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VGSRQEISAACGRFHTVNSRTPSSRRGHSSRSRSKDGNSRETLSREERKEATRRAIVDAALHLLAERGFS ALSLREVTREAGIVPAAFYRHFDSMEALGLVLIDESFRSLREMLRGARAGKLDPNRVIESSVDILIDGVQ QRREHWRFIGRERSTGVTVLRYAIRTEIRLITSELAIDLARFPALNTWSSEDLNILASVFVNSMIAIAEQ LEDVTDTASVDEIRRTAVKQLRMITVGVAGWRSG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4816 | - | - | 100% (244) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_2460 | - | 4e-10 | 25.64% (195) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_1947 | - | 6e-08 | 26.72% (131) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1998c | - | 3e-07 | 25.74% (202) | transcriptional regulatory protein |
| M. tuberculosis H37Rv | Rv1963c | mce3R | 3e-07 | 25.74% (202) | transcriptional repressor (probably TETR-family) MCE3R |
| M. leprae Br4923 | MLBr_01733 | - | 2e-05 | 30.72% (166) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_1424c | - | 6e-37 | 41.18% (204) | TetR family transcriptional regulator |
| M. marinum M | MMAR_0334 | - | 4e-89 | 74.01% (227) | TetR family transcriptional regulator |
| M. avium 104 | MAV_5169 | - | 2e-82 | 74.15% (205) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_1741 | - | 2e-90 | 74.89% (227) | TetR-family protein transcriptional regulator |
| M. thermoresistible (build 8) | TH_0641 | - | 4e-08 | 48.65% (74) | transcriptional regulator, TetR family protein |
| M. ulcerans Agy99 | MUL_4787 | - | 3e-89 | 74.01% (227) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_1626 | - | 1e-104 | 88.99% (227) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4816|M.gilvum_PYR-GCK ----------------MGSRQEISAACGRFHTVNSRTPSSRRGHSSRSRS
Mvan_1626|M.vanbaalenii_PYR-1 --------------------------------MNSRTPSSRSGRS-RSRE
MSMEG_1741|M.smegmatis_MC2_155 --------------------------------MNRRTPSTRTRRSETSRS
MMAR_0334|M.marinum_M --------------------------------MNERTPSSRPHRSGRSRD
MUL_4787|M.ulcerans_Agy99 --------------------------------MNERTPSSRPHRSSRSRD
MAV_5169|M.avium_104 ---------------------------------------MRGSGRERSRE
MAB_1424c|M.abscessus_ATCC_199 ---------------------------------------MR---------
Mb1998c|M.bovis_AF2122/97 ---------------------------------------------MASVA
Rv1963c|M.tuberculosis_H37Rv ---------------------------------------------MASVA
MLBr_01733|M.leprae_Br4923 MTRRSIHTRKPLKWSGCAGQHVRSGKVFDVGRISLSYPSMKPGVKIDARS
TH_0641|M.thermoresistible__bu ---------------------------------------------MAAET
Mflv_4816|M.gilvum_PYR-GCK KDGNSRETLSREERKEATRRAIVDAALHLLAERGFSALSLREVTREAGIV
Mvan_1626|M.vanbaalenii_PYR-1 KD-----TLSREERKEATRRAIVAAALSLLAERSFSGLSLREVTREAGIV
MSMEG_1741|M.smegmatis_MC2_155 RD-----TLTREERKEATRRALIAAALKLLKDHSFSALSLREVTREAGIV
MMAR_0334|M.marinum_M SP-------SREERKEATRRAIIAAALKLVHDRSFSALSLREVTREAGIV
MUL_4787|M.ulcerans_Agy99 SP-------SREERKEATRRAIIAAALKLVHDRSFSALSLREVTREAGIV
MAV_5169|M.avium_104 SQ-------SREERKEATRRAIIAAALKLLQDRSFSSLSLREVTREVGIV
MAB_1424c|M.abscessus_ATCC_199 --------HSRAEKKLHTRRTLLDGTLELLKVRGFAAVSLREVAKSAGLV
Mb1998c|M.bovis_AF2122/97 QP--------VRRRPKDRKKQILDQAVGLFIERGFHSVKLEDIAEAAGVT
Rv1963c|M.tuberculosis_H37Rv QP--------VRRRPKDRKKQILDQAVGLFIERGFHSVKLEDIAEAAGVT
MLBr_01733|M.leprae_Br4923 ER--------WREHRKKVRGEIVDAAFRALDRLG-PEVSVREIAEEAGTA
TH_0641|M.thermoresistible__bu ----------LSSKGRQTRLALEQAARKLFAERGFHGTTLADITSAAGKS
: : : : . . .: ::: .*
Mflv_4816|M.gilvum_PYR-GCK PAAFYRHFDSMEALGLVLIDESFRSLREMLRGAR----AGKLDPN-RVIE
Mvan_1626|M.vanbaalenii_PYR-1 PAAFYRHFESMEALGLVLIDESFRALREMLRGAR----AGKLDPN-RVIE
MSMEG_1741|M.smegmatis_MC2_155 PAAFYRHFDSMDALGLVLIDESFRSLRDMLRGAR----AGKLDPH-HVIE
MMAR_0334|M.marinum_M PAAFYRHFESMEALGLVLIDESFRTLRDTLRGAR----AGRLDPN-RVIE
MUL_4787|M.ulcerans_Agy99 PAAFYRHFESMEALGLVLIDESFRTLRDTLRGAR----AGRLDPN-RVIE
MAV_5169|M.avium_104 PAAFYRHFESMESLGLVLIDESFRSLRDTLRDAR----AGKLDPN-RVIE
MAB_1424c|M.abscessus_ATCC_199 PTAFYRHFESMEDLGTVLAEESVHALRDTFRQARR-E-AGSDNPA-KILR
Mb1998c|M.bovis_AF2122/97 ARALYRHYDNKQAL----LAEAIRTGQDQYQSARR-LTEGETEPTPRPLN
Rv1963c|M.tuberculosis_H37Rv ARALYRHYDNKQAL----LAEAIRTGQDQYQSARR-LTEGETEPTPRPLN
MLBr_01733|M.leprae_Br4923 KPKIYRHFTDKSDL----FEAIGIRLRDMLWAAIFPAIDLATDSAREIIR
TH_0641|M.thermoresistible__bu PAVFYRYFVDKEDLLAALAESFLREVLAPGWLSVR---LPDSPDDDEFFT
:**:: . . * : . :
Mflv_4816|M.gilvum_PYR-GCK SSVDILIDGVQQRREHWRFIGRERSTGVTVLRYAIRTEIRLITS------
Mvan_1626|M.vanbaalenii_PYR-1 SSVDILIDSVQQRREHWRFIGRERSTGVTVLRYAIRTEIRLITS------
MSMEG_1741|M.smegmatis_MC2_155 SSAEILVSSFNERREHWRFIARERSGGASALRYAIRTEIRLITS------
MMAR_0334|M.marinum_M SSVEILIGSVAERREHWRFIVRERSTGLSVLRYAIRTEIRLITS------
MUL_4787|M.ulcerans_Agy99 SSVEILIGSVAERREHWRFIVRERSTGLSVLRYAIRTDIRLITS------
MAV_5169|M.avium_104 SSVEILVASVADRREHWRLIARERNSGLSVLRYAIRTEIRLITS------
MAB_1424c|M.abscessus_ATCC_199 ----LMVDRVNEHANNFRFLVRERHGGSPQIRRAINNEMRMLTN------
Mb1998c|M.bovis_AF2122/97 ADLEDLIAAAVASRALTVLWQREARYLNEDDRTAVRRRINAIVAGMRDSV
Rv1963c|M.tuberculosis_H37Rv ADLEDLIAAAVASRALTVLWQREARYLNEDDRTAVRRRINAIVAGMRDSV
MLBr_01733|M.leprae_Br4923 RSVDEYVSLVDKHPNVLRVFIQGRFSAQSEATVRTLDEGREITL------
TH_0641|M.thermoresistible__bu TVVGGYWNMFKQN--IGIMIAVDQLAATQQRFADVQNEFRRFGM------
. . :
Mflv_4816|M.gilvum_PYR-GCK -------------------------------------------ELAIDLA
Mvan_1626|M.vanbaalenii_PYR-1 -------------------------------------------ELAIDLA
MSMEG_1741|M.smegmatis_MC2_155 -------------------------------------------ELAIDLA
MMAR_0334|M.marinum_M -------------------------------------------ELATDLA
MUL_4787|M.ulcerans_Agy99 -------------------------------------------ELATDLA
MAV_5169|M.avium_104 -------------------------------------------ELATDLA
MAB_1424c|M.abscessus_ATCC_199 -------------------------------------------DVVVELA
Mb1998c|M.bovis_AF2122/97 LLEVPDLSPQHSELRAWAVSSTLTSLGRHSLSLPGEELKKLLYQACMAAA
Rv1963c|M.tuberculosis_H37Rv LLEVPDLSPQHSELRAWAVSSTLTSLGRHSLSLPGEELKKLLYQACMAAA
MLBr_01733|M.leprae_Br4923 -------------------------------------------TMAEMFN
TH_0641|M.thermoresistible__bu -------------------------------------------DIVAASV
Mflv_4816|M.gilvum_PYR-GCK RFPALNTWS--------SEDLNILASVFVNSMIAIAEQLEDVTDT--ASV
Mvan_1626|M.vanbaalenii_PYR-1 RFPNLNTWS--------SEDLNILASVFVNSMIVIAESLEDATDP--ASI
MSMEG_1741|M.smegmatis_MC2_155 RFPALKDWS--------SEDLNILANLFVNSMISLAEALEDAADA--ESI
MMAR_0334|M.marinum_M RFPGLNEWS--------TEDLNILATLFVNAMIVTAEAIEDAQSS--EAL
MUL_4787|M.ulcerans_Agy99 RFPGLNEWS--------TEDLNILATMFVNAMIVTAEAIEDAQSS--EAL
MAV_5169|M.avium_104 RFPGLHEWT--------TEDLNVLATLFVNAMIVIAEAIEDSQSA--EAR
MAB_1424c|M.abscessus_ATCC_199 RNPATNHHT--------TEDLEIAAELIASSILNTIGMLVDTDHPTKADA
Mb1998c|M.bovis_AF2122/97 RTPPVCELPPLPAGDAARDEADVLFSRYETLLAAGARLFRAQGYPAVNTS
Rv1963c|M.tuberculosis_H37Rv RTPPVCELPPLPAGDAARDEADVLFSRYETLLAAGARLFRAQGYPAVNTS
MLBr_01733|M.leprae_Br4923 NELREMELN--------RAASELAAFAAFGSVASATEWWLGPEPD--SPR
TH_0641|M.thermoresistible__bu RHAQQQGYG-------TDLDPQHIAAAIALMFENFTAVFVGRGGP---GL
. : .
Mflv_4816|M.gilvum_PYR-GCK DEIRRTAVK-------------QLRMITVGVAGWRSG-------------
Mvan_1626|M.vanbaalenii_PYR-1 AEIRRIAIK-------------QLRMITVGVAGWRSS-------------
MSMEG_1741|M.smegmatis_MC2_155 EAIHRTAVK-------------QMRMIAVGVNGWRSTD------------
MMAR_0334|M.marinum_M EEIRRIAVK-------------QLRMVAIGVAGWKSRP------------
MUL_4787|M.ulcerans_Agy99 EEIRRIAVK-------------QLRMVAIGVAGWKSRP------------
MAV_5169|M.avium_104 EDIRRLAVK-------------QLRMIATGIAGWRSTP------------
MAB_1424c|M.abscessus_ATCC_199 DAALNRALR-------------QLDLVTSGLAHTRTMTTIIAEPAARPSE
Mb1998c|M.bovis_AF2122/97 EIGKGAGIAGPGLYRSFSSKQAILDALIRRLDEWRCLECIRALRANQQAA
Rv1963c|M.tuberculosis_H37Rv EIGKGAGIAGPGLYRSFSSKQAILDALIRRLDEWRCLECIRALRANQQAA
MLBr_01733|M.leprae_Br4923 RMPREQFVA-------------HLTIIMMAVIVGTAETLGISMNPDRPIH
TH_0641|M.thermoresistible__bu QISDADAVR-------------TLATIWKKTLYGC---------------
: : :
Mflv_4816|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1626|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1741|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0334|M.marinum_M --------------------------------------------------
MUL_4787|M.ulcerans_Agy99 --------------------------------------------------
MAV_5169|M.avium_104 --------------------------------------------------
MAB_1424c|M.abscessus_ATCC_199 SSATTAAP------------------------------------------
Mb1998c|M.bovis_AF2122/97 QRLRGLVQGHVRISLDAPDLVAVSVTELSHASVEVRDGYLRNQGDREAVW
Rv1963c|M.tuberculosis_H37Rv QRLRGLVQGHVRISLDAPDLVAVSVTELSHASVEVRDGYLRNQGDREAVW
MLBr_01733|M.leprae_Br4923 DAVPLDRSAS----------------------------------------
TH_0641|M.thermoresistible__bu --------------------------------------------------
Mflv_4816|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1626|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1741|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0334|M.marinum_M --------------------------------------------------
MUL_4787|M.ulcerans_Agy99 --------------------------------------------------
MAV_5169|M.avium_104 --------------------------------------------------
MAB_1424c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1998c|M.bovis_AF2122/97 IDLIGKLVPATSVAQGRLLVAAAISFIEDVARTWHLTRYAGVADEISGLA
Rv1963c|M.tuberculosis_H37Rv IDLIGKLVPATSVAQGRLLVAAAISFIEDVARTWHLTRYAGVADEISGLA
MLBr_01733|M.leprae_Br4923 --------------------------------------------------
TH_0641|M.thermoresistible__bu --------------------------------------------------
Mflv_4816|M.gilvum_PYR-GCK --------------
Mvan_1626|M.vanbaalenii_PYR-1 --------------
MSMEG_1741|M.smegmatis_MC2_155 --------------
MMAR_0334|M.marinum_M --------------
MUL_4787|M.ulcerans_Agy99 --------------
MAV_5169|M.avium_104 --------------
MAB_1424c|M.abscessus_ATCC_199 --------------
Mb1998c|M.bovis_AF2122/97 LAILTSGAGNLLRA
Rv1963c|M.tuberculosis_H37Rv LAILTSGAGNLLRA
MLBr_01733|M.leprae_Br4923 --------------
TH_0641|M.thermoresistible__bu --------------