 58.93% (375) | hypothetical protein MAV_0066 |
| M. smegmatis MC2 155 | MSMEG_2811 | - | 3e-21 | 31.58% (209) | hydride transferase 1 |
| M. thermoresistible (build 8) | TH_2487 | - | 1e-23 | 35.65% (230) | PUTATIVE putative conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_1043 | - | 8e-22 | 31.42% (226) | hypothetical protein MUL_1043 |
| M. vanbaalenii PYR-1 | Mvan_0698 | - | 4e-19 | 36.57% (175) | luciferase family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4402|M.gilvum_PYR-GCK -----------MPLELASFFRTTLPLDLKGLDAADDGR-YHSLWMPDHLV
MAV_0066|M.avium_104 -----------MTVQPAAFLRTTLPLDLSRLDEFDSGR-YHSVWLPDHMV
Mb2975c|M.bovis_AF2122/97 ---MGGLRFGFVDALVHSRLPPTLPARSSMAAATVMG--ADSYWVGDHLN
Rv2951c|M.tuberculosis_H37Rv ---MGGLRFGFVDALVHSRLPPTLPARSSMAAATVMG--ADSYWVGDHLN
MLBr_00131|M.leprae_Br4923 ---MAGFRFGFVDALVHTLFPPSLPARASIVSGAVLG--ADSYWVGDHLN
MMAR_1758|M.marinum_M MKKSSGFRYGFVDAPVHSRLPPSMIARSSMMAGAVMG--ADSYWIGDHLN
MAB_0968c|M.abscessus_ATCC_199 -----------MRFSIWGQTNQSWADLLDIAQYADDGT-WRAFYAADHFM
TH_2487|M.thermoresistible__bu -----------MTDYGHDLLFGTFVTPSNHPPHHPVEQ-AVVADRAGLDL
MSMEG_2811|M.smegmatis_MC2_155 ---------MQISLHALGIGAGARREIIDAVAVAAERAGFTTLWCGEHVV
MUL_1043|M.ulcerans_Agy99 -----------MHSHPYHPELASGAGVAAVAAAAERAG-FHGFGFTDHPA
Mvan_0698|M.vanbaalenii_PYR-1 --------MAELKLGYKASAEQFAPRELVELAVAAEEHGMDSATVSDHFQ
:
Mflv_4402|M.gilvum_PYR-GCK SFWPDSIW-TPEFTDLAEVSP---SPHRYLDTIALAGAVAARTTRTRLAT
MAV_0066|M.avium_104 SFWPDSIW-APEFTDLATASA---SPHRHLDGLAVAAAAAVLTERVPLVS
Mb2975c|M.bovis_AF2122/97 ALVPRSIA-TSEYLGIAAKFVPKIDANYEPWTMLGNLAFG-LPSRLRLGV
Rv2951c|M.tuberculosis_H37Rv ALVPRSIA-TSEYLGIAAKFVPKIDANYEPWTMLGNLAFG-LPSRLRLGV
MLBr_00131|M.leprae_Br4923 ALVPRSVA-TPKYLGVAAKVVPKIDANYEPWTMLGNLAAGNRLNGLRLGV
MMAR_1758|M.marinum_M ALVPRSVA-TPEFLGLGARLVPKVDANYEPWTMLGNLAAGNRINRLRLGV
MAB_0968c|M.abscessus_ATCC_199 SHADTAEE-RTDFHEATALFA----------------ALAAATSRIRLAP
TH_2487|M.thermoresistible__bu VTFQDHPY-VAKYHDTWTLMS----------------YAAARTQRVRLSA
MSMEG_2811|M.smegmatis_MC2_155 MVDRPRSR-YPYSADGRIAVA---ADADWLDPMIALSFAAAATSTIRIAT
MUL_1043|M.ulcerans_Agy99 PSQRWLEAGGHDSLDPFVALG----------------FAAAQTTSLRLIP
Mvan_0698|M.vanbaalenii_PYR-1 PWRHEGGH-APFSLAWMTAVG-------------------ERTKRLQLGT
:
Mflv_4402|M.gilvum_PYR-GCK SVLDTVRRH-PVMLAQSALTLSHLSDGRFILGLGAGE-REN-LAPYGFDP
MAV_0066|M.avium_104 AVVDTVRRH-PALLAQTALTLDHLSKGRFILGLGSGE-SEN-TVPYGFDF
Mb2975c|M.bovis_AF2122/97 CVTDAGRRN-PAVTAQAAATLHLLTRGRAILGIGVGE-REG-NEPYGVEW
Rv2951c|M.tuberculosis_H37Rv CVTDAGRRN-PAVTAQAAATLHLLTRGRAILGIGVGE-REG-NEPYGVEW
MLBr_00131|M.leprae_Br4923 CVTDAGRRN-PAVTAQAAATLHLLTRGKAMLGIGVGE-REG-NEPYGVEW
MMAR_1758|M.marinum_M CVTDVGRRN-PAVTAQAAATVHLLTRGRAILGIGVGE-REG-NEPYGVEW
MAB_0968c|M.abscessus_ATCC_199 LVLSMTFRH-PAVLANWAATVDHVSQGRFTLGLGAGW-QENEHQRYGLEL
TH_2487|M.thermoresistible__bu NVANLPLRP-PAVLARSAAGLDLLSGGRVELGLGAGA-FWDGVVAMGGER
MSMEG_2811|M.smegmatis_MC2_155 GVLLLPEHN-PVIMAKQAASVDQLSGGRLLLGVGIGW-SREEFEALGVPF
MUL_1043|M.ulcerans_Agy99 NIVVLPYRN-PFVVAKSAATLDLLSGGRFILAVGVGY-LKREFAALGVDH
Mvan_0698|M.vanbaalenii_PYR-1 SVLTPTFRYNPAVIAQAFATMGCLYPGRIFLGVGTGEALNEIATGYEGDW
: : * : *. : : *: *.:* *
Mflv_4402|M.gilvum_PYR-GCK RGT---VSRFAEALQLIRLLWNADG--PIDFTGRYFTLEHARLDTEVHRS
MAV_0066|M.avium_104 ARP---VSRFEEALRVIRLLWDTDG--PVDFNGEFYSLHQARLDTEPYHD
Mb2975c|M.bovis_AF2122/97 TKP---VARFEEALATIRALWNSNGE-LISRESPYFPLHNALFDLPPYRG
Rv2951c|M.tuberculosis_H37Rv TKP---VARFEEALATIRALWNSNGE-LISRESPYFPLHNALFDLPPYRG
MLBr_00131|M.leprae_Br4923 TKP---VARFQEALATIRALWDSNGE-LVSRESQFFPLHNALFDLPPYRG
MMAR_1758|M.marinum_M SKP---VARFEEGLATIRALWDSNGA-LVTRESPYFPLRNALFDLPPYKG
MAB_0968c|M.abscessus_ATCC_199 GKPGARVDRFSEGLQVITGLLNEPVT-TVDG--QYYRLAEGICEPKPLQR
TH_2487|M.thermoresistible__bu RSPGAAIKALEEAIAVIRGIWDVDAAGVLDVDGAHYRIRGAKRGPAPAH-
MSMEG_2811|M.smegmatis_MC2_155 ARRG---ARTAEYVEAMRTLWRQDVA---DFTGEFAAFDAVRLHPKPSAG
MUL_1043|M.ulcerans_Agy99 AER---AELFDEALQVIRAVWTSDDI---SFEGRHFSARGITAHPRPASN
Mvan_0698|M.vanbaalenii_PYR-1 PEFKERYARLRESVRLMRDLWLGDRV---DFEGEYYKTKGASIYDVPEGG
* : : : .
Mflv_4402|M.gilvum_PYR-GCK GPPPIWIGANGPRMLHLVGEYGDGWWPTGSAGP---ETYARQLTRIREAA
MAV_0066|M.avium_104 RLPPIWIGASGPRMLDIAGRYADGWWPAGAWTP---EHYAEMLGAVRVSA
Mb2975c|M.bovis_AF2122/97 KWPEIWVAAHGPRMLRATGRYADAWIPIVVVRP---SDYSRALEAVRSAA
Rv2951c|M.tuberculosis_H37Rv KWPEIWVAAHGPRMLRATGRYADAWIPIVVVRP---SDYSRALEAVRSAA
MLBr_00131|M.leprae_Br4923 KWPEIWVAAHGPRMLQATGRYADAWIPIVLVRP---TDYSCALEVVRTAA
MMAR_1758|M.marinum_M KWPEIWVAAHGPRMLRATGRYADAWVPIVIIRP---TDYSRALEAVRAAA
MAB_0968c|M.abscessus_ATCC_199 PLP-ILIGATQPRMLALTARYAHEWN--QWSSP---GTFREVSGRLDAAA
TH_2487|M.thermoresistible__bu -RISIWIGGYGPRMLGLVGRLADGWLPSLQYLSGGVSDLTAMNQRIDDAA
MSMEG_2811|M.smegmatis_MC2_155 SIP-IIVGGNGDRALARVASWGDGWYGFNLDGV---AAVGERMDMLRRLC
MUL_1043|M.ulcerans_Agy99 PYPPIWVGGNTAAARRRVAVHGDGWCPFPAPAP--LAQTAGTAAIDSADR
Mvan_0698|M.vanbaalenii_PYR-1 --IPIYIAAGGPQVAKYAGRAGDGFICTSGKGE--ELYKDKLIPAMREGA
* :.. .. .. :
Mflv_4402|M.gilvum_PYR-GCK ERAGRDPQAITPAKMVVCLIGEPD-ELREILQRPLVKSLVLQLTADALAD
MAV_0066|M.avium_104 ERAGRDPMAITPCFIQVCLIGEDDDALAEILRAPLVKAFLLQVSAKTLGE
Mb2975c|M.bovis_AF2122/97 SDAGRDPMSITPAAVRGIITGRNRDDVEEALESVVVKMTALGVPGEAWAR
Rv2951c|M.tuberculosis_H37Rv SDAGRDPMSITPAAVRGIITGRNRDDVEEALESVVVKMTALGVPGEAWAR
MLBr_00131|M.leprae_Br4923 SDAGRDPMSITPAAVRGIITGRTRDDVDEALDSVLVRMIALGVPGEAWAR
MMAR_1758|M.marinum_M SDAGRDPMSITPSAVRGVVTGWSRDDVDEALDSVIVKMNALGMPAEAWAR
MAB_0968c|M.abscessus_ATCC_199 EKIGRDPATIWRSTQARVIVTDGPQSEARAAETAAASPIP----------
TH_2487|M.thermoresistible__bu VAAGRDPRQIR-----RLLNVGGQPSADELADIALSHGIS----------
MSMEG_2811|M.smegmatis_MC2_155 ARAGRDVDDLHCAVALQAPAVGDIPALVDLGVDELVIVES----------
MUL_1043|M.ulcerans_Agy99 LAAGIDDLRRKCDAAGRDFSAIDVTFTNFDGGGPASADFN----------
Mvan_0698|M.vanbaalenii_PYR-1 EAAGKNPDDIDRMIEIKISYDTDPELALENTRFWAPLSLTAEQKHSIDDP
* :
Mflv_4402|M.gilvum_PYR-GCK TGHRHPMGQRWRGIQDIDPRVLTRDRLLRLFEQVDPAAILSVVPHGTPTQ
MAV_0066|M.avium_104 FGFEHPMGDGWRGFQDIDPAALGRDRIVEFLHRVRPEMVLAVVPHGTPKQ
Mb2975c|M.bovis_AF2122/97 HGVEHPMGADFSGVQDIIPQTMDKQTVLSYAAKVPAALMKEVVFSGTPDE
Rv2951c|M.tuberculosis_H37Rv HGVEHPMGADFSGVQDIIPQTMDKQTVLSYAAKVPAALMKEVVFSGTPDE
MLBr_00131|M.leprae_Br4923 HGVEHPMGADFAGVQDIIPQTIDEETVVSYAAKVPAALMKEVLFSGTPEE
MMAR_1758|M.marinum_M HGVEHPMGADFTGVQDLIPQTMDRETVLSYTAKVPPGLIREVVASGTPDE
MAB_0968c|M.abscessus_ATCC_199 ------------------------------------------VLYGTAER
TH_2487|M.thermoresistible__bu ----------------------------------------AFILASDDTA
MSMEG_2811|M.smegmatis_MC2_155 -------------------------------------------PPQDPDV
MUL_1043|M.ulcerans_Agy99 ----------------------------------------ADAYLGGLEK
Mvan_0698|M.vanbaalenii_PYR-1 IEMEKAADALP-----------------------IEQVAKRWIVASDPDE
Mflv_4402|M.gilvum_PYR-GCK VAAQVAEFGEAGARVVSVLDYSGMAGQAYAAESARKVREVE---MQLTGS
MAV_0066|M.avium_104 VAKIVKSYVDAGLRVPKILDYGAMAGLSHAQSSAANVRATEDELMRLCGD
Mb2975c|M.bovis_AF2122/97 VIDQVAEWRDHGLRYVVLINGSLVNPSLRKTVTAVLPHAKVLRGLKKL--
Rv2951c|M.tuberculosis_H37Rv VIDQVAEWRDHGLRYVVLINGSLVNPSLRKTVTAVLPHAKVLRGLKKL--
MLBr_00131|M.leprae_Br4923 VIDQVAEWRDHGLKYLVVINGSLVNSSLRKTVSALLPHARVLRGLKKL--
MMAR_1758|M.marinum_M VIDQVAEWRDHGLRYLLVINGSLVNPSLRKTVTAVLPHAKVLRGLKKL--
MAB_0968c|M.abscessus_ATCC_199 IAEQMAPWTQEGVDEVILPDHLLGSGSARRDAYDALAQALRPLSNETD--
TH_2487|M.thermoresistible__bu TTERFAAEVAPAVRELVTAQR-----------------------------
MSMEG_2811|M.smegmatis_MC2_155 AADWVDALADRWITCI----------------------------------
MUL_1043|M.ulcerans_Agy99 LAMLGVTWVHVGLPGDGLAHALECIDRFRVQVIEAA--------------
Mvan_0698|M.vanbaalenii_PYR-1 AVAKVKDYVDWGLNHLVFHAPGHDQRRFLELFRRDLEPRLRKLG------
Mflv_4402|M.gilvum_PYR-GCK GA
MAV_0066|M.avium_104 GS
Mb2975c|M.bovis_AF2122/97 --
Rv2951c|M.tuberculosis_H37Rv --
MLBr_00131|M.leprae_Br4923 --
MMAR_1758|M.marinum_M --
MAB_0968c|M.abscessus_ATCC_199 --
TH_2487|M.thermoresistible__bu --
MSMEG_2811|M.smegmatis_MC2_155 --
MUL_1043|M.ulcerans_Agy99 --
Mvan_0698|M.vanbaalenii_PYR-1 --