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AEPNEDVEITRGDRFIKTAVAILGETGRTDFTVQEVVARSKTSLRAFYQHFSSKDELLLALFDRTIAQSA QTWRAETAGLDSTAALKLVIDRVSQQPESSTQDSLNRALTLYNQHLAETRPREYARVLSPLHRLIRDIVG QGITEGVFNPGLDVGAAAAIVMQTMMGAQRLHWLGAELNGTPVDAGQLYDFCSRALGIRDTDEDAGAPSL AELFGQIGMRPGTRNGQFAMTMPVSPAVVNTSGALQGGLIATLVDVAGGQFGLDYLRPGTTMTTADLFVR YLRPVRQGSAFAVPRMLRSGRRAMVMQVDIFGDGDDELLATATVNFAIINGDTPSSGLPPAE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1626 | - | - | 100% (343) | hypothetical protein MAV_1626 |
| M. avium 104 | MAV_2439 | - | 8e-09 | 29.47% (190) | transcriptional regulator, TetR family protein, putative |
| M. avium 104 | MAV_0603 | - | 1e-06 | 24.06% (187) | transcriptional regulator, TetR family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0140c | - | 2e-05 | 30.56% (108) | transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_3791 | - | 8e-60 | 58.33% (192) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0135c | - | 2e-05 | 30.56% (108) | transcriptional regulatory protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2494c | - | 2e-06 | 28.83% (163) | putative transcriptional regulator |
| M. marinum M | MMAR_3987 | - | 1e-152 | 81.82% (341) | putative transcriptional regulatory protein |
| M. smegmatis MC2 155 | MSMEG_2995 | - | 9e-63 | 58.08% (198) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_0537 | - | 3e-58 | 55.87% (213) | transcriptional regulator, TetR family protein |
| M. ulcerans Agy99 | MUL_3848 | - | 1e-152 | 81.82% (341) | putative transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_2603 | - | 2e-59 | 59.36% (187) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3987|M.marinum_M MAGPSE----------QVEA---TRADRFIKTAVEILGET-GRTDFTVQE
MUL_3848|M.ulcerans_Agy99 MAGPSE----------QVEA---TRADRFIKTAVEILGET-GRTDFTVQE
MAV_1626|M.avium_104 MAEPNE----------DVEI---TRGDRFIKTAVAILGET-GRTDFTVQE
Mflv_3791|M.gilvum_PYR-GCK MSAKAQPDPTVRQDPAVRQDRAQSRAGRFMRSALDILGET-GRTDFTVLE
Mvan_2603|M.vanbaalenii_PYR-1 MSAKAQPSPTAQRDGAQQE----SRASRFMRSALDILGET-GRTDFTVLE
MSMEG_2995|M.smegmatis_MC2_155 MARPTQRSPDGAR--ADPE----DRTARFMRSALAILGET-GRTDFTVLE
TH_0537|M.thermoresistible__bu MANPTS---------ADTE----SRADRFLRSALTILGET-GRTDFTVLE
Mb0140c|M.bovis_AF2122/97 MTAVAAG---------ALVVETDSFRLRLLDGLVASIGER-GYRATTVSD
Rv0135c|M.tuberculosis_H37Rv MTAVAAG---------ALVVETDSFRLRLLDGLVASIGER-GYRATTVSD
MAB_2494c|M.abscessus_ATCC_199 MSSPAGRSYSG----LPADERLARRRQRLLEVGLDILGTPDGSGDLTLRT
*: *:: : :* * *:
MMAR_3987|M.marinum_M VVTRSKTSLRAFYQHFSSKDELLLALFDRTMSQTAQLWRAEAAG-LDSTA
MUL_3848|M.ulcerans_Agy99 VVTRSKTSLRAFYQHFSSKDELLLALFDRTMSQTAQLWRAEAAG-LDSTA
MAV_1626|M.avium_104 VVARSKTSLRAFYQHFSSKDELLLALFDRTIAQSAQTWRAETAG-LDSTA
Mflv_3791|M.gilvum_PYR-GCK VVERSKTSLRAFYQHFSTKDELLLALVEKIMAEATERWRAETEQ-LAGPD
Mvan_2603|M.vanbaalenii_PYR-1 VVERSKTSLRAFYQHFATKDELLLALVERVMVDATERWRAETDR-MTSDD
MSMEG_2995|M.smegmatis_MC2_155 VVERSKTSLRSFYQHFSSKDELLLALIDRIMAESAQRWRADTEA-LPGPE
TH_0537|M.thermoresistible__bu VVERSKTSLRSFYQHFSTKDELLLALIDTIMAESAARWRAELEG-LPAAQ
Mb0140c|M.bovis_AF2122/97 IVRHARTSKRTFYDRFTSKEQCFLELLLADNETLGNSIRAAVDPNADWHD
Rv0135c|M.tuberculosis_H37Rv IVRHARTSKRTFYDRFTSKEQCFLELLLADNETLGNSIRAAVDPNADWHD
MAB_2494c|M.abscessus_ATCC_199 VCQRSGLAQRYFYESFADKDEYAAAIFDWAIEGLAATVEAEVAAAHPRLQ
: :: : * **: *: *:: :. .*
MMAR_3987|M.marinum_M ALKLVIDRISAQPESSTQDSLNRALSLYNQHLAETRPREYARVLSPLHRL
MUL_3848|M.ulcerans_Agy99 ALKLVIDRISAQPESSTQDSLNRALSLYNQHLAETRPREYARVLSPLHRL
MAV_1626|M.avium_104 ALKLVIDRVSQQPESSTQDSLNRALTLYNQHLAETRPREYARVLSPLHRL
Mflv_3791|M.gilvum_PYR-GCK ALRVLIDRISAPAQSSTQDSINRGLTYYNDHLLETRPKEFATVLAPLHRL
Mvan_2603|M.vanbaalenii_PYR-1 ALRLLIERISAPAESSTQDSINRGLTYYNDHLLETRPKEFAKVLAPLHRL
MSMEG_2995|M.smegmatis_MC2_155 ALRVLVEKITAPASSSTQDSINRGLTYYNDHLAESLPREYARVLAPLHDL
TH_0537|M.thermoresistible__bu ALRTLIERICTPAGSSRQDYINRGLTSYNDRLADTLPREYARVLAPLHQL
Mb0140c|M.bovis_AF2122/97 QIRQAVEAYVTHIESRPAVTLS-----WIREFPSLGAAAYPVQRRGMEQL
Rv0135c|M.tuberculosis_H37Rv QIRQAVEAYVTHIESRPAVTLS-----WIREFPSLGAAAYPVQRRGMEQL
MAB_2494c|M.abscessus_ATCC_199 VRAGITSVVRAVSADRRIGQLLYSRHQVNPVLVRRRFDATAMFVSLFAQH
. . : : . :
MMAR_3987|M.marinum_M IRDIVGQGITEGMFN----------PGLDVGAAAAIVMQTVLGALRLRWL
MUL_3848|M.ulcerans_Agy99 IRDIVGQGITEGMFN----------PGLDVGAAAAIVMQTVLGALRLRWL
MAV_1626|M.avium_104 IRDIVGQGITEGVFN----------PGLDVGAAAAIVMQTMMGAQRLHWL
Mflv_3791|M.gilvum_PYR-GCK LGDILRRGIAEGSFR----------ADLDVDTDAAILMQTVLGTLRLREL
Mvan_2603|M.vanbaalenii_PYR-1 VADILRRGIDEGTFR----------ADLDVDTDAAILMHTVLGVLRLRDL
MSMEG_2995|M.smegmatis_MC2_155 IRGIVRRGIDAGDFH----------SGVEVDTTSALILQSVLGAMRLRSL
TH_0537|M.thermoresistible__bu IVDILRRGVAEGAFRGPGETAPDGGVDADLDAVAALIMQTALGAMRLRAL
Mb0140c|M.bovis_AF2122/97 TSLLIELSASPGFRR------------ANLPPLNVPLAVILLGGLRELTA
Rv0135c|M.tuberculosis_H37Rv TSLLIELSASPGFRR------------ANLPPLNVPLAVILLGGLRELTA
MAB_2494c|M.abscessus_ATCC_199 LHDWFRR---------------------DDQGNLPVLAHFIVGGVGQAVT
. : : :*
MMAR_3987|M.marinum_M GTELNATPIDAGELYEFCSRALGVRDAEESA-ASSLTELFAQIGMRQEPS
MUL_3848|M.ulcerans_Agy99 GTELNAMPIDAGELYEFCSRALGVRDTEESA-ASSLTELFAQIGMRQEPS
MAV_1626|M.avium_104 GAELNGTPVDAGQLYDFCSRALGIRDTDEDAGAPSLAELFGQIGMRPG-T
Mflv_3791|M.gilvum_PYR-GCK GADLNGIPIEGSHVHTFCLRGLTPP-------------------------
Mvan_2603|M.vanbaalenii_PYR-1 GAELNGVPIVGDHVHTFCVRGLTG--------------------------
MSMEG_2995|M.smegmatis_MC2_155 GVELNGTPIEGPHIYEFCVRSLSNPPTPDDQAFPRRP-------------
TH_0537|M.thermoresistible__bu GAELGGAPIDAELIYTFCLHGLARTTDS----------------------
Mb0140c|M.bovis_AF2122/97 LTVEDGQPIRN-IVEPAVDASIALLGPRS---------------------
Rv0135c|M.tuberculosis_H37Rv LTVEDGQPIRN-IVEPAVDASIALLGPRS---------------------
MAB_2494c|M.abscessus_ATCC_199 AWLHQEVTISEDELIEQLVDMLLAHGPAGSGQR-----------------
.: : :
MMAR_3987|M.marinum_M HDDGFAMTMPVSPQVVNTSGALQGGLIATLADVAGGQLGLQYLPPGAAMT
MUL_3848|M.ulcerans_Agy99 HDDGFAMTMPVSPQVVNTSGALQGGLIATLADVAGGQLGLQYLPPGAAMT
MAV_1626|M.avium_104 RNGQFAMTMPVSPAVVNTSGALQGGLIATLVDVAGGQFGLDYLRPGTTMT
Mflv_3791|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2603|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2995|M.smegmatis_MC2_155 --------------------------------------------------
TH_0537|M.thermoresistible__bu --------------------------------------------------
Mb0140c|M.bovis_AF2122/97 --------------------------------------------------
Rv0135c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_2494c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_3987|M.marinum_M TADLFIRYLRPIRQGAARAVPRMLRAGRRALVMQVDIFGDSADELAATAT
MUL_3848|M.ulcerans_Agy99 TADLFIRYLRPIRQGAARAVPRMLRAGRRALVMQVDIFGDSADELAATAT
MAV_1626|M.avium_104 TADLFVRYLRPVRQGSAFAVPRMLRSGRRAMVMQVDIFGDGDDELLATAT
Mflv_3791|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2603|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2995|M.smegmatis_MC2_155 --------------------------------------------------
TH_0537|M.thermoresistible__bu --------------------------------------------------
Mb0140c|M.bovis_AF2122/97 --------------------------------------------------
Rv0135c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_2494c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_3987|M.marinum_M VNFAIIDRNDTTETG-----
MUL_3848|M.ulcerans_Agy99 VNFAIIDRNDTTETG-----
MAV_1626|M.avium_104 VNFAIIN-GDTPSSGLPPAE
Mflv_3791|M.gilvum_PYR-GCK --------------------
Mvan_2603|M.vanbaalenii_PYR-1 --------------------
MSMEG_2995|M.smegmatis_MC2_155 --------------------
TH_0537|M.thermoresistible__bu --------------------
Mb0140c|M.bovis_AF2122/97 --------------------
Rv0135c|M.tuberculosis_H37Rv --------------------
MAB_2494c|M.abscessus_ATCC_199 --------------------