For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MPDYHALIVGAGFSGIGAAIKLDRAGFSDYLVVEAGDGVGGTWHWNTYPGIAVDIPSFSYQFSFEQSRHW SRTYAPGHELKAYAEHCVDKYGIRSRIRLNTKVLAAEFDDEHSLWRVQTDPGGEITARFLISACGILTVP KLPDIDGVDSFEGVTMHTARWDHTQDLTGKRVGIIGTGASAVQVIPEMAPIVSHLTVFQRTPIWCFPKFD VPLPTAVRWAMRIPGGKAVHRLLSQAFVEATFPIAAHYFAVFPLAKHMESAGRRYLRQQVHDPVVREQLT PRYAVGCKRPGFHNTYLSTFNRDNVRLVTEPIDKITPTAVATTDGASHEIDVLVLATGFKVLDTDSIPTY AVTGTGGASLSRFWDEHRLQAYEGVSVPGYPNFFTVFGPYGYVGSSYFALIETQAHHIIRCLKRARRTGA TRIEVTEEANARYFAEVMRRRHRQVFWQDSCRLANSYYFDKNGDVPLRPTTTVEAYWRSRRFDLGDYRIS S*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1393c | - | - | 100% (492) | PROBABLE MONOXYGENASE |
| M. tuberculosis H37Rv | Rv3049c | - | 9e-88 | 38.51% (483) | monooxygenase |
| M. tuberculosis H37Rv | Rv0892 | - | 8e-78 | 36.64% (464) | monooxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1428c | - | 0.0 | 100.00% (492) | monoxygenase |
| M. gilvum PYR-GCK | Mflv_4607 | - | 0.0 | 65.64% (489) | cyclohexanone monooxygenase |
| M. leprae Br4923 | MLBr_00065 | - | 3e-27 | 27.18% (412) | putative monooxygenase |
| M. abscessus ATCC 19977 | MAB_4024c | - | 1e-143 | 48.37% (492) | monooxygenase |
| M. marinum M | MMAR_2207 | - | 0.0 | 83.78% (487) | monoxygenase |
| M. avium 104 | MAV_3378 | - | 0.0 | 84.49% (490) | lipolytic enzyme |
| M. smegmatis MC2 155 | MSMEG_0816 | - | 1e-111 | 42.31% (494) | flavin-binding monooxygenase |
| M. thermoresistible (build 8) | TH_4080 | - | 5e-86 | 39.05% (461) | PUTATIVE conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_1793 | - | 0.0 | 82.78% (482) | monoxygenase |
| M. vanbaalenii PYR-1 | Mvan_2671 | - | 0.0 | 73.04% (497) | cyclohexanone monooxygenase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1393c|M.tuberculosis_H37Rv -------------------MMPDYHALIVGAGFSGIGAAIKLD-RAGFSD
Mb1428c|M.bovis_AF2122/97 -------------------MMPDYHALIVGAGFSGIGAAIKLD-RAGFSD
MMAR_2207|M.marinum_M -----------------MSIEPDYQIVIVGAGFSGIGAAISLD-KAGFGD
MUL_1793|M.ulcerans_Agy99 --------------------------MIVGAGFSGIGAAISLD-KAGFGD
MAV_3378|M.avium_104 ---------------MSSPAVPDHHTLIIGAGFSGIGAAIKLD-KAGLPD
Mvan_2671|M.vanbaalenii_PYR-1 --------------------MHDVETVIVGAGFSGIGAAIGLD-RVGMSD
Mflv_4607|M.gilvum_PYR-GCK MSVHVAGDENAPTSGAPTYEVPTHEILVIGAGFSGIGVGIKLL-KEGFSD
MAB_4024c|M.abscessus_ATCC_199 ------MSPAARHATTAELEQPDHEVAVIGAGFGGIGTGISLQ-RKGIHD
MSMEG_0816|M.smegmatis_MC2_155 ------------------MRPVVHDAVIVGAGFAGLGAAIQLK-KMSFDD
TH_4080|M.thermoresistible__bu -MTVTEPSADITPANTPTQPPVRTRALIVGTGFSGLGMAIALQ-RRGI-D
MLBr_00065|M.leprae_Br4923 --------------MVVMAETEYLDVVIVGAGISGVSAAWHLQDRCPNKS
::*:*:.*:. . * : .
Rv1393c|M.tuberculosis_H37Rv YLVVEAGDGVGGTWHWNTYPGIAVDIPSFSYQFSFEQSRHWSRTYAPGHE
Mb1428c|M.bovis_AF2122/97 YLVVEAGDGVGGTWHWNTYPGIAVDIPSFSYQFSFEQSRHWSRTYAPGHE
MMAR_2207|M.marinum_M YLVIEAGDGVGGTWFWNTYPGIAVDIPSFSYQFSFEQSPDWSRSYAPGRE
MUL_1793|M.ulcerans_Agy99 YLVIEAGDAVGGTWFWNTYPGIAVDIPSFSYQFSFEQSPDWSRSYAPGRE
MAV_3378|M.avium_104 YRVIEAGDGVGGTWHWNTYPGIAVDIPSFSYQFSFEQSRHWSRTYAPGRE
Mvan_2671|M.vanbaalenii_PYR-1 YVVVEAGDEPGGTWYWNTYPGIAVDIPSFSYQFSFEQSSAWSRTYAHGHE
Mflv_4607|M.gilvum_PYR-GCK FLIVDEAQGVGGTWYWNTYPGIAVDIPSYSYQFSFEKRPSWSRTYAPGIE
MAB_4024c|M.abscessus_ATCC_199 FIILDKWDQVGGTWHANTYPGVAVDIPSVVYSFSYEQRGDWSRLFAPGIE
MSMEG_0816|M.smegmatis_MC2_155 FVILEREDDLGGTWYVNHYPGLAVDVPTTTYSYFFEPNPSWSRLFSTGRE
TH_4080|M.thermoresistible__bu FLMLEKADDIGGTWRDNTYPGCACDIPSHLYSFSFEPKADWRHLFSYQDE
MLBr_00065|M.leprae_Br4923 YVILEKRAGMGGTWDLFRYPGIRSDSDMYTLGFRFRP-WTKCQAIADGKP
: ::: **** *** * : :. : :
Rv1393c|M.tuberculosis_H37Rv LKAYAEHCVDKYGIRSRIRLNTKVLAAEFDDEHSLWRVQTDPGG---EIT
Mb1428c|M.bovis_AF2122/97 LKAYAEHCVDKYGIRSRIRLNTKVLAAEFDDEHSLWRVQTDPGG---EIT
MMAR_2207|M.marinum_M LRAYAEHCADKYGIRPRIRFNTKVLGAEFDDERSLWRLQTDPGG---ELT
MUL_1793|M.ulcerans_Agy99 LRAYAEHCADKYGIRPRIRFNTKVLGAELDDERSLWRLQTDPGG---DLI
MAV_3378|M.avium_104 LKAYAEHCADKYGIRSRIRFNTKVLAAEFDDEQRLWRVQTDPGG---EVT
Mvan_2671|M.vanbaalenii_PYR-1 LKTYAEHCVDKYGLRPRIRFATTVRSADFDEAQGIWRLALDTADGPATLS
Mflv_4607|M.gilvum_PYR-GCK LKNYAKHCVKKYGLASRIRFGVTVVRAEFDEESTLWRLFTSTDE---ELT
MAB_4024c|M.abscessus_ATCC_199 LQQYAESMVHKYGLRDKLRLGTSITRAEFDERNSLWRLATDGGK---EIT
MSMEG_0816|M.smegmatis_MC2_155 IKRYADDVADKYDVRRHIRFGTTVTGARWDEDDNVWQVSLTDGE---QLQ
TH_4080|M.thermoresistible__bu IQEYLQGVTAKYGLRRYIHFDSLVDRAHWDDTEHRWHVFTADGR---EYI
MLBr_00065|M.leprae_Br4923 ILEYIKSTAVMHGIDKYIRLNHKVTGADWSSIENRWTVQVENNGTPRMIS
: * . . :.: ::: : * .. * :
Rv1393c|M.tuberculosis_H37Rv ARFLISACGILTVPK--LPDIDGVDSFEGVTMHTARWDHTQDLTGKRVGI
Mb1428c|M.bovis_AF2122/97 ARFLISACGILTVPK--LPDIDGVDSFEGVTMHTARWDHTQDLTGKRVGI
MMAR_2207|M.marinum_M TRFIINASGVLTVPK--LPDIAGVDSFAGVTMHTARWDHSQELTGKRVGI
MUL_1793|M.ulcerans_Agy99 TRFIINASGVLTVPK--LPDIAGVDSFAGVTMHTARWDHSQELTGKRVGI
MAV_3378|M.avium_104 ARFLISACGVLTVPN--LPDIDGVDSFAGITMHTARWDHGQDLRGKRVAV
Mvan_2671|M.vanbaalenii_PYR-1 ARFLVNAGGVLTVPK--LPDIAGVDSFAGVTMHTARWDHTQDLRGKRVAI
Mflv_4607|M.gilvum_PYR-GCK ARFVINASGVLTRPK--SPDIPGVGDFGGVTMHTSRWDHQQTLTGKRVAV
MAB_4024c|M.abscessus_ATCC_199 ARYCVMAVGGLERPK--MPDIPGVHDFGGTLMHTALWDHDVALAGKRVAV
MSMEG_0816|M.smegmatis_MC2_155 ARFLITATGFLSQPH--TPDIPGITEFDGKVIHTTDWDDGCSLYGRRAAV
TH_4080|M.thermoresistible__bu AQFLISCAGALHIPS--IPDFPGRDQFAGPAFHSAQWDHSVDLTGKRVAV
MLBr_00065|M.leprae_Br4923 CSFLFLCSGYYNYEQGYAPTFLGSEDFTGPIIHPQHWPEDLDYAAKNIVV
: . . * * : * .* * :*. * . .:. :
Rv1393c|M.tuberculosis_H37Rv IGTGASAVQVIPEMAP-IVSHLTVFQRTPIWCFPKFDVPLPTAVRWAMRI
Mb1428c|M.bovis_AF2122/97 IGTGASAVQVIPEMAP-IVSHLTVFQRTPIWCFPKFDVPLPTAVRWAMRI
MMAR_2207|M.marinum_M IGTGASAVQVIPEIAP-IVKHLTVFQRTPIWCFPKFDFPLPAALRWAMRI
MUL_1793|M.ulcerans_Agy99 IGTGASAVQVIPEIAP-IVKHLTVFQRTPIWCFPKFDFPLPAALRWAMRI
MAV_3378|M.avium_104 IGTGASAVQVIPEIAP-IVSSLTVFQRTPIWCFPKLDVPLPAPARWAMRF
Mvan_2671|M.vanbaalenii_PYR-1 IGTGASAVQVIPEIAP-IVERLTVFQRTPIWCFPKFDVPLSKTAQTMMRL
Mflv_4607|M.gilvum_PYR-GCK IGTGASAVQLIPSIAK-DVDTLTVFQRTPIWCLPKFDFAVPRPLSALLRL
MAB_4024c|M.abscessus_ATCC_199 IGTGATSLQLVPAIVD-ETSHLTVFQRTPIWVGPKFDLEIGPLGRIILGN
MSMEG_0816|M.smegmatis_MC2_155 VGTGATAVQLIPELAE-RVAELTVYQRTPIWVVPKVDVRFPPAVRALFAR
TH_4080|M.thermoresistible__bu IGTGASAIQIVPEIID-RVAQLQLYQRTPAWVVPRTNDELPAWLRRALEN
MLBr_00065|M.leprae_Br4923 IGSGATAVTLVPALANSGAKHVTMLQRSPTYIVSQPAKDKIAARLNRWLP
:*:**::: ::* : . : : **:* : .:
Rv1393c|M.tuberculosis_H37Rv P-GGKAVHRLLSQAFVEATFP--IAAHYFAVFPLAKHMESAGRRYLRQQV
Mb1428c|M.bovis_AF2122/97 P-GGKAVHRLLSQAFVEATFP--IAAHYFAVFPLAKHMESAGRRYLRQQV
MMAR_2207|M.marinum_M P-GGKALQRLLSQAYVEATFP--ISAHYFTVFPLARWSAVLGRRYLRQRV
MUL_1793|M.ulcerans_Agy99 P-GGKALQRLLSQAYVEATFP--ISAHYFTVFPLARWSAVLGRRYLRQRV
MAV_3378|M.avium_104 P-GGKALQRLLSQAYVELTFP--ISAHYFTVIPLAKRMAALGRAYLRRQV
Mvan_2671|M.vanbaalenii_PYR-1 P-FGKSLQRLISQAFVELTFP--LAAQYFTVNPMAKRMGAVGRAYLRKQV
Mflv_4607|M.gilvum_PYR-GCK APGAQIAARGASQAFVELTFP--VAAHFHTAIPLASAIERAAISYMRRQV
MAB_4024c|M.abscessus_ATCC_199 S-RIRSAIRAIATVGIEMAMSGQVAGPAWLINAVRRAGEAPMRRWMRSQV
MSMEG_0816|M.smegmatis_MC2_155 VPLTQRVVRAITDAIYAFMVDTAVLKHRYFRR-LNIAAADLGRLHLAASI
TH_4080|M.thermoresistible__bu IPGLRLALRGGIYALQEALAVG-----MTKYPGMLRIGHLLGKWNINRSV
MLBr_00065|M.leprae_Br4923 DKYAYTAVRWKNILRQSALYG---ACQKWPQRMRNILLGHVARRLPKGYD
*
Rv1393c|M.tuberculosis_H37Rv HDPVVREQLTPRYAVGCKRPGFHNTYLSTFNRDNVRLVTEPIDKITPTAV
Mb1428c|M.bovis_AF2122/97 HDPVVREQLTPRYAVGCKRPGFHNTYLSTFNRDNVRLVTEPIDKITPTAV
MMAR_2207|M.marinum_M NDPVVRDQLTPRYAVGCKRPGFHNGYLSTFNRDNVQLVTEPIEKITPTAV
MUL_1793|M.ulcerans_Agy99 DDPVVRDQLTPRYAVDCKRPGFHNGYLSTFNRDNVQLVTEPIEKITPTSV
MAV_3378|M.avium_104 RDPAVREQLTPRYAVGCKRPGFHNGYLATFNRDNVRLVTEPIDKITPDAV
Mvan_2671|M.vanbaalenii_PYR-1 DDPVLRDKLTPRYAVGCKRPGFHNTYLSTFNRDNVDLVTEPIDKITGSGV
Mflv_4607|M.gilvum_PYR-GCK TDPVVREKLTPRYALGCKRPSFHNEYLKTFNRENVLLETNPITRVDETAV
MAB_4024c|M.abscessus_ATCC_199 DDPVIREKLIPRYGLGCKRPSMSNEYLKTFNRDDVSLITESIECVTPDGV
MSMEG_0816|M.smegmatis_MC2_155 RDPDLRSKLTPDYDFGCKRPTFSNSYYRTFTKPHVHLQADGIDHVEPDGI
TH_4080|M.thermoresistible__bu KDPQLRAKLTPDYRLGCKRILNSSTYYPAVADPRTEVITESIDRITTDGI
MLBr_00065|M.leprae_Br4923 VQKHFGPHYNPWEQRLCLVP--DGDLFRAIRKGTVDMVTDAIDRFTSTGI
: . : * * . :. . : :: * . .:
Rv1393c|M.tuberculosis_H37Rv ATTDGASHEIDVLVLATGFKVLDT----DSIPTYAVTGTGGASLSRFWDE
Mb1428c|M.bovis_AF2122/97 ATTDGASHEIDVLVLATGFKVLDT----DSIPTYAVTGTGGASLSRFWDE
MMAR_2207|M.marinum_M ATDDGTDHEIDVLILATGFKVLDT----DDVLTYPVIGRAGRSLSQFWEE
MUL_1793|M.ulcerans_Agy99 ATDDGTDHEIDVLILATGFKVLDT----DDVLTYPVIGRAGRSLSQFWEE
MAV_3378|M.avium_104 ATTDGETHEIDVLILATGFKVMDP----DSVPTFAVTGSGGRSLSRFWDE
Mvan_2671|M.vanbaalenii_PYR-1 STTDGSLHEVDVLILATGFKVFAAHDGDDSVATFPVTGPGGRSLARFWDD
Mflv_4607|M.gilvum_PYR-GCK ITADGVRHEIDVLVLATGFKVMES----DSMPTYSLRGVAGRDQAQWWDE
MAB_4024c|M.abscessus_ATCC_199 RTVDGVEHVVDVLICATGFRLWDK----GSVPPFPVHGRGGQDLGEFWDR
MSMEG_0816|M.smegmatis_MC2_155 VNADGSKTVIDTLVLATGFDLWEA-----NFPAIEVIGRQGRDLGKWWRE
TH_4080|M.thermoresistible__bu VTSDGTERAVDVIVYATGFHVSDS------YKYVQIKGLNGEDIVDRFNR
MLBr_00065|M.leprae_Br4923 RLKSGNELRADIIVTATGLNLQLFG------------GAVATVDGQPVDL
.* * :: ***: : * .
Rv1393c|M.tuberculosis_H37Rv HRLQAYEGVSVPGYPNFFTVFGPYGYVGS-SYFALIETQAHHIIRCLKRA
Mb1428c|M.bovis_AF2122/97 HRLQAYEGVSVPGYPNFFTVFGPYGYVGS-SYFALIETQAHHIIRCLKRA
MMAR_2207|M.marinum_M HRAQAYQGVSVPGYPNFFAVFGPYGYVGS-SYFALIETQTHHILRCLKRA
MUL_1793|M.ulcerans_Agy99 HRAQAYQGVSVPGYRNFFAVFGPYGYVGS-SYFALIETQTHHILRCLKRA
MAV_3378|M.avium_104 HRLQAYEGVTVPGFPNLFTVFGPYGYVGS-SYFALIEAQTHHIVRCLKRA
Mvan_2671|M.vanbaalenii_PYR-1 NRLQAYEGVSVPGFPNFFTVFGPYGYVGS-SYFALIEAQTRHIVRCLDAA
Mflv_4607|M.gilvum_PYR-GCK NRLQAYEGVSVPGFPNHFSVFGPYGYNGS-SYFALIEAQAGHILRCLRHA
MAB_4024c|M.abscessus_ATCC_199 HRFQSYQGVSVPGYPNMFSITGPYGFVLG-SYLWMIEATSAHLARAIAET
MSMEG_0816|M.smegmatis_MC2_155 TRFQAYQGVSMPYFPNYLSLAGPYAFLGL-NFFNTMEYQMRLMERLLGEV
TH_4080|M.thermoresistible__bu EGPMAHRGTAVADLPNAYLLLGPNTGLGHNSMVYMIESQINYVIEAIKAV
MLBr_00065|M.leprae_Br4923 AQTMSYKGMMLSGLPNMIYTVG-YTNASWTLKADLVSEFFCRLLNYMNAN
::.* :. * * :. : . :
Rv1393c|M.tuberculosis_H37Rv RRTGATRIEVTEEANARYFAEVMRRRHRQVFWQDSCRLANSYYFDKNGDV
Mb1428c|M.bovis_AF2122/97 RRTGATRIEVTEEANARYFAEVMRRRHRQVFWQDSCRLANSYYFDKNGDV
MMAR_2207|M.marinum_M RRDGATRVEVTEEANARYFAEMMRRRYRQVFWQDSCRRANSYYFDKNGDV
MUL_1793|M.ulcerans_Agy99 RRDGATRVEVTEEANARYFAEMMRRRYRQVFWQDSCRRANSYYFDKNGDV
MAV_3378|M.avium_104 QRLGATRVEVSEEANDRYFAEMMRRRHRQIFWQDSCRLANSYYFDKNGDV
Mvan_2671|M.vanbaalenii_PYR-1 RRRRATRVEVRREANDRYFAEMMRKRHRQIFWQDSCQLSNSYYFDQHGDV
Mflv_4607|M.gilvum_PYR-GCK RTADSNYVEVREEANQRFFAEMLARRHTQVFWQDSCAGANSYYFDKHGDV
MAB_4024c|M.abscessus_ATCC_199 KRRGATVCEIRQEAHDEYFRKCLKRQEKNFLFTDVCAGSNTYYLDQNGDS
MSMEG_0816|M.smegmatis_MC2_155 ARRDARTFEVTEEANRRYLDRMTDALGDSLFTLGNCASARSYYFNPSGEA
TH_4080|M.thermoresistible__bu DKAGAQALAPTREAQDRYNAELQARLGRSVWNTGGCR---SWYLDEHGNN
MLBr_00065|M.leprae_Br4923 DFDTVAVEYPGSDVEERPFMDFTPGYVLRSLDALPKQGSRTPWRLNQNYL
:.. . : : .
Rv1393c|M.tuberculosis_H37Rv -PLRPTTTVEAYWRSRRFDLGDYRISS-----------------
Mb1428c|M.bovis_AF2122/97 -PLRPTTTVEAYWRSRRFDLGDYRISS-----------------
MMAR_2207|M.marinum_M -PLRPTTTVEAYWRGRHFDLDNYRFGR-----------------
MUL_1793|M.ulcerans_Agy99 -PLRPTTTVEAYWRGRHFDLDDYRFGR-----------------
MAV_3378|M.avium_104 -PLRPGTTPEVYWRSRRFDLDDYRFTG-----------------
Mvan_2671|M.vanbaalenii_PYR-1 -PLRPASTPEAYWRSRRFPIDDYEFSC-----------------
Mflv_4607|M.gilvum_PYR-GCK -PLRPTTTVESIWRSRRFDLADYRFERRPAKKADTAPQKVDTAG
MAB_4024c|M.abscessus_ATCC_199 -PFRPTTHGEMYWQNRHYNLDVYRYSTASVVPETVASTAGESV-
MSMEG_0816|M.smegmatis_MC2_155 TLLRPMTTRRAVAEASRFPLSDYTFA------------------
TH_4080|M.thermoresistible__bu RVLWGGFTWQYRLATRTLDPAEYRFWG-----------------
MLBr_00065|M.leprae_Br4923 RDIRLIRRGKVADEGLLFAKKTTPVTV-----------------
: .