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GKPPSTGGVQSIERGFELLEIMASVSSSIGVSELSERTGLPVPTIHRLIRTLLNNGYVRQLPSRRYALGP RLIRLGESATQQFGRSSRERLAELVEAIGETANMAVLDVNMAVYVAQVPSAHTMRMFTEVGRRVHLHCTG VGKALLMQMRDNDVRDLLTRSGMPAYTKATITDVDAMIDELQRSRERGYAADEAEQEIGVRCFAVPVPNA PTLTAISVSGPDGRVTVDAATYVVPILQRVAGELSAEFQREPQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5475 | - | - | 100% (254) | acetate operon repressor |
| M. smegmatis MC2 155 | MSMEG_2483 | - | 2e-26 | 33.33% (219) | transcriptional regulator, IclR family protein |
| M. smegmatis MC2 155 | MSMEG_3784 | - | 8e-24 | 28.51% (242) | transcriptional regulator, IclR family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1748 | - | 9e-21 | 31.65% (218) | transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_3174 | - | 2e-61 | 49.58% (240) | regulatory protein, IclR |
| M. tuberculosis H37Rv | Rv1719 | - | 9e-21 | 31.65% (218) | transcriptional regulatory protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4493 | - | 2e-29 | 31.72% (227) | IclR family transcriptional regulator |
| M. marinum M | MMAR_4423 | - | 6e-26 | 34.23% (222) | transcriptional regulatory protein |
| M. avium 104 | MAV_3513 | - | 3e-24 | 33.19% (229) | transcriptional regulator, IclR family protein |
| M. thermoresistible (build 8) | TH_3251 | - | 6e-22 | 34.83% (201) | PUTATIVE putative transcriptional regulator |
| M. ulcerans Agy99 | MUL_1967 | - | 1e-12 | 28.64% (220) | transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_4411 | - | 5e-23 | 33.03% (221) | regulatory proteins, IclR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1748|M.bovis_AF2122/97 --------------MSAEEQDTRSGGIQVIARAAELLRVLQAHPGGLSQA
Rv1719|M.tuberculosis_H37Rv --------------MSAEEQDTRSGGIQVIARAAELLRVLQAHPGGLSQA
MAB_4493|M.abscessus_ATCC_1997 --------------------------MSVLTRAAQILDALAESNSGLSVR
MSMEG_5475|M.smegmatis_MC2_155 --------------MGK---PPSTGGVQSIERGFELLEIMASVSSSIGVS
Mflv_3174|M.gilvum_PYR-GCK --------MESSSVVGSGRMAERSGGVQSVERAFELMELIGRAGGECSLT
TH_3251|M.thermoresistible__bu MTATLDQPTPNTTVKRTGTERTGETPSAVLDRISLVLDAFDGP-GRLTLA
Mvan_4411|M.vanbaalenii_PYR-1 MNQASIAIDP---VRSSEHDSIHQSPTNSVRRTLQVLAAFDGSRTVLGVS
MMAR_4423|M.marinum_M MSSGISSMIMGTGNDGGASESDPAPTVQSVDRALLVLELLADL-GKAGVT
MAV_3513|M.avium_104 MPAKRARVAGPAAAAPAADALAPQYPIESVDNALKLLLLLGEQ-PEIRLS
MUL_1967|M.ulcerans_Agy99 --------------------MRQDSGIGVIDKAVGLLRATAKS--PCGLA
: . ::
Mb1748|M.bovis_AF2122/97 EIGERVGMARSTVSRILNALEDEGLVASRGARGPYRLGPEITRMATTVR-
Rv1719|M.tuberculosis_H37Rv EIGERVGMARSTVSRILNALEDEGLVASRGARGPYRLGPEITRMATTVR-
MAB_4493|M.abscessus_ATCC_1997 ELAEATGLPKSSVHRIVQELTVSQYVMAGGRGGSYQLGPGLLKLGLNNR-
MSMEG_5475|M.smegmatis_MC2_155 ELSERTGLPVPTIHRLIRTLLNNGYVRQLP-SRRYALGPRLIRLGESAT-
Mflv_3174|M.gilvum_PYR-GCK ELSAESPLPPPTIHRLLRTLVGLGYVRQLP-NRRYALGPRLIRLGEVAN-
TH_3251|M.thermoresistible__bu QVVRRTGLPRSSAHRMLERLVQLRWLRRD--GRDYELGMRLVELGSLAVH
Mvan_4411|M.vanbaalenii_PYR-1 EVAARADVPKSTAHRLLNVMSQQGFVRRE--GNRYRLGERLFELGARALE
MMAR_4423|M.marinum_M EVADELGVHKSTASRLITALEARGYVEQLSDRGKYQLGIGVSRLARARSG
MAV_3513|M.avium_104 EATRYLGVASSTAHRLLAMLAYRGFVRQDPVSKAYLPGPSLTGVAFAIFG
MUL_1967|M.ulcerans_Agy99 ELCERTGLPRATAYRLAAALEVHRLLGRDE-DGRWGLGPAITELAAHVD-
: : .: *: : : : * : :.
Mb1748|M.bovis_AF2122/97 -LGVVTEMHPFLTELSRELDETVDLSILDGDRADVVDQVVPPQRLRAVSA
Rv1719|M.tuberculosis_H37Rv -LGVVTEMHPFLTELSRELDETVDLSILDGDRADVVDQVVPPQRLRAVSA
MAB_4493|M.abscessus_ATCC_1997 -RQFVAPMRKAIATVAREVNENIDLAMLSGGELVIIEQIATVRNLPTVTV
MSMEG_5475|M.smegmatis_MC2_155 -QQFGRSSRERLAELVEAIGETANMAVLDVNMAVYVAQVPSAHTMRMFTE
Mflv_3174|M.gilvum_PYR-GCK -RQLGAVAGPVLQSLADDLSETASLAVLDGDMVIYTGQVLSAHMMRTNNE
TH_3251|M.thermoresistible__bu QDRLHRAAIPRLHELHAATGLVVHLAVLDGSDVVYLEKVGSRLAAAIPTR
Mvan_4411|M.vanbaalenii_PYR-1 PRGLRERAIPFMAELHHSTLETIHLAVLRGDQVLYVEKIYGHGAAPCPTT
MMAR_4423|M.marinum_M HSDLVKLSQDACDKLAADLGETANLAILDENRAVNIVEAVSTAEIALQTW
MAV_3513|M.avium_104 RLDIARSAAPIMRALSEQLRETVHVGMLDGASVRFVAAVEGPAAVRVASR
MUL_1967|M.ulcerans_Agy99 -DPLLTAGATVLPRLCETTGESVQLYRREGTSRVCVAALEPPAGLRDTVP
. : :
Mb1748|M.bovis_AF2122/97 VGESFPLYCCANGKALLAALPPERQARALPSR-LAPLTANTITDRAALRD
Rv1719|M.tuberculosis_H37Rv VGESFPLYCCANGKALLAALPPERQARALPSR-LAPLTANTITDRAALRD
MAB_4493|M.abscessus_ATCC_1997 VGRTFALHASSIGKALLSQLPPDQVRNMLPAD-LEVFTTNTITDVTALLR
MSMEG_5475|M.smegmatis_MC2_155 VGRRVHLHCTGVGKALLMQMRDNDVRDLLTRSGMPAYTKATITDVDAMID
Mflv_3174|M.gilvum_PYR-GCK VGKRVGLHTSGVGKAVLAELEDARILKLVTQSGLPAPTENSASTLSAVFA
TH_3251|M.thermoresistible__bu VGGRRPANCAAVGKAILAYAEDDGVLSGTGP--LPRNTKYSISDPARLRA
Mvan_4411|M.vanbaalenii_PYR-1 VGGRNPATCTGLGKAILSSCSEEAVDAILGSR-LPRPTRNSLHTRQALHR
MMAR_4423|M.marinum_M VGQSCPVHATSSGKVLLAGLDADEVRQRVG-ATLDSFTENTIVTIDALEA
MAV_3513|M.avium_104 LGRALPAHCTSTGKVMLAQLSAAELRALLPRERLKRITAHSIGSRAALET
MUL_1967|M.ulcerans_Agy99 VGARLPMTAGSGAKVLLAHSDP-------------ATQQAVLPTAKFTDR
:* . .*.:*
Mb1748|M.bovis_AF2122/97 ELNRIRVDGVAYDREEQTEGICAVGAVLRG--VSVELVAVSVPVPAQRFY
Rv1719|M.tuberculosis_H37Rv ELNRIRVDGVAYDREEQTEGICAVGAVLRG--VSVELVAVSVPVPAQRFY
MAB_4493|M.abscessus_ATCC_1997 ELDDVRSTGVAFDHEEHDVGISSVAVPLPH--PAAIPQAMAIVAPTPRFA
MSMEG_5475|M.smegmatis_MC2_155 ELQRSRERGYAADEAEQEIGVRCFAVPVPN---APTLTAISVSGPDGRVT
Mflv_3174|M.gilvum_PYR-GCK NVERVRAEGYAVDDEEFEIGVRSVAMAVPG---APTPMAIGISGPTARMG
TH_3251|M.thermoresistible__bu ELAKVRAHGVAFDREESLPGIGCVAAPIGD--PGEAVAAISVCGPMNQMA
Mvan_4411|M.vanbaalenii_PYR-1 NLTISREEGVAVDYEELRMGLACVSAPIIDRSTGAAVAALSISAPTSRFN
MMAR_4423|M.marinum_M QLAATRAAGWASAREELEIGLNAVAAPVYDS-TGRVAAALSVSGPAYRLP
MAV_3513|M.avium_104 ELAAIRERGYATNREESEEGVASVAVPIPTR-APGLRLALNAAAPQNRLD
MUL_1967|M.ulcerans_Agy99 VLAEVRRRGWAQSVAEREPGVASVSAPVRDG-RGVVVAAISVSGPIDRIG
: * * * * *: ... : *: * :.
Mb1748|M.bovis_AF2122/97 GR---------------------EAELAGALLAWVSKVDAWFNGTEDRK-
Rv1719|M.tuberculosis_H37Rv GR---------------------EAELAGALLAWVSKVDAWFNGTEDRK-
MAB_4493|M.abscessus_ATCC_1997 QR---------------------KTKYVAALDSLTKRANST---------
MSMEG_5475|M.smegmatis_MC2_155 VD--------------------AATYVVPILQRVAGELSAEFQREPQ---
Mflv_3174|M.gilvum_PYR-GCK KD--------------------LIARAVPALKKATGVISEALIGAKEA--
TH_3251|M.thermoresistible__bu FDHRLVAPVRMAALGIWRAMEGARQRVVPTLQQVRPLRPGPTAQSLSHSA
Mvan_4411|M.vanbaalenii_PYR-1 R----------------------RRFTVQLLKATEALSLG----SLRSA-
MMAR_4423|M.marinum_M AAD--------------------FEEVAQQTIAAADAVSRGLGWTDRIS-
MAV_3513|M.avium_104 AAR--------------------YPAVAAALVAAAKEIGDQLG-------
MUL_1967|M.ulcerans_Agy99 RRP--------------------GARWAADLLAAADELARRL--------
.
Mb1748|M.bovis_AF2122/97 ---------------------
Rv1719|M.tuberculosis_H37Rv ---------------------
MAB_4493|M.abscessus_ATCC_1997 ---------------------
MSMEG_5475|M.smegmatis_MC2_155 ---------------------
Mflv_3174|M.gilvum_PYR-GCK ---------------------
TH_3251|M.thermoresistible__bu LSHPAQSHPARSHRADTRRFA
Mvan_4411|M.vanbaalenii_PYR-1 ---------------------
MMAR_4423|M.marinum_M ---------------------
MAV_3513|M.avium_104 ---------------------
MUL_1967|M.ulcerans_Agy99 ---------------------