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MESSSVVGSGRMAERSGGVQSVERAFELMELIGRAGGECSLTELSAESPLPPPTIHRLLRTLVGLGYVRQ LPNRRYALGPRLIRLGEVANRQLGAVAGPVLQSLADDLSETASLAVLDGDMVIYTGQVLSAHMMRTNNEV GKRVGLHTSGVGKAVLAELEDARILKLVTQSGLPAPTENSASTLSAVFANVERVRAEGYAVDDEEFEIGV RSVAMAVPGAPTPMAIGISGPTARMGKDLIARAVPALKKATGVISEALIGAKEA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3174 | - | - | 100% (264) | regulatory protein, IclR |
| M. gilvum PYR-GCK | Mflv_0686 | - | 5e-25 | 31.84% (245) | regulatory protein, IclR |
| M. gilvum PYR-GCK | Mflv_0596 | - | 8e-25 | 32.23% (242) | regulatory protein, IclR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1748 | - | 1e-19 | 29.73% (222) | transcriptional regulatory protein |
| M. tuberculosis H37Rv | Rv1719 | - | 1e-19 | 29.73% (222) | transcriptional regulatory protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4493 | - | 4e-23 | 29.17% (216) | IclR family transcriptional regulator |
| M. marinum M | MMAR_4423 | - | 1e-21 | 32.51% (243) | transcriptional regulatory protein |
| M. avium 104 | MAV_3513 | - | 1e-21 | 29.39% (245) | transcriptional regulator, IclR family protein |
| M. smegmatis MC2 155 | MSMEG_5475 | - | 2e-61 | 49.58% (240) | acetate operon repressor |
| M. thermoresistible (build 8) | TH_3251 | - | 3e-19 | 34.63% (231) | PUTATIVE putative transcriptional regulator |
| M. ulcerans Agy99 | MUL_1967 | - | 2e-08 | 25.20% (246) | transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_0462 | - | 4e-26 | 32.79% (247) | regulatory proteins, IclR |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_3513|M.avium_104 MPAKRARVAGPAAAAPAADALAPQYPIESVDNALKLLLLLGEQ-PEIRLS
Mvan_0462|M.vanbaalenii_PYR-1 --MQKPPVAG---MEHDSTGKLPQYPIESVDNALRLILLLGDR-SEIRLT
MMAR_4423|M.marinum_M MSSGISSMIMGTGNDGGASESDPAPTVQSVDRALLVLELLADL-GKAGVT
Mflv_3174|M.gilvum_PYR-GCK --------MESSSVVGSGRMAERSGGVQSVERAFELMELIGRAGGECSLT
MSMEG_5475|M.smegmatis_MC2_155 --------------MGK---PPSTGGVQSIERGFELLEIMASVSSSIGVS
Mb1748|M.bovis_AF2122/97 --------------MSAEEQDTRSGGIQVIARAAELLRVLQAHPGGLSQA
Rv1719|M.tuberculosis_H37Rv --------------MSAEEQDTRSGGIQVIARAAELLRVLQAHPGGLSQA
MAB_4493|M.abscessus_ATCC_1997 --------------------------MSVLTRAAQILDALAESNSGLSVR
MUL_1967|M.ulcerans_Agy99 --------------------MRQDSGIGVIDKAVGLLRATAKS--PCGLA
TH_3251|M.thermoresistible__bu MTATLDQPTPNTTVKRTGTERTGETPSAVLDRISLVLDAFDGP-GRLTLA
: . ::
MAV_3513|M.avium_104 EATRYLGVASSTAHRLLAMLAYRGFVRQDPVSKAYLPGPSLTGVAFAIFG
Mvan_0462|M.vanbaalenii_PYR-1 DASEYLHVASSTAHRLLSMLQYRGFVRQDPISRAYQPGPSLTNVAFAVHS
MMAR_4423|M.marinum_M EVADELGVHKSTASRLITALEARGYVEQLSDRGKYQLGIGVSRLARARSG
Mflv_3174|M.gilvum_PYR-GCK ELSAESPLPPPTIHRLLRTLVGLGYVRQLPNR-RYALGPRLIRLGEVAN-
MSMEG_5475|M.smegmatis_MC2_155 ELSERTGLPVPTIHRLIRTLLNNGYVRQLPSR-RYALGPRLIRLGESAT-
Mb1748|M.bovis_AF2122/97 EIGERVGMARSTVSRILNALEDEGLVASRGARGPYRLGPEITRMATTVR-
Rv1719|M.tuberculosis_H37Rv EIGERVGMARSTVSRILNALEDEGLVASRGARGPYRLGPEITRMATTVR-
MAB_4493|M.abscessus_ATCC_1997 ELAEATGLPKSSVHRIVQELTVSQYVMAGGRGGSYQLGPGLLKLGLNNR-
MUL_1967|M.ulcerans_Agy99 ELCERTGLPRATAYRLAAALEVHRLLGR-DEDGRWGLGPAITELAAHVD-
TH_3251|M.thermoresistible__bu QVVRRTGLPRSSAHRMLERLVQLRWLRRDGRD--YELGMRLVELGSLAVH
: : .: *: * : : * : :.
MAV_3513|M.avium_104 RLDIARSAAPIMRALSEQLRETVHVGMLDGASVRFVAAVEGPAAVRVASR
Mvan_0462|M.vanbaalenii_PYR-1 RMDIPRTAAPILRRLADTLQETVHVGTLDGRLVRFIAALESPSAVRVISR
MMAR_4423|M.marinum_M HSDLVKLSQDACDKLAADLGETANLAILDENRAVNIVEAVSTAEIALQTW
Mflv_3174|M.gilvum_PYR-GCK -RQLGAVAGPVLQSLADDLSETASLAVLDGDMVIYTGQVLSAHMMRTNNE
MSMEG_5475|M.smegmatis_MC2_155 -QQFGRSSRERLAELVEAIGETANMAVLDVNMAVYVAQVPSAHTMRMFTE
Mb1748|M.bovis_AF2122/97 -LGVVTEMHPFLTELSRELDETVDLSILDGDRADVVDQVVPPQRLRAVSA
Rv1719|M.tuberculosis_H37Rv -LGVVTEMHPFLTELSRELDETVDLSILDGDRADVVDQVVPPQRLRAVSA
MAB_4493|M.abscessus_ATCC_1997 -RQFVAPMRKAIATVAREVNENIDLAMLSGGELVIIEQIATVRNLPTVTV
MUL_1967|M.ulcerans_Agy99 -DPLLTAGATVLPRLCETTGESVQLYRREGTSRVCVAALEPPAGLRDTVP
TH_3251|M.thermoresistible__bu QDRLHRAAIPRLHELHAATGLVVHLAVLDGSDVVYLEKVGSRLAAAIPTR
. : : .
MAV_3513|M.avium_104 LGRALPAHCTSTGKVMLAQLSAAELRALLPRERLKRITAHSIGSRAALET
Mvan_0462|M.vanbaalenii_PYR-1 LGGTRPAHCTSTGKVLLAGLSDDELDQLYPDPHLEPLTEHSVRTLTELRT
MMAR_4423|M.marinum_M VGQSCPVHATSSGKVLLAGLDADEVRQRVG-ATLDSFTENTIVTIDALEA
Mflv_3174|M.gilvum_PYR-GCK VGKRVGLHTSGVGKAVLAELEDARILKLVTQSGLPAPTENSASTLSAVFA
MSMEG_5475|M.smegmatis_MC2_155 VGRRVHLHCTGVGKALLMQMRDNDVRDLLTRSGMPAYTKATITDVDAMID
Mb1748|M.bovis_AF2122/97 VGESFPLYCCANGKALLAALPPERQARALP-SRLAPLTANTITDRAALRD
Rv1719|M.tuberculosis_H37Rv VGESFPLYCCANGKALLAALPPERQARALP-SRLAPLTANTITDRAALRD
MAB_4493|M.abscessus_ATCC_1997 VGRTFALHASSIGKALLSQLPPDQVRNMLP-ADLEVFTTNTITDVTALLR
MUL_1967|M.ulcerans_Agy99 VGARLPMTAGSGAKVLLAHSDPATQQAVLP-------------TAKFTDR
TH_3251|M.thermoresistible__bu VGGRRPANCAAVGKAILAYAEDDGVLSGTG--PLPRNTKYSISDPARLRA
:* . .*.:*
MAV_3513|M.avium_104 ELAAIRERGYATNREESEEGVASVAVPIPTRAPGLR--LALNAAAPQ---
Mvan_0462|M.vanbaalenii_PYR-1 QLAEVRKSGFAISNQESEEGVASVAVAVPQGGSGIRLALALNASAPS---
MMAR_4423|M.marinum_M QLAATRAAGWASAREELEIGLN--AVAAPVYDSTGRVAAALSVSGPA---
Mflv_3174|M.gilvum_PYR-GCK NVERVRAEGYAVDDEEFEIGVRSVAMAVPG----APTPMAIGISGPT---
MSMEG_5475|M.smegmatis_MC2_155 ELQRSRERGYAADEAEQEIGVRCFAVPVPN----APTLTAISVSGPD---
Mb1748|M.bovis_AF2122/97 ELNRIRVDGVAYDREEQTEGICAVGAVLRGV---SVELVAVSVPVPA---
Rv1719|M.tuberculosis_H37Rv ELNRIRVDGVAYDREEQTEGICAVGAVLRGV---SVELVAVSVPVPA---
MAB_4493|M.abscessus_ATCC_1997 ELDDVRSTGVAFDHEEHDVGISSVAVPLPHP---AAIPQAMAIVAPT---
MUL_1967|M.ulcerans_Agy99 VLAEVRRRGWAQSVAEREPGVASVSAPVRDG--RGVVVAAISVSGPI---
TH_3251|M.thermoresistible__bu ELAKVRAHGVAFDREESLPGIGCVAAPIGDP---GEAVAAISVCGPMNQM
: * * * * *: . *: *
MAV_3513|M.avium_104 ---NRLDAARYPAVAAALVAAAKEIGDQLG--------------------
Mvan_0462|M.vanbaalenii_PYR-1 ---YRFRPSDVRKACSALKDAAAELARNLG--------------------
MMAR_4423|M.marinum_M ---YRLPAADFEEVAQQTIAAADAVSRGLGWTDRIS--------------
Mflv_3174|M.gilvum_PYR-GCK ---ARMGKDLIARAVPALKKATGVISEALIGAKEA---------------
MSMEG_5475|M.smegmatis_MC2_155 ---GRVTVDAATYVVPILQRVAGELSAEFQREPQ----------------
Mb1748|M.bovis_AF2122/97 ---QRFYGREAELAGALLAWVSKVDAWFNGTEDRK---------------
Rv1719|M.tuberculosis_H37Rv ---QRFYGREAELAGALLAWVSKVDAWFNGTEDRK---------------
MAB_4493|M.abscessus_ATCC_1997 ---PRFAQRKTKYVAALDSLTKRANST-----------------------
MUL_1967|M.ulcerans_Agy99 ---DRIGRRPGARWAADLLAAADELARRL---------------------
TH_3251|M.thermoresistible__bu AFDHRLVAPVRMAALGIWRAMEGARQRVVPTLQQVRPLRPGPTAQSLSHS
*.
MAV_3513|M.avium_104 ----------------------
Mvan_0462|M.vanbaalenii_PYR-1 ----------------------
MMAR_4423|M.marinum_M ----------------------
Mflv_3174|M.gilvum_PYR-GCK ----------------------
MSMEG_5475|M.smegmatis_MC2_155 ----------------------
Mb1748|M.bovis_AF2122/97 ----------------------
Rv1719|M.tuberculosis_H37Rv ----------------------
MAB_4493|M.abscessus_ATCC_1997 ----------------------
MUL_1967|M.ulcerans_Agy99 ----------------------
TH_3251|M.thermoresistible__bu ALSHPAQSHPARSHRADTRRFA