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MSGRLASQPSAGRWHAIGLIAFLWLVGIYSVKARLGGAGDPRLYGLLGGAALAAVAAALVGRLRGRQESR VLLAGWPVASLLLTTVVGAVDPPVTRDFPGTITITFAYIGLTCPRWRSLAFVPLGVAAFVVGGAKALPDG STSVLLAAAMWVIVAEVPAWLIARLEEQSALLRKVAHTDALTQLLDRSTLGPRLSAHASESAVVVIDLDN FKRYNDTHGHSAGDELLVAFADALRWSVGADDAVFRIGGDEFLIMLVDADREQAERVLDRLRGRWAELGE PVGFSAGIAAGAQDLMRLADEHMYANKRSRDLSAD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4127 | - | - | 100% (315) | diguanylate cyclase |
| M. avium 104 | MAV_1410 | - | 1e-17 | 34.91% (212) | cyclic diguanylate phosphodiesterase domain-containing protein |
| M. avium 104 | MAV_4962 | - | 5e-15 | 30.77% (195) | sensory box histidine kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1389c | - | 5e-14 | 30.88% (217) | hypothetical protein Mb1389c |
| M. gilvum PYR-GCK | Mflv_4251 | - | 4e-22 | 41.67% (156) | diguanylate cyclase with PAS/PAC sensor |
| M. tuberculosis H37Rv | Rv1354c | - | 5e-14 | 30.88% (217) | hypothetical protein Rv1354c |
| M. leprae Br4923 | MLBr_01750 | - | 1e-14 | 34.13% (208) | hypothetical protein MLBr_01750 |
| M. abscessus ATCC 19977 | MAB_1839 | - | 7e-14 | 35.09% (171) | diguanylate cyclase/phosphodiesterase |
| M. marinum M | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_2196 | - | 3e-11 | 31.80% (217) | sensory box/response regulator |
| M. thermoresistible (build 8) | TH_0811 | - | 1e-13 | 32.35% (204) | sensory box/response regulator |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_2109 | - | 1e-19 | 41.61% (149) | diguanylate cyclase with PAS/PAC sensor |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_2196|M.smegmatis_MC2_155 -----MSESLDVLVTSVATQLMAVEAATSVSVSQQVLAELVSFFDVDVSF
TH_0811|M.thermoresistible__bu -----VSTELDLLVTGVATKLMAADAATARDVSRRVLADLVRAFELDFSF
MLBr_01750|M.leprae_Br4923 -----MTRSLDELVTRVASKLMAATAATAVTISEGVLAILVEHFGVDVSF
Mb1389c|M.bovis_AF2122/97 MCNDTATPQLEELVTTVANQLMTVDAATSAEVSQRVLAYLVEQLGVDVSF
Rv1354c|M.tuberculosis_H37Rv MCNDTATPQLEELVTTVANQLMTVDAATSAEVSQRVLAYLVEQLGVDVSF
Mflv_4251|M.gilvum_PYR-GCK --------MNVTGWCSLSGKIPGRGPSPGDAK-DDEVARLLALESFDILD
Mvan_2109|M.vanbaalenii_PYR-1 ------MSAGFTGLMLLAGKLSSRG---ADCRPDGESARLLALESFEILD
MAV_4127|M.avium_104 --------------------------------------------------
MAB_1839|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_2196|M.smegmatis_MC2_155 LRHNDHRAHATRLVAEWPPRPVDAATDPIAVVHFADADPVFAMAEHLKEP
TH_0811|M.thermoresistible__bu LRHNDHEIRASKLIAEWPVRENVPDPDPIGVVHFEGADPVFALAEHAKEI
MLBr_01750|M.leprae_Br4923 LRHNNHDIHETKLIVEWPPRDYVPDPDPIGVVYFADADPVFAMAEYLKEP
Mb1389c|M.bovis_AF2122/97 LRHNDRDRRATRLVAEWPPRLNIPDPDPLRLIYFADADPVFALCEHAKEP
Rv1354c|M.tuberculosis_H37Rv LRHNDRDRRATRLVAEWPPRLNIPDPDPLRLIYFADADPVFALCEHAKEP
Mflv_4251|M.gilvum_PYR-GCK TPPEESFDGLTALAAYVCD-------VPMALIGFLDAERQWLKSRQGVGH
Mvan_2109|M.vanbaalenii_PYR-1 TVPETPFDGLTALAAYVCG-------APMALLSFVDATRQWIKSRHGVDV
MAV_4127|M.avium_104 --------------------------------------------------
MAB_1839|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_2196|M.smegmatis_MC2_155 AVFRPEPLYDDYQRTIEAGRHIPATSMACVPLLSGDVTTGVLGFVKFGDR
TH_0811|M.thermoresistible__bu HIFRPEPATDEFQRLIEESSGVPASTVAAVPLVSGEITTGVLGFVKYGDR
MLBr_01750|M.leprae_Br4923 AVLRPEPANADYQRRIEEGASVPAVSLACVPLLSGEITTGVLGFVKYGDR
Mb1389c|M.bovis_AF2122/97 LVFRPEPATEDYQRLIEEARGVPVTSAAAVPLVSGEITTGLLGFIKFGDR
Rv1354c|M.tuberculosis_H37Rv LVFRPEPATEDYQRLIEEARGVPVTSAAAVPLVSGEITTGLLGFIKFGDR
Mflv_4251|M.gilvum_PYR-GCK SEIARELSFCASTMGDGDTLIEIPDTRLDSRLAGHPMVTGDPHLRFYAGM
Mvan_2109|M.vanbaalenii_PYR-1 AEIDREVSFCARTLA-AASLLEIPDTHLDPRFAPHPMVTGDPHVRFYAGV
MAV_4127|M.avium_104 ---------------------------MSGRLASQPSAG-----------
MAB_1839|M.abscessus_ATCC_1997 ------------------------------------------MVTTYPGR
MSMEG_2196|M.smegmatis_MC2_155 EWLPAELNALKAIASLFAQVQARIEAEERLRYLADHDHLTGLYNRRALMA
TH_0811|M.thermoresistible__bu QWHPDELNALKAIASLFAQVQARVEAEERLRYLAEHDDLTGLHNRRALLA
MLBr_01750|M.leprae_Br4923 EWHDDELRALQAIATLFAQLQARIVAEEQLRYLAEHDDLTGLLNRRALIA
Mb1389c|M.bovis_AF2122/97 KWHEAELNALMTIATLFAQVQARVAAEARLRYLADHDDLTGLHNRRALLQ
Rv1354c|M.tuberculosis_H37Rv KWHEAELNALMTIATLFAQVQARVAAEARLRYLADHDDLTGLHNRRALLQ
Mflv_4251|M.gilvum_PYR-GCK PIRTAEGHALGTICVMDVEPRT-LSDAQRSHLRTLADQVMNLLDLRRRAR
Mvan_2109|M.vanbaalenii_PYR-1 PIVTGDGHALGALCVMDREPRT-LSDPQRVHLQTLADQVLTLLQLRSRTR
MAV_4127|M.avium_104 -----RWHAIGLIAFLW---------------------LVGIYSVKARLG
MAB_1839|M.abscessus_ATCC_1997 NGFGSESNRCSTGAQVYG---------------ANNDILERVGLRRPVSR
. . : : : :
MSMEG_2196|M.smegmatis_MC2_155 HLEARLAPGQPGPVAVMFFDLDRLKAINDYLGHTAGDAFISILAQRLQRG
TH_0811|M.thermoresistible__bu HLDARLAAGQPGPVSALYFDLDRLKAVNDYLGHTVGDWFIRVLAERLREG
MLBr_01750|M.leprae_Br4923 HLDERLADGQRGPVTLLFLGLDRLKAVNDYLGHNAGDRLIEVFADRLREA
Mb1389c|M.bovis_AF2122/97 HLDQRLAPGQPGPVAALFLDLDRLKAINDYLGHAAGDQFIHVFAQRIGDA
Rv1354c|M.tuberculosis_H37Rv HLDQRLAPGQPGPVAALFLDLDRLKAINDYLGHAAGDQFIHVFAQRIGDA
Mflv_4251|M.gilvum_PYR-GCK QYAVEMTRRLEIDEALR----QQQRLLSGVLDHTDVLVYTKDVEGRFVMA
Mvan_2109|M.vanbaalenii_PYR-1 QTASEIDRRLAADAALR----QQQRMLEAVLEHTDVLIFAKDVDGRFVMA
MAV_4127|M.avium_104 GAGD--------------------PRLYGLLGGAALAAVAAALVGRLRGR
MAB_1839|M.abscessus_ATCC_1997 ANAVFITAVGAAAILLAATGMSTIPLLCISLSIPAFLWGIRYARARAVTY
: * *
MSMEG_2196|M.smegmatis_MC2_155 DDAPKLIARLGGDEFVVVPDDPMSLDEATALAYRLQSVLRERVTVDGEML
TH_0811|M.thermoresistible__bu AGPDDLIARLGGDEFVVVPSGPVDADAALELANRLRSRLQQQVCVDGEML
MLBr_01750|M.leprae_Br4923 AESLTVIARFGGDEFVVVPAESVSVDVAESFAHRLQTRLQKQVVIDGEIL
Mb1389c|M.bovis_AF2122/97 LVGESLIARLGGDEFVLIPASPMSADAAQPLAERLRDQLKDHVAIGGEVL
Rv1354c|M.tuberculosis_H37Rv LVGESLIARLGGDEFVLIPASPMSADAAQPLAERLRDQLKDHVAIGGEVL
Mflv_4251|M.gilvum_PYR-GCK NNAVQHVTQADRSMIGATDYDFFDATVADSYRRNDRRIMETR---EWQVF
Mvan_2109|M.vanbaalenii_PYR-1 NRALEHVTRAESTLIGFTDHDFFDAEIADDYRRNDRRIMAGR---EWQVF
MAV_4127|M.avium_104 QESRVLLAGWPVASLLLTT-------------------------------
MAB_1839|M.abscessus_ATCC_1997 GESVAYVLYCD---------------------------------------
:
MSMEG_2196|M.smegmatis_MC2_155 TRTVSIGIAQGIPGKDSTSDVLNRADHAVLTAKGSGGNRVAVFSDAMAME
TH_0811|M.thermoresistible__bu TRTASIGVAQGTPGRDTTSDLLRRADQAVLTAKSAGGNQITVFTDDMSLE
MLBr_01750|M.leprae_Br4923 TRTVSIGVATGLPGRDTTSDLLRWADHAALSAK-SDGSKVVVLDHGISAQ
Mb1389c|M.bovis_AF2122/97 TRTVSIGVASGTPGQHTPSDLLRRADQAALAAKHAGGDSVAIFTADMSVS
Rv1354c|M.tuberculosis_H37Rv TRTVSIGVASGTPGQHTPSDLLRRADQAALAAKHAGGDSVAIFTADMSVS
Mflv_4251|M.gilvum_PYR-GCK SEDVVHPDGSVHTYRSTKFPLISDSGEVLGVGGLSTDVTELAAARAAHEA
Mvan_2109|M.vanbaalenii_PYR-1 SEEVVHPDGSVHTYRSTKFPLFDDGGEVIGTGGVSTDVTELVAARAAHAA
MAV_4127|M.avium_104 ----------------------------------------VVGAVDPPVT
MAB_1839|M.abscessus_ATCC_1997 ---------------------------------------VAILIGICVVT
MSMEG_2196|M.smegmatis_MC2_155 IDFRNDIELHLQSVIEGGALVLHYLPEIDMRTGEVLAAEALVRWEHPTRG
TH_0811|M.thermoresistible__bu AEFRNDIELHLQSVIQDEALLLHFLPEVDMRTGEILATEALVRWHHPTRG
MLBr_01750|M.leprae_Br4923 HTLRTEVELHLAGMID-TDLVLHYLPEVDMSTGKVLGTEALVRWQHPTRG
Mb1389c|M.bovis_AF2122/97 GELRNDIELHLRRGIESDALRLVYLPEVDLRTGDIVGTEALVRWQHPTRG
Rv1354c|M.tuberculosis_H37Rv GELRNDIELHLRRGIESDALRLVYLPEVDLRTGDIVGTEALVRWQHPTRG
Mflv_4251|M.gilvum_PYR-GCK AEERWRALVEQSPAPVIVVDAEGALAYVNPEGLALLGVARGADVSLLPAE
Mvan_2109|M.vanbaalenii_PYR-1 AEQRWRALVEQSPAAVIVIDRDGGLSYVNPEAVTLLGGETAEQITAQPGL
MAV_4127|M.avium_104 RDFPGTITITFA-YIGLTCPRWRSLAFVPLGVAAFVVGGAKALPDGSTSV
MAB_1839|M.abscessus_ATCC_1997 TTGVAFVKLAWLLAVSAYVSLVHGRVAVAMQSLVTTAGTVLAVVGAVSRD
: : .
MSMEG_2196|M.smegmatis_MC2_155 LLSPDSFIGVAESINLAGELGRWVLRTACAEFSRWRANGVGRNIVLRINV
TH_0811|M.thermoresistible__bu LLAPDTFIGVAESVNLAGELGRWVMRTACGEFAKWRAEGIGLDAVLRINV
MLBr_01750|M.leprae_Br4923 LLFPDSFIPVAESINLAGKLGRMVMHSACAEFSRWRSAGVGLDALLRINV
Mb1389c|M.bovis_AF2122/97 LLAPGCFIPVAESINLAGELDRWVLRRACNEFSEWQSAGLGHDALLRINV
Rv1354c|M.tuberculosis_H37Rv LLAPGCFIPVAESINLAGELDRWVLRRACNEFSEWQSAGLGHDALLRINV
Mflv_4251|M.gilvum_PYR-GCK DFIPPQLRRATQKLLDETMAGTRVVRGERGVLRRRD----GTEITVEINA
Mvan_2109|M.vanbaalenii_PYR-1 DFVPAHLRAAAQTLLEVALSGGTPARSQRGLLRRVD----GTVIAVEFNG
MAV_4127|M.avium_104 LLAAAMWVIVAEVP------------------------------------
MAB_1839|M.abscessus_ATCC_1997 EYSAAALAAAVVTMLLANLFAGLVIYVG----------------------
. ..
MSMEG_2196|M.smegmatis_MC2_155 SPVQLVTDGFVESVAGIMKEFGLPRGSVCLEITESVVVQDIETTRTTLTG
TH_0811|M.thermoresistible__bu SPVQLVTDGFVASVADIIDEFGLDGSSVCLEITESVVVQDIKTTRITLEG
MLBr_01750|M.leprae_Br4923 SPVQLVAEGFVDNVAGTLDEFGLDGSMVCLEITENVVVQNIDATRKTLAG
Mb1389c|M.bovis_AF2122/97 SAGQLVTGGFVDFVADTIGQHGLDASSVCLEITENVVVQDLHTARATLAR
Rv1354c|M.tuberculosis_H37Rv SAGQLVTGGFVDFVADTIGQHGLDASSVCLEITENVVVQDLHTARATLAR
Mflv_4251|M.gilvum_PYR-GCK TVVSHSGERSVQLEIRDVSEVAAAHAALEHSASTDPLTGVLNRKAWDARV
Mvan_2109|M.vanbaalenii_PYR-1 TVVDHSDERSVQLEVRDVSADAAAHAALKLSASTDPLTGALNRRGWDARV
MAV_4127|M.avium_104 --------------AWLIARLEEQSALLRKVAHTDALTQLLDRSTLGPR-
MAB_1839|M.abscessus_ATCC_1997 -----------------KAQFSEHADGRDRLARHDVLTGLLNRR--GLQE
. :. :.
MSMEG_2196|M.smegmatis_MC2_155 LHNVGVQVAIDDFGTGYSVLSLLKSLPVDT-LKIDRSFVAELGSNPGDLP
TH_0811|M.thermoresistible__bu LNEVGVQVAIDDFGTGYSVLSHLKTLPVDT-LKIDKGFVQDLGNSPGDLA
MLBr_01750|M.leprae_Br4923 LKEVGVHLAIDDFGTGYSVLTHLKSLPVDT-IKIDKSFVAELGSNASDLA
Mb1389c|M.bovis_AF2122/97 LKEVGVHIAIDDFGTGYSAISLLQTLPIDT-LKIDKTFVRQLGTNTSDLV
Rv1354c|M.tuberculosis_H37Rv LKEVGVHIAIDDFGTGYSAISLLQTLPIDT-LKIDKTFVRQLGTNTSDLV
Mflv_4251|M.gilvum_PYR-GCK ATLLPEVSDTSPMTIAVIDLDNFKTYNDTRGHTAGDALLQQFAGAAAACL
Mvan_2109|M.vanbaalenii_PYR-1 AALL---ADGAAMTVAVLDLDNFKSYNDAHGHTAGDALLQNFAAAAGASI
MAV_4127|M.avium_104 -----LSAHASESAVVVIDLDNFKRYNDTHGHSAGDELLVAFADALRWSV
MAB_1839|M.abscessus_ATCC_1997 AYEATVGVPGMHVTVVVVDLNLFKQINDTFGHHVGDQVLQRTAHRLRSVV
: :: . .: .
MSMEG_2196|M.smegmatis_MC2_155 IVRAVIALAGAFGLQLVAEGVETERAALTLLRHGCYRAQGFLLSKPILGS
TH_0811|M.thermoresistible__bu IVRAIIALAEAFGLQLVAEGVETEAAALTLLRHGCHRAQGFLLSRPIPSN
MLBr_01750|M.leprae_Br4923 IVRAIMALAKEFELEVVAEGVETAVAAQVLLELGCNRAQGFLLSRPVDGA
Mb1389c|M.bovis_AF2122/97 IVRGIMTLAEGFQLDVVAEGVETEAAARILLDQRCYRAQGFLFSRPVPGE
Rv1354c|M.tuberculosis_H37Rv IVRGIMTLAEGFQLDVVAEGVETEAAARILLDQRCYRAQGFLFSRPVPGE
Mflv_4251|M.gilvum_PYR-GCK GADDVFARWGGEEFIVALPGADPDRAEPILDRLRGHVPSEQTCSIGYTGH
Mvan_2109|M.vanbaalenii_PYR-1 RDGDVFARWGGEEFIVALPDTTPDQAERILNRLRNCVPYGQTCSIGYTAH
MAV_4127|M.avium_104 GADDAVFRIGGDEFLIMLVDADREQAERVLDRLRG-RWAELGEPVGFSAG
MAB_1839|M.abscessus_ATCC_1997 GPDALLARLGGDEFGIVVVGDAPPHIDYQRAVEEALNSASEDVPVSASVG
. : : . .
MSMEG_2196|M.smegmatis_MC2_155 EMQTLLAKGRVPVHFSAAPRM------------------
TH_0811|M.thermoresistible__bu EMRELLARGRIPMRFSATP--------------------
MLBr_01750|M.leprae_Br4923 AMESLLAKGVIPMALGTCQSPEPSEHQIHRS--------
Mb1389c|M.bovis_AF2122/97 AMRHMLSARRLPPTCIPATDPALS---------------
Rv1354c|M.tuberculosis_H37Rv AMRHMLSARRLPPTCIPATDPALS---------------
Mflv_4251|M.gilvum_PYR-GCK VPPEALTDTVIRADKALYQAKRRGKNRIARL--------
Mvan_2109|M.vanbaalenii_PYR-1 TPADTLTDTVARADKALYEAKSRGRNQLRLL--------
MAV_4127|M.avium_104 IAAGAQDLMRLADEHMYANKRSRDLSAD-----------
MAB_1839|M.abscessus_ATCC_1997 VAAAILPESDRTTIHTLGPIVTHLLVEADGAMYGAKKAG