For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
SAKAQPSPTAQRDGAQQESRASRFMRSALDILGETGRTDFTVLEVVERSKTSLRAFYQHFATKDELLLAL VERVMVDATERWRAETDRMTSDDALRLLIERISAPAESSTQDSINRGLTYYNDHLLETRPKEFAKVLAPL HRLVADILRRGIDEGTFRADLDVDTDAAILMHTVLGVLRLRDLGAELNGVPIVGDHVHTFCVRGLTG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2603 | - | - | 100% (208) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_4220 | - | 2e-18 | 34.85% (198) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_0360 | - | 8e-07 | 25.00% (160) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3587c | - | 3e-06 | 26.54% (162) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_3791 | - | 7e-95 | 81.04% (211) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv3557c | - | 4e-06 | 26.54% (162) | TetR family transcriptional regulator |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4946 | - | 4e-05 | 24.74% (194) | putative transcriptional regulator, TetR |
| M. marinum M | MMAR_3987 | - | 4e-61 | 61.38% (189) | putative transcriptional regulatory protein |
| M. avium 104 | MAV_1626 | - | 9e-60 | 59.36% (187) | hypothetical protein MAV_1626 |
| M. smegmatis MC2 155 | MSMEG_2995 | - | 2e-73 | 62.80% (207) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_0537 | - | 2e-66 | 61.17% (206) | transcriptional regulator, TetR family protein |
| M. ulcerans Agy99 | MUL_3848 | - | 2e-61 | 61.38% (189) | putative transcriptional regulatory protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3587c|M.bovis_AF2122/97 MDRVAG----------QVN----SRRGELLELAAAMFAERGLRATTVRDI
Rv3557c|M.tuberculosis_H37Rv MDRVAG----------QVN----SRRGELLELAAAMFAERGLRATTVRDI
Mvan_2603|M.vanbaalenii_PYR-1 MSAKAQPSPTAQRDGAQQE----SRASRFMRSALDILGETGRTDFTVLEV
Mflv_3791|M.gilvum_PYR-GCK MSAKAQPDPTVRQDPAVRQDRAQSRAGRFMRSALDILGETGRTDFTVLEV
MSMEG_2995|M.smegmatis_MC2_155 MARPTQRSPDGAR--ADPE----DRTARFMRSALAILGETGRTDFTVLEV
TH_0537|M.thermoresistible__bu MANPTS---------ADTE----SRADRFLRSALTILGETGRTDFTVLEV
MMAR_3987|M.marinum_M MAGPSE----------QVEA---TRADRFIKTAVEILGETGRTDFTVQEV
MUL_3848|M.ulcerans_Agy99 MAGPSE----------QVEA---TRADRFIKTAVEILGETGRTDFTVQEV
MAV_1626|M.avium_104 MAEPNE----------DVEI---TRGDRFIKTAVAILGETGRTDFTVQEV
MAB_4946|M.abscessus_ATCC_1997 MEDPAEPPIRMAD--RQRARRSELVKEEVVEAALAEFSERGYHQTSIAHI
* ..:. * :.* * :: .:
Mb3587c|M.bovis_AF2122/97 ADGAGILSGSLYHHFASKEEMVDELLRGFLDWLFARYRDIVDS-TANP--
Rv3557c|M.tuberculosis_H37Rv ADGAGILSGSLYHHFASKEEMVDELLRGFLDWLFARYRDIVDS-TANP--
Mvan_2603|M.vanbaalenii_PYR-1 VERSKTSLRAFYQHFATKDELLLALVERVMVDATERWRAETDR-MTSDDA
Mflv_3791|M.gilvum_PYR-GCK VERSKTSLRAFYQHFSTKDELLLALVEKIMAEATERWRAETEQ-LAGPDA
MSMEG_2995|M.smegmatis_MC2_155 VERSKTSLRSFYQHFSSKDELLLALIDRIMAESAQRWRADTEA-LPGPEA
TH_0537|M.thermoresistible__bu VERSKTSLRSFYQHFSTKDELLLALIDTIMAESAARWRAELEG-LPAAQA
MMAR_3987|M.marinum_M VTRSKTSLRAFYQHFSSKDELLLALFDRTMSQTAQLWRAEAAG-LDSTAA
MUL_3848|M.ulcerans_Agy99 VTRSKTSLRAFYQHFSSKDELLLALFDRTMSQTAQLWRAEAAG-LDSTAA
MAV_1626|M.avium_104 VARSKTSLRAFYQHFSSKDELLLALFDRTIAQSAQTWRAETAG-LDSTAA
MAB_4946|M.abscessus_ATCC_1997 AERLGTGHSMFYRYFTNKRDILEHVVQHATQRTIETLSHTLPGRITSLNE
. :*::*:.* ::: :.
Mb3587c|M.bovis_AF2122/97 LERLQGLFMASFEAIEHHHAQVVIYQDEAQRLASQPRFSYIEDRNKQQRK
Rv3557c|M.tuberculosis_H37Rv LERLQGLFMASFEAIEHHHAQVVIYQDEAQRLASQPRFSYIEDRNKQQRK
Mvan_2603|M.vanbaalenii_PYR-1 LRLLIERISAPAESSTQDSINRGLTYYNDHLLETRPKE--FAKVLAPLHR
Mflv_3791|M.gilvum_PYR-GCK LRVLIDRISAPAQSSTQDSINRGLTYYNDHLLETRPKE--FATVLAPLHR
MSMEG_2995|M.smegmatis_MC2_155 LRVLVEKITAPASSSTQDSINRGLTYYNDHLAESLPRE--YARVLAPLHD
TH_0537|M.thermoresistible__bu LRTLIERICTPAGSSRQDYINRGLTSYNDRLADTLPRE--YARVLAPLHQ
MMAR_3987|M.marinum_M LKLVIDRISAQPESSTQDSLNRALSLYNQHLAETRPRE--YARVLSPLHR
MUL_3848|M.ulcerans_Agy99 LKLVIDRISAQPESSTQDSLNRALSLYNQHLAETRPRE--YARVLSPLHR
MAV_1626|M.avium_104 LKLVIDRVSQQPESSTQDSLNRALTLYNQHLAETRPRE--YARVLSPLHR
MAB_4946|M.abscessus_ATCC_1997 FHDFSVNLGLAYIDLVVADPRLSRLLLQQGAAVDAEMTAQFCGVFDAGAA
:. . . . :
Mb3587c|M.bovis_AF2122/97 MWVDVLNQGIEEGYFRP----------DLDVDLVYRFIRDTTWVSVRWYR
Rv3557c|M.tuberculosis_H37Rv MWVDVLNQGIEEGYFRP----------DLDVDLVYRFIRDTTWVSVRWYR
Mvan_2603|M.vanbaalenii_PYR-1 LVADILRRGIDEGTFRA----------DLDVDTDAAILMHTVLGVLRLRD
Mflv_3791|M.gilvum_PYR-GCK LLGDILRRGIAEGSFRA----------DLDVDTDAAILMQTVLGTLRLRE
MSMEG_2995|M.smegmatis_MC2_155 LIRGIVRRGIDAGDFHS----------GVEVDTTSALILQSVLGAMRLRS
TH_0537|M.thermoresistible__bu LIVDILRRGVAEGAFRGPGETAPDGGVDADLDAVAALIMQTALGAMRLRA
MMAR_3987|M.marinum_M LIRDIVGQGITEGMFNP----------GLDVGAAAAIVMQTVLGALRLRW
MUL_3848|M.ulcerans_Agy99 LIRDIVGQGITEGMFNP----------GLDVGAAAAIVMQTVLGALRLRW
MAV_1626|M.avium_104 LIRDIVGQGITEGVFNP----------GLDVGAAAAIVMQTMMGAQRLHW
MAB_4946|M.abscessus_ATCC_1997 VLGGLLRDGIESGYVRE----------DIDVEAVADSVVGIPLGILARYG
: .:: *: * .. . :: :
Mb3587c|M.bovis_AF2122/97 PGGPLTAQQVG-QQYLAIVLGGITKEGV----------------------
Rv3557c|M.tuberculosis_H37Rv PGGPLTAQQVG-QQYLAIVLGGITKEGV----------------------
Mvan_2603|M.vanbaalenii_PYR-1 LGAELNGVPIVGDHVHTFCVRGLTG-------------------------
Mflv_3791|M.gilvum_PYR-GCK LGADLNGIPIEGSHVHTFCLRGLTPP------------------------
MSMEG_2995|M.smegmatis_MC2_155 LGVELNGTPIEGPHIYEFCVRSLSNPPTPDDQAFPRRP------------
TH_0537|M.thermoresistible__bu LGAELGGAPIDAELIYTFCLHGLAR--TTDS-------------------
MMAR_3987|M.marinum_M LGTELNATPIDAGELYEFCSRALGVRDAEESA-ASSLTELFAQIGMRQEP
MUL_3848|M.ulcerans_Agy99 LGTELNAMPIDAGELYEFCSRALGVRDTEESA-ASSLTELFAQIGMRQEP
MAV_1626|M.avium_104 LGAELNGTPVDAGQLYDFCSRALGIRDTDEDAGAPSLAELFGQIGMRPG-
MAB_4946|M.abscessus_ATCC_1997 HEPNQDILAARVRATADLVCRGIAP-------------------------
: .:
Mb3587c|M.bovis_AF2122/97 --------------------------------------------------
Rv3557c|M.tuberculosis_H37Rv --------------------------------------------------
Mvan_2603|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3791|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2995|M.smegmatis_MC2_155 --------------------------------------------------
TH_0537|M.thermoresistible__bu --------------------------------------------------
MMAR_3987|M.marinum_M SHDDGFAMTMPVSPQVVNTSGALQGGLIATLADVAGGQLGLQYLPPGAAM
MUL_3848|M.ulcerans_Agy99 SHDDGFAMTMPVSPQVVNTSGALQGGLIATLADVAGGQLGLQYLPPGAAM
MAV_1626|M.avium_104 TRNGQFAMTMPVSPAVVNTSGALQGGLIATLVDVAGGQFGLDYLRPGTTM
MAB_4946|M.abscessus_ATCC_1997 --------------------------------------------------
Mb3587c|M.bovis_AF2122/97 --------------------------------------------------
Rv3557c|M.tuberculosis_H37Rv --------------------------------------------------
Mvan_2603|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3791|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2995|M.smegmatis_MC2_155 --------------------------------------------------
TH_0537|M.thermoresistible__bu --------------------------------------------------
MMAR_3987|M.marinum_M TTADLFIRYLRPIRQGAARAVPRMLRAGRRALVMQVDIFGDSADELAATA
MUL_3848|M.ulcerans_Agy99 TTADLFIRYLRPIRQGAARAVPRMLRAGRRALVMQVDIFGDSADELAATA
MAV_1626|M.avium_104 TTADLFVRYLRPVRQGSAFAVPRMLRSGRRAMVMQVDIFGDGDDELLATA
MAB_4946|M.abscessus_ATCC_1997 --------------------------------------------------
Mb3587c|M.bovis_AF2122/97 ---------------------
Rv3557c|M.tuberculosis_H37Rv ---------------------
Mvan_2603|M.vanbaalenii_PYR-1 ---------------------
Mflv_3791|M.gilvum_PYR-GCK ---------------------
MSMEG_2995|M.smegmatis_MC2_155 ---------------------
TH_0537|M.thermoresistible__bu ---------------------
MMAR_3987|M.marinum_M TVNFAIIDRNDTTETG-----
MUL_3848|M.ulcerans_Agy99 TVNFAIIDRNDTTETG-----
MAV_1626|M.avium_104 TVNFAIIN-GDTPSSGLPPAE
MAB_4946|M.abscessus_ATCC_1997 ---------------------