For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
VKVTAALSASPAAPFTLQELELDEPRSDEVLVKIHATGLCHTDLTFKSQVPIPAVLGHEGAGIVTAVGEA VSGISPGDHVVLSYRSCGGCRSCAAGERAYCSRSMRLNSAGVRADGSPTLSDNGTPVYGSFFGQSSFAQY ALTGADNTVVVDPSIDLAVAAPLGCGFQTGAGAVLNVLSPEPDSRLVVFGAGGVGLAAVMAAKAQGVETI IAVDPVASRRAKATELGATQTVDPAMEDVAAMARGATHALDTTANAGVIATALGLLRQRGVLVLVGLGAQ PGPIDLNDLMLGGKVIRGCIEGDANPQEFIPELLQMHARGHFPIESLITTYPAADIEQAVADARSGAAIK PVLLW
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4388 | - | - | 100% (355) | zinc-containing alcohol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0983c | - | 9e-56 | 39.37% (348) | zinc-containing alcohol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_2084 | - | 1e-46 | 34.70% (366) | zinc-type alcohol dehydrogenase AdhD |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3113 | adhD | 2e-50 | 34.86% (370) | zinc-type alcohol dehydrogenase AdhD |
| M. gilvum PYR-GCK | Mflv_0725 | - | 2e-99 | 51.11% (360) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv3086 | adhD | 2e-50 | 34.86% (370) | zinc-type alcohol dehydrogenase AdhD |
| M. leprae Br4923 | MLBr_01784 | adhE2 | 3e-41 | 30.41% (365) | putative alcohol dehydrogenase (Zn dependent) |
| M. marinum M | MMAR_0127 | adhD_1 | 2e-52 | 35.41% (370) | zinc-containing alcohol dehydrogenase NAD- dependent, |
| M. avium 104 | MAV_2646 | - | 1e-53 | 33.78% (370) | alcohol dehydrogenase B |
| M. smegmatis MC2 155 | MSMEG_2034 | - | 4e-87 | 48.45% (355) | aryl-alcohol dehydrogenase |
| M. thermoresistible (build 8) | TH_2558 | - | 7e-78 | 46.15% (351) | PUTATIVE putative aryl-alcohol dehydrogenase |
| M. ulcerans Agy99 | MUL_4872 | adhD | 2e-49 | 34.56% (379) | zinc-type alcohol dehydrogenase AdhD |
| M. vanbaalenii PYR-1 | Mvan_5270 | - | 5e-50 | 32.88% (371) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_2646|M.avium_104 --MQTQAAVLFERNTPWSIESIELDAPKATEVLIELHASGMCHSDDHLVT
Mvan_5270|M.vanbaalenii_PYR-1 --MKTNAAILWEYGGDWTVEEIDLDPPGDGEVLVSWEATGLCHSDEHIRT
Mb3113|M.bovis_AF2122/97 --MKTTAAVLFEAGKPFELMELDLDGPGPGEVLVKYTAAGLCHSDLHLTD
Rv3086|M.tuberculosis_H37Rv --MKTTAAVLFEAGKPFELMELDLDGPGPGEVLVKYTAAGLCHSDLHLTD
MMAR_0127|M.marinum_M --MKTTAAVLLEAGKPFEIMELELDGPRVGEVLIKYTAAGLCHSDLHLTD
MUL_4872|M.ulcerans_Agy99 --MRSRAAILYGYGHPWTVEEFELDPPRAGEVLLQLSATGLCHSDEHIRR
MLBr_01784|M.leprae_Br4923 MSQTVRGVISRKKDEPVELVDIVIPDPGPGEAVVDVTACGVCHTDLTYRE
MAB_4388|M.abscessus_ATCC_1997 --MKVTAALSASPAAPFTLQELELDEPRSDEVLVKIHATGLCHTDLT--F
Mflv_0725|M.gilvum_PYR-GCK -MPETTAVLSYAPEDPFSVAEVRVDDPRADEILVRIEAAGVCHTDLVNRV
MSMEG_2034|M.smegmatis_MC2_155 -MLNARAAVLLDAGADPRLTDVQVRPPVGDELLVEIEAVGICHTDIS--V
TH_2558|M.thermoresistible__bu --------VLRGETDPYQIEELDLPDPAAHQILVRIAGTGHCHTDVLPRA
: : .. : * : :: . * **:*
MAV_2646|M.avium_104 G------------DMPIRLPCIGGHEGAGVVKAVGEHVSWLSPGDHVVFS
Mvan_5270|M.vanbaalenii_PYR-1 G------------DLPAPLPLIGGHEGAGIVREVGPGVVGLAPGDHVVAS
Mb3113|M.bovis_AF2122/97 G------------DLPPRFPIVGGHEGSGVIEEVGAGVTRVKPGDHVVCS
Rv3086|M.tuberculosis_H37Rv G------------DLPPRFPIVGGHEGSGVIEEVGAGVTRVKPGDHVVCS
MMAR_0127|M.marinum_M G------------DLPPRYPIVGGHEGSGVIEEVGPGVSKVKPGDHVVCS
MUL_4872|M.ulcerans_Agy99 GNLAPPPETLRSFGLPTMSPTIGGHEGSGVVLEVGEGVTRFAPGDHVVTS
MLBr_01784|M.leprae_Br4923 G------------GINDRYPFLLGHEAAGTVEVVGPGVTAVEPGDFVILN
MAB_4388|M.abscessus_ATCC_1997 KSQV-------------PIPAVLGHEGAGIVTAVGEAVSGISPGDHVVLS
Mflv_0725|M.gilvum_PYR-GCK AGKP-------------DRPVLLGHEGAGIVERVGDGLQSVKPGDRVVLS
MSMEG_2034|M.smegmatis_MC2_155 AARFR------------KVPMVFGHEGAGTVIDAGPAAAGR-IGERVVLT
TH_2558|M.thermoresistible__bu GAGFG------------TPPIVVGHEGSGVVEAVGAAVDTVAVGDHVVLS
* : ***.:* : .* *: *: .
MAV_2646|M.avium_104 FIPSCGRCPSCSTGHQSLCDLGAKIYSGMQIHDGTARHH-LGGDDLA-LA
Mvan_5270|M.vanbaalenii_PYR-1 FLPACGRCRFCSTGHQNLCDLGAMIMAGTQL-DGTYRRH-VRGQDVG-VM
Mb3113|M.bovis_AF2122/97 FIPNCGTCRYCCTGRQNLCDMGATILEGCMP-DGSFRFH-SQGTDFG-AM
Rv3086|M.tuberculosis_H37Rv FIPNCGTCRYCCTGRQNLCDMGATILEGCMP-DGSFRFH-SQGTDFG-AM
MMAR_0127|M.marinum_M FIPNCGTCRYCSTGRQNLCDMGATILEGCMS-DGSFRFH-RKGVDFG-AM
MUL_4872|M.ulcerans_Agy99 FIAVCGQCRWCATGMEYLCDTGYGTLAPGMPTDGTFRHHSLDGRDLG-HV
MLBr_01784|M.leprae_Br4923 WRAVCGQCRACKRGRPSYCFDTFNAQQKMTL---------IDGTELT-PA
MAB_4388|M.abscessus_ATCC_1997 YRS-CGGCRSCAAGERAYCSRSMRLNSAGVRADGSPTLS-DNGTPVYGSF
Mflv_0725|M.gilvum_PYR-GCK FRS-CGACTNCRARRPAYCRKAVRLNQFGQRADGTPRVT-VDGRSVLDGF
MSMEG_2034|M.smegmatis_MC2_155 FAS-CGVCDRCGAGSPAYCDHSTDLNMRGGRLDETAALR-LDGAPVAGEF
TH_2558|M.thermoresistible__bu FDS-CGTCGSCLAAHPAYCDTFLERNLGGPGVDGAAQLTDVDGQPVAGRW
: . ** * * * * .
MAV_2646|M.avium_104 CGIGSFAHHTVVHEASCVKIPDHYRLDLACLLGCGFITGWGSSVYAANVR
Mvan_5270|M.vanbaalenii_PYR-1 ALVGTFSQYGTVPEASIVKIDDDIPLSRACLLGCGVTTGWGSAVNTADVS
Mb3113|M.bovis_AF2122/97 CMLGTFAERATVSQHSVVKVDDWLPLETAVLVGCGVPSGWGTAVNAGNLR
Rv3086|M.tuberculosis_H37Rv CMLGTFAERATVSQHSVVKVDDWLPLETAVLVGCGVPSGWGTAVNAGNLR
MMAR_0127|M.marinum_M CMLGTFSERATISQHSVVKIDDWLPLTTAVLVGCGVPTGWGTSVYAGGVR
MUL_4872|M.ulcerans_Agy99 SKIGPFAEHTVVSADSLVKIDQTFPLVPAALLACAIPTRYGSAARRAQVR
MLBr_01784|M.leprae_Br4923 LGIGAFADKTLVHSGQCTKVDPAADPAVAGLLGCGVMAGLGAAINTAAVS
MAB_4388|M.abscessus_ATCC_1997 FGQSSFAQYALTGADNTVVVDPSIDLAVAAPLGCGFQTGAGAVLNVLSPE
Mflv_0725|M.gilvum_PYR-GCK FGQSSLAGYALTTQDNTVVVGPDVDPVLAAPLGCGFQTGAGAVLNLMQPA
MSMEG_2034|M.smegmatis_MC2_155 FGQSSFATHAISKSRNAVTIPGDLDPALAAPLGCSVQTGVGAVLNVLTPG
TH_2558|M.thermoresistible__bu FGQSSFASHAVVDAANAVVVDKDLPLELLGPLGCGVQTGAGAVLEVLRIG
..:: . . : :.*.. : *:
MAV_2646|M.avium_104 PGDTVAIAGVGGIGAAAVQGARLAGARTITVIDPSEYKRAEAVKMGATHT
Mvan_5270|M.vanbaalenii_PYR-1 PGDTVVIIGLGGIGSGAIQGARLAGAEKIVVIEPVESKRELAFRFGATHF
Mb3113|M.bovis_AF2122/97 AGDTAVIYGVGGLGINAVQGATAAGCKYVVVVDPVAFKRETALKFGATHA
Rv3086|M.tuberculosis_H37Rv AGDTAVIYGVGGLGINAVQGATAAGCKYVVVVDPVAFKRETALKFGATHA
MMAR_0127|M.marinum_M PGDTTVIYGAGGLGINAVQGAVSAGAKHVVVVDPVAFKRDTALKFGATHA
MUL_4872|M.ulcerans_Agy99 GGDIAVVIGAGGIGTAAIQGARIQGATRIIAVDPVEFERKSALTFGATHT
MLBr_01784|M.leprae_Br4923 RDDTVAVIGCGGVGDAAISGAALVGANRIIAVDIDDTKLEWARTFGATHT
MAB_4388|M.abscessus_ATCC_1997 PDSRLVVFGAGGVGLAAVMAAKAQGVETIIAVDPVASRRAKATELGATQT
Mflv_0725|M.gilvum_PYR-GCK AGSSVAVFGAGAVGLAGVLAALAVDVETVIVVEPSPQRRALAESLGVRAA
MSMEG_2034|M.smegmatis_MC2_155 ADDAVVVFGAGAVGLSAVMGARIAGCRTIVAVDPVAGRRALATELGATIT
TH_2558|M.thermoresistible__bu PGESIVITGTGAVGLSAVMAAKVAGASTIIAVDLNTERLALAEEFGATHT
.. .: * *.:* .: .* . : .:: . * :*.
MAV_2646|M.avium_104 A-ADWNEAKAVVAEATWNRGVDKFICAMGVGDGQLVGQALAMTAKRGRLV
Mvan_5270|M.vanbaalenii_PYR-1 V-TSMEEATALVADLTRGVMADSAILTVGLLEGSMLEEAANIIRKGGAVV
Mb3113|M.bovis_AF2122/97 F-ADAASAAAKVDELTWGQGADAALILVGTVDDEVVSAATAVIGKGGTVV
Rv3086|M.tuberculosis_H37Rv F-ADAASAAAKVDELTWGQGADAALILVGTVDDEVVSAATAVIGKGGTVV
MMAR_0127|M.marinum_M F-PDAASAAAKVNEITWGQGADQALILVGTVDTEVVSAAAAVIGKGGTVV
MUL_4872|M.ulcerans_Agy99 A-ATTDEAVETVRELTRGVMADVVVVSPATIGPADVAAALSLTRKGGTCV
MLBr_01784|M.leprae_Br4923 VNALELEVVKTIQDLTSGFGVDVVIDTVGR--PETWKQAFYARDLAGTVV
MAB_4388|M.abscessus_ATCC_1997 VDP-AMEDVAAM----ARGATHALDTTANA---GVIATALGLLRQRGVLV
Mflv_0725|M.gilvum_PYR-GCK LSP-DDHTVRAIREITGGGVDYALDTTGRP---EVLASAVAALAVGGTAV
MSMEG_2034|M.smegmatis_MC2_155 IDP-TDTDVTRAVLDATGGAACAIDTTARP---DVIATAVMALRSRGTLA
TH_2558|M.thermoresistible__bu IVANTGELTEQIRAIVPGGTHYGLDTTGLP---AVIAAALEAVAVRGTMG
. * *
MAV_2646|M.avium_104 VTNIHPMLEREIRANLMDLTLTEKQIVGTLYGSGNPRADIPKILELYSAG
Mvan_5270|M.vanbaalenii_PYR-1 MTALSTMADNQPTLGMMMFTLFQKRLLGSLYGEANPRADIPRLLSLYREG
Mb3113|M.bovis_AF2122/97 ITGLADPAKLTVHVSGTDLTLHEKTIKGSLFGSCNPQYDIVRLLRLYDAG
Rv3086|M.tuberculosis_H37Rv ITGLADPAKLTVHVSGTDLTLHEKTIKGSLFGSCNPQYDIVRLLRLYDAG
MMAR_0127|M.marinum_M ITGLANPEKLTVQLSGLDLTLNEKTIKGTLFGSANPQYDIVRLLRLYDAG
MUL_4872|M.ulcerans_Agy99 LTGLPDPAMHSIAVGLQDFVLMNKTLCGTVFGSCNPKSDIPLLATMYQSG
MLBr_01784|M.leprae_Br4923 LVGVPTP-DMRLDMPLLDFFSHGGSLKSSWYGDCLPERDFPTLVDLYLQG
MAB_4388|M.abscessus_ATCC_1997 LVGLGAQ---PGPIDLNDLMLGGKVIRGCIEGDANPQEFIPELLQMHARG
Mflv_0725|M.gilvum_PYR-GCK AVGLGTG---VPAIDLADLVLRGKTVHGCLEGDSIPSVFIPELLALHARG
MSMEG_2034|M.smegmatis_MC2_155 LLGLGAL---TAELPVALIMGKGLTVRGVVEGDSEPHSFIPALLEHHRRG
TH_2558|M.thermoresistible__bu LVGVQQG---ELAIGPLALTIG-RTITGILEGDAEPRTFIPRLIELWRAG
: : : . *. * : : *
MAV_2646|M.avium_104 QVDLESMVTRTYPLEKVNDGYADMHAGANIRGVLIYPPAEGSLG
Mvan_5270|M.vanbaalenii_PYR-1 KLLLDETVTHEYKLAEVNEGYEDMRAGRNIRGVILHDH------
Mb3113|M.bovis_AF2122/97 QLMLDELVTTTYNLEQVNQGYQDLRDGKNIRGVIVH--------
Rv3086|M.tuberculosis_H37Rv QLMLDELVTTTYNLEQVNQGYQDLRDGKNIRGVIVH--------
MMAR_0127|M.marinum_M QLKLDELITTQYRLEDVNQGYQDLRDGKNIRGVIVHD-------
MUL_4872|M.ulcerans_Agy99 QLLLDAMITKRYSLHSINDAYADLVAGELIRGVIDFSLS-----
MLBr_01784|M.leprae_Br4923 RLPLGKFVSERIGLGDVEEAFHKIHGGKVLRSVVML--------
MAB_4388|M.abscessus_ATCC_1997 HFPIESLITT-YPAADIEQAVADARSGAAIKPVLLW--------
Mflv_0725|M.gilvum_PYR-GCK RFPIERLVTE-FSHRDVTEALAAQHAGDVVKPVLTWP-------
MSMEG_2034|M.smegmatis_MC2_155 ELPVDKLVTT-CPFEEFDRAWAAAKAGEVVKPVLVTRR------
TH_2558|M.thermoresistible__bu RFPFDRMIET-FPLSEINTAEQRALAGEIIKPVLIPGA------
.. . : .. . * :: *: