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TIPRTPADLTPTWLESVLDAGVDDVTVTAIGTGQTGATYRVSATYDNPTAADLPATFAVKLPAQDDAVRE RVALGYLSEVDFYSTITADVAVPVPGCYHSEISSDGTDFVLVLADMAPAEQGDQIAGCTAAEAALAVEAI AGLHGPSWGDRRYFDLPSIVMPKPGDEAAASGMGEVAVMAANMTLEKLGGSVDDEDRDTLLTSMSLVTPW LMAVPDRFSLMHGDYRLDNLLYDPERTRVTVVDWQTVGIGLPTRDLAYFTATSLLPDDRAAVERDLVQRY HAALLAHGVSGYDVETCWQDYRLGVFQAPLITALGFAFAASTERGDEMILTMLHRGCRAIRELGAIDLVR SYQASTQPSSPTTA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3102 | - | - | 100% (365) | aminoglycoside phosphotransferase |
| M. gilvum PYR-GCK | Mflv_3155 | - | 1e-39 | 33.97% (365) | hypothetical protein Mflv_3155 |
| M. gilvum PYR-GCK | Mflv_4330 | - | 2e-24 | 27.91% (369) | hypothetical protein Mflv_4330 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3787c | fadE36 | 6e-05 | 35.82% (67) | acyl-CoA dehydrogenase |
| M. tuberculosis H37Rv | Rv3761c | fadE36 | 6e-05 | 35.82% (67) | acyl-CoA dehydrogenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4589c | - | 8e-09 | 26.16% (279) | putative phosphotransferase |
| M. marinum M | MMAR_4035 | - | 1e-117 | 59.15% (355) | hypothetical protein MMAR_4035 |
| M. avium 104 | MAV_1568 | - | 1e-125 | 61.69% (355) | phosphotransferase enzyme family protein, putative |
| M. smegmatis MC2 155 | MSMEG_3876 | - | 1e-132 | 64.29% (350) | phosphotransferase enzyme family protein, putative |
| M. thermoresistible (build 8) | TH_0441 | - | 1e-129 | 63.10% (355) | phosphotransferase enzyme family protein, putative |
| M. ulcerans Agy99 | MUL_1045 | - | 7e-20 | 27.35% (362) | hypothetical protein MUL_1045 |
| M. vanbaalenii PYR-1 | Mvan_3433 | - | 1e-174 | 82.47% (365) | aminoglycoside phosphotransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3102|M.gilvum_PYR-GCK ---------------------------MTIPRTPADLTPTWLESVLDAG-
Mvan_3433|M.vanbaalenii_PYR-1 ---------------------------MTIPRSPQDITPTWLASVLGTE-
MSMEG_3876|M.smegmatis_MC2_155 -----------------------MTAAVSIPGRPVDVTPSWLSGVLGTE-
TH_0441|M.thermoresistible__bu -----------------------MSTVLSIPSGPAEVTPEWLSTVLSADG
MMAR_4035|M.marinum_M --------------------------MVSIPRHPTDVTPQWLAAVLGERG
MAV_1568|M.avium_104 --------------------------MLSIPRYPGDVTPQWLSAALSGRG
Mb3787c|M.bovis_AF2122/97 -----------------------MTSVDRLDGLDLGALDRYLRSLGIGR-
Rv3761c|M.tuberculosis_H37Rv -----------------------MTSVDRLDGLDLGALDRYLRSLGIGR-
MUL_1045|M.ulcerans_Agy99 MIALARLATHLGRGLGRVATDAVLRNARAFPRRIHDLDPPALSEIMGRR-
MAB_4589c|M.abscessus_ATCC_199 --------------MHKDVSSDSDGPTGDAASLDADAIPTSLSEYLNREL
*
Mflv_3102|M.gilvum_PYR-GCK ----VDDVTVTAIGTGQTGATYRVSATYDNPTAADLPATFAVKLPAQDDA
Mvan_3433|M.vanbaalenii_PYR-1 ----VSGVEVAAIGTGQTGATYRVTATY--PESPSPPATFAVKLPAQDDA
MSMEG_3876|M.smegmatis_MC2_155 ----VATAATEPIGTGQTGATYRVTVTY-AGD-SALPTTFAIKLPSQDDT
TH_0441|M.thermoresistible__bu TPVRVRSVDVVPIGTGQTGATYRLTVGY-ETERADLPPTFAIKLPAQDES
MMAR_4035|M.marinum_M TPVGVSGVDVVPIGTGQTGATYRLTVIY-DPDPAGLPDTFVIKLPAQDDT
MAV_1568|M.avium_104 APVEVAEVDVAAIGTGQTGATYRVTARY-ATDPGDLPQTFVIKLPAQDDT
Mb3787c|M.bovis_AF2122/97 ----DGELRGELISGGRSNLTFRVYDDA-SSWLVRRPPLHGLTPSAHDMA
Rv3761c|M.tuberculosis_H37Rv ----DGELRGELISGGRSNLTFRVYDDA-SSWLVRRPPLHGLTPSAHDMA
MUL_1045|M.ulcerans_Agy99 ----VSSVSVLDDSSGTTSRARLALSGN------DVPESVFVKMAAATAA
MAB_4589c|M.abscessus_ATCC_199 G----EQVSVRRLSAGHSNLTYVVTGSSGTQWILRRPPFGRLQAGAHDVM
. * :. : * : :
Mflv_3102|M.gilvum_PYR-GCK VRERVALGY--LSEVDFYSTITADVAVPVPGCYHSEISSDGTDFVLVLAD
Mvan_3433|M.vanbaalenii_PYR-1 VRERVALGY--LSEVDFYAAINRDVAIPVPDCFHTEISTDGKDFVLVLAD
MSMEG_3876|M.smegmatis_MC2_155 VRDRVAIGY--RSEHAFYTSLAGQVRIPVPHCYHCEIAGEGADFVLVLAD
TH_0441|M.thermoresistible__bu VRERVALGY--RAEHAFYTRVAAHMAIPVPHCYHCEIGGDGAEFAMLMAD
MMAR_4035|M.marinum_M VRDRVVVGY--RSECAFYSSVADRVRVPTPRCFYCEITEDAMDFALLLED
MAV_1568|M.avium_104 VRDRVVIGY--RSECAFYSSVADRVQVPTPRCFYSEITEDAMDFALLLAD
Mb3787c|M.bovis_AF2122/97 REYRVVAALG-DTPVPVARTISLCQDDSVLGAPFQVVEFVAGQVVRRRAE
Rv3761c|M.tuberculosis_H37Rv REYRVVAALG-DTPVPVARTISLCQDDSVLGAPFQVVEFVAGQVVRRRAE
MUL_1045|M.ulcerans_Agy99 TRFIGELGRLAETEVSFYRDLSPELAPDAPTAYGCAFDPLTGRFVLVLED
MAB_4589c|M.abscessus_ATCC_199 REYRVLDALS-TAQVRVPRVTLASTDAEIFGAPFYLMERQDGEVIRDVSP
. . : . . . .
Mflv_3102|M.gilvum_PYR-GCK MAPAEQG-----DQIAGCTAAEAALAVEAIAGLHGPSWGDRRYFDLPSIV
Mvan_3433|M.vanbaalenii_PYR-1 MAPAEQG-----DQIAGCTPAEAALAVEALAGLHGPSWNERRYFDLPSIV
MSMEG_3876|M.smegmatis_MC2_155 MAPAEQG-----DQIAGCSPAEAALAVRALADLHGPTWCDPQWANFPGIA
TH_0441|M.thermoresistible__bu MAPAVQG-----DQIVGCSPAEARLAVTALAGLHGPSWCDPQWADVPGIA
MMAR_4035|M.marinum_M QAPAVQG-----DQLTGCGEREARLAVVALAGLHGPSWCDPVWLDQPGIA
MAV_1568|M.avium_104 QAPAVQG-----DQLLGCGETEARLAVTALAGLHAPSWCDPVWLDFPGIA
Mb3787c|M.bovis_AF2122/97 LEALGSR-----SVIEGCVDA----LIRVLVDLHS---IDPKAVGLSDFG
Rv3761c|M.tuberculosis_H37Rv LEALGSR-----SVIEGCVDA----LIRVLVDLHS---IDPKAVGLSDFG
MUL_1045|M.ulcerans_Agy99 LAAPAEGTCDFSDTLHPFDNDQAALVVELLARLHATYWVRLNHGGVRPFG
MAB_4589c|M.abscessus_ATCC_199 EWFVGSAR-----------RELVLDLAVALAEIHN---ADPTRLVEAKLG
. :. :* :
Mflv_3102|M.gilvum_PYR-GCK MPKPGDEAAASGMGEVAVMAANMTLEKLGGSVDDEDRDTLLTSMSLVTPW
Mvan_3433|M.vanbaalenii_PYR-1 MPKPGDEAAAAGMGEVAKMAADITLDKLGGSVSDEDRDTLVTSMSLVTPW
MSMEG_3876|M.smegmatis_MC2_155 MPKP-EPDSAKGFGDIAKMAADITLDKLGDRLSIGDRETLSASMSVVTPW
TH_0441|M.thermoresistible__bu MPKP-DDAAAEGLGEIAEMAADITIDKLGPRMRPEDRETTLTAMSMVTAW
MMAR_4035|M.marinum_M FPFP-DEPFANGLGEVARMSAEITLDKLGDRLSAADRETFTETMNLVTPW
MAV_1568|M.avium_104 FGRP-DEAGAGGMGEVAKMSADITLERLGDRMSAEDRETFAAAMGVIAPW
Mb3787c|M.bovis_AF2122/97 KPDGYLERQVRRWGSQWELVR----------LPDDHRDADISRLHLALQQ
Rv3761c|M.tuberculosis_H37Rv KPDGYLERQVRRWGSQWELVR----------LPDDHRDADISRLHLALQQ
MUL_1045|M.ulcerans_Agy99 WRYAASRDPSVPLVPTMLRASWRRLGGHAAALLPG-RDFVFEHYRAITGL
MAB_4589c|M.abscessus_ATCC_199 RESGYLARQLKTWGGQWESIK---------ELPTGRDLQDHTTITAWLTE
:
Mflv_3102|M.gilvum_PYR-GCK LMAVPDRFSLMHGDYRLDNLLYDPER--TRVTVVDWQTVGIGLPTRDLAY
Mvan_3433|M.vanbaalenii_PYR-1 LLAVPDRFSLMHGDYRLDNLLYDPDR--TRVTVVDWQTMGIGLPSRDLAY
MSMEG_3876|M.smegmatis_MC2_155 LLAEPDRFAVLHGDYRLDNMLFDPDR--TRVTVVDWQTLGSGLPARDLSY
TH_0441|M.thermoresistible__bu LRTEKSRFALMHGDYRLDNMLFDPDR--TRVTVVDWQTMGAGLPARDLSY
MMAR_4035|M.marinum_M LLAERDRFALLHGDYRLDNLLFDPDL--RRVAVVDWQTLGIGLPARDLGY
MAV_1568|M.avium_104 LLSEYDRFALLHGDYRLDNLLFDPDR--TRVSVVDWQTLGVGLPARDLAY
Mb3787c|M.bovis_AF2122/97 AIPQQSRTSIVHGDYRIDNTILDTDDPCHVRAVVDWELSTLGDPLSDAAL
Rv3761c|M.tuberculosis_H37Rv AIPQQSRTSIVHGDYRIDNTILDTDDPCHVRAVVDWELSTLGDPLSDAAL
MUL_1045|M.ulcerans_Agy99 IDAPP--HTVLHGDAHPGNWYFRSSGGPLAAGLLDWQAIRLGHPARDLAY
MAB_4589c|M.abscessus_ATCC_199 NYPGDRPAAVVHGDYKLDNVLVDPAT-ARITAVLDWEMATVGDPLADLGY
. :::*** : .* . ::**: * * * .
Mflv_3102|M.gilvum_PYR-GCK FTAT--------SLLPDDRAAVERDLVQRYHAALLAHGVSGYDVETCWQD
Mvan_3433|M.vanbaalenii_PYR-1 FTAT--------SLLPETRAEVERDLVEHYHAALLGHGVSGYDVETCWHD
MSMEG_3876|M.smegmatis_MC2_155 FTAT--------SLDPADRAAAERDLVGEYHRTLLAHGVTGYDRETCWRD
TH_0441|M.thermoresistible__bu FLGT--------SLLPEVRSEVERDLVEVYHRALRSHGVADYDSETCWRD
MMAR_4035|M.marinum_M FTAT--------SLNSQLRSDIEESLVDDYHRKLLSYGVTGYDWETCWRD
MAV_1568|M.avium_104 FTAT--------SLDSPLRAAIEEELVADYHRALVAGGVNGYDRETCWRD
Mb3787c|M.bovis_AF2122/97 MCVYRDPA---LDLIVHAQAAWTSPLLPAADELADRYSLVSGQPLGHWEF
Rv3761c|M.tuberculosis_H37Rv MCVYRDPA---LDLIVHAQAAWTSPLLPAADELADRYSLVSGQPLGHWEF
MUL_1045|M.ulcerans_Agy99 TLIT--------GMTTTDRRVTERELLDVYRRALAAAGGPELDREEPWLR
MAB_4589c|M.abscessus_ATCC_199 LLYMTPEPGGEVAMSELTGSVTAQEGCPSHTEIAQAYREARSGDQSYWTP
: *
Mflv_3102|M.gilvum_PYR-GCK YRLGVFQAP----LITALGFAFAASTERGDEMILTMLHRGCRAIRELGAI
Mvan_3433|M.vanbaalenii_PYR-1 YRLGVLQAP----LITVLGTAFASSTERGDEMMLTMLHRGCRAIRELASI
MSMEG_3876|M.smegmatis_MC2_155 YRLGMLQAP----LITVLGCAFASSTDRGDDMMVVMAQRGCQAIRELGTL
TH_0441|M.thermoresistible__bu YRLGMLQVP----LLTVLGFAFAASTERGDDMMLTMLERGGRAIRELDSL
MMAR_4035|M.marinum_M YRLGMPHTV----LISALGFAFATATERGDEMVLTMLGRGCQAIRDLETL
MAV_1568|M.avium_104 YRLGVLQAP----LISALGFAFAAATERGDDMVLTMLGRGCRAIRELGTL
Mb3787c|M.bovis_AF2122/97 YMALAYFKL----AIIAAGIDYRRRMSEQAEGKDTAAESVPDVVAPLIAR
Rv3761c|M.tuberculosis_H37Rv YMALAYFKL----AIIAAGIDYRRRMSEQAEGKDTAAESVPDVVAPLIAR
MUL_1045|M.ulcerans_Agy99 YRQAAACAY----VATTIAAGLGG--MQAADIALTGLDLTVAALHDLQTV
MAB_4589c|M.abscessus_ATCC_199 EDLVYYQVLGGWKLATLLEVSYQRHLAGTTDDPFFAELDEGVPRLLSVAR
: :
Mflv_3102|M.gilvum_PYR-GCK DLVRSYQASTQPSSPTTA--------------------------------
Mvan_3433|M.vanbaalenii_PYR-1 DLVRSYQVS----SPTTA--------------------------------
MSMEG_3876|M.smegmatis_MC2_155 DLIDAAS-------------------------------------------
TH_0441|M.thermoresistible__bu ELVNPAAS------------------------------------------
MMAR_4035|M.marinum_M ELIG----------------------------------------------
MAV_1568|M.avium_104 ELIG----------------------------------------------
Mb3787c|M.bovis_AF2122/97 GLAEIAKKSG----------------------------------------
Rv3761c|M.tuberculosis_H37Rv GLAEIAKKSG----------------------------------------
MUL_1045|M.ulcerans_Agy99 AALRAADLGGTSWAWRPGMARSARIRPGASARRCPMVWSTSSHILGVSRH
MAB_4589c|M.abscessus_ATCC_199 SLIPAAG-------------------------------------------
Mflv_3102|M.gilvum_PYR-GCK ------
Mvan_3433|M.vanbaalenii_PYR-1 ------
MSMEG_3876|M.smegmatis_MC2_155 ------
TH_0441|M.thermoresistible__bu ------
MMAR_4035|M.marinum_M ------
MAV_1568|M.avium_104 ------
Mb3787c|M.bovis_AF2122/97 ------
Rv3761c|M.tuberculosis_H37Rv ------
MUL_1045|M.ulcerans_Agy99 FAMGAW
MAB_4589c|M.abscessus_ATCC_199 ------