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MAEILGILTATGQQPLKFTAYDGSTAGHDDAEIGLDLCSPRGATYLATAPGELGIARAYVAGDLQARGVH PGDPYTLLKTLTDRVQFKRPSLRVLASVVRSLGVEHLLPIAPPPQETPPRWRRITDGLLHSKTRDAEAIR HHYDVSNRFYEWVLGPSMTYTCAVYPNAEATLEEAQENKYRLIFEKLRLQPGDRLLDVGCGWGGMVRYAA RRGVRVIGATLSAEQAKWARKAIDNEGLAEIAQVRYSDYRDIRETEFDAVSSIGLTEHIGVKNYPAYFNF LKLKLRTGGLLLNHCITRRDNKSTSFAGGFTDRYVFPDGELTGSGRITTEIQEVGLEVLHEENFRHHYAM TLRDWCHNLVEHWEDAVAEVGLPIAKVWGLYMAASRVAFEQNNLQLHHILATKVDVWGDNSLPTRPWWTP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. leprae Br4923 | MLBr_02334 | - | - | 100% (420) | hypothetical protein MLBr_02334 |
| M. leprae Br4923 | MLBr_02426 | cmaA2 | 5e-30 | 33.09% (272) | cyclopropane mycolic acid synthase |
| M. leprae Br4923 | MLBr_02459 | umaA2 | 1e-27 | 31.82% (242) | Mycolic acid synthase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3747 | - | 0.0 | 86.43% (420) | fatty acid synthase |
| M. gilvum PYR-GCK | Mflv_1283 | - | 0.0 | 72.79% (419) | cyclopropane-fatty-acyl-phospholipid synthase |
| M. tuberculosis H37Rv | Rv3720 | - | 0.0 | 86.43% (420) | fatty acid synthase |
| M. abscessus ATCC 19977 | MAB_0310c | - | 0.0 | 72.86% (420) | putative cyclopropane-fatty-acyl-phospholipid synthase |
| M. marinum M | MMAR_5236 | - | 0.0 | 83.29% (419) | cyclopropane-fatty-acyl-phospholipid synthase |
| M. avium 104 | MAV_0383 | - | 0.0 | 84.05% (420) | cyclopropane-fatty-acyl-phospholipid synthase |
| M. smegmatis MC2 155 | MSMEG_6284 | - | 0.0 | 75.00% (420) | cyclopropane-fatty-acyl-phospholipid synthase |
| M. thermoresistible (build 8) | TH_2292 | - | 0.0 | 73.87% (421) | POSSIBLE FATTY ACID SYNTHASE |
| M. ulcerans Agy99 | MUL_1402 | ufaA1 | 4e-34 | 27.61% (402) | cyclopropane-fatty-acyl-phospholipid synthase UfaA1 |
| M. vanbaalenii PYR-1 | Mvan_5532 | - | 0.0 | 75.24% (420) | cyclopropane-fatty-acyl-phospholipid synthase |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_02334|M.leprae_Br4923 ------------------------MAEILGILTATGQQPLKFTAYDGSTA
MAV_0383|M.avium_104 ---MTTT-----KQPHRSRTGKLSMAEILEVFAATGRHPLKFTAYDGSTA
Mb3747|M.bovis_AF2122/97 ------------------------MAEILEIFTATGQHPLKFTAYDGSTA
Rv3720|M.tuberculosis_H37Rv ------------------------MAEILEIFTATGQHPLKFTAYDGSTA
MMAR_5236|M.marinum_M MTATKEA-----NQPPNANGGRLSIAEVLAIFTATGGQPLKFSAYDGSTA
Mflv_1283|M.gilvum_PYR-GCK MTTFREH----TDSSASDPDRKLTLAEVLEIFAA-GRRPLKFTAYDGSSC
Mvan_5532|M.vanbaalenii_PYR-1 MTTFRDG----AADTGLHGDRKLTLAEVLEVFAS-GRLPLKFTAYDGSSA
MSMEG_6284|M.smegmatis_MC2_155 MTTFKER----ETSTA---DRKLTLAEILEIFAA-GKEPLKFTAYDGSSA
TH_2292|M.thermoresistible__bu MTTFKEHPGFKEHPGRLATDRKLSLAEIFEIVAD-GDLPIRFTAYDGSAA
MAB_0310c|M.abscessus_ATCC_199 MTTTQAK-------NARGENGKLSLAEILELMAA-GDLPLRFSAYDGSTA
MUL_1402|M.ulcerans_Agy99 MSVDTVR-----EPLQERSEVIDSRRWPAVAKPPSGPLSAVAAAIAHRLL
. * . :*
MLBr_02334|M.leprae_Br4923 GHDDAEIGLDLCSPRGATYLATAPGELGIARAYVAGDLQARG--VHPGDP
MAV_0383|M.avium_104 GSEDAELGLDLRSPRGATYLATAPGELGLARAYVAGDLQAYG--VHPGDP
Mb3747|M.bovis_AF2122/97 GQDDATLGLDLRTPRGATYLATAPGELGLARAYVSGDLQAHG--VHPGDP
Rv3720|M.tuberculosis_H37Rv GQDDATLGLDLRTPRGATYLATAPGELGLARAYVSGDLQAHG--VHPGDP
MMAR_5236|M.marinum_M GCNDAELGLELTSPRGTTYLATAPGELGLARAYVSGDLQPHG--VHPGDP
Mflv_1283|M.gilvum_PYR-GCK GPEDATLGLDLLTPRGTTYLATAPGDLGLARAYIAGDLRLSG--VHPGDP
Mvan_5532|M.vanbaalenii_PYR-1 GPDDATLGLDLLTPRGTTYLATAPGDLGLARAYVSGDLQLQG--VHPGDP
MSMEG_6284|M.smegmatis_MC2_155 GPEDATMGLDLKTPRGTTYLATAPGDLGLARAYVSGDLEPHG--VHPGDP
TH_2292|M.thermoresistible__bu GPEDARLGIDLLAPRGTTYLATAPGDLGLARAYVSGDLEPRG--VHPGDP
MAB_0310c|M.abscessus_ATCC_199 GPENAELGLDLLTPRGTTYLATAPGDLGLARAYVSGDIEMQG--VHPGDP
MUL_1402|M.ulcerans_Agy99 RRAVARLPLRLVYPDGTSIGAADGPTIVVHQPAALARRIGRNGLIGFGES
* : : * * *:: *: : : :. . . : *:.
MLBr_02334|M.leprae_Br4923 YTLLKTLTDRVQFKRPSLRVLASVVRSLGVEHLLPIAPPPQETPPRWRRI
MAV_0383|M.avium_104 YRLLKTLTDRVQFKRPPARVLANVVRSIGFERLLPVAPPPQETRPRWRRI
Mb3747|M.bovis_AF2122/97 YELLKTLTERVDFKRPSARVLANVVRSIGVEHILPIAPPPQEARPRWRRM
Rv3720|M.tuberculosis_H37Rv YELLKTLTERVDFKRPSARVLANVVRSIGVEHILPIAPPPQEARPRWRRM
MMAR_5236|M.marinum_M YELLKALTDRVEFKRPSARVLANVVRSIGVEHLLPIAPPPQETPPRWRRM
Mflv_1283|M.gilvum_PYR-GCK HDLLTALTERLEYRRPPVRVLANVLRSIGIEHLKPVAPPPQEHLPRWRRI
Mvan_5532|M.vanbaalenii_PYR-1 YDLLNALVQKLDFKRPSARVLAQVVRSIGIEHLKPIAPPPQEALPRWRRI
MSMEG_6284|M.smegmatis_MC2_155 YPLLRALAERMEFKRPPARVLANIVRSIGIEHLKPIAPPPQEALPRWRRI
TH_2292|M.thermoresistible__bu YELLKTLDQ-VSFRRPPARVLAHIVRSIGFEHLKPIAPPPQEALPRWRRI
MAB_0310c|M.abscessus_ATCC_199 YELLKAMAERLDFKRPPARVLANIVRSIGLEHLRPIAPPPQEALPRWRRM
MUL_1402|M.ulcerans_Agy99 YMAAEWSSNDLAAALTVFAESVAELIPPSLQWLRPIAPAFR---PRWR--
: : : . . : . ..: : *:**. : ****
MLBr_02334|M.leprae_Br4923 TDGLLHSKTRDAEAIRHHYDVSNRFYEWVLGPSMTYTCAVY---PNAEAT
MAV_0383|M.avium_104 ADGLMHTKARDAEAIHHHYDVSNRFYELVLGPSMTYTCAVY---PHPDAT
Mb3747|M.bovis_AF2122/97 ANGLLHSKTRDAEAIHHHYDVSNNFYEWVLGPSMTYTCAVF---PNAEAS
Rv3720|M.tuberculosis_H37Rv ANGLLHSKTRDAEAIHHHYDVSNNFYEWVLGPSMTYTCAVF---PNAEAS
MMAR_5236|M.marinum_M AEGVLHSKTRDAEAIHHHYDVSNTFYEWVLGPSMTYTCAVY---PNEQAT
Mflv_1283|M.gilvum_PYR-GCK AEGLRHSKTRDAEAIQHHYDVSNTFYSWVLGPSMTYTCACY---PHPDAT
Mvan_5532|M.vanbaalenii_PYR-1 AEGLRHSKTRDADAIHHHYDVSNTFYEWVLGPSMTYTCACY---PHPDAT
MSMEG_6284|M.smegmatis_MC2_155 MEGLRHSKTRDAEAIHHHYDVSNTFYEWVLGPSMTYTCACY---PTEDAT
TH_2292|M.thermoresistible__bu AEGLRHSKTRDAEAIHHHYDVSNTFYRYVLGPSMTYTCACY---PDADAS
MAB_0310c|M.abscessus_ATCC_199 VEGFRHSKTRDSEAIHHHYDVSNTFYEWVLGPSMTYTCACY---PDAEAT
MUL_1402|M.ulcerans_Agy99 ----DPSRDEARRNIAEHYDLSNELFAQFLDDTMTYSSALFDQLPAAWPD
:: . * .***:** :: .*. :***:.* : * .
MLBr_02334|M.leprae_Br4923 LEEAQENKYRLIFEKLRLQPGDRLLDVGCGWGGMVRYAARRGVRVIGATL
MAV_0383|M.avium_104 LEEAQENKYRLIFDKLRLAPGDRLLDVGCGWGGMVRYAARRGVRAIGATL
Mb3747|M.bovis_AF2122/97 LEQAQENKYRLIFEKLRLEPGDRLLDVGCGWGGMVRYAARRGVRVIGATL
Rv3720|M.tuberculosis_H37Rv LEQAQENKYRLIFEKLRLEPGDRLLDVGCGWGGMVRYAARRGVRVIGATL
MMAR_5236|M.marinum_M LEEAQENKYRLVFEKLRLRPGDRLLDVGCGWGGMVRYAARHGVRVIGATL
Mflv_1283|M.gilvum_PYR-GCK LEEAQENKYRLVFEKLRLKPGDRLLDVGCGWGGMVRYAARHGVKVLGVTL
Mvan_5532|M.vanbaalenii_PYR-1 LEEAQENKYRLVFEKLRLKPGDRLLDVGCGWGGMVRYAARHGVKAIGVTL
MSMEG_6284|M.smegmatis_MC2_155 LEEAQDNKYRLVFEKLRLKPGDRLLDVGCGWGGMVRYAARHGVKALGVTL
TH_2292|M.thermoresistible__bu LEEAQENKYRLVFEKLRLQPGDRLLDVGCGWGGMVRYAARHGVNAIGVTL
MAB_0310c|M.abscessus_ATCC_199 LEEAQENKYRLVFDKLALKAGDRLLDVGCGWGSMVRYAARRGVRATGVTL
MUL_1402|M.ulcerans_Agy99 LAAAQRRKIDRLLDMAEVRDGSRVLEIGTGWGELCIRAASRGAQVRSITL
* ** .* ::: : *.*:*::* *** : ** :*... . **
MLBr_02334|M.leprae_Br4923 SAEQAKWARKAIDNEGLAEIAQVRYSDYRDIRE--TEFDAVSSIGLTEHI
MAV_0383|M.avium_104 SAEQAKWAQRRIDDEGLGDLAQVRHSDYRDVAE--TGFDAVSSIGLTEHI
Mb3747|M.bovis_AF2122/97 SAEQAKWGQKAVEDEGLSDLAQVRHSDYRDVAE--TGFDAVSSIGLTEHI
Rv3720|M.tuberculosis_H37Rv SAEQAKWGQKAVEDEGLSDLAQVRHSDYRDVAE--TGFDAVSSIGLTEHI
MMAR_5236|M.marinum_M SAEQATWAQQKISDEGLAQLAEVRHCDYRDVVE--TGFDAVSSIGMTEHI
Mflv_1283|M.gilvum_PYR-GCK SKEQAQWAADAVERDGLGELAEVRHGDYRDVRE--SHFDAVSSLGLTEHI
Mvan_5532|M.vanbaalenii_PYR-1 SREQAQWARAAIERDGLGDLAEVRHSDYRDVRE--SQFDAVSSLGLTEHI
MSMEG_6284|M.smegmatis_MC2_155 SREQATWAQKAIAQEGLTDLAEVRHGDYRDVIE--SGFDAVSSIGLTEHI
TH_2292|M.thermoresistible__bu SREQALWGQKAIAEEGLGQHAEIRHGDYRDVVE--TGFDAVSSLGLTEHV
MAB_0310c|M.abscessus_ATCC_199 SAEQAAWAQKAIADEGLADLAEVRHADYRDTTE--REFDAVSSIGLTEHI
MUL_1402|M.ulcerans_Agy99 SVEQQRLARRRVAEASLSHLVQIDLCDYRDVGSEGAAYDSVLSVEMIEAI
* ** . : .* . .:: **** . :*:* *: : * :
MLBr_02334|M.leprae_Br4923 GVKNYPAYFNFLKLKLRTGGLLLNHCITRRDNKSTSFAG--GFTDRYVFP
MAV_0383|M.avium_104 GVKNYPAYFGFLKSKLRTGGLLLNHCITRHDNTSTSFAG--GFTDRYVFP
Mb3747|M.bovis_AF2122/97 GVKNYPFYFGFLKSKLRTGGLLLNHCITRHDNRSTSFAG--GFTDRYVFP
Rv3720|M.tuberculosis_H37Rv GVKNYPFYFGFLKSKLRTGGLLLNHCITRHDNRSTSFAG--GFTDRYVFP
MMAR_5236|M.marinum_M GVRNYPAYFGLLKSKLRTGGLLLNHCITRHDNKSTSFAG--GFTDRYVFP
Mflv_1283|M.gilvum_PYR-GCK GVANYPSYFRFLKSKLRPGGLLLNHCITRNNNRSHATAG--GFIDRYVFP
Mvan_5532|M.vanbaalenii_PYR-1 GVANYPSYFRFLKSKLRPGGLLLNHCITRHNNRTGPAAG--GFIDRYVFP
MSMEG_6284|M.smegmatis_MC2_155 GVHNYPAYFNFLKSKLRTGGLLLNHCITRPDNRSAPSAG--GFIDRYVFP
TH_2292|M.thermoresistible__bu GVQNYPAYFRFLQSKLRPGGLLLNHCITRPDNRSAATAG--DFIDRYVFP
MAB_0310c|M.abscessus_ATCC_199 GIANYPAYFRFLQSRLKTGGLLLNHCITRPDNRTSAVAG--YFIDRYVFP
MUL_1402|M.ulcerans_Agy99 GYHSWPKYFAALQRLVRPGGKVAIQAITMPHDRMLTSRNTLTWVQKYIFP
* .:* ** *: ::.** : :.** .: . . : ::*:**
MLBr_02334|M.leprae_Br4923 DGELTGSGRITTEIQ-EVGLEVLHEENFRHHYAMTLRDWCHNLVEH-WED
MAV_0383|M.avium_104 DGELTGSGRITCAIQ-DVGFEVLHGENFRHHYAMTLRDWCRNLVEH-WDA
Mb3747|M.bovis_AF2122/97 DGELTGSGRITTEIQ-QVGLEVLHEENFRHHYAMTLRDWCGNLVEH-WDD
Rv3720|M.tuberculosis_H37Rv DGELTGSGRITTEIQ-QVGLEVLHEENFRHHYAMTLRDWCGNLVEH-WDD
MMAR_5236|M.marinum_M DGELTGSGRIITEIQ-EVGFEVLHEENLRQHYALTLRDWCHNLVKH-WDV
Mflv_1283|M.gilvum_PYR-GCK DGELTGSGRIITEMQ-DVGLEVVHEENLRHHYALTLRDWSRNLVAH-WDD
Mvan_5532|M.vanbaalenii_PYR-1 DGELTGSGRIITEIQ-DVGLEVMHEENLRRHYALTLRDWCRNLVQH-WDE
MSMEG_6284|M.smegmatis_MC2_155 DGELTGSGRIITEAQ-DVGLEVIHEENLRNHYAMTLRDWCRNLVEH-WDE
TH_2292|M.thermoresistible__bu DGELTGSGRIITEAQ-NVGLEVLHEENLRHHYALTLRDWCRNLVEN-WDE
MAB_0310c|M.abscessus_ATCC_199 DGELTGSGRIITEIQ-NVGLEVLHEENLRHHYALTLKEWCANLVEH-WDE
MUL_1402|M.ulcerans_Agy99 GGLLPSTQAIADITERHTALRTIDTASLRPHYAQTLRLWRERFLQRQGEL
.* *..: * : ...:..:. .:* *** **: * .:: . :
MLBr_02334|M.leprae_Br4923 AVAEVGLPIAKVWGLYMAASRVAFEQNNLQLHHILATKVDVWGDNS-LPT
MAV_0383|M.avium_104 AVDEVGLPTAKVWGLYMAASRVAFEQNNLQLHHVLAANVDARGDDD-LPL
Mb3747|M.bovis_AF2122/97 AVAEVGLPTAKVWGLYMAASRVAFERNNLQLHHVLATKVDPRGDDS-LPL
Rv3720|M.tuberculosis_H37Rv AVAEVGLPTAKVWGLYMAASRVAFERNNLQLHHVLATKVDPRGDDS-LPL
MMAR_5236|M.marinum_M AVAEVGLPIAKVWGLYMAASRVAFERNNLQLHHVLAANVDTWGEDD-LPL
Mflv_1283|M.gilvum_PYR-GCK AVTEVGLPTAKVWGLYIAASRVGFEQNAIQLHQVLSVKLDERGSDGGLPL
Mvan_5532|M.vanbaalenii_PYR-1 AVAEVGLPTAKVWGLYMAASRVGFEQNSIQLHQVLAVKLDERGGDGGLPL
MSMEG_6284|M.smegmatis_MC2_155 AVEEVGLPTAKVWGLYMAGSRLGFETNVVQLHQVLAVKLDDQGKDGGLPL
TH_2292|M.thermoresistible__bu AVAEVGLPTAKVWGLYMAGSRLGFETNVVQLHQVLAVKLDESGNDGGLPL
MAB_0310c|M.abscessus_ATCC_199 AVAEVGEATAKVWGLYMAGSRLGFERNVVQLHQVLATKLDERGGSE-LPL
MUL_1402|M.ulcerans_Agy99 AQLGFDDVFKRMWELYLAYSEAGFRSGYLDVYQWTFEREDGR--------
* .. ::* **:* *. .*. . ::::: . *
MLBr_02334|M.leprae_Br4923 RPWWTP
MAV_0383|M.avium_104 RPWWSP
Mb3747|M.bovis_AF2122/97 RPWWQP
Rv3720|M.tuberculosis_H37Rv RPWWQP
MMAR_5236|M.marinum_M RPWWTA
Mflv_1283|M.gilvum_PYR-GCK RPWWNA
Mvan_5532|M.vanbaalenii_PYR-1 RPWWTA
MSMEG_6284|M.smegmatis_MC2_155 RPWWSA
TH_2292|M.thermoresistible__bu RPWWTP
MAB_0310c|M.abscessus_ATCC_199 RPWWQP
MUL_1402|M.ulcerans_Agy99 ------