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MQKPSLAGMERDSTGKPPQYPIESVDNALRLLLLLGERSEIRLTDASEYLRVASSTAHRLLSMLQYRGFV RQDPASKAYQPGPSLTNVAFAVHSRMDIPRTAAPILRQLVDTLQETVHVGTLDGRLVRFIAALESPSAVR VISRLGSTRPAHCTSTGKVLLAGLSVDELDQLYPDPHLEPLTEHSVRTLTELRTQLAEVRKSGFAISRQE SEEGVASVAVAVPQGGSGIRLALNASAPSYRFRPSDVRKACSALKDAAAELARNLG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0686 | - | - | 100% (266) | regulatory protein, IclR |
| M. gilvum PYR-GCK | Mflv_0596 | - | e-139 | 96.56% (262) | regulatory protein, IclR |
| M. gilvum PYR-GCK | Mflv_3087 | - | 1e-27 | 31.44% (264) | transcriptional regulator, TrmB |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1748 | - | 1e-21 | 30.63% (222) | transcriptional regulatory protein |
| M. tuberculosis H37Rv | Rv1719 | - | 1e-21 | 30.63% (222) | transcriptional regulatory protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0077 | - | 7e-15 | 27.48% (222) | IclR family transcriptional regulator |
| M. marinum M | MMAR_4423 | - | 4e-30 | 32.69% (260) | transcriptional regulatory protein |
| M. avium 104 | MAV_3513 | - | 6e-81 | 62.25% (249) | transcriptional regulator, IclR family protein |
| M. smegmatis MC2 155 | MSMEG_4174 | - | 1e-23 | 30.16% (252) | transcriptional regulator, IclR family protein |
| M. thermoresistible (build 8) | TH_3647 | - | 3e-31 | 38.50% (226) | PUTATIVE putative transcriptional regulator, IclR family |
| M. ulcerans Agy99 | MUL_1967 | - | 1e-15 | 29.75% (242) | transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_0462 | - | 1e-137 | 94.03% (268) | regulatory proteins, IclR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1748|M.bovis_AF2122/97 MSAEEQD--------------TRSGGIQVIARAAELLRVLQAHPGGLSQA
Rv1719|M.tuberculosis_H37Rv MSAEEQD--------------TRSGGIQVIARAAELLRVLQAHPGGLSQA
Mflv_0686|M.gilvum_PYR-GCK --MQKPSLAG---MERDSTGKPPQYPIESVDNALRLLLLLGERSE-IRLT
Mvan_0462|M.vanbaalenii_PYR-1 --MQKPPVAG---MEHDSTGKLPQYPIESVDNALRLILLLGDRSE-IRLT
MAV_3513|M.avium_104 MPAKRARVAGPAAAAPAADALAPQYPIESVDNALKLLLLLGEQPE-IRLS
TH_3647|M.thermoresistible__bu ---VRKRARG--------AIERPTYLLESVDNALRLLQMLRDGGA-VRLT
MMAR_4423|M.marinum_M MSSGISSMIMGTGNDGGASESDPAPTVQSVDRALLVLELLADLGK-AGVT
MUL_1967|M.ulcerans_Agy99 --------------------MRQDSGIGVIDKAVGLLRATAKSPC--GLA
MSMEG_4174|M.smegmatis_MC2_155 ---------------------MEIAGAQSAYRVLDVLTEVSLNPG-ATAG
MAB_0077|M.abscessus_ATCC_1997 -----------------MTITADSATPSAVIDRVSLLLDAFDGPGRLTLA
::
Mb1748|M.bovis_AF2122/97 EIGERVGMARSTVSRILNALEDEGLVASRGARGPYRLGPEITRMATTVR-
Rv1719|M.tuberculosis_H37Rv EIGERVGMARSTVSRILNALEDEGLVASRGARGPYRLGPEITRMATTVR-
Mflv_0686|M.gilvum_PYR-GCK DASEYLRVASSTAHRLLSMLQYRGFVRQDPASKAYQPGPSLTNVAFAVHS
Mvan_0462|M.vanbaalenii_PYR-1 DASEYLHVASSTAHRLLSMLQYRGFVRQDPISRAYQPGPSLTNVAFAVHS
MAV_3513|M.avium_104 EATRYLGVASSTAHRLLAMLAYRGFVRQDPVSKAYLPGPSLTGVAFAIFG
TH_3647|M.thermoresistible__bu EAAEELGVAPSTAHRLLAMLVYRGFAVQD-EKRTYLPGPALRAGPAERGW
MMAR_4423|M.marinum_M EVADELGVHKSTASRLITALEARGYVEQLSDRGKYQLGIGVSRLARARSG
MUL_1967|M.ulcerans_Agy99 ELCERTGLPRATAYRLAAALEVHRLLGRD-EDGRWGLGPAITELAAHVD-
MSMEG_4174|M.smegmatis_MC2_155 EVAKATNLTAPTAHRLLRVLCDRGFAIQN-DAGKYVPGPQMRVLAGDRVD
MAB_0077|M.abscessus_ATCC_1997 QLVRRTGLPRSSVHRMLERLVQLRWLRRD--GRDYELGTRLVELGSLAVH
: : .:. *: * : * :
Mb1748|M.bovis_AF2122/97 -LGVVTEMHPFLTELSRELDETVDLSILDGDRADVVDQVVPPQRLRAVSA
Rv1719|M.tuberculosis_H37Rv -LGVVTEMHPFLTELSRELDETVDLSILDGDRADVVDQVVPPQRLRAVSA
Mflv_0686|M.gilvum_PYR-GCK RMDIPRTAAPILRQLVDTLQETVHVGTLDGRLVRFIAALESPSAVRVISR
Mvan_0462|M.vanbaalenii_PYR-1 RMDIPRTAAPILRRLADTLQETVHVGTLDGRLVRFIAALESPSAVRVISR
MAV_3513|M.avium_104 RLDIARSAAPIMRALSEQLRETVHVGMLDGASVRFVAAVEGPAAVRVASR
TH_3647|M.thermoresistible__bu TREFTDVCLPHLEALSTVCGETVNLVIRVGTGVRFLTSVESTAMLRVGDR
MMAR_4423|M.marinum_M HSDLVKLSQDACDKLAADLGETANLAILDENRAVNIVEAVSTAEIALQTW
MUL_1967|M.ulcerans_Agy99 -DPLLTAGATVLPRLCETTGESVQLYRREGTSRVCVAALEPPAGLRDTVP
MSMEG_4174|M.smegmatis_MC2_155 RAILEELGRPLLARLRDESTETVFLAVREGLQLTYLVVMTSSHSVQMYGE
MAB_0077|M.abscessus_ATCC_1997 QDRLHAAALPMLHELHRATGLVVHLSILDGADVVYLEKIGAGIGAAVATR
. * . : :
Mb1748|M.bovis_AF2122/97 VGESFPLYCCANGKALLAALPPERQARALPSR-LAPLTANTITDRAALRD
Rv1719|M.tuberculosis_H37Rv VGESFPLYCCANGKALLAALPPERQARALPSR-LAPLTANTITDRAALRD
Mflv_0686|M.gilvum_PYR-GCK LGSTRPAHCTSTGKVLLAGLSVDELDQLYPDPHLEPLTEHSVRTLTELRT
Mvan_0462|M.vanbaalenii_PYR-1 LGGTRPAHCTSTGKVLLAGLSDDELDQLYPDPHLEPLTEHSVRTLTELRT
MAV_3513|M.avium_104 LGRALPAHCTSTGKVMLAQLSAAELRALLPRERLKRITAHSIGSRAALET
TH_3647|M.thermoresistible__bu RGQVLPAERTAGGRALLAELDDEVVERLYADR--------SAGQRAELLT
MMAR_4423|M.marinum_M VGQSCPVHATSSGKVLLAGLDADEVRQRVGAT-LDSFTENTIVTIDALEA
MUL_1967|M.ulcerans_Agy99 VGARLPMTAGSGAKVLLAHSDPATQQAVLPTA-------------KFTDR
MSMEG_4174|M.smegmatis_MC2_155 VGQQIPLHATSQGKVVLAFLPPGVGERIIDQLELARYTPSTITTAKELHE
MAB_0077|M.abscessus_ATCC_1997 IGGRQPAHCTASGKAILAYRAQILDGCTALAR----KTRYSIGSAAQLRP
* * : .:.:**
Mb1748|M.bovis_AF2122/97 ELNRIRVDGVAYDREEQTEGICAVGAVLRGVSVELVA----VSVPVPAQR
Rv1719|M.tuberculosis_H37Rv ELNRIRVDGVAYDREEQTEGICAVGAVLRGVSVELVA----VSVPVPAQR
Mflv_0686|M.gilvum_PYR-GCK QLAEVRKSGFAISRQESEEGVASVAVAVPQG-GSGIR--LALNASAPSYR
Mvan_0462|M.vanbaalenii_PYR-1 QLAEVRKSGFAISNQESEEGVASVAVAVPQG-GSGIRLALALNASAPSYR
MAV_3513|M.avium_104 ELAAIRERGYATNREESEEGVASVAVPIPTR-APGLR--LALNAAAPQNR
TH_3647|M.thermoresistible__bu ELAAVREVGFGLNVEHTEEGVAAFGAVVRNRLGRAVG---AVTVAVPIVR
MMAR_4423|M.marinum_M QLAATRAAGWASAREELEIGLNAVAAPVYDSTGRVAA---ALSVSGPAYR
MUL_1967|M.ulcerans_Agy99 VLAEVRRRGWAQSVAEREPGVASVSAPVRDGRGVVVA---AISVSGPIDR
MSMEG_4174|M.smegmatis_MC2_155 AMYEIRRDGYALNLEERELGVRSVAAPVLDPSGNVVAS---VCVGGPIFR
MAB_0077|M.abscessus_ATCC_1997 ELDKVRGHGVAFDREELQQGIGCVAAPIGSIGDAVAA----VSVCGPMTR
: * * . . *: .... : : . * *
Mb1748|M.bovis_AF2122/97 FYG------REAELAGALLAWVSKVDAWFNGTEDRK--------------
Rv1719|M.tuberculosis_H37Rv FYG------REAELAGALLAWVSKVDAWFNGTEDRK--------------
Mflv_0686|M.gilvum_PYR-GCK FRPS-----DVRKACSALKDAAAELARNLG--------------------
Mvan_0462|M.vanbaalenii_PYR-1 FRPS-----DVRKACSALKDAAAELARNLG--------------------
MAV_3513|M.avium_104 LDAA-----RYPAVAAALVAAAKEIGDQLG--------------------
TH_3647|M.thermoresistible__bu YQRH-----ARGDLVRQLFRTADEISVDLDGRFDSLEP------------
MMAR_4423|M.marinum_M LPAA-----DFEEVAQQTIAAADAVSRGLGWTDRIS--------------
MUL_1967|M.ulcerans_Agy99 IGRR-----PGARWAADLLAAADELARRL---------------------
MSMEG_4174|M.smegmatis_MC2_155 FSEDD----LRGKFARMVCGTAEAITAELRRRVKPVDVLDERPAQ-----
MAB_0077|M.abscessus_ATCC_1997 MTFDQRLAAPVRMTAMGIWRNVENGPSRVAPTLQPIRPLRCGPAASSTGR
. .
Mb1748|M.bovis_AF2122/97 ----------
Rv1719|M.tuberculosis_H37Rv ----------
Mflv_0686|M.gilvum_PYR-GCK ----------
Mvan_0462|M.vanbaalenii_PYR-1 ----------
MAV_3513|M.avium_104 ----------
TH_3647|M.thermoresistible__bu ----------
MMAR_4423|M.marinum_M ----------
MUL_1967|M.ulcerans_Agy99 ----------
MSMEG_4174|M.smegmatis_MC2_155 ----------
MAB_0077|M.abscessus_ATCC_1997 EMNSPALQYA