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VVTTYPGRNGFGSESNRCSTGAQVYGANNDILERVGLRRPVSRANAVFITAVGAAAILLAATGMSTIPLL CISLSIPAFLWGIRYARARAVTYGESVAYVLYCDVAILIGICVVTTTGVAFVKLAWLLAVSAYVSLVHGR VAVAMQSLVTTAGTVLAVVGAVSRDEYSAAALAAAVVTMLLANLFAGLVIYVGKAQFSEHADGRDRLARH DVLTGLLNRRGLQEAYEATVGVPGMHVTVVVVDLNLFKQINDTFGHHVGDQVLQRTAHRLRSVVGPDALL ARLGGDEFGIVVVGDAPPHIDYQRAVEEALNSASEDVPVSASVGVAAAILPESDRTTIHTLGPIVTHLLV EADGAMYGAKKAG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_1839 | - | - | 100% (363) | diguanylate cyclase/phosphodiesterase |
| M. abscessus ATCC 19977 | MAB_3940c | - | 2e-22 | 29.59% (294) | hypothetical protein MAB_3940c |
| M. abscessus ATCC 19977 | MAB_0124 | - | 2e-16 | 27.53% (247) | hypothetical protein MAB_0124 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1389c | - | 3e-14 | 34.69% (196) | hypothetical protein Mb1389c |
| M. gilvum PYR-GCK | Mflv_1914 | - | 1e-26 | 31.15% (321) | diguanylate cyclase |
| M. tuberculosis H37Rv | Rv1354c | - | 3e-14 | 34.69% (196) | hypothetical protein Rv1354c |
| M. leprae Br4923 | MLBr_00397 | - | 4e-20 | 35.75% (221) | putative transporter protein |
| M. marinum M | - | - | - | - | - |
| M. avium 104 | MAV_1995 | - | 2e-18 | 29.15% (343) | diguanylate cyclase |
| M. smegmatis MC2 155 | MSMEG_2196 | - | 4e-15 | 36.81% (182) | sensory box/response regulator |
| M. thermoresistible (build 8) | TH_0811 | - | 8e-18 | 38.33% (180) | sensory box/response regulator |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_0679 | - | 3e-25 | 29.41% (340) | diguanylate cyclase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1914|M.gilvum_PYR-GCK --------------MQRDQRHSDHYEWFSDFLQARGVAVYVRAGVAAIGL
MAV_1995|M.avium_104 -----------MKWLAAWWGQPDHFDWLTGYLQDHGFGTATRRAMAVVGA
Mvan_0679|M.vanbaalenii_PYR-1 --------MGLREFLLTWWRQPHEFDWTARYFRARGLLRLHQVFIGCFSL
Mb1389c|M.bovis_AF2122/97 --------------------------MCNDTATPQLEELVTTVANQLMTV
Rv1354c|M.tuberculosis_H37Rv --------------------------MCNDTATPQLEELVTTVANQLMTV
MSMEG_2196|M.smegmatis_MC2_155 -------------------------------MSESLDVLVTSVATQLMAV
TH_0811|M.thermoresistible__bu -------------------------------VSTELDLLVTGVATKLMAA
MAB_1839|M.abscessus_ATCC_1997 MVTTYPGRNGFGSESNRCSTGAQVYGANNDILERVGLRRPVSRANAVFIT
MLBr_00397|M.leprae_Br4923 --------------------------------------------------
Mflv_1914|M.gilvum_PYR-GCK LMAVSSVILVLGAGGPTSQPQVAMMWVAAAGG-VASAALWVRR-WPTRGQ
MAV_1995|M.avium_104 SLVLVPANVLWGATPFFPGLTLTVSVLAGMVG-LGMAVLWLHG-WPTRRQ
Mvan_0679|M.vanbaalenii_PYR-1 LYGLTALLTVVWAYYDGGSVAARVLVISIAASSCVLGVIWVFGPWPTERQ
Mb1389c|M.bovis_AF2122/97 DAATSAEVSQRVLAYLVEQLGVDVSFLRHNDR--DRRATRLVAEWPPRLN
Rv1354c|M.tuberculosis_H37Rv DAATSAEVSQRVLAYLVEQLGVDVSFLRHNDR--DRRATRLVAEWPPRLN
MSMEG_2196|M.smegmatis_MC2_155 EAATSVSVSQQVLAELVSFFDVDVSFLRHNDH--RAHATRLVAEWPPRPV
TH_0811|M.thermoresistible__bu DAATARDVSRRVLADLVRAFELDFSFLRHNDH--EIRASKLIAEWPVREN
MAB_1839|M.abscessus_ATCC_1997 AVGAAAILLAATGMSTIPLLCISLSIPAFLWG-----IRYARARAVTYGE
MLBr_00397|M.leprae_Br4923 MDHTTKCDAEQYFQAIVTSMADGVIVVDIDGR--------IESINPAATR
.
Mflv_1914|M.gilvum_PYR-GCK SAAFAAVTTCSITLACLAYPDALAALLGCITFMTIGAYLAFFHSTRSVLG
MAV_1995|M.avium_104 SVVFALTGSVAIGAGCLWQTEPLVGLMACSALSVTGGYNAFFHTAKFMGL
Mvan_0679|M.vanbaalenii_PYR-1 SVAFAVYADVAVVAVMACYQDAFTAMPGLALLAANGIYIVVVHGPRALVL
Mb1389c|M.bovis_AF2122/97 IPDPDPLRLIYFADADPVFALCEHAKEPLVFRPEP-ATEDYQRLIEEARG
Rv1354c|M.tuberculosis_H37Rv IPDPDPLRLIYFADADPVFALCEHAKEPLVFRPEP-ATEDYQRLIEEARG
MSMEG_2196|M.smegmatis_MC2_155 DAATDPIAVVHFADADPVFAMAEHLKEPAVFRPEP-LYDDYQRTIEAGRH
TH_0811|M.thermoresistible__bu VPDPDPIGVVHFEGADPVFALAEHAKEIHIFRPEP-ATDEFQRLIEESSG
MAB_1839|M.abscessus_ATCC_1997 SVAYVLYCDVAILIGICVVTTTGVAFVKLAWLLAVSAYVSLVHGRVAVAM
MLBr_00397|M.leprae_Br4923 ILGLRAHDVVDMKHGHPFCFYDTDNQR--------------VDLEREVMR
.
Mflv_1914|M.gilvum_PYR-GCK VVALAIVVASLH--AVELAVAGRPALAAVDLFIVVQANLAMPLAIHSLLR
MAV_1995|M.avium_104 NFGLAGAIGALQ--AARLAASGQAMLAFTGYFLVLELNVIVPLSIQIVVR
Mvan_0679|M.vanbaalenii_PYR-1 HLAFTAAVFAVTYWLAIAQATAPVSVITVRLLVLLPTVIGVPVIVQSYLL
Mb1389c|M.bovis_AF2122/97 VPVTSAAAVPLVSGEITTGLLGFIKFGDRKWHEAELNALMTIATLFAQVQ
Rv1354c|M.tuberculosis_H37Rv VPVTSAAAVPLVSGEITTGLLGFIKFGDRKWHEAELNALMTIATLFAQVQ
MSMEG_2196|M.smegmatis_MC2_155 IPATSMACVPLLSGDVTTGVLGFVKFGDREWLPAELNALKAIASLFAQVQ
TH_0811|M.thermoresistible__bu VPASTVAAVPLVSGEITTGVLGFVKYGDRQWHPDELNALKAIASLFAQVQ
MAB_1839|M.abscessus_ATCC_1997 QSLVTTAGTVLAVVGAVSRDEYSAAALAAAVVTMLLANLFAGLVIYVGKA
MLBr_00397|M.leprae_Br4923 VVRREVTTVSKVVGIDQHSGQRLWLSVNVSLLAYKAPPHSALVVSFSDIS
.
Mflv_1914|M.gilvum_PYR-GCK ALRGDLVHALTDANHDPLTGLLNRRAFRTQTLGLFERGGDGHHLVVALID
MAV_1995|M.avium_104 ALWLDLLR----ANRDPLTGLLNRRACNRAIIGRMLTGASHMFLAVAMVD
Mvan_0679|M.vanbaalenii_PYR-1 ALRMGADD----ALHDPLTRLYNRRGLDVHLAELVAPGG--VQVGVLALD
Mb1389c|M.bovis_AF2122/97 ARVAAEARLRYLADHDDLTGLHNRRALLQHLDQRLAPGQP-GPVAALFLD
Rv1354c|M.tuberculosis_H37Rv ARVAAEARLRYLADHDDLTGLHNRRALLQHLDQRLAPGQP-GPVAALFLD
MSMEG_2196|M.smegmatis_MC2_155 ARIEAEERLRYLADHDHLTGLYNRRALMAHLEARLAPGQP-GPVAVMFFD
TH_0811|M.thermoresistible__bu ARVEAEERLRYLAEHDDLTGLHNRRALLAHLDARLAAGQP-GPVSALYFD
MAB_1839|M.abscessus_ATCC_1997 QFSEHADGRDRLARHDVLTGLLNRRGLQEAYEATVGVPG--MHVTVVVVD
MLBr_00397|M.leprae_Br4923 AHHLSIERLTYEATHDCLTGLANRRFAEDQITKSLQHDERSRLAAVLLLD
* :* ** * *** . . .*
Mflv_1914|M.gilvum_PYR-GCK LDKFKALNDTHGHHVGDQALVAVADALRATATSS---AVISRSGGEEFLI
MAV_1995|M.avium_104 LDRFKALNDTHGHAAGDEALIAVAGALTAACGDT---TVVGRVGGEEFLV
Mvan_0679|M.vanbaalenii_PYR-1 IDKFKAINDRHGHDAGDRVLVAVAEAARTAVTDLGVRSVTARTGGEEFVV
Mb1389c|M.bovis_AF2122/97 LDRLKAINDYLGHAAGDQFIHVFAQRIGDALVGE---SLIARLGGDEFVL
Rv1354c|M.tuberculosis_H37Rv LDRLKAINDYLGHAAGDQFIHVFAQRIGDALVGE---SLIARLGGDEFVL
MSMEG_2196|M.smegmatis_MC2_155 LDRLKAINDYLGHTAGDAFISILAQRLQRGDDAP---KLIARLGGDEFVV
TH_0811|M.thermoresistible__bu LDRLKAVNDYLGHTVGDWFIRVLAERLREGAGPD---DLIARLGGDEFVV
MAB_1839|M.abscessus_ATCC_1997 LNLFKQINDTFGHHVGDQVLQRTAHRLRSVVGPD---ALLARLGGDEFGI
MLBr_00397|M.leprae_Br4923 LDDFKVINDSLGHDVGDAVLQTVAQRLRSAVRPD---DVVARLGGDEFIV
:: :* :** ** .** : * : .* **:** :
Mflv_1914|M.gilvum_PYR-GCK ADV-APA-DEALARYQGLCDAVAALHIPVTASVGTATAALDVVSDHDPDG
MAV_1995|M.avium_104 ADI-VTT-EQLPGWGQQLCEAVAALDPPVTASVGTATLPLRDLVSEYAEH
Mvan_0679|M.vanbaalenii_PYR-1 VVE-GGT-QTVRRLATLLHDAVARCDAATVPTVSIGAAAAR--VDGDLGG
Mb1389c|M.bovis_AF2122/97 IPA-SPMSADAAQPLAERLRDQLKDHVAIGGEVLTRTVSIGVASGTPGQH
Rv1354c|M.tuberculosis_H37Rv IPA-SPMSADAAQPLAERLRDQLKDHVAIGGEVLTRTVSIGVASGTPGQH
MSMEG_2196|M.smegmatis_MC2_155 VPD-DPMSLDEATALAYRLQSVLRERVTVDGEMLTRTVSIGIAQGIPGKD
TH_0811|M.thermoresistible__bu VPS-GPVDADAALELANRLRSRLQQQVCVDGEMLTRTASIGVAQGTPGRD
MAB_1839|M.abscessus_ATCC_1997 VVVGDAPPHIDYQRAVEEALNSASEDVPVSASVGVAAAILPESDRTTIHT
MLBr_00397|M.leprae_Br4923 LLR-GPLSDMNANDVAKRLHTTLSESLVVDQLTVPIGASVGILEVRPDDR
Mflv_1914|M.gilvum_PYR-GCK V---VDHLIAAADMAMYRAKR-----NGGNQCHHHGSWPTLGSPP-----
MAV_1995|M.avium_104 A---FHQLVAQADSAMYEAKR-----CGGNQTRHR---PAQVST------
Mvan_0679|M.vanbaalenii_PYR-1 A---VRTMIELADAAMYRAKH-----AGGNQTVIVGDAVAAGD-------
Mb1389c|M.bovis_AF2122/97 T---PSDLLRRADQAALAAKH-----AGGDSVAIFTADMSVSGELRNDIE
Rv1354c|M.tuberculosis_H37Rv T---PSDLLRRADQAALAAKH-----AGGDSVAIFTADMSVSGELRNDIE
MSMEG_2196|M.smegmatis_MC2_155 S---TSDVLNRADHAVLTAKG-----SGGNRVAVFSDAMAMEIDFRNDIE
TH_0811|M.thermoresistible__bu T---TSDLLRRADQAVLTAKS-----AGGNQITVFTDDMSLEAEFRNDIE
MAB_1839|M.abscessus_ATCC_1997 LGPIVTHLLVEADGAMYGAKK-----AG----------------------
MLBr_00397|M.leprae_Br4923 RR--AADILRDADSAMYAAKNKKQCAVTPQQLVPFVALIALFVFFTAAAG
:: ** * **
Mflv_1914|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1995|M.avium_104 --------------------------------------------------
Mvan_0679|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 LHLRRGIESDALRLVYLPEVDLRTGDIVGTEALVRWQHPTRGLLAPGCFI
Rv1354c|M.tuberculosis_H37Rv LHLRRGIESDALRLVYLPEVDLRTGDIVGTEALVRWQHPTRGLLAPGCFI
MSMEG_2196|M.smegmatis_MC2_155 LHLQSVIEGGALVLHYLPEIDMRTGEVLAAEALVRWEHPTRGLLSPDSFI
TH_0811|M.thermoresistible__bu LHLQSVIQDEALLLHFLPEVDMRTGEILATEALVRWHHPTRGLLAPDTFI
MAB_1839|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00397|M.leprae_Br4923 AKFYAPSNLLVILQQTVVLAIVGYGMTFVIMAGSVDLSVGSIVALTGVTA
Mflv_1914|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1995|M.avium_104 --------------------------------------------------
Mvan_0679|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 PVAESINLAGELDRWVLRRACNEFSEWQSAGLGHDALLRINVSAGQLVTG
Rv1354c|M.tuberculosis_H37Rv PVAESINLAGELDRWVLRRACNEFSEWQSAGLGHDALLRINVSAGQLVTG
MSMEG_2196|M.smegmatis_MC2_155 GVAESINLAGELGRWVLRTACAEFSRWRANGVGRNIVLRINVSPVQLVTD
TH_0811|M.thermoresistible__bu GVAESVNLAGELGRWVMRTACGEFAKWRAEGIGLDAVLRINVSPVQLVTD
MAB_1839|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00397|M.leprae_Br4923 ALVAAQNQFAAIVTALLVGLAAGMVNGIVFAYGKIPSFVSTLGMLQVCRG
Mflv_1914|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1995|M.avium_104 --------------------------------------------------
Mvan_0679|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 GFVDFVADTIGQHGLDASSVCLEITENVVVQDLHTARATLARLKEVGVHI
Rv1354c|M.tuberculosis_H37Rv GFVDFVADTIGQHGLDASSVCLEITENVVVQDLHTARATLARLKEVGVHI
MSMEG_2196|M.smegmatis_MC2_155 GFVESVAGIMKEFGLPRGSVCLEITESVVVQDIETTRTTLTGLHNVGVQV
TH_0811|M.thermoresistible__bu GFVASVADIIDEFGLDGSSVCLEITESVVVQDIKTTRITLEGLNEVGVQV
MAB_1839|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00397|M.leprae_Br4923 ITLMISDSSAKPMPFHGILGAMGAMPWILIVCLFVTILAGILFQFTMFGR
Mflv_1914|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1995|M.avium_104 --------------------------------------------------
Mvan_0679|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 AIDDFGTGYSAISLLQTLPIDTLKIDKTFVRQLGTNTSDLVIVRGIMTLA
Rv1354c|M.tuberculosis_H37Rv AIDDFGTGYSAISLLQTLPIDTLKIDKTFVRQLGTNTSDLVIVRGIMTLA
MSMEG_2196|M.smegmatis_MC2_155 AIDDFGTGYSVLSLLKSLPVDTLKIDRSFVAELGSNPGDLPIVRAVIALA
TH_0811|M.thermoresistible__bu AIDDFGTGYSVLSHLKTLPVDTLKIDKGFVQDLGNSPGDLAIVRAIIALA
MAB_1839|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00397|M.leprae_Br4923 WVKAIG-GNERVATLAGVPTRGIKVAIFAICGLTAGLGGIVLASRLGAGT
Mflv_1914|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1995|M.avium_104 --------------------------------------------------
Mvan_0679|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 EGFQLDVVAEGVETEAAARILLDQRCYRAQGFLFSRPVPGEAMRHMLSAR
Rv1354c|M.tuberculosis_H37Rv EGFQLDVVAEGVETEAAARILLDQRCYRAQGFLFSRPVPGEAMRHMLSAR
MSMEG_2196|M.smegmatis_MC2_155 GAFGLQLVAEGVETERAALTLLRHGCYRAQGFLLSKPILGSEMQTLLAKG
TH_0811|M.thermoresistible__bu EAFGLQLVAEGVETEAAALTLLRHGCHRAQGFLLSRPIPSNEMRELLARG
MAB_1839|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00397|M.leprae_Br4923 PTAATGFEIDVIAAVVIGGTPLTGGLGRLSGTLIGAIIISMLSNGMVFMG
Mflv_1914|M.gilvum_PYR-GCK -------------------------------
MAV_1995|M.avium_104 -------------------------------
Mvan_0679|M.vanbaalenii_PYR-1 -------------------------------
Mb1389c|M.bovis_AF2122/97 RLPPTCIPATDPALS----------------
Rv1354c|M.tuberculosis_H37Rv RLPPTCIPATDPALS----------------
MSMEG_2196|M.smegmatis_MC2_155 RVPVHFSAAPRM-------------------
TH_0811|M.thermoresistible__bu RIPMRFSATP---------------------
MAB_1839|M.abscessus_ATCC_1997 -------------------------------
MLBr_00397|M.leprae_Br4923 VGNAASQIIKGIMLAAAVFVFLQRRKIGIIK