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ARRSPVQSVHVFPSRAASEPPVTTPSEEPAWKQRAVERSIKTAKLRAAQRVQRFLDAAQAIIIEKGSTDF TVQEVVDRSRQSLRSFYLQFDGKHELLLALFEDALSRSAEQIRAATSGQESPIDRLKVAIQLLFESSRPD PSAKRPLFTDFAPRLLVSHPSEVKVAHAPLLALLTELMEEASEAGQLREGINPKRMAAMTMQTVMFVAQS SGEYDENAAHPITADEVWDFCAHGFAAG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2432 | - | - | 100% (239) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_3791 | - | 4e-21 | 35.14% (222) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_1674 | - | 2e-07 | 32.97% (91) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1561 | - | 1e-05 | 26.54% (211) | transcriptional regulator |
| M. tuberculosis H37Rv | Rv1534 | - | 1e-05 | 26.54% (211) | transcriptional regulator |
| M. leprae Br4923 | MLBr_01070 | - | 2e-05 | 28.71% (101) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_4479 | - | 9e-08 | 33.98% (103) | TetR family transcriptional regulator |
| M. marinum M | MMAR_4752 | - | 1e-103 | 85.19% (216) | transcriptional regulatory protein |
| M. avium 104 | MAV_1626 | - | 8e-23 | 36.56% (186) | hypothetical protein MAV_1626 |
| M. smegmatis MC2 155 | MSMEG_4847 | - | 1e-105 | 89.81% (216) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_2023 | - | 1e-107 | 89.81% (216) | transcriptional regulator, TetR family protein |
| M. ulcerans Agy99 | MUL_0323 | - | 1e-102 | 84.72% (216) | transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_4220 | - | 1e-123 | 93.28% (238) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2432|M.gilvum_PYR-GCK MARRSPVQSVHVFPSRAASEPPVTTPSEEPAWKQRAVERSIKTAKLRAAQ
Mvan_4220|M.vanbaalenii_PYR-1 MARRSPVQSVRVLPNRPASEPPVTSPSEEPAWKQRAVERSIKTAKLRAAQ
MSMEG_4847|M.smegmatis_MC2_155 ----------------------MTSAGEEPAWKQRAVERSIKTAKLRAAQ
TH_2023|M.thermoresistible__bu ----------------------VTTPSEEPAWKQRAVERSIKTAKLRAAQ
MMAR_4752|M.marinum_M ----------------------MTNPSEEPAWKQRAVERSIKTAKLRAAQ
MUL_0323|M.ulcerans_Agy99 ----------------------MTNPSEEPAWKQRAVERSIKTAKLRAAQ
Mb1561|M.bovis_AF2122/97 -------------------------MSRASARRRRAVSDEDK------SQ
Rv1534|M.tuberculosis_H37Rv -------------------------MSRASARRRRAVSDEDK------SQ
MAV_1626|M.avium_104 ----------------------MAEPNEDVEIT-----------------
MAB_4479|M.abscessus_ATCC_1997 ------------------------MAASPGLWGGRTAAQRR-------AE
MLBr_01070|M.leprae_Br4923 ----------------------MIVVGNFTQSNYVPASRGRRSSQLSGDD
Mflv_2432|M.gilvum_PYR-GCK RVQRFLDAAQAIIIEKGSTDFTVQEVVDRSRQSLRSFYLQFDGKHELLLA
Mvan_4220|M.vanbaalenii_PYR-1 RVQRFLDAAQAIIIEKGSTDFTVQEVVDRSRQSLRSFYLQFDGKHELLLA
MSMEG_4847|M.smegmatis_MC2_155 RVQRFLDAAQAIIIEKGSTDFTVQEVVDRSRQSLRSFYLQFDGKHELLLA
TH_2023|M.thermoresistible__bu RVQRFLDAAQAIIIEKGSTDFTVQEVVDRSRQSLRSFYLQFDGKHELLLA
MMAR_4752|M.marinum_M RVQRFLDAAQAIIIEKGSTDFTVQEVVDRSRQSLRSFYLQFDGKHELLLA
MUL_0323|M.ulcerans_Agy99 RVQRFLDAAQAIIIEKGSTDFTVQEVVDRSRQSLRSFYLQFDGKHELLLA
Mb1561|M.bovis_AF2122/97 RRDEILAAAKIVFAHKGFHATTVADIAKQAGLAYGLIYWYFDSKDDLFHA
Rv1534|M.tuberculosis_H37Rv RRDEILAAAKIVFAHKGFHATTVADIAKQAGLAYGLIYWYFDSKDDLFHA
MAV_1626|M.avium_104 RGDRFIKTAVAILGETGRTDFTVQEVVARSKTSLRAFYQHFSSKDELLLA
MAB_4479|M.abscessus_ATCC_1997 RRERLVGAAQEIWIEQGWAAVTMRGVCARTSLNDRYFYEDFADREDLLAA
MLBr_01070|M.leprae_Br4923 REQAILAVAERLLAERPLGDFSVDELAKGAGISRPTFYFYFPSKNAVLLS
* : :: .* : . :: : : :* * .:. :: :
Mflv_2432|M.gilvum_PYR-GCK LFED-----ALSRSAEQIRAATSGQESPIDRLKVAIQLLFESSRPDPSAK
Mvan_4220|M.vanbaalenii_PYR-1 LFED-----ALSRSADQIRAATGGHEEPIERLKVAIQLLFESSRPDPAAK
MSMEG_4847|M.smegmatis_MC2_155 LFED-----ALSRSADQIRAATASHSDPLERLKVAIQLLFESSRPDPAAK
TH_2023|M.thermoresistible__bu LFED-----ALSRSADQIRAATAGKTDPLERLKTAIELLFESSRPDPNAK
MMAR_4752|M.marinum_M LFED-----ALSRSADQIRAATETHADPLERLKVAVELLYEASRPDPTAK
MUL_0323|M.ulcerans_Agy99 LFED-----ALSRSADQIRAATETHADPLERLKVAVELLYEASRPDPTAK
Mb1561|M.bovis_AF2122/97 LMAGEEEALRAHVAAELARVGGSTEAPLRALLQAAVQATFEFFETDKATV
Rv1534|M.tuberculosis_H37Rv LMAGEEEALRAHVAAELARVGGSTEAPLRALLQAAVQATFEFFETDKATV
MAV_1626|M.avium_104 LFDR-----TIAQSAQTWRAETAGLDSTAALKLVIDRVSQQPESSTQDSL
MAB_4479|M.abscessus_ATCC_1997 VWDG---VRDELIAQISAIVAEDPDRPPLDTLRKTITLVVERVSGDPGWA
MLBr_01070|M.leprae_Br4923 LLDD----LNMKSRSAVEALAEQLPADPAAVWRSAITAFFEVCGTHR--A
: :
Mflv_2432|M.gilvum_PYR-GCK RPLFTDFAPRLLVSHPSEVKVAHAPLLALLTELMEEASEAGQLREGINPK
Mvan_4220|M.vanbaalenii_PYR-1 RPLFTDFAPRLLVSHPSEVKVAHAPLLALLTELMEEASAAGQLRDGINPK
MSMEG_4847|M.smegmatis_MC2_155 RPLFTDFAPRLLVSHPSEVKVAHAPLLALLTELMEEAGEAGLLREGINPK
TH_2023|M.thermoresistible__bu RPLFTDFAPRLLVSHPEEVKVAHAPLLALLTELMEEAAAAGKLREGINPK
MMAR_4752|M.marinum_M RPLFTDFAPRLLVSHPAEVKVAHAPLVALLTELMEAAAEAGELREDLNPR
MUL_0323|M.ulcerans_Agy99 RPLFTDFAPRLLVSHPTEVKVAHAPLVTLLTELMEAAAEAGELREDLNPR
Mb1561|M.bovis_AF2122/97 KLLFRD-AYALGGRFEEHLGGIYERFIDDIEAVVVAAQRRGEVVE--APS
Rv1534|M.tuberculosis_H37Rv KLLFRD-AYALGGRFEEHLGGIYERFIDDIEAVVVAAQRRGEVVE--APS
MAV_1626|M.avium_104 NRALTLYNQHLAETRPREYARVLSPLHRLIRDIVGQGITEGVFNPGLDVG
MAB_4479|M.abscessus_ATCC_1997 DIIFVRHVGSAVLEQ-RRIDLLHQATAVLIAAAEPYLVKNIDRTGFRMDT
MLBr_01070|M.leprae_Br4923 VAVAGAAAKATSPEVRRLWSTVMQQWIDYNTAAIQAERKCGVAPDTIPAE
Mflv_2432|M.gilvum_PYR-GCK RMAAMTMQTVM-FVAQSSGEYDENAAHPITADEVWDFCAHGFAAG-----
Mvan_4220|M.vanbaalenii_PYR-1 RMAAMTMQTVM-FVAQSSGDVDENAANPITADEVWDFCAHGFAAV-----
MSMEG_4847|M.smegmatis_MC2_155 RMAAMTMQTVM-FVAQSSGGADESTPNPITADEVWDFVAHGFSADPPA--
TH_2023|M.thermoresistible__bu RMAAMTMQTVM-FVAQSSGGTGDGTVHPITADEVWDFVAHGFAADD----
MMAR_4752|M.marinum_M RIAAMTMQTVM-FIAQSSGGTDDATTHPITADEVWDFCSRGFAAS-----
MUL_0323|M.ulcerans_Agy99 RIAAMTMQTVM-FIAQSSGGTDDATTHPITADEVWDFCSRGFAAS-----
Mb1561|M.bovis_AF2122/97 RMAAYTLAALVGQLAHRRLNTDDNVTAAQVADFVVSLVLDGLRPRALAVG
Rv1534|M.tuberculosis_H37Rv RMAAYTLAALVGQLAHRRLNTDDNVTAAQVADFVVSLVLDGLRPRALAVG
MAV_1626|M.avium_104 AAAAIVMQTMMGAQRLHWLGAELNG-TPVDAGQLYDFCSRALGIRDTDED
MAB_4479|M.abscessus_ATCC_1997 LVGIGGFSELVNAWRSGLLDVSADELIEHSTRIGATLASRYLAAG-----
MLBr_01070|M.leprae_Br4923 DLAVALQLMTERVMAATFSDEKPLIPDKKVIDTLVHIWLASIYGS-----
. : :
Mflv_2432|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4220|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4847|M.smegmatis_MC2_155 --------------------------------------------------
TH_2023|M.thermoresistible__bu --------------------------------------------------
MMAR_4752|M.marinum_M --------------------------------------------------
MUL_0323|M.ulcerans_Agy99 --------------------------------------------------
Mb1561|M.bovis_AF2122/97 ARGGRAART-----------------------------------------
Rv1534|M.tuberculosis_H37Rv ARGGRAART-----------------------------------------
MAV_1626|M.avium_104 AGAPSLAELFGQIGMRPGTRNGQFAMTMPVSPAVVNTSGALQGGLIATLV
MAB_4479|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01070|M.leprae_Br4923 --------------------------------------------------
Mflv_2432|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4220|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4847|M.smegmatis_MC2_155 --------------------------------------------------
TH_2023|M.thermoresistible__bu --------------------------------------------------
MMAR_4752|M.marinum_M --------------------------------------------------
MUL_0323|M.ulcerans_Agy99 --------------------------------------------------
Mb1561|M.bovis_AF2122/97 --------------------------------------------------
Rv1534|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1626|M.avium_104 DVAGGQFGLDYLRPGTTMTTADLFVRYLRPVRQGSAFAVPRMLRSGRRAM
MAB_4479|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01070|M.leprae_Br4923 --------------------------------------------------
Mflv_2432|M.gilvum_PYR-GCK --------------------------------------
Mvan_4220|M.vanbaalenii_PYR-1 --------------------------------------
MSMEG_4847|M.smegmatis_MC2_155 --------------------------------------
TH_2023|M.thermoresistible__bu --------------------------------------
MMAR_4752|M.marinum_M --------------------------------------
MUL_0323|M.ulcerans_Agy99 --------------------------------------
Mb1561|M.bovis_AF2122/97 --------------------------------------
Rv1534|M.tuberculosis_H37Rv --------------------------------------
MAV_1626|M.avium_104 VMQVDIFGDGDDELLATATVNFAIINGDTPSSGLPPAE
MAB_4479|M.abscessus_ATCC_1997 --------------------------------------
MLBr_01070|M.leprae_Br4923 --------------------------------------