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AFLVAEPQVMATVAGQVEEIGSAIGVANEFAAGSISGVAAAAGDEVSAAIASFFAAHGQAYQAVAGQVEA FHTEFQQALAQAGNAYVQAEAAGAAALAGALGVPATSAAAPAATIPPFPANLTTLVMGGTGIPIPGPGFI NLANELYVRSANALLGLNTPEELYPLTGTKSLTLDASVSEGLTILDNAIMEQLAIPGNTVTVFGVSQSAV IASLEMQKLAALGPAAPTASQLNFVLLGNEMNPNGGLLARFPDLSIPSLGLTFYGGTPSDTIYPTANYTL EYDGFADFPRYPLNFISDLNAVMGIVYVHPTYLDLTQAQVDNAIPLATSPGYSGVTSYYILPTENLPLLE PLRAIPVIGNPLANLIQPDLKVLVNLGYGDPAYGYSTSPADITTPFGLFPDVPPHVIADALVAGTKQGIS DFSADIQQMFSQPATLPSPPMLQAPDLMAALAAAPTPVEVVNTLTKIVSDDYATLLPLADIGTAFVITMP TYDATLFVDQLLQGNLINAFGYPIAADVGLTAISGGVVALVAIGTLQSNIKDLQSLFP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3427 | - | - | 100% (549) | PE family protein |
| M. marinum M | MMAR_0370 | - | 0.0 | 68.55% (550) | PE family protein |
| M. marinum M | MMAR_0372 | - | e-145 | 51.53% (555) | PE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0157c | PE2 | 1e-167 | 66.16% (458) | PE family protein |
| M. gilvum PYR-GCK | Mflv_1918 | - | 8e-37 | 35.48% (310) | hypothetical protein Mflv_1918 |
| M. tuberculosis H37Rv | Rv0152c | PE2 | 1e-167 | 66.16% (458) | PE family protein |
| M. leprae Br4923 | MLBr_01183 | - | 2e-11 | 36.46% (96) | hypothetical protein MLBr_01183 |
| M. abscessus ATCC 19977 | MAB_4141 | - | 8e-25 | 28.43% (313) | PE/PPE family protein |
| M. avium 104 | MAV_1760 | - | 5e-16 | 28.06% (278) | hypothetical protein MAV_1760 |
| M. smegmatis MC2 155 | MSMEG_5455 | - | 2e-35 | 33.55% (304) | PE family protein |
| M. thermoresistible (build 8) | TH_3724 | - | 1e-44 | 39.67% (305) | PUTATIVE putative PE-PPE, C-terminal domain protein |
| M. ulcerans Agy99 | MUL_0967 | - | 1e-126 | 47.79% (542) | PE family protein |
| M. vanbaalenii PYR-1 | Mvan_4726 | - | 2e-36 | 32.06% (315) | hypothetical protein Mvan_4726 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1918|M.gilvum_PYR-GCK -------------MGKGDFGLKASEFTGRSSTRFADSVRRRPGGATYGLY
MSMEG_5455|M.smegmatis_MC2_155 -------------MGRLLHSLSTAFLVFVAVVVLCVSTS-----------
Mb0157c|M.bovis_AF2122/97 ------------------------------MRCRPPSRNRSAHTARNTRP
Rv0152c|M.tuberculosis_H37Rv ------------------------------MRCRPPSRNRSAHTARNTRP
MMAR_3427|M.marinum_M --MAFLVAEPQVMATVAGQVEEIGSAIGVANEFAAGSISGVAAAAGDEVS
MLBr_01183|M.leprae_Br4923 -MPLFLNAEPQALTAAANTLEGLSAATVASNAAAAQLTTEIAPPAADDVS
MUL_0967|M.ulcerans_Agy99 MAVIDLLASPQAMTATATEVAEIGLAINQADLAVAGPTTGLAAAAAAEVS
TH_3724|M.thermoresistible__bu --------------VVAVGALTWGGXGVASPAGQP---------------
Mvan_4726|M.vanbaalenii_PYR-1 -------------MRRRLRSAAWGLLSLVIAVLFAWG-------------
MAB_4141|M.abscessus_ATCC_1997 -----------MAGQYSVPGKRHSLRRYVATITAVAATCTVLAP------
MAV_1760|M.avium_104 -------------MKQLLAGVTALLSVSTAGYFGIGTAAADGGP------
Mflv_1918|M.gilvum_PYR-GCK RHDGLGVGTWAWVFARSSRSFPRSRRCWRYPRGVPTPVAVLVANTTALVM
MSMEG_5455|M.smegmatis_MC2_155 ---------------------------------MPTAAHLLLNHPHALVI
Mb0157c|M.bovis_AF2122/97 CSLKS----------------RRFTVRFHQTLAAAANSYADAEAAIASTR
Rv0152c|M.tuberculosis_H37Rv CSLKS----------------RRFTVRFHQTLAAAANSYADAEAAIASTR
MMAR_3427|M.marinum_M AAIASFFAAHGQAYQAVAGQVEAFHTEFQQALAQAGNAYVQAEAAGAAAL
MLBr_01183|M.leprae_Br4923 ILLAHFFSGHGRQYQAHASQGATNHQDLIQSLLTSSSAYAGTETANHDSL
MUL_0967|M.ulcerans_Agy99 EAIATLFDNYAQGYQAVSRQTAAFHDAFAQTLFAASDSYVRAEAAAVKAL
TH_3724|M.thermoresistible__bu ---------------------------------ERAAALRLTATADAIIM
Mvan_4726|M.vanbaalenii_PYR-1 ----------------------------------SVVTSTSAGAGTALVM
MAB_4141|M.abscessus_ATCC_1997 -------------------------------LAMESRTIASTLASYVIGI
MAV_1760|M.avium_104 --------------------------------IGGPPTPGAPGDQTAYAL
Mflv_1918|M.gilvum_PYR-GCK GGT-------------FHPLTGPRDSPEFVTAYLDNAVDNQISAAYGYAV
MSMEG_5455|M.smegmatis_MC2_155 GGT-------------GTPVP----PPEYVNGQTDNYIGAEFPGEYRYAV
Mb0157c|M.bovis_AF2122/97 QNQ------------LAVPAAAPTPAAAAMIPPFPANLTTLFFGPTGIPL
Rv0152c|M.tuberculosis_H37Rv QNQ------------LAVPAAAPTPAAAAMIPPFPANLTTLFFGPTGIPL
MMAR_3427|M.marinum_M AGA------------LGVPATS-AAAPAATIPPFPANLTTLVMGGTGIPI
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MUL_0967|M.ulcerans_Agy99 AGLTEPVANLFAPVLSGPESVAASATALLSGAPLKPVEAALILSESGVPT
TH_3724|M.thermoresistible__bu PGT----------------KIGYIPSQDEFTAYATAVIGATAGAPGAVDY
Mvan_4726|M.vanbaalenii_PYR-1 GGN-------------GHPLSVPQDTPDYINKYVTAADDAFIAPSGLCGP
MAB_4141|M.abscessus_ATCC_1997 GGN---------------------------NDGASANIPRKLGGAYSVDY
MAV_1760|M.avium_104 GGAHVLG--------IPYDQYIRMEGADWFPGQQRQIVRYPAGQVQGHVL
Mflv_1918|M.gilvum_PYR-GCK TNA---------------------VAVYTPEEFFPLGG---LTFDDSVAE
MSMEG_5455|M.smegmatis_MC2_155 H---------------------------TPQNFWPVYGS--MSFDESTVA
Mb0157c|M.bovis_AF2122/97 PPPSMLTPP-----IRCRSVRRALQAVFTPEELYPLTGVRSLVLNTSVEE
Rv0152c|M.tuberculosis_H37Rv PPPSMLTPP-----IRCRSVRRALQAVFTPEELYPLTGVRSLVLNTSVEE
MMAR_3427|M.marinum_M PGPGFINLAN---ELYVRSAN-ALLGLNTPEELYPLTGTKSLTLDASVSE
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MUL_0967|M.ulcerans_Agy99 PSASYISDVYTKYVEPNFPSATAPQGVSTPNGLYPFTGIKDLSLDISLAR
TH_3724|M.thermoresistible__bu LG--------------------------VPGEFWPATGLDSLTFDASVAX
Mvan_4726|M.vanbaalenii_PYR-1 QCS--------------------LVATYTPAQIRFVNGIFDMTYDESVAV
MAB_4141|M.abscessus_ATCC_1997 HP------------------------VSYPGAIWPVSGLTAPTFKTSVAQ
MAV_1760|M.avium_104 ERLFP--------------------GIGKLDESFPGLGMDGPSVGESVAE
Mflv_1918|M.gilvum_PYR-GCK GLANLGRCLRAEPGCVFNADPAVAARVGTVAPRHDDTFVVFGYSQSAAVA
MSMEG_5455|M.smegmatis_MC2_155 GLAALQAEMAKEG-------------------HFGSPLVILGYSSSTRIL
Mb0157c|M.bovis_AF2122/97 GLTILHDAIMVELAT----------------TGN--AVTVFGWSQSAIIA
Rv0152c|M.tuberculosis_H37Rv GLTILHDAIMVELAT----------------TGN--AVTVFGWSQSAIIA
MMAR_3427|M.marinum_M GLTILDNAIMEQLAI----------------PGN--TVTVFGVSQSAVIA
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MUL_0967|M.ulcerans_Agy99 GATILNDAILQQLAA----------------LPAGSSVAVLGYSQSAVLS
TH_3724|M.thermoresistible__bu GQAMLTPMVDGAIES-------------------DTPIVVFGHSQSAVIA
Mvan_4726|M.vanbaalenii_PYR-1 GQANLNDCIQGSDCTATLAPYSETG----PHTVADSTYVIYAYSQSATVA
MAB_4141|M.abscessus_ATCC_1997 GRTNLNDEIVTAGNQ---------------------PITIVGYSLGAVVV
MAV_1760|M.avium_104 GIDNLDAAIRTTGRP----------------------GTAIGLSEGAFVV
Mflv_1918|M.gilvum_PYR-GCK SLLKRQLIDAP--GPEPAATTFMLAANPMRPNGGVLGRFPALTIPILGIT
MSMEG_5455|M.smegmatis_MC2_155 TADKNRRIAD---GDYAVDINYVLVSDVAKGNGGVMARFPGWHIPILGVT
Mb0157c|M.bovis_AF2122/97 SLEMQRFTAMGGAAPSASDLNFVLVGNEMNPNGGMLARFPDLTLPTLDLT
Rv0152c|M.tuberculosis_H37Rv SLEMQRFTAMGGAAPSASDLNFVLVGNEMNPNGGMLARFPDLTLPTLDLT
MMAR_3427|M.marinum_M SLEMQKLAALGPAAPTASQLNFVLLGNEMNPNGGLLARFPDLSIPSLGLT
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MUL_0967|M.ulcerans_Agy99 SRVMPKLLAEG---VTSSQVNFVLLGNPMNPNGGVLARFPDLTLPSLGFT
TH_3724|M.thermoresistible__bu TKEKQRLLAEYPDPDTAPDVTFVMVANPNRPNGGLLARFPGLYIPILGVT
Mvan_4726|M.vanbaalenii_PYR-1 ANQKLQLIAHP----VASTVSFLLVANPNRPDGGILERFVGAYIPLLGIT
MAB_4141|M.abscessus_ATCC_1997 SKSHSDLLQRYP--GGNPNIQFVLMGSANTPNGGIFARFPWLKIPLADIE
MAV_1760|M.avium_104 DGEQARLANDP-TAPPPNTLNFATFGDPIG-RHAFGQSFLTAMFGVGSVV
Mflv_1918|M.gilvum_PYR-GCK FHGATPTAG-VDGAYRTVDVVRQYDGLGGDFPVRPLNLLATVNALLGYGI
MSMEG_5455|M.smegmatis_MC2_155 FDGATRTDS-DGYAFDTKSISFVHDGWS-DFPVYPLNVLALANAVAGIAV
Mb0157c|M.bovis_AF2122/97 FYGATPS----DTIYPTAIYTLEYDGFA-DFSRYPLNFISDLNAVAGITF
Rv0152c|M.tuberculosis_H37Rv FYGATPS----DTIYPTAIYTLEYDGFA-DFSRYPLNFISDLNAVAGITF
MMAR_3427|M.marinum_M FYGGTPS----DTIYPTANYTLEYDGFA-DFPRYPLNFISDLNAVMGIVY
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MUL_0967|M.ulcerans_Agy99 FYGATP-----DNAFPTVSYTLEYDGFA-DFPRYPINLLADINAVMGIPF
TH_3724|M.thermoresistible__bu FNGATPAP--ADGPFDSYDVAREFDGWA-DFPRYPLNLVATANAILGIYY
Mvan_4726|M.vanbaalenii_PYR-1 FNGSTPTFSPQPRPLTTVDVARQYDGWA-DFPTNPLNLLADLNAIMGTIL
MAB_4141|M.abscessus_ATCC_1997 SNGAWEP-----DQFKTKVINTEYDTYG-DFPAY-FNPLALANSIAAIQY
MAV_1760|M.avium_104 PALDYTMPPPYESQYDTNRFVAAYDSIA-DFPDRPDNMFALANTLMGLAT
Mflv_1918|M.gilvum_PYR-GCK MHG-ETVDVPFAQARFQ-GRE-------GDTDYYLIGTDLLPLLQPLLLF
MSMEG_5455|M.smegmatis_MC2_155 LHP-TYPELDRPDLVPV-GST-------GDTEYFVIGTDIMPLLMPLETI
Mb0157c|M.bovis_AF2122/97 VHT-KYLDLTPAQVEGA-TKLPTSPGYTGVTDYYIIRTENRPLLQPLRAV
Rv0152c|M.tuberculosis_H37Rv VHT-KYLDLTPAQVEGA-TKLPTSPGYTGVTDYYIIRTENRPLLQPLRAV
MMAR_3427|M.marinum_M VHP-TYLDLTQAQVDNA-IPLATSPGYSGVTSYYILPTENLPLLEPLRAI
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MUL_0967|M.ulcerans_Agy99 VHA-DYQDLTQAQLDSA-VQLPTEG--PTQSTYYMIPTEHLPLLAPLRFI
TH_3724|M.thermoresistible__bu LHG-GYYELLTENPDILDDPERTIVQQYGDTTYYLIRTEQLPLLRPLRDL
Mvan_4726|M.vanbaalenii_PYR-1 LHP-NYSDAGTPQLQGQ----------YQDSTYYLIPAPITPVLVPLTWV
MAB_4141|M.abscessus_ATCC_1997 AHPDAYYDRIDPAALDDPDNPNVVKTVQGNTTYYLVRAEHLPLLQPLRDL
MAV_1760|M.avium_104 GHT--AVAFTNPSMVPPQNIRTTINSRGAKDTTIMIPEKHLPLVMPLKYI
Mflv_1918|M.gilvum_PYR-GCK ---VPRPILSALDAP-LRVLVEDAYDRDAG------PGDPTTARWWPV--
MSMEG_5455|M.smegmatis_MC2_155 G--VPRPILLAVDEP-LRVLVEAGYRRDIA------PGAPTPARLIPI--
Mb0157c|M.bovis_AF2122/97 P--VIGDPLADLIQPNLKVIVNLGYGDPNYGYSTSYADVRTPFGLWPN--
Rv0152c|M.tuberculosis_H37Rv P--VIGDPLADLIQPNLKVIVNLGYGDPNYGYSTSYADVRTPFGLWPN--
MMAR_3427|M.marinum_M P--VIGNPLANLIQPDLKVLVNLGYGDPAYGYSTSPADITTPFGLFPD--
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MUL_0967|M.ulcerans_Agy99 P--YVGDPLAELLEPNLRVLVNFGYGDPAYGYDTGPANVPTPFGLFPP--
TH_3724|M.thermoresistible__bu G--VP-EEFVDALEPYVRRIVDLGYDRNTP------YGEPAPVRVLPP--
Mvan_4726|M.vanbaalenii_PYR-1 P--IVGKPLAIALDPAVRVLVEMGYDRTVN------PGQPTPARYLYVP-
MAB_4141|M.abscessus_ATCC_1997 TNPIGASFVLDAIEPTLRVFIDMAYDRDTG------PGTTTQFSFFTPSK
MAV_1760|M.avium_104 G---IDENTLNKLDAILTPRVNAGYSRNDD-------PATAPVQVDPVHG
Mflv_1918|M.gilvum_PYR-GCK --KDFAG-TAAKLIASVPVAVDNLTEGFGLGRVLGTPVPGVFGVGG----
MSMEG_5455|M.smegmatis_MC2_155 --VNPIT-LTRNFIAAIPVGVDDAMEELGHGRPLGTQPSGVFGVGGEDTE
Mb0157c|M.bovis_AF2122/97 --VPPQV-IADALAAGTQEGILDFTADLQALSAQPLTLPQIQLPQP----
Rv0152c|M.tuberculosis_H37Rv --VPPQV-IADALAAGTQEGILDFTADLQALSAQPLTLPQIQLPQP----
MMAR_3427|M.marinum_M --VPPHV-IADALVAGTKQGISDFSADIQQMFSQPATLPSPPMLQA----
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MUL_0967|M.ulcerans_Agy99 --VSPLT-VAEHLAAGTQQGIVNSGAALQAQGPPSIPLSDIAHTLT----
TH_3724|M.thermoresistible__bu --LTPAPGPATQHNAGQGITVASATSTPDKRTPVVEAPVEEPPVQTG---
Mvan_4726|M.vanbaalenii_PYR-1 NLIKAALNFAMAIPTGWDDAISYLTGDPDCRPFHTTVPASPFGVGGPPVY
MAB_4141|M.abscessus_ATCC_1997 NIVDAFNKLPTAIAEGAHNVENGLAGATPKQSASPEKPASPPVPQPGPTN
MAV_1760|M.avium_104 --FDPAEVTAPANQATFGGGADPLSQIMAGAMSVLSHGAGEADH------
Mflv_1918|M.gilvum_PYR-GCK -------------PDLPDVDEGGAVTSDIDEDAVAQRDSASSTERS----
MSMEG_5455|M.smegmatis_MC2_155 LKGLPAGVISLAKPTLPVSSHTTVVEKTERKDLAKPAAEPEPVVED----
Mb0157c|M.bovis_AF2122/97 -------------ADLVAAVAAAPTPAEVVNTLARIISTNYAVLLP----
Rv0152c|M.tuberculosis_H37Rv -------------ADLVAAVAAAPTPAEVVNTLARIISTNYAVLLP----
MMAR_3427|M.marinum_M -------------PDLMAALAAAPTPVEVVNTLTKIVSDDYATLLP----
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MUL_0967|M.ulcerans_Agy99 -------------ANPPWAGTPALPPSTSP------ASSIEDFILA----
TH_3724|M.thermoresistible__bu ------------------RSTLKREKPVSARHLVRNSLRAVPGLRR----
Mvan_4726|M.vanbaalenii_PYR-1 TGAIDPYGEPTPYLAPPVETHGEAAPGSGSPAAHPAGTEPPETVTF----
MAB_4141|M.abscessus_ATCC_1997 PGSATTQIPAPEAPTPSVVSLSTAEPPAPPASAKAADPTAISVSTAGAST
MAV_1760|M.avium_104 --------------------------------------------------
Mflv_1918|M.gilvum_PYR-GCK ------APAEESRSAVGGADSDGRD----------DVVDPEPAAPEAETS
MSMEG_5455|M.smegmatis_MC2_155 ------EPAVEDETPVADTKKASPK----------PLRPKVRGPISFDAP
Mb0157c|M.bovis_AF2122/97 ------TVDIALALVTTLPLYTTQL----------FVRQLAAGNLINAIG
Rv0152c|M.tuberculosis_H37Rv ------TVDIALALVTTLPLYTTQL----------FVRQLAAGNLINAIG
MMAR_3427|M.marinum_M ------LADIGTAFVITMPTYDATL----------FVDQLLQGNLINAFG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MUL_0967|M.ulcerans_Agy99 ------VQAANSSISRGFVKTLSTA----------YATLLPTTDIASELV
TH_3724|M.thermoresistible__bu ------GEPAATPTPDVTPDVTPDA----------PAGQPEPAEPNESAA
Mvan_4726|M.vanbaalenii_PYR-1 ------SPTTESTPSTLLPETPAESEDMPPDFVENDTPDSDEVSPTEDDA
MAB_4141|M.abscessus_ATCC_1997 ARDQDFQPDTKPDPKSTPPPTKDSVGEADKSKNTLKPTLRLPKLPVAQPG
MAV_1760|M.avium_104 --------------------------------------------------
Mflv_1918|M.gilvum_PYR-GCK EAETVTETEADD---------ADDADDGADADDEDIDADGADADGEDTAG
MSMEG_5455|M.smegmatis_MC2_155 KLPTIRKATGDRPLKRLLSALTPKRPKPASSHDAGPAAGNKDTDNADKPA
Mb0157c|M.bovis_AF2122/97 YPLAATVGLGTIDSGRRGIAHPPRGGLGHRSKHRGPRHLTDSRRHRRPPT
Rv0152c|M.tuberculosis_H37Rv YPLAATVGLGTIDSGRRGIAHPPRGGLGHRSKHRGPRHLTDSRRHRRPPT
MMAR_3427|M.marinum_M YPIAADVGLTAISGG--VVALVAIGTL--QSNIKDLQSLFP---------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MUL_0967|M.ulcerans_Agy99 FTLPSYNLNLFLDGVIQAINGQPIGD------------------------
TH_3724|M.thermoresistible__bu PPAAAEADDASE--------------------------------------
Mvan_4726|M.vanbaalenii_PYR-1 LKDTETINESQDGPTESASGVSGEDAADADSRSADADSLSADAGDSAPAD
MAB_4141|M.abscessus_ATCC_1997 TAPKSPKFPSLKNHLKSVPGLSEKKNPAADASSKHSQPANAPAHTSDKTS
MAV_1760|M.avium_104 --------------------------------------------------
Mflv_1918|M.gilvum_PYR-GCK NTAEAA-----
MSMEG_5455|M.smegmatis_MC2_155 ARADDAA----
Mb0157c|M.bovis_AF2122/97 TVYRPRQ----
Rv0152c|M.tuberculosis_H37Rv TVYRPRQ----
MMAR_3427|M.marinum_M -----------
MLBr_01183|M.leprae_Br4923 -----------
MUL_0967|M.ulcerans_Agy99 -----------
TH_3724|M.thermoresistible__bu -----------
Mvan_4726|M.vanbaalenii_PYR-1 AAAADTAA---
MAB_4141|M.abscessus_ATCC_1997 DHASETGRGAA
MAV_1760|M.avium_104 -----------