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TSVDRLDGLDLGALDRYLRSLGIGRDGELRGELISGGRSNLTFRVYDDASSWLVRRPPLHGLTPSAHDMA REYRVVAALGDTPVPVARTISLCQDDSVLGAPFQVVEFVAGQVVRRRAELEALGSRSVIEGCVDALIRVL VDLHSIDPKAVGLSDFGKPDGYLERQVRRWGSQWELVRLPDDHRDADISRLHLALQQAIPQQSRTSIVHG DYRIDNTILDTDDPCHVRAVVDWELSTLGDPLSDAALMCVYRDPALDLIVHAQAAWTSPLLPAADELADR YSLVSGQPLGHWEFYMALAYFKLAIIAAGIDYRRRMSEQAEGKDTAAESVPDVVAPLIARGLAEIAKKSG *
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3761c | fadE36 | - | 100% (351) | POSSIBLE ACYL-CoA DEHYDROGENASE FADE36 |
| M. tuberculosis H37Rv | Rv3168 | - | 4e-07 | 28.22% (241) | hypothetical protein Rv3168 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3787c | fadE36 | 0.0 | 100.00% (351) | acyl-CoA dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1204 | - | 1e-127 | 66.28% (341) | aminoglycoside phosphotransferase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4589c | - | 2e-35 | 30.77% (325) | putative phosphotransferase |
| M. marinum M | MMAR_5304 | fadE36 | 1e-175 | 86.49% (348) | acyl-CoA dehydrogenase FadE36 |
| M. avium 104 | MAV_0316 | - | 1e-172 | 84.90% (351) | phosphotransferase enzyme family protein |
| M. smegmatis MC2 155 | MSMEG_6337 | - | 1e-137 | 71.14% (343) | phosphotransferase enzyme family protein |
| M. thermoresistible (build 8) | TH_1657 | fadE36 | 1e-135 | 68.91% (341) | POSSIBLE ACYL-CoA DEHYDROGENASE FADE36 |
| M. ulcerans Agy99 | MUL_4942 | fadE36_1 | 2e-44 | 36.47% (329) | acyl-CoA dehydrogenase FadE36_1 |
| M. vanbaalenii PYR-1 | Mvan_5603 | - | 1e-135 | 69.48% (344) | aminoglycoside phosphotransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3761c|M.tuberculosis_H37Rv ---------MTSVDRLDGLDLGALDRYLRSLG-IGRDGELRGELISGGRS
Mb3787c|M.bovis_AF2122/97 ---------MTSVDRLDGLDLGALDRYLRSLG-IGRDGELRGELISGGRS
MMAR_5304|M.marinum_M ---------MTSVDRLDGLDLAALDGYLRSLG-LGREGELRGELISGGRS
MAV_0316|M.avium_104 ---------MTSADQLEGLDLAALDSYLRSLG-IGRDGELRAEFISGGRS
Mflv_1204|M.gilvum_PYR-GCK ------------MTELEGLDLAALDRHLREVG-VPRSGELRAELIAGGRS
Mvan_5603|M.vanbaalenii_PYR-1 ------------MTELEGLDLAALDRHLCDVG-VPRSGELRAEFISGGRS
TH_1657|M.thermoresistible__bu ----------MAVTSLDGLDLDALDRHLRQVG-VPRSGELRAELIAGGRS
MSMEG_6337|M.smegmatis_MC2_155 ------------MTSLEGLDLDALDRHLRAEG-IARAGDLRAELIAGGRS
MUL_4942|M.ulcerans_Agy99 -----------MSEDIPGVHAHAVSRWLVTLG-HQVAAPLRFQRIGLGQA
MAB_4589c|M.abscessus_ATCC_199 MHKDVSSDSDGPTGDAASLDADAIPTSLSEYLNRELGEQVSVRRLSAGHS
.:. *: * : . :. *::
Rv3761c|M.tuberculosis_H37Rv NLTFRVYDDA-SSWLVRRPPLHGLTPSAHDMAREYRVVAALGDTPVPVAR
Mb3787c|M.bovis_AF2122/97 NLTFRVYDDA-SSWLVRRPPLHGLTPSAHDMAREYRVVAALGDTPVPVAR
MMAR_5304|M.marinum_M NLTFRVYDDA-TSWLVRRPPLHGLTPSAHDMAREYRVVAALQDTPVPVAR
MAV_0316|M.avium_104 NLTFRVYDDA-TSWLVRRPPLHGLTPSAHDMAREYRVVAALQDTPVPVAR
Mflv_1204|M.gilvum_PYR-GCK NLTFLVGDDA-SEWVLRRPPLHGLTPSAHDMAREYKVVAALAGTKVPVAR
Mvan_5603|M.vanbaalenii_PYR-1 NLTFLVFDDA-SKWVLRRPPLHGLTPSAHDMAREYRVVAALADTAVPVAR
TH_1657|M.thermoresistible__bu NLTFLVFDDQ-SRWVLRRPPLHGLTPSAHDMAREYRVVAALADTPVPVAR
MSMEG_6337|M.smegmatis_MC2_155 NLTFLVFDDA-SKWVLRRPPLHGLTPSAHDMAREYRVVAALAGTPVPVAR
MUL_4942|M.ulcerans_Agy99 NLTYRVTDAAGRAWVLRHPPLGHLLASAHDVVREARIMAALAETDVPVPR
MAB_4589c|M.abscessus_ATCC_199 NLTYVVTGSSGTQWILRRPPFGRLQAGAHDVMREYRVLDALSTAQVRVPR
***: * . *::*:**: * ..***: ** ::: ** : * *.*
Rv3761c|M.tuberculosis_H37Rv TISLCQDDSVLGAPFQVVEFVAGQVVRRRAELEALGSRSVIEGCVDALIR
Mb3787c|M.bovis_AF2122/97 TISLCQDDSVLGAPFQVVEFVAGQVVRRRAELEALGSRSVIEGCVDALIR
MMAR_5304|M.marinum_M AIALCEDDTVLGAPFQIVEFVAGQVVRRRAQLEVLGSR-AIDGCVDSLIR
MAV_0316|M.avium_104 TIGLCEDESVLGAPFQIVEFVAGQVVRRRAQLESFSHT-VIEGCVDSLIR
Mflv_1204|M.gilvum_PYR-GCK AVTMSDDDSVLGAPFQMVERVAGLVVRHTPQLAALGDETVISNVVDSLIQ
Mvan_5603|M.vanbaalenii_PYR-1 AVTMRNDDSVLGAPFQMVEYVAGRVVRHTDQLAALGDRATIEKCVDALIK
TH_1657|M.thermoresistible__bu AVTMSNDDSVLGAPFQMVEHVPGLVVRYTDDLKSVGDRDAIEACVDSLIR
MSMEG_6337|M.smegmatis_MC2_155 AVTMRNDDSVLGAPFQMVDHVDGRVVRTAAELAALGDQTVIDNCIDALIK
MUL_4942|M.ulcerans_Agy99 ILGVTTDSEFSEAPLVLMEFVDGLVVDTMEVAEALTPR-QRRQIALSLPR
MAB_4589c|M.abscessus_ATCC_199 VTLASTDAEIFGAPFYLMERQDGEVIRDVSPEWFVGSA--RRELVLDLAV
* . **: ::: * *: . *
Rv3761c|M.tuberculosis_H37Rv VLVDLHSIDPKAVGLSDFGKPDGYLERQVRRWGSQWELVR-LPDDHRDAD
Mb3787c|M.bovis_AF2122/97 VLVDLHSIDPKAVGLSDFGKPDGYLERQVRRWGSQWELVR-LPDDHRDAD
MMAR_5304|M.marinum_M VLVDLHSIDPGAVGLGDFGKPDGYLQRQVRRWGSQWDLVR-LPDDRRDGD
MAV_0316|M.avium_104 VLVDLHSVDPDAVGLADFGKPSGYLERQVRRWGSQWALVR-LPEDRRDAD
Mflv_1204|M.gilvum_PYR-GCK VLADLHEVDPESVGLGDFGKASGYLERQVRRWGSQWDLVK-RDDDPSDAD
Mvan_5603|M.vanbaalenii_PYR-1 VLADLHSVDPDAVGLSDFGKPSGYLERQVRRWGSQWDLVR-RADDPCDAD
TH_1657|M.thermoresistible__bu VLADLHAVDYEAVGLGDFGKPSGYLERQVRRWASQWELVK-HPDDARDGD
MSMEG_6337|M.smegmatis_MC2_155 ALSDLHAVDPYAVGLGDFGKPDGYLERQVRRWGSQWEHVR-LPDDARDDD
MUL_4942|M.ulcerans_Agy99 TLAKIHAVDLAKVGLDDLASHKPYAQRQLKRWAGQWELSK-TRELP---E
MAB_4589c|M.abscessus_ATCC_199 ALAEIHNADPTRLVEAKLGRESGYLARQLKTWGGQWESIKELPTGRDLQD
.* .:* * : .:. . * **:: *..** : :
Rv3761c|M.tuberculosis_H37Rv ISRLHLALQQAIPQQSRTSIVHGDYRIDNTILDTDDPCHVRAVVDWELST
Mb3787c|M.bovis_AF2122/97 ISRLHLALQQAIPQQSRTSIVHGDYRIDNTILDTDDPCHVRAVVDWELST
MMAR_5304|M.marinum_M VARLHSALQQAIPTQSRTSIVHGDYRIDNTILDADDPTRVRAVVDWELST
MAV_0316|M.avium_104 VERLHSGLGQAIPQQSRTSIVHGDYRIDNTILDADDPTKVRAVVDWELST
Mflv_1204|M.gilvum_PYR-GCK VRKLHQRLAESVPEQSRASIVHGDYRIDNTILDADDPTKVAAVLDWEMST
Mvan_5603|M.vanbaalenii_PYR-1 VRRLHERLSAALPPQSRSSIVHGDYRIDNTILDAEDPTKVVAVLDWEMST
TH_1657|M.thermoresistible__bu VKKLHARLEQAVPPQSRTSIVHGDYRIDNTILDADDPTEVVAVLDWEMST
MSMEG_6337|M.smegmatis_MC2_155 VRRLHAALADAVPPQSGTSIVHGDYRIDNTVLDAEDATVVRAVLDWEMST
MUL_4942|M.ulcerans_Agy99 LDDLTRRLVAAAPEQREISLVHGDFHLRN-LITSPETGAVVATLDWELST
MAB_4589c|M.abscessus_ATCC_199 HTTITAWLTENYPGDRPAAVVHGDYKLDNVLVDP-ATARITAVLDWEMAT
: * * : ::****::: * :: . . : *.:***::*
Rv3761c|M.tuberculosis_H37Rv LGDPLSDAALMCVYRDPALDLIVHAQAA---WTSPLLPAADELADRYSLV
Mb3787c|M.bovis_AF2122/97 LGDPLSDAALMCVYRDPALDLIVHAQAA---WTSPLLPAADELADRYSLV
MMAR_5304|M.marinum_M LGDPLSDAALMCVYRDPALDLIVNTQAA---WTSPLLPTADELADRYSLV
MAV_0316|M.avium_104 LGDPLSDAALMCVYRDPALDLIVNAQAA---WTSPLLPTADELADRYSLV
Mflv_1204|M.gilvum_PYR-GCK LGDPLSDAALMCVYRLPAFN-EVHDDAA---WACDLMPPTDDLAQRYALA
Mvan_5603|M.vanbaalenii_PYR-1 LGDPLSDAALMCVYRHPMFN-MVHADAA---WASELIPDADALADKYSRA
TH_1657|M.thermoresistible__bu LGDPLSDAALMCVYRHPTFN-YVHSDAA---WASELIPSADALAEKYSTA
MSMEG_6337|M.smegmatis_MC2_155 LGDPLSDAALMCVYRNPMFG-HIHTDAA---WSSDLVPPADELADRYSKV
MUL_4942|M.ulcerans_Agy99 LGDPLADMGSLLTYWMEPGESGVGDFAP---STLDGFPDRAEMTRLYLEE
MAB_4589c|M.abscessus_ATCC_199 VGDPLADLGYLLYMTPEPGGEVAMSELTGSVTAQEGCPSHTEIAQAYREA
:****:* . : . : * :: *
Rv3761c|M.tuberculosis_H37Rv SGQPLGHWE-----FYMALAYFKLAIIAAGIDYRRRMSEQAEGKDTAAES
Mb3787c|M.bovis_AF2122/97 SGQPLGHWE-----FYMALAYFKLAIIAAGIDYRRRMSEQAEGKDTAAES
MMAR_5304|M.marinum_M SGMSLGHWE-----FYMALAYFKLAIIAAGIDFRRRMSELADGKTDASDE
MAV_0316|M.avium_104 AGIPLAHWE-----FYMALAYFKLAIIAAGIDFRRRMSDQARGLGEAAEH
Mflv_1204|M.gilvum_PYR-GCK SGKPLDHWD-----FYMALGYFKIAIIAAGIAYRARMGGGV---AEGTDE
Mvan_5603|M.vanbaalenii_PYR-1 AGQPLDHWD-----FYMALAYFKLAIIGAGIAYRAREAG-V---VDDTDK
TH_1657|M.thermoresistible__bu AGQDLVHWD-----FYMALAYFKLAIIAAGIDYRARESG-A---GGSTDR
MSMEG_6337|M.smegmatis_MC2_155 SGRDLAHWD-----FYMALAYFKLAIIAAGIDYRRREGA------DGPEQ
MUL_4942|M.ulcerans_Agy99 TGRDPAALQ-----YWHVLGLWKLAIIAEGVMRRAMDEPQNKASEGTPTV
MAB_4589c|M.abscessus_ATCC_199 RSGDQSYWTPEDLVYYQVLGGWKLATLLE-VSYQRHLAGTTDDPFFAELD
. :: .*. :*:* : : :
Rv3761c|M.tuberculosis_H37Rv VPDVVAPLIARGLAEIAKKSG------
Mb3787c|M.bovis_AF2122/97 VPDVVAPLIARGLAEIAKKSG------
MMAR_5304|M.marinum_M APEVVSPLISRGLAEIAKPVS------
MAV_0316|M.avium_104 TPEVVAPLISRGLAELAKLPG------
Mflv_1204|M.gilvum_PYR-GCK VDRAVRPFVAAGLHILS----------
Mvan_5603|M.vanbaalenii_PYR-1 VGEAVAPLIAAGLSQLA----------
TH_1657|M.thermoresistible__bu VGEAVAPLIDAGLRTLRA---------
MSMEG_6337|M.smegmatis_MC2_155 VGEAVAPMIAAGLAALG----------
MUL_4942|M.ulcerans_Agy99 AWIDARVHMAREIADAAGMNQVSDSAF
MAB_4589c|M.abscessus_ATCC_199 EGVPRLLSVARSLIPAAG---------
: :