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LKKSSGFRYGFVDAPVHSRLPPSMIARSSMMAGAVMGADSYWIGDHLNALVPRSVATPEFLGLGARLVPK VDANYEPWTMLGNLAAGNRINRLRLGVCVTDVGRRNPAVTAQAAATVHLLTRGRAILGIGVGEREGNEPY GVEWSKPVARFEEGLATIRALWDSNGALVTRESPYFPLRNALFDLPPYKGKWPEIWVAAHGPRMLRATGR YADAWVPIVIIRPTDYSRALEAVRAAASDAGRDPMSITPSAVRGVVTGWSRDDVDEALDSVIVKMNALGM PAEAWARHGVEHPMGADFTGVQDLIPQTMDRETVLSYTAKVPPGLIREVVASGTPDEVIDQVAEWRDHGL RYLLVINGSLVNPSLRKTVTAVLPHAKVLRGLKKL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_1758 | - | - | 100% (385) | ketoreductase |
| M. marinum M | MMAR_5411 | - | 2e-17 | 35.68% (185) | hypothetical protein MMAR_5411 |
| M. marinum M | MMAR_2559 | - | 3e-15 | 29.46% (241) | oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2975c | - | 0.0 | 83.68% (380) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_3380 | - | 1e-162 | 72.44% (381) | luciferase family protein |
| M. tuberculosis H37Rv | Rv2951c | - | 0.0 | 83.68% (380) | oxidoreductase |
| M. leprae Br4923 | MLBr_00131 | - | 0.0 | 81.10% (381) | putative oxidoreductase |
| M. abscessus ATCC 19977 | MAB_0968c | - | 2e-16 | 32.31% (229) | luciferase-like hypothetical protein |
| M. avium 104 | MAV_0066 | - | 2e-56 | 39.24% (316) | hypothetical protein MAV_0066 |
| M. smegmatis MC2 155 | MSMEG_6454 | - | 9e-17 | 34.25% (181) | hypothetical protein MSMEG_6454 |
| M. thermoresistible (build 8) | TH_2487 | - | 2e-18 | 33.69% (187) | PUTATIVE putative conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_5034 | - | 5e-17 | 35.14% (185) | hypothetical protein MUL_5034 |
| M. vanbaalenii PYR-1 | Mvan_0698 | - | 1e-16 | 30.48% (292) | luciferase family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2975c|M.bovis_AF2122/97 ------MGG--LRFGFVDALVHSRLPPTLPARSSMAAATVMG-ADSYWVG
Rv2951c|M.tuberculosis_H37Rv ------MGG--LRFGFVDALVHSRLPPTLPARSSMAAATVMG-ADSYWVG
MLBr_00131|M.leprae_Br4923 ------MAG--FRFGFVDALVHTLFPPSLPARASIVSGAVLG-ADSYWVG
MMAR_1758|M.marinum_M ---MKKSSG--FRYGFVDAPVHSRLPPSMIARSSMMAGAVMG-ADSYWIG
Mflv_3380|M.gilvum_PYR-GCK MSPRPRSAGSQFRFGLLDGIVNTRVSPTLLPSAAMLTASATG-ADSFWVG
MAV_0066|M.avium_104 ----------------MTVQPAAFLRTTLPLDLSRLDEFDSGRYHSVWLP
MSMEG_6454|M.smegmatis_MC2_155 -----------MRFAFKTSPQNTTWADMLAIWKAADN---IDVFESGWTF
MUL_5034|M.ulcerans_Agy99 -----------MRFAFKNSPQNTTWEQMLAVWQTADG---IDVYESGWTF
MAB_0968c|M.abscessus_ATCC_199 -----------MRFSIWG-QTNQSWADLLDIAQYADD----GTWRAFYAA
TH_2487|M.thermoresistible__bu ---------------MTDYGHDLLFGTFVTPSNHPPHHPVEQAVVADRAG
Mvan_0698|M.vanbaalenii_PYR-1 --------MAELKLGYKASAEQFAPRELVELAVAAEEHG----MDSATVS
: :
Mb2975c|M.bovis_AF2122/97 DHLNALVPRSIATSEYLGIAAKFVPKIDANYEPWTMLGNLAFG-LPSRLR
Rv2951c|M.tuberculosis_H37Rv DHLNALVPRSIATSEYLGIAAKFVPKIDANYEPWTMLGNLAFG-LPSRLR
MLBr_00131|M.leprae_Br4923 DHLNALVPRSVATPKYLGVAAKVVPKIDANYEPWTMLGNLAAGNRLNGLR
MMAR_1758|M.marinum_M DHLNALVPRSVATPEFLGLGARLVPKVDANYEPWTMLGNLAAGNRINRLR
Mflv_3380|M.gilvum_PYR-GCK DHINSLVPRSVATPEHLGLAAKLVPKVDAILEPWTMLGHLAAR-HRGRLR
MAV_0066|M.avium_104 DHMVSFWPDSIWAPEFTDLATASASPHRHLDG---LAVAAAAAVLTERVP
MSMEG_6454|M.smegmatis_MC2_155 DHFYPIFSDSAGP----------------CLEGWTTLTALAQA--TERLR
MUL_5034|M.ulcerans_Agy99 DHFYPIFSDPTGP----------------CLEGWTTLTALAQA--TTRLR
MAB_0968c|M.abscessus_ATCC_199 DHFMSHADTAEER--------------TDFHEATALFAALAAA--TSRIR
TH_2487|M.thermoresistible__bu LDLVTFQDHPYVAK---------------YHDTWTLMSYAAAR--TQRVR
Mvan_0698|M.vanbaalenii_PYR-1 DHFQPWRHEGGHAP-------------------FSLAWMTAVGERTKRLQ
.: . * :
Mb2975c|M.bovis_AF2122/97 LGVCVTDAGRRN-PAVTAQAAATLHLLTRGRAILGIGVGEREGNE--PYG
Rv2951c|M.tuberculosis_H37Rv LGVCVTDAGRRN-PAVTAQAAATLHLLTRGRAILGIGVGEREGNE--PYG
MLBr_00131|M.leprae_Br4923 LGVCVTDAGRRN-PAVTAQAAATLHLLTRGKAMLGIGVGEREGNE--PYG
MMAR_1758|M.marinum_M LGVCVTDVGRRN-PAVTAQAAATVHLLTRGRAILGIGVGEREGNE--PYG
Mflv_3380|M.gilvum_PYR-GCK FGVGVTDASRRH-PAVTAQAAATLHLLTRGRAILGIGVGEREGNE--PYG
MAV_0066|M.avium_104 LVSAVVDTVRRH-PALLAQTALTLDHLSKGRFILGLGSGESENTV--PYG
MSMEG_6454|M.smegmatis_MC2_155 VGVLVTGIHYRH-PAVLANMAAALDIISNGRLELGIGAGWNEEESG-AYG
MUL_5034|M.ulcerans_Agy99 LGTLVTGIHYRH-PAVLANMAAALDIISHGRLELGIGAGWNEEESG-AYG
MAB_0968c|M.abscessus_ATCC_199 LAPLVLSMTFRH-PAVLANWAATVDHVSQGRFTLGLGAGWQENEHQ-RYG
TH_2487|M.thermoresistible__bu LSANVANLPLRP-PAVLARSAAGLDLLSGGRVELGLGAGAFWDGVV-AMG
Mvan_0698|M.vanbaalenii_PYR-1 LGTSVLTPTFRYNPAVIAQAFATMGCLYPGRIFLGVGTGEALNEIATGYE
. * * **: *. : : *: **:* *
Mb2975c|M.bovis_AF2122/97 VEWT---KPVARFEEALATIRALWNSNGE-LISRESPYFPLHNALFDLPP
Rv2951c|M.tuberculosis_H37Rv VEWT---KPVARFEEALATIRALWNSNGE-LISRESPYFPLHNALFDLPP
MLBr_00131|M.leprae_Br4923 VEWT---KPVARFQEALATIRALWDSNGE-LVSRESQFFPLHNALFDLPP
MMAR_1758|M.marinum_M VEWS---KPVARFEEGLATIRALWDSNGA-LVTRESPYFPLRNALFDLPP
Mflv_3380|M.gilvum_PYR-GCK VEWT---KPVARFVEALATIRALWESGGE-PVTRESDYFPLRHAVFDLPP
MAV_0066|M.avium_104 FDFA---RPVSRFEEALRVIRLLWDTDG--PVDFNGEFYSLHQARLDTEP
MSMEG_6454|M.smegmatis_MC2_155 IELGSIKERFDRFEEACEVLKGLLTQET---TTFDGKFYQLKDARNEPKG
MUL_5034|M.ulcerans_Agy99 IELGSVKERFDRFEEACAVLTGLLSQPS---TTFDGKYYQLEDARNEPKG
MAB_0968c|M.abscessus_ATCC_199 LELGKPGARVDRFSEGLQVITGLLNEPV---TTVDGQYYRLAEGICEPKP
TH_2487|M.thermoresistible__bu GERRSPGAAIKALEEAIAVIRGIWDVDAAGVLDVDGAHYRIRGAKRGPAP
Mvan_0698|M.vanbaalenii_PYR-1 GDWPEFKERYARLRESVRLMRDLWLGDR---VDFEGEYYKTKGASIYDVP
: : *. : : :. .: .
Mb2975c|M.bovis_AF2122/97 YRGKWPEIWVAAHGP-RMLRATGRYADAWIPIVVVRP---SDYSRALEAV
Rv2951c|M.tuberculosis_H37Rv YRGKWPEIWVAAHGP-RMLRATGRYADAWIPIVVVRP---SDYSRALEAV
MLBr_00131|M.leprae_Br4923 YRGKWPEIWVAAHGP-RMLQATGRYADAWIPIVLVRP---TDYSCALEVV
MMAR_1758|M.marinum_M YKGKWPEIWVAAHGP-RMLRATGRYADAWVPIVIIRP---TDYSRALEAV
Mflv_3380|M.gilvum_PYR-GCK YKGRWPEIWVAAHGP-RMLRATGRYADGWVPFVISRP---ADYARALDAV
MAV_0066|M.avium_104 YHDRLPPIWIGASGP-RMLDIAGRYADGWWPAGAWTP---EHYAEMLGAV
MSMEG_6454|M.smegmatis_MC2_155 PQQPHPPFCIGGSGEKRTLRITAKYADHWN-FVGGTP---EEFARKRDVL
MUL_5034|M.ulcerans_Agy99 PQRPHSPICIGGSGEKRTLRITARYAQHWN-FAGGTP---EEFARKRDVL
MAB_0968c|M.abscessus_ATCC_199 LQRPLP-ILIGATQP-RMLALTARYAHEWN--QWSSP---GTFREVSGRL
TH_2487|M.thermoresistible__bu --AHRISIWIGGYGP-RMLGLVGRLADGWLPSLQYLSGGVSDLTAMNQRI
Mvan_0698|M.vanbaalenii_PYR-1 --EGGIPIYIAAGGP-QVAKYAGRAGDGFICTSGKGEE--LYKDKLIPAM
: :.. : ..: .. : :
Mb2975c|M.bovis_AF2122/97 RSAASDAGRDPMSITPAAVRGIITGRNRDDVEEALESVVVKMTALGVPGE
Rv2951c|M.tuberculosis_H37Rv RSAASDAGRDPMSITPAAVRGIITGRNRDDVEEALESVVVKMTALGVPGE
MLBr_00131|M.leprae_Br4923 RTAASDAGRDPMSITPAAVRGIITGRTRDDVDEALDSVLVRMIALGVPGE
MMAR_1758|M.marinum_M RAAASDAGRDPMSITPSAVRGVVTGWSRDDVDEALDSVIVKMNALGMPAE
Mflv_3380|M.gilvum_PYR-GCK RTAASDNGRDPMAIVPAVNRTVVTGRTRADVDEALDSVIVKSVALAAPAE
MAV_0066|M.avium_104 RVSAERAGRDPMAITPCFIQVCLIGEDDDALAEILRAPLVKAFLLQVSAK
MSMEG_6454|M.smegmatis_MC2_155 AAHCADLGRDPKEITLSAHVRLGEDRD-----------------------
MUL_5034|M.ulcerans_Agy99 AAHCADIGRDPKEITLSAHRGLAPERD-----------------------
MAB_0968c|M.abscessus_ATCC_199 DAAAEKIGRDPATIWRSTQARVIVTDGPQSEARAAETAAASPIP------
TH_2487|M.thermoresistible__bu DDAAVAAGRDPRQIRRLLNVGGQ---------------------------
Mvan_0698|M.vanbaalenii_PYR-1 REGAEAAGKNPDDIDRMIEIKISYDTDPELALENTRFWAPLSLTAEQKHS
. *::* *
Mb2975c|M.bovis_AF2122/97 AWARHGVEHPMGADFSGVQDIIPQTMDKQTVLSYAAKVPAALMKEVVFSG
Rv2951c|M.tuberculosis_H37Rv AWARHGVEHPMGADFSGVQDIIPQTMDKQTVLSYAAKVPAALMKEVVFSG
MLBr_00131|M.leprae_Br4923 AWARHGVEHPMGADFAGVQDIIPQTIDEETVVSYAAKVPAALMKEVLFSG
MMAR_1758|M.marinum_M AWARHGVEHPMGADFTGVQDLIPQTMDRETVLSYTAKVPPGLIREVVASG
Mflv_3380|M.gilvum_PYR-GCK AWARHGVEHPLGSDFSGVQDLVPQMIDKEAALAYTASVPASLMKEICFHG
MAV_0066|M.avium_104 TLGEFGFEHPMGDGWRGFQDIDPAALGRDRIVEFLHRVRPEMVLAVVPHG
MSMEG_6454|M.smegmatis_MC2_155 --------------------------------------------------
MUL_5034|M.ulcerans_Agy99 --------------------------------------------------
MAB_0968c|M.abscessus_ATCC_199 ----------------------------------------------VLYG
TH_2487|M.thermoresistible__bu -------------------------------------------------P
Mvan_0698|M.vanbaalenii_PYR-1 IDDPIEMEKAADALP-----------------------IEQVAKRWIVAS
Mb2975c|M.bovis_AF2122/97 TPDEVIDQVAEWRDHGLRYVVLINGSLVNPSLRKTVTAVLPHAKVLRGLK
Rv2951c|M.tuberculosis_H37Rv TPDEVIDQVAEWRDHGLRYVVLINGSLVNPSLRKTVTAVLPHAKVLRGLK
MLBr_00131|M.leprae_Br4923 TPEEVIDQVAEWRDHGLKYLVVINGSLVNSSLRKTVSALLPHARVLRGLK
MMAR_1758|M.marinum_M TPDEVIDQVAEWRDHGLRYLLVINGSLVNPSLRKTVTAVLPHAKVLRGLK
Mflv_3380|M.gilvum_PYR-GCK TADEVLDQVAEWRDHGLRYLLVINGSQLNPKLRKGVSATLPYNRVLRGLK
MAV_0066|M.avium_104 TPKQVAKIVKSYVDAGLRVPKILDYG-AMAGLSHAQSSAANVRATEDELM
MSMEG_6454|M.smegmatis_MC2_155 -YAKVIDEAAALGAEGLDLAIIYLPPPYDPAVLEPLAQAIRDSGQLTAA-
MUL_5034|M.ulcerans_Agy99 -FGQVIENAAALAAEGLDLGIVYIAPPHDPAVLEPMAEAIRESGLIDG--
MAB_0968c|M.abscessus_ATCC_199 TAERIAEQMAPWTQEGVDEVILPDHLLGSGSARRDAYDALAQALRPLSNE
TH_2487|M.thermoresistible__bu SADELADIALSHGIS--AFILASDDTATTERFAAEVAPAVRELVTAQR--
Mvan_0698|M.vanbaalenii_PYR-1 DPDEAVAKVKDYVDWGLNHLVFHAPGHDQRRFLELFRRDLEPRLRKLG--
.
Mb2975c|M.bovis_AF2122/97 KL-----
Rv2951c|M.tuberculosis_H37Rv KL-----
MLBr_00131|M.leprae_Br4923 KL-----
MMAR_1758|M.marinum_M KL-----
Mflv_3380|M.gilvum_PYR-GCK KL-----
MAV_0066|M.avium_104 RLCGDGS
MSMEG_6454|M.smegmatis_MC2_155 -------
MUL_5034|M.ulcerans_Agy99 -------
MAB_0968c|M.abscessus_ATCC_199 TD-----
TH_2487|M.thermoresistible__bu -------
Mvan_0698|M.vanbaalenii_PYR-1 -------