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VKVQPAAFLRTTLPLDLGQLAQLDSGRYHSIWLPDHMVSFWPDSIWTPEFTDLAVASPSPHRHLDGMAVA AAAAVLTENVPLATSVVDTVRRHPASLAQSALTIDHLSKGRFILGLGSGERENILPYGFDFRSPVGRFEE ALHVIRLLWDTEGPVDFDGRFYRLRHARLDTEPYEGRRPPIWVGASGPRSLDIAGRYADGWWPAGAWTPD DYAEKLTRVRSSAERAGRDPQQITPCFIQVCLMGRDDAALAEILQAPLVKSFLLQVSAEVLRRFGFEHPM GPDWNGFHDIDPAVLTRERIVEFLDRVQPEMVLAMVPHGTPKQVARVIKDYVDVGLRVPKILDYAAMAGG GYAAQSAGNVREAEDELLRLCG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2493 | - | - | 100% (372) | luciferase family protein |
| M. gilvum PYR-GCK | Mflv_4402 | - | e-131 | 60.77% (362) | luciferase family protein |
| M. gilvum PYR-GCK | Mflv_3380 | - | 6e-57 | 40.51% (311) | luciferase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2975c | - | 1e-56 | 37.98% (337) | oxidoreductase |
| M. tuberculosis H37Rv | Rv2951c | - | 1e-56 | 37.98% (337) | oxidoreductase |
| M. leprae Br4923 | MLBr_00131 | - | 3e-56 | 37.13% (342) | putative oxidoreductase |
| M. abscessus ATCC 19977 | MAB_0968c | - | 9e-25 | 37.05% (224) | luciferase-like hypothetical protein |
| M. marinum M | MMAR_1758 | - | 1e-57 | 39.56% (316) | ketoreductase |
| M. avium 104 | MAV_0066 | - | 1e-176 | 79.19% (370) | hypothetical protein MAV_0066 |
| M. smegmatis MC2 155 | MSMEG_6454 | - | 1e-21 | 33.96% (212) | hypothetical protein MSMEG_6454 |
| M. thermoresistible (build 8) | TH_2487 | - | 2e-24 | 37.82% (193) | PUTATIVE putative conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_3202 | - | 2e-22 | 33.73% (249) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_2247 | - | 4e-19 | 30.97% (268) | luciferase family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_6454|M.smegmatis_MC2_155 -------------MRFAFKTSPQNT-----TWADMLAIWKAADNIDVFES
Mvan_2247|M.vanbaalenii_PYR-1 ----------MSRPEIGVYLPQMGF-----SFDELLHRARRCEKLG-IDS
MUL_3202|M.ulcerans_Agy99 MHENTSNPPQHGGPQFGLILALMTQGLAISDYPDMVRVSTLAESYG-FDS
Mflv_2493|M.gilvum_PYR-GCK --------------MKVQPAAFLRT---TLPLDLGQLAQLDSGRYH---S
MAV_0066|M.avium_104 --------------MTVQPAAFLRT---TLPLDLSRLDEFDSGRYH---S
Mb2975c|M.bovis_AF2122/97 ----------MGGLRFGFVDALVHS---RLPPTLPARSSMAAATVMGADS
Rv2951c|M.tuberculosis_H37Rv ----------MGGLRFGFVDALVHS---RLPPTLPARSSMAAATVMGADS
MLBr_00131|M.leprae_Br4923 ----------MAGFRFGFVDALVHT---LFPPSLPARASIVSGAVLGADS
MMAR_1758|M.marinum_M -------MKKSSGFRYGFVDAPVHS---RLPPSMIARSSMMAGAVMGADS
MAB_0968c|M.abscessus_ATCC_199 -------------MRFSIWGQTNQS------WADLLDIAQYADDGT-WRA
TH_2487|M.thermoresistible__bu ------MTDYGHDLLFGTFVTPSNH-----PPHHPVEQAVVADRAG-LDL
.
MSMEG_6454|M.smegmatis_MC2_155 GWTFDHFYPIFS---------------------DSAGPCLEGWTTLTALA
Mvan_2247|M.vanbaalenii_PYR-1 LWLYDHLYGPG----------------------MPDYPSMEAWTLATALL
MUL_3202|M.ulcerans_Agy99 VWLCDHFLTLSPDDYVTQAGISGEHERRDGRDRPGTMPLLEAWTALSALA
Mflv_2493|M.gilvum_PYR-GCK IWLPDHMVSFWPDSIWTPEFTD---LAVASP---SPHRHLDGMAVAAAAA
MAV_0066|M.avium_104 VWLPDHMVSFWPDSIWAPEFTD---LATASA---SPHRHLDGLAVAAAAA
Mb2975c|M.bovis_AF2122/97 YWVGDHLNALVPRSIATSEYLG---IAAKFVPKIDANYEPWTMLGNLAFG
Rv2951c|M.tuberculosis_H37Rv YWVGDHLNALVPRSIATSEYLG---IAAKFVPKIDANYEPWTMLGNLAFG
MLBr_00131|M.leprae_Br4923 YWVGDHLNALVPRSVATPKYLG---VAAKVVPKIDANYEPWTMLGNLAAG
MMAR_1758|M.marinum_M YWIGDHLNALVPRSVATPEFLG---LGARLVPKVDANYEPWTMLGNLAAG
MAB_0968c|M.abscessus_ATCC_199 FYAADHFMSHADT-------------------AEERTDFHEATALFAALA
TH_2487|M.thermoresistible__bu VTFQDHP---------------------------YVAKYHDTWTLMSYAA
**
MSMEG_6454|M.smegmatis_MC2_155 QATERLRVGVLVTGIHYRHPAVLANMAAALDIISNGRLELGIGAGWNEEE
Mvan_2247|M.vanbaalenii_PYR-1 SRTDTLRVGHMVLCNQFRHPVTLAKMATTLDQISGGRLSLGIGSGSIEDE
MUL_3202|M.ulcerans_Agy99 RDTTYIRLGTSVLCNSYRHPAVLAKMAATLDIISEGRLDLGLGAGWFERE
Mflv_2493|M.gilvum_PYR-GCK VLTENVPLATSVVDTVRRHPASLAQSALTIDHLSKGRFILGLGSGERENI
MAV_0066|M.avium_104 VLTERVPLVSAVVDTVRRHPALLAQTALTLDHLSKGRFILGLGSGESENT
Mb2975c|M.bovis_AF2122/97 -LPSRLRLGVCVTDAGRRNPAVTAQAAATLHLLTRGRAILGIGVGEREGN
Rv2951c|M.tuberculosis_H37Rv -LPSRLRLGVCVTDAGRRNPAVTAQAAATLHLLTRGRAILGIGVGEREGN
MLBr_00131|M.leprae_Br4923 NRLNGLRLGVCVTDAGRRNPAVTAQAAATLHLLTRGKAMLGIGVGEREGN
MMAR_1758|M.marinum_M NRINRLRLGVCVTDVGRRNPAVTAQAAATVHLLTRGRAILGIGVGEREGN
MAB_0968c|M.abscessus_ATCC_199 AATSRIRLAPLVLSMTFRHPAVLANWAATVDHVSQGRFTLGLGAGWQENE
TH_2487|M.thermoresistible__bu ARTQRVRLSANVANLPLRPPAVLARSAAGLDLLSGGRVELGLGAGAFWDG
: : * * *. *. * :. :: *: **:* *
MSMEG_6454|M.smegmatis_MC2_155 SGAYGIELGSIKERFDRFEEACEVLKGLLTQET---TTFDGKFYQLKDAR
Mvan_2247|M.vanbaalenii_PYR-1 HRRAGLPWGSFAERSEQLGETLQILHQAFGDER---IDFTGKHFTVTDMP
MUL_3202|M.ulcerans_Agy99 FTAYGIPFLPVGDRVTGLGEALEVITAIWTQPD---PVYSGRFYTLDGAI
Mflv_2493|M.gilvum_PYR-GCK L-PYGFDFRSPVGR---FEEALHVIRLLWDTEG--PVDFDGRFYRLRHAR
MAV_0066|M.avium_104 V-PYGFDFARPVSR---FEEALRVIRLLWDTDG--PVDFNGEFYSLHQAR
Mb2975c|M.bovis_AF2122/97 E-PYGVEWTKPVAR---FEEALATIRALWNSNGE-LISRESPYFPLHNAL
Rv2951c|M.tuberculosis_H37Rv E-PYGVEWTKPVAR---FEEALATIRALWNSNGE-LISRESPYFPLHNAL
MLBr_00131|M.leprae_Br4923 E-PYGVEWTKPVAR---FQEALATIRALWDSNGE-LVSRESQFFPLHNAL
MMAR_1758|M.marinum_M E-PYGVEWSKPVAR---FEEGLATIRALWDSNGA-LVTRESPYFPLRNAL
MAB_0968c|M.abscessus_ATCC_199 HQRYGLELGKPGARVDRFSEGLQVITGLLNEPV---TTVDGQYYRLAEGI
TH_2487|M.thermoresistible__bu VVAMGGERRSPGAAIKALEEAIAVIRGIWDVDAAGVLDVDGAHYRIRGAK
* : * : . .: :
MSMEG_6454|M.smegmatis_MC2_155 NEPKGPQQPHPPFCIGGSGEKRTLRITAKYADHWN-FVGGTPE---EFAR
Mvan_2247|M.vanbaalenii_PYR-1 IKPGPVQRPRPPIVVGGVGEKFTLPLVARYADVWN-VPTYALG---QIKE
MUL_3202|M.ulcerans_Agy99 CDPPPVQTPHPPLWVGGEGDR-VHRIAARSAQGIN-VRWWLPQ---KVKQ
Mflv_2493|M.gilvum_PYR-GCK LDTEPYEGRRPPIWVGASGPR-SLDIAGRYADGWWPAGAWTPD---DYAE
MAV_0066|M.avium_104 LDTEPYHDRLPPIWIGASGPR-MLDIAGRYADGWWPAGAWTPE---HYAE
Mb2975c|M.bovis_AF2122/97 FDLPPYRGKWPEIWVAAHGPR-MLRATGRYADAWIPIVVVRPS---DYSR
Rv2951c|M.tuberculosis_H37Rv FDLPPYRGKWPEIWVAAHGPR-MLRATGRYADAWIPIVVVRPS---DYSR
MLBr_00131|M.leprae_Br4923 FDLPPYRGKWPEIWVAAHGPR-MLQATGRYADAWIPIVLVRPT---DYSC
MMAR_1758|M.marinum_M FDLPPYKGKWPEIWVAAHGPR-MLRATGRYADAWVPIVIIRPT---DYSR
MAB_0968c|M.abscessus_ATCC_199 CEPKPLQRPLP-ILIGATQPR-MLALTARYAHEWN--QWSSPG---TFRE
TH_2487|M.thermoresistible__bu RGPAP--AHRISIWIGGYGPR-MLGLVGRLADGWLPSLQYLSGGVSDLTA
: :.. : ..: *.
MSMEG_6454|M.smegmatis_MC2_155 KRDVLAAHCADLGRDPKEITLSAHVRLGEDRDYAKVIDEA----AALGAE
Mvan_2247|M.vanbaalenii_PYR-1 KIAALRSICEDVGRDPQTITLSIEAVMALAPDEASLPTVRSLAEKRFGGE
MUL_3202|M.ulcerans_Agy99 RKDFLAQTCATAQRDPTTLRFSVTALLAPTDSAEQEAQIR----TEFSAV
Mflv_2493|M.gilvum_PYR-GCK KLTRVRSSAERAGRDPQQITPCFIQVCLMGRDDAALAEILQAPLVKSFLL
MAV_0066|M.avium_104 MLGAVRVSAERAGRDPMAITPCFIQVCLIGEDDDALAEILRAPLVKAFLL
Mb2975c|M.bovis_AF2122/97 ALEAVRSAASDAGRDPMSITPAAVRGIITGRNRDDVEEALESVVVKMTAL
Rv2951c|M.tuberculosis_H37Rv ALEAVRSAASDAGRDPMSITPAAVRGIITGRNRDDVEEALESVVVKMTAL
MLBr_00131|M.leprae_Br4923 ALEVVRTAASDAGRDPMSITPAAVRGIITGRTRDDVDEALDSVLVRMIAL
MMAR_1758|M.marinum_M ALEAVRAAASDAGRDPMSITPSAVRGVVTGWSRDDVDEALDSVIVKMNAL
MAB_0968c|M.abscessus_ATCC_199 VSGRLDAAAEKIGRDPATIWRSTQARVIVTDGPQSEARAAETAAASPIP-
TH_2487|M.thermoresistible__bu MNQRIDDAAVAAGRDPRQIRRLLNVGGQPSADELADIALS----------
: . *** :
MSMEG_6454|M.smegmatis_MC2_155 GLD--------------------------------------------LAI
Mvan_2247|M.vanbaalenii_PYR-1 GFG--------------------------------------------LHD
MUL_3202|M.ulcerans_Agy99 PYD--------------------------------------------GLI
Mflv_2493|M.gilvum_PYR-GCK QVSAEVLRRFGFEHPMGPDWNGFHDIDPAVLTRERIVEFLDRVQPEMVLA
MAV_0066|M.avium_104 QVSAKTLGEFGFEHPMGDGWRGFQDIDPAALGRDRIVEFLHRVRPEMVLA
Mb2975c|M.bovis_AF2122/97 GVPGEAWARHGVEHPMGADFSGVQDIIPQTMDKQTVLSYAAKVPAALMKE
Rv2951c|M.tuberculosis_H37Rv GVPGEAWARHGVEHPMGADFSGVQDIIPQTMDKQTVLSYAAKVPAALMKE
MLBr_00131|M.leprae_Br4923 GVPGEAWARHGVEHPMGADFAGVQDIIPQTIDEETVVSYAAKVPAALMKE
MMAR_1758|M.marinum_M GMPAEAWARHGVEHPMGADFTGVQDLIPQTMDRETVLSYTAKVPPGLIRE
MAB_0968c|M.abscessus_ATCC_199 --------------------------------------------------
TH_2487|M.thermoresistible__bu --------------------------------------------------
MSMEG_6454|M.smegmatis_MC2_155 IYLPPP---------------YDPAVLEPLAQAIRDSGQLTAA-------
Mvan_2247|M.vanbaalenii_PYR-1 TDLIGTPAEMVDRLGALAEMGFGQIVLFTHDRCSDQTLELLAAEVIPRL-
MUL_3202|M.ulcerans_Agy99 VGPADR---CIERINEYYESGVDTFLFTIPDVARSDLIHTVGQEVLPAFD
Mflv_2493|M.gilvum_PYR-GCK MVPHGTPKQVARVIKDYVDVGLRVPKILDYAAMAGGGYAAQSAGNVREAE
MAV_0066|M.avium_104 VVPHGTPKQVAKIVKSYVDAGLRVPKILDYGAMAGLSHAQSSAANVRATE
Mb2975c|M.bovis_AF2122/97 VVFSGTPDEVIDQVAEWRDHGLRYVVLINGSLVNPSLRKTVTAVLPHAKV
Rv2951c|M.tuberculosis_H37Rv VVFSGTPDEVIDQVAEWRDHGLRYVVLINGSLVNPSLRKTVTAVLPHAKV
MLBr_00131|M.leprae_Br4923 VLFSGTPEEVIDQVAEWRDHGLKYLVVINGSLVNSSLRKTVSALLPHARV
MMAR_1758|M.marinum_M VVASGTPDEVIDQVAEWRDHGLRYLLVINGSLVNPSLRKTVTAVLPHAKV
MAB_0968c|M.abscessus_ATCC_199 -VLYGTAERIAEQMAPWTQEGVDEVILPDHLLGSGSARRDAYDALAQALR
TH_2487|M.thermoresistible__bu -------------------HGISAFILASDDTATTERFAAEVAPAVRELV
.
MSMEG_6454|M.smegmatis_MC2_155 -----------
Mvan_2247|M.vanbaalenii_PYR-1 -----------
MUL_3202|M.ulcerans_Agy99 -----------
Mflv_2493|M.gilvum_PYR-GCK DELLRLCG---
MAV_0066|M.avium_104 DELMRLCGDGS
Mb2975c|M.bovis_AF2122/97 LRGLKKL----
Rv2951c|M.tuberculosis_H37Rv LRGLKKL----
MLBr_00131|M.leprae_Br4923 LRGLKKL----
MMAR_1758|M.marinum_M LRGLKKL----
MAB_0968c|M.abscessus_ATCC_199 PLSNETD----
TH_2487|M.thermoresistible__bu TAQR-------