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VTDDPRPTGGLDDFFDSAPCGLLLTSPDGRIIRANETFSRWVGYRSEHLTGRQFPDLLAAGSRIHYETHF VSMLHMNGSLDGVAADLLTADGTRLAGFVTANVERDAAGAVVALRIAIQDASERRSYERELLETRRRADR ERERAQVLAATLQRSLIPPTLSPPRGLTAAAHYHNASRDDVGGDFYDLFPMAEDRWGMFLGDVSGKGAGA AAVTSLTRYTLRAAAVNDRDPVAVLHTLDAVLSHEFHGDDPRFCTVIFGVITAAPDGFDVQLATGGHPPA LLLPVDGPARYVATPGGQAVGLIRNPRFVSTSVHLGPGDTLVMYTDGLTEAKTGRTRRFDDDDALLEFAG RHTPTDAGAFVEAVRVLLASFGDGLEDDAAVIALSVPR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3857 | - | - | 100% (388) | putative PAS/PAC sensor protein |
| M. gilvum PYR-GCK | Mflv_2742 | - | 1e-47 | 39.50% (319) | protein phosphatase 2C domain-containing protein |
| M. gilvum PYR-GCK | Mflv_1031 | - | 8e-27 | 32.30% (291) | putative GAF sensor protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1399c | - | 7e-18 | 30.51% (295) | hypothetical protein Mb1399c |
| M. tuberculosis H37Rv | Rv1364c | - | 1e-17 | 30.51% (295) | hypothetical protein Rv1364c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_5186 | - | 1e-21 | 33.60% (253) | sensor-component of a two-component regulator |
| M. avium 104 | MAV_0430 | - | 6e-21 | 33.67% (196) | stage II sporulation protein E (SpoIIE) |
| M. smegmatis MC2 155 | MSMEG_6131 | - | 8e-11 | 27.50% (280) | magnesium or manganese-dependent protein phosphatase |
| M. thermoresistible (build 8) | TH_3243 | - | 2e-28 | 35.37% (328) | PUTATIVE putative putative GAF sensor protein |
| M. ulcerans Agy99 | MUL_3853 | rsbU | 3e-19 | 27.39% (398) | regulator of sigma subunit, anti-anti-sigma factor RsbU |
| M. vanbaalenii PYR-1 | Mvan_5805 | - | 1e-27 | 35.35% (297) | putative GAF sensor protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1399c|M.bovis_AF2122/97 ---------------------------------MAAEMDWDKTVGAAEDV
Rv1364c|M.tuberculosis_H37Rv ---------------------------------MAAEMDWDKTVGAAEDV
MUL_3853|M.ulcerans_Agy99 ---------MLLLDLLRQRTYSFVRSVHRRDGYMAAEMDWDKNVGTANTV
TH_3243|M.thermoresistible__bu --------------------------------------------------
Mvan_5805|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_5186|M.marinum_M MTETGDFGAVDAFQTQYADALRAYLDTRDENSLAVGHEFGRRALQEQISI
MAV_0430|M.avium_104 MSDD------NDFHDQYARALRAYLASRDEASLAVGHELGRRALQEQISL
Mflv_3857|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 RRIFEHIPAILVGLEGPDHRFVAVNAAYRGFSPLLDTVGQPAREVYPELE
Rv1364c|M.tuberculosis_H37Rv RRIFEHIPAILVGLEGPDHRFVAVNAAYRGFSPLLDTVGQPAREVYPELE
MUL_3853|M.ulcerans_Agy99 RRIFENVPTMLVGLEGPEHRFVAANAAYRRFSPTFTAVGQPAREVYPELE
TH_3243|M.thermoresistible__bu --------------------------------------------------
Mvan_5805|M.vanbaalenii_PYR-1 --MWRGCEEATMGAGPPLDVDSGNDAAWAAVPHPVLVVDRDGIVRTSSGS
MMAR_5186|M.marinum_M LDIIENHFRLLDEISPNPGSDRSVALEFLLQTLAALDVATRGFLDGTKRY
MAV_0430|M.avium_104 LEIIEQHVRLVFEISQDVRIDAPIALEFLLQLLVPLDVATRGFIDGNRRY
Mflv_3857|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 GQ----------------QIYEMLDRVYQTGEPQSGSEWRLQTDYDGSGV
Rv1364c|M.tuberculosis_H37Rv GQ----------------QIYEMLDRVYQTGEPQSGSEWRLQTDYDGSGV
MUL_3853|M.ulcerans_Agy99 SQ----------------QIYHMLDRVYETGEPQSGAEWRLQADFDGSGI
TH_3243|M.thermoresistible__bu -----------------------VSAHTDIGDTAPASMG-----------
Mvan_5805|M.vanbaalenii_PYR-1 AR----------------SLLPGLSPGVALKDLAPSWLSGAHQHLTAASG
MMAR_5186|M.marinum_M EEQRARAEDLAHRDKFRSALVNSLQEGFFVADDEGAVIDMNSAFAEILGY
MAV_0430|M.avium_104 AEQRARAEGLADRDKFRNALVNSLQEGFFVADHEGSVIEVNNAFIEILGF
Mflv_3857|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 EERYFDFVVTPRRRADGSIEGVQLIVDDVTSRVRARQAAEARVEELSERY
Rv1364c|M.tuberculosis_H37Rv EERYFDFVVTPRRRADGSIEGVQLIVDDVTSRVRARQAAEARVEELSERY
MUL_3853|M.ulcerans_Agy99 DERYFDFLVTPRRREDGSIEGVQILFDDVTTRVRARLAAEARVEELSERY
TH_3243|M.thermoresistible__bu --------------------------------------------------
Mvan_5805|M.vanbaalenii_PYR-1 SVHGRDFDAHPTPLPGGEVA--WWLVEDSDRSARDARRALTVERE----R
MMAR_5186|M.marinum_M PPEGLPYRWPHPWLVDRKSA--AQQQERVRHEGSADYETPVRHQDGHLSW
MAV_0430|M.avium_104 PAEGLPYRWPHPWLVDPKTA--SEQIGVVLRTGSAEYETPIRHADGHLAW
Mflv_3857|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 RNVRDSATVMQQALLAASVPVVPGADIAAEYLVAAEDTAAGGDWFDALAL
Rv1364c|M.tuberculosis_H37Rv RNVRDSATVMQQALLAASVPVVPGADIAAEYLVAAEDTAAGGDWFDALAL
MUL_3853|M.ulcerans_Agy99 RHLRDSAIVMQQALLAPSVPVVSGPDIAAQYLVAAQDTAAGGDWFDAVAL
TH_3243|M.thermoresistible__bu ESVIADVAETLGGSLNLRRTALRLISLIQPRLADWAMVVLPDPRAGVLVA
Mvan_5805|M.vanbaalenii_PYR-1 AAFLDEASAVLMASLNIDRCMEATVQMAARHLADAAVLVTP-VAGGRIPV
MMAR_5186|M.marinum_M VAVSINAVRGSGSDRDVYVGTVRDITAERAFAARESAVLRLATSVSVAKS
MAV_0430|M.avium_104 VKVSINAVKDSGSDRDAYVGTIRDVTAERAFAARESAVLRLATAVAVAKS
Mflv_3857|M.gilvum_PYR-GCK -----------------MTDDPRPTGGLDDFFDSAPCGLLLTSPDGRIIR
MSMEG_6131|M.smegmatis_MC2_155 --MRAPFDRVIASPVDLTGPGQRRLSLLLVEDDRADAILVEELIADAPDI
Mb1399c|M.bovis_AF2122/97 GDRLVLVVGDVVGHGVEAAAVMSQLRTALRMQISTGYTVVEALEAVDRFH
Rv1364c|M.tuberculosis_H37Rv GDRLVLVVGDVVGHGVEAAAVMSQLRTALRMQISAGYTVVEALEAVDRFH
MUL_3853|M.ulcerans_Agy99 GDRLVLIVGDVVGHGVEAAAVMSQLRTALRLQIAAGRSIGEALEALDAFH
TH_3243|M.thermoresistible__bu VGDAAPAGVPLRRADLDDLPLGRVLRS---------GSVEQIHDTDLAGL
Mvan_5805|M.vanbaalenii_PYR-1 VCSGTDGTAEHRRVDADPSDVAGLSEA---------LRGFPPVPSRWIDP
MMAR_5186|M.marinum_M VSEVLSITLEECRTAVDVQRVVAVMWPPSDGEPTVQVAGEPAESSWRALD
MAV_0430|M.avium_104 VDELLSITLDECSTAIDVQRVVAVSWPSGDGDPAVQVAGRPAASSWRELD
Mflv_3857|M.gilvum_PYR-GCK ANETFSRWVGYRSEHLTGRQFPDLLAAG------SRIHYETHFVSMLHMN
MSMEG_6131|M.smegmatis_MC2_155 DFVWAKSMSDAERTLADHRPDCVLLDLN----------LPDAAGIDALHH
Mb1399c|M.bovis_AF2122/97 KQVPGSKSATMCVGSLDFTSGEFQYCTAGHPPPLLVTADASARYVEPTGA
Rv1364c|M.tuberculosis_H37Rv KQVPGSKSATMCVGSLDFTSGEFQYCTAGHPPPLLVTADASARYVEPTGA
MUL_3853|M.ulcerans_Agy99 EHVPGSNSATLCVGSLDFTTGEFQYCTAGHPPPLVVTAEAKARYLEPSGA
TH_3243|M.thermoresistible__bu IPVEPFQQSAVALAPAEVVAVG-LTARGSTFGALVVLRRG-DTGFR----
Mvan_5805|M.vanbaalenii_PYR-1 ASVPGWLVPESFPGPVGSVVITPLPGHGVAAGALVLLRRTSQTAFS----
MMAR_5186|M.marinum_M PQLRETFLGARAQLPLTARPIEWPDSPGRAQGLVAVLSGTADVALWLELG
MAV_0430|M.avium_104 PWLRDTFAEARHQLPLTAKTVDHPDNPGKSRGLVAVLSGAGDLALWLELR
Mflv_3857|M.gilvum_PYR-GCK GSLDGVAADLLTADGTRLAGFVTANVERDAAGAVVALRIAIQDASE----
MSMEG_6131|M.smegmatis_MC2_155 LGKLDARIPIIVLTGLNDEHFGVSAVASGAQDYLVKGRVEPEMLRR----
:
Mb1399c|M.bovis_AF2122/97 GPLGSGTGFPVRSEVLNIGDAILFYTDGLIERPGRPLEASTAEFAD-LAA
Rv1364c|M.tuberculosis_H37Rv GPLGSGTGFPVRSEVLNIGDAILFYTDGLIERPGRPLEASTAEFAD-LAA
MUL_3853|M.ulcerans_Agy99 GPLGSDTGFPVRTELIGVGDVVLLYTDGLIERPGRPLGASTAEFAD-LAA
TH_3243|M.thermoresistible__bu ------ADELDVVARVADRAAVAFDSARLYEEQARVASVLQQSLHP-PSL
Mvan_5805|M.vanbaalenii_PYR-1 ------EGEEVFARLFAARAGAALSAARLYAEQSAITRTLLRDLLP-PQL
MMAR_5186|M.marinum_M APRWVTAEDRLLVTVLVGHLSLAIGHVRQFESARETSLTLQRAMLP-PVK
MAV_0430|M.avium_104 TPRWVSGEDRLLVTVLIGHLSLALQHVRQFENARETSLTLQRAMLP-PVQ
Mflv_3857|M.gilvum_PYR-GCK -----------RRSYERELLETRRRADRERERAQVLAATLQRSLIP-PTL
MSMEG_6131|M.smegmatis_MC2_155 ---------AVLYAIERKRAELTSVDLHASQLRAQENARLERGLLPSPLL
:
Mb1399c|M.bovis_AF2122/97 SIASGSGGFVLDAPARPIDRLCSDTLELLLRSTGYNDDVTLL--AMQRRA
Rv1364c|M.tuberculosis_H37Rv SIASGSGGFVLDAPARPIDRLCSDTLELLLRSTGYNDDVTLL--AMQRRA
MUL_3853|M.ulcerans_Agy99 NITSG-GGFVIDAQSRPIDRLCSETLELLLRSTGYNDDITLL--AVQRRA
TH_3243|M.thermoresistible__bu PDIPGVRLAACYRPAAEHLDIGGDFYDVT---GSDHDWLIAIGDVCGKGV
Mvan_5805|M.vanbaalenii_PYR-1 HRLDGIELAGGYRASEDHEAVGGDFYDVHPAATPDDETLVVLGDVCGKGL
MMAR_5186|M.marinum_M PPPG---FAVRYEPAVPPLEIGGDWYDVLP--IGEHRIGIVVGDCVGRGL
MAV_0430|M.avium_104 PPPG---FAVRYEPAVPPLEIGGDWYDVLP--IGDHRIGIVVGDCVGRGL
Mflv_3857|M.gilvum_PYR-GCK SPPRGLTAAAHYHNAS-RDDVGGDFYDLFP--MAEDRWGMFLGDVSGKGA
MSMEG_6131|M.smegmatis_MC2_155 MEGSGVDIVVEARPSRQHALIGGDFYDVVQ--TPDRTVHVMIGDVAGHGP
: : .: :: : :
Mb1399c|M.bovis_AF2122/97 PTPPLHITLDATINAARTVRAQLREWLAEIGADH---SDIADIVHAISEF
Rv1364c|M.tuberculosis_H37Rv PTPPLHITLDATINAARTVRAQLREWLAEIGADH---SDIADIVHAISEF
MUL_3853|M.ulcerans_Agy99 PTPPLNITEDATIHAARAIRSRLRQWLSEIGADS---GDISDIVHAISEF
TH_3243|M.thermoresistible__bu EAAALTGQTRQSLRTAAHFDRSPDVVLGAVNSVL---CDLRVKQFVTVLC
Mvan_5805|M.vanbaalenii_PYR-1 EAAVLTGKIRNTLMALSPLAQDHAGVLRLLNAAL---LCVDDSRFATLVL
MMAR_5186|M.marinum_M PAAAIMGQLRSSARALLLTGAQPALLLEQLDAAA---SLIPDAYCTTVFL
MAV_0430|M.avium_104 PAAAIMGQLRSSARALLINGAEPAVLLDQLDSAA---SLIPNAYCTTVFL
Mflv_3857|M.gilvum_PYR-GCK GAAAVTSLTRYTLRAAAVNDRDPVAVLHTLDAVLSHEFHGDDPRFCTVIF
MSMEG_6131|M.smegmatis_MC2_155 DEAALGVALRIGWRALTFAGLRGNERMRQLDRIL---TTERPGKGIFATL
. : : : :.
Mb1399c|M.bovis_AF2122/97 VENAVEHGYATDVSKGIVVEAALAGDGNVRASVIDRGQWKDHRDGARGRG
Rv1364c|M.tuberculosis_H37Rv VENAVEHGYATDVSKGIVVAAALAGDGNVRASVIDRGQWKDHRDGARGRG
MUL_3853|M.ulcerans_Agy99 VENAVEHGYSTDVSDGLAVAAALGGDGKLRVAVIDHGTWKHHREGERGRG
TH_3243|M.thermoresistible__bu ARIRARP--------GGGVGVDLATAGHPAPLIVR--GDGRVEQAEVYGT
Mvan_5805|M.vanbaalenii_PYR-1 ASVSRR---------DGQVLLRLTSAGHLAPLIVR--NDGRVEEAETAGT
MMAR_5186|M.marinum_M AILDTE-----------SGILDYSNAGHMPAVLAEPKSGP-VLLTDARSV
MAV_0430|M.avium_104 AILDTE-----------TGVLQYSNAGHMPAVLAGPEPGTTTLLTDAASV
Mflv_3857|M.gilvum_PYR-GCK GVITAAP---------DGFDVQLATGGHPPALLLPVDGPARYVATP-GGQ
MSMEG_6131|M.smegmatis_MC2_155 CSVALEP---------DSGRFTVVRAGHPGLLVHG---NGTVDWLEPRPG
*: :
Mb1399c|M.bovis_AF2122/97 RGLAMAEALVSEARIMHGAGGTTATLTHRLSRPARFVTDTMVRRAAFQQT
Rv1364c|M.tuberculosis_H37Rv RGLAMAEALVSEARIMHGAGGTTATLTHRLSRPARFVTDTMVRRAAFQQT
MUL_3853|M.ulcerans_Agy99 RGLAMAEALVSETHVSHDGAGTTATVVHRLSRPAQFVTDPVVSRAPNRPA
TH_3243|M.thermoresistible__bu AAGLVSGMRYGATALELHRGDTMVMFTDGIDEAWG---AGGQYGMARLHA
Mvan_5805|M.vanbaalenii_PYR-1 LVGVMPQIRARTVETSLAPGETCLLYTDGVTEARGGPLGTDMFGEQRLSA
MMAR_5186|M.marinum_M PLAVRRVEPRPEATQVLPPGSTLLLFTDGLVERRY---ESIDEGLGRVAD
MAV_0430|M.avium_104 PLAVRREDPRPQATRLLPPGSTLMLFTDGLVERKH---EPIDDGIGRAAE
Mflv_3857|M.gilvum_PYR-GCK AVGLIRNPRFVSTSVHLGPGDTLVMYTDGLTEAKTG-RTRRFDDDDALLE
MSMEG_6131|M.smegmatis_MC2_155 AALGLGAREWPVNHYELPEGHGLLLLTDGLFEGHAGRGDERLGESGLLAV
. .. : .
Mb1399c|M.bovis_AF2122/97 IDSEFVS-LVESGRIVVRGDVD----------------------------
Rv1364c|M.tuberculosis_H37Rv IDSEFVS-LVESGRIVVRGDVD----------------------------
MUL_3853|M.ulcerans_Agy99 IDSEFASTVTESGHIVVRGDVD----------------------------
TH_3243|M.thermoresistible__bu LLPAYAGAAPEVVCEAVEQDVM----------------------------
Mvan_5805|M.vanbaalenii_PYR-1 ALAECAGLPAEAVVERIMMLTT----------------------------
MMAR_5186|M.marinum_M VVADSVMLPIDAVADAVLSQLAPTGGYDDDVAMVAYRYQHGPLRIETSAT
MAV_0430|M.avium_104 VLAQTMTLPLDTVADEVLRELAPAAGYDDDVAMVIYRHQQSPLRIETAAT
Mflv_3857|M.gilvum_PYR-GCK FAGRHTPTDAGAFVEAVRVLLAS---------------------------
MSMEG_6131|M.smegmatis_MC2_155 ARALAATPGRDFVTSLINEAESR---------------------------
:
Mb1399c|M.bovis_AF2122/97 -----------------STTAATLDRQIAVESRSGIAPVTIDLSAVTHLG
Rv1364c|M.tuberculosis_H37Rv -----------------STTAATLDRQIAVESRSGIAPVTIDLSAVTHLG
MUL_3853|M.ulcerans_Agy99 -----------------SNTAPTLDRQIAVESRSGIASLTIDLSAVTHLG
TH_3243|M.thermoresistible__bu -----------------EYLDGRPHDDMAMVAVTCVR-------------
Mvan_5805|M.vanbaalenii_PYR-1 -----------------GWLNERAHDDIAVVAITAPRRTHLSAVDGRTAG
MMAR_5186|M.marinum_M PDQLVIVRRQLLSWLQAAEVPDEQAGDIVLVVSEACTNCIEHAYRGQSVG
MAV_0430|M.avium_104 ADQLVRIRHRLADWLGAAGITGELAADIVLVVNEACTNCVEHAYRGFVAG
Mflv_3857|M.gilvum_PYR-GCK -------------------FGDGLEDDAAVIALSVPR-------------
MSMEG_6131|M.smegmatis_MC2_155 -----------------AQTHGGLSDDIAVIRVERSRR------------
: .:
Mb1399c|M.bovis_AF2122/97 SAGVGALAAACDRARKQGTECVLVAPPGSPAHHVLSLVQLPVVGADTEDI
Rv1364c|M.tuberculosis_H37Rv SAGVGALAAACDRARKQGTECVLVAPPGSPAHHVLSLVQLPVVGADTEDI
MUL_3853|M.ulcerans_Agy99 SAGVSALVTARDRARKQGGRCVLMAPPGSPAHHVLSLVQIPVISGETENV
TH_3243|M.thermoresistible__bu --------------------------------------------------
Mvan_5805|M.vanbaalenii_PYR-1 RYTA----------------------------------------------
MMAR_5186|M.marinum_M TMLLDVEAADWAIHARVVDSGSWKKPAADPGNGGRGMTLIRAISDEVEID
MAV_0430|M.avium_104 TMVLDARLGEGEVHTRITDYGSWKTPAANPVNSGRGLPLMKALSQAMELR
Mflv_3857|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 FAQE--------------
Rv1364c|M.tuberculosis_H37Rv FAQE--------------
MUL_3853|M.ulcerans_Agy99 FAED--------------
TH_3243|M.thermoresistible__bu ------------------
Mvan_5805|M.vanbaalenii_PYR-1 ------------------
MMAR_5186|M.marinum_M NSPGGTAIDMTFRLPSED
MAV_0430|M.avium_104 TSATGTVADITFRRPAE-
Mflv_3857|M.gilvum_PYR-GCK ------------------
MSMEG_6131|M.smegmatis_MC2_155 ------------------