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QATTVQTPAGAWMTTTDKPPPKRTRRTEPITRRNAKNGAVSYTFQVDVGTHADGTRDRQRFTFSTFAEAR REYRKISTEVAAGTFVKRDLTTVAEYLARWLDGRRDVRVNTLAGYRHSLKPVIDNLGGLGLQQLRTSDID ALVTLRLNGTPISQRERRGRRAAEVLAYLRSRSGGAQYADVRDELGNPGVKALDRLVASGEVIRPSRGRY VAVRDSDPVQSKIPGNVSSRTVVTMLVVLSSALDDAMREGLVARNVARLVKRPAVEHHEMATWTAEQAVR FREHVRGDRLAACWLLTLAGLRRSEVLGLRWSDVDLDGGTVTIAQGRVVAEGQGTITGDPKSKRSRRALP MPAEVLAALRAFRLRQSEERLAIGSEYPDTGLVAVNVIGLPIRPETYSGEFMRHAKDAGVPLIRLHDVRH TAATMLLDRGTTPSATAKWLGHDPAITLRVYGHVYDGALAAAGDTLLRGH*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2786 | - | - | 100% (471) | phage integrase family protein |
| M. gilvum PYR-GCK | Mflv_1985 | - | 1e-12 | 29.76% (336) | phage integrase family protein |
| M. gilvum PYR-GCK | Mflv_3500 | xerD | 5e-08 | 25.38% (260) | site-specific tyrosine recombinase XerD |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1727 | xerD | 3e-07 | 23.81% (252) | site-specific tyrosine recombinase XerD |
| M. tuberculosis H37Rv | Rv2659c | - | 3e-09 | 28.07% (171) | phiRv2 prophage integrase |
| M. leprae Br4923 | MLBr_01365 | xerD | 7e-09 | 24.60% (252) | site-specific tyrosine recombinase XerD |
| M. abscessus ATCC 19977 | MAB_1723 | - | 3e-15 | 27.27% (231) | putative phage integrase |
| M. marinum M | MMAR_4848 | - | 9e-17 | 29.33% (225) | prophage integrase |
| M. avium 104 | MAV_0253 | - | 1e-51 | 32.54% (418) | site-specific recombinase, phage integrase family protein |
| M. smegmatis MC2 155 | MSMEG_5754 | - | 7e-49 | 31.98% (419) | gp41 protein |
| M. thermoresistible (build 8) | TH_1542 | xerD | 2e-08 | 25.77% (260) | tyrosine recombinase XerD |
| M. ulcerans Agy99 | MUL_0529 | - | 6e-15 | 26.53% (245) | prophage integrase |
| M. vanbaalenii PYR-1 | Mvan_3747 | - | 0.0 | 99.36% (471) | phage integrase family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2786|M.gilvum_PYR-GCK ---------MQATTVQTPAGAWMTTTDKPPPKRTRRTEPITRRNAKNGAV
Mvan_3747|M.vanbaalenii_PYR-1 ---------MQATTVQTPAGAWMTTTDKPPPKRTRRTEPIMRRNAKNGAV
MAV_0253|M.avium_104 ---------------------------------MAKIPDYVKALDLDSGR
MSMEG_5754|M.smegmatis_MC2_155 -----------------------------MLQRMARIPDYVKVIDLDSGR
MMAR_4848|M.marinum_M -------------------------------MAGSVPRGIRKRTNSAGQA
MUL_0529|M.ulcerans_Agy99 -------------------------------MAGNTPRGIRKRLNAAGEP
Mb1727|M.bovis_AF2122/97 ------------------------------------------------MK
TH_1542|M.thermoresistible__bu --------------------------------VTTSEQVPRSDEPPHPHR
MLBr_01365|M.leprae_Br4923 ----------------------------------------------MTTA
Rv2659c|M.tuberculosis_H37Rv ---------------------------------MTQTGKRQRRKFGRIRQ
MAB_1723|M.abscessus_ATCC_1997 MEQTERVKKRPACKCKHVYFAHPNEGPCNQCGDCPKYRERERRERGEGGL
Mflv_2786|M.gilvum_PYR-GCK SYTFQ----VDVG-THADGTRDRQRFTFSTFAEARREYRKISTEVA----
Mvan_3747|M.vanbaalenii_PYR-1 SYTFQ----VDVG-THADGTRDRQRFTFSTFAEARREYRKISTEVA----
MAV_0253|M.avium_104 RYEVR----PEV--TGPDGKRKQQRKRFKTLKEATDFYTRIAGDRS----
MSMEG_5754|M.smegmatis_MC2_155 RYEVR----PEV--TGADGKRRQKRERFKTLKEAVDHYTAIAGDRG----
MMAR_4848|M.marinum_M RYQVR----YLVRDPNSPSGWVETSSTFATMREARAFKADRDGEAA----
MUL_0529|M.ulcerans_Agy99 RYQVR----YLIRDPDAPSGWVETSATFPTLREAKAFKSERDNEAA----
Mb1727|M.bovis_AF2122/97 TLALQ----LQGYLDHLTIERGVAANTLSSYRRDLRRYSKHLEERG----
TH_1542|M.thermoresistible__bu VLDDQ----IQGYLDHLSIERGVAANTLSSYRRDLRRYAEHLLARG----
MLBr_01365|M.leprae_Br4923 ALQTQ----LQGYLDYLIIERSIAANTLSSYRRDLIRYSKHLSDRG----
Rv2659c|M.tuberculosis_H37Rv FNSGR----WQASYTGPDGRVYIAPKTFNAKIDAEAWLTDRRREIDRQLW
MAB_1723|M.abscessus_ATCC_1997 FQRADGMWVGSVEVPSEDGLRRRQTVSAKDKGVALDKLRDLRSAIR----
Mflv_2786|M.gilvum_PYR-GCK --AGTFVKRDLTTVAEYLARWLD----GRRDVRVNTLAGYRHSLKP-VID
Mvan_3747|M.vanbaalenii_PYR-1 --AGTFVKRDLTTVAEYLGRWLD----GRRDVRVNTLAGYRHSLKP-VID
MAV_0253|M.avium_104 --RGVHVAPSELTVEAAVDAWLA----AQR-VRTKAMTGYVTALRP-LVD
MSMEG_5754|M.smegmatis_MC2_155 --RGVHVAPSELTVEDAVDSWLL----GQR-IRPKTMSAYITSLRP-IVD
MMAR_4848|M.marinum_M --IGARRFDPRLGRASLSAIWTQYSASKQPAVSPKTWSGYAQHWELRISP
MUL_0529|M.ulcerans_Agy99 --LGARRFDPRLGRTPLSRIWTQFSDSKKPAVSPKTWSGYNQHWELRIKP
Mb1727|M.bovis_AF2122/97 --ITDLAKVGEHDVSEFLVALRR----GDPDSGTAALSAVSAARALIAVR
TH_1542|M.thermoresistible__bu --IDDLAKVHESDVADFLVALRR----GDPDTGAAGLSAVSAARALIAVR
MLBr_01365|M.leprae_Br4923 --IEDLAKVGEHDVSEFLVALRR----GDPDSGVAALSAVSAARALIAVR
Rv2659c|M.tuberculosis_H37Rv SPASGQEDRPGAPFGEYAEGWLK-----QRGIKDRTRAHYRKLLDNHILA
MAB_1723|M.abscessus_ATCC_1997 --SGKSPTSSKVHLEQWLNHWLET--IQKPRVRPTTYKYYETTVRLYILP
Mflv_2786|M.gilvum_PYR-GCK NLGGLGLQQ-LRTSDIDALVTLRLNGTPISQRERRGRRAAEVLAYLRSRS
Mvan_3747|M.vanbaalenii_PYR-1 NLGGLGLQQ-LRTSDIDALVTLRLNGTPISQRERRGRRAAEVLAYLRSRS
MAV_0253|M.avium_104 HLGGKAVQA-VTKADIEKVVAALRGGT-----------------------
MSMEG_5754|M.smegmatis_MC2_155 HLGKRTVQS-ITKDDLEQVVQALRAGT-----------------------
MMAR_4848|M.marinum_M RFGHVPVDE-ISRKDVQQFIGGLTVGP-----------------------
MUL_0529|M.ulcerans_Agy99 RFGHVPVDE-ITRADVRAFVDGLTVGP-----------------------
Mb1727|M.bovis_AF2122/97 GLHRFAAAEGLAELDVARAVRPPTPSR-----------------------
TH_1542|M.thermoresistible__bu GLHRFAAAEGVTELDVARSVKPPTPSR-----------------------
MLBr_01365|M.leprae_Br4923 GLHRFAVAEGLVDLDVARAVRPPTPGR-----------------------
Rv2659c|M.tuberculosis_H37Rv TFADTDLRD-ITPAAVRRWYATTAVGTP----------------------
MAB_1723|M.abscessus_ATCC_1997 FIDGRTQLGKLTPAQVRKMIAKNGTRN-----------------------
: : :
Mflv_2786|M.gilvum_PYR-GCK GGAQYADVRDELGNPGVKALDRLVASGEVIRPSRGRYVAVRDSDPVQSKI
Mvan_3747|M.vanbaalenii_PYR-1 GGAQYADVRDELGNPGVKALDRLVASGEVIRPSRGRYVAVRDSDPVQSKI
MAV_0253|M.avium_104 -------------------------------SKMGTWNAPEKIK--GKQV
MSMEG_5754|M.smegmatis_MC2_155 -------------------------------SKMGTWNAPTKLTKAAKKV
MMAR_4848|M.marinum_M --------------------------------------------------
MUL_0529|M.ulcerans_Agy99 --------------------------------------------------
Mb1727|M.bovis_AF2122/97 --------------------------------------------------
TH_1542|M.thermoresistible__bu --------------------------------------------------
MLBr_01365|M.leprae_Br4923 --------------------------------------------------
Rv2659c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1723|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2786|M.gilvum_PYR-GCK PGNVSSRTVVTMLVVLSSALDDAMREGLVARNVARLVKRPA-VEHHEMAT
Mvan_3747|M.vanbaalenii_PYR-1 PGNVSSRTVVTMLVVLSSALDDAMREGLVARNVARLVKRPA-VEHHEMAT
MAV_0253|M.avium_104 RAKWGPSGTNHFIRRSRAVFEDLVQQGVLGRNPAALVQPVP-MARAELNT
MSMEG_5754|M.smegmatis_MC2_155 RSPWAASSINPMLARTRSIFEDLVNQGVVVRNVAALVKPLATDTEKTMNT
MMAR_4848|M.marinum_M ------WAKLATLRLLRSILDMAREDGRIHINPAQGVSSGR-IPARERHR
MUL_0529|M.ulcerans_Agy99 ------WAKVSTLRLLRSILDVAHQDGRIHRNPALGVSAGR-IPERERHR
Mb1727|M.bovis_AF2122/97 --------RLPKSLTIDEVLSLLEGAGGDKPSDGPLTLRNR---------
TH_1542|M.thermoresistible__bu --------RLPKSLTVDEVLALLAGAGGDSESDGPLTLRNR---------
MLBr_01365|M.leprae_Br4923 --------RLPKSLTVDEVLALLESVGGESRADGPLVLRNR---------
Rv2659c|M.tuberculosis_H37Rv ------TMRAHSYSLLRAIMQTALADDLIDSNPCRISGASTARRVHKIRP
MAB_1723|M.abscessus_ATCC_1997 --------AQKAHQTLVKALGDAMDEGMLDKNVAAVVDKPK-HVAIERQP
: .
Mflv_2786|M.gilvum_PYR-GCK WTAEQAVRFREHVR---GDRLAACWLLTLAGLRRSEVLGLRWSDVDLDGG
Mvan_3747|M.vanbaalenii_PYR-1 WTAEQAVRFREHVR---GDRLAACWLLTLAGLRRSEVLGLRWSDVDLDGG
MAV_0253|M.avium_104 LTAAQAERLLAATR---NDVFAAAWRLALMGLRRGEILGLSWDSVDLDAG
MSMEG_5754|M.smegmatis_MC2_155 LNAEQVTQLLAVTD---SHCYGIAWRLAVLGLRRGEILALRWDAVDFDAG
MMAR_4848|M.marinum_M YLSATEVAALAHAC---GDQGDIVTILAFTGLRWSELVGLRVGDIDLKAR
MUL_0529|M.ulcerans_Agy99 YLTAQEVRMLATAC---GDQGDVVTILAYTGLRWSEPVGLRVKDIDLTAR
Mb1727|M.bovis_AF2122/97 ---------------------AVLELLYSTGARISEAVGLDLDDIDTHAR
TH_1542|M.thermoresistible__bu ---------------------ALLELLYSTGARISEAVGLDIDDVDTVAR
MLBr_01365|M.leprae_Br4923 ---------------------ALLELLYSTGSRISEAVGLDVDDVDTQAR
Rv2659c|M.tuberculosis_H37Rv ATLDELETITKAMP---DPYQAFVLMAAWLAMRYGELTELRRKDIDLHGE
MAB_1723|M.abscessus_ATCC_1997 FTFDEARQIIATAIKRNDPWATMWAAMFFTGARQGEIIGMEWDRCDLEKG
. * .* : *
Mflv_2786|M.gilvum_PYR-GCK TVTIAQGRVVAE------------GQGTITGDPKSKRSRRALPMPAEVLA
Mvan_3747|M.vanbaalenii_PYR-1 TVTIAQGRVVAE------------GQGTITGDPKSKRSRRALPMPAEVLA
MAV_0253|M.avium_104 LLTVRANRAPVP------------G-GVEVGSPKTAAGLRTLPMPAELTV
MSMEG_5754|M.smegmatis_MC2_155 TLAISAARLATA------------G-GATTGAPKTKTSVRTLPMPEDLTA
MMAR_4848|M.marinum_M RLYVRQAAPDVE------------G-RIIVGPPKTRAAVRTVPLPRIVID
MUL_0529|M.ulcerans_Agy99 RLYVRRAAPEVE------------G-HIVIGPPKTRAGIRTVPLPQVVVD
Mb1727|M.bovis_AF2122/97 SVLLRG----------------------------KGGKQRLVPVGRPAVH
TH_1542|M.thermoresistible__bu SVLLRG----------------------------KGGKQRLVPIGRPAVS
MLBr_01365|M.leprae_Br4923 TVLLQG----------------------------KGGKQRLVPVGRPAVQ
Rv2659c|M.tuberculosis_H37Rv VARVRRAVVR-V------------GEGFKVTTPKSDAGVRDISIPPHLIP
MAB_1723|M.abscessus_ATCC_1997 LFDFSWQLQQLPPELPRGFKHRPCHLSLAWTKPKTKAGARVAPMTKPLQA
. . * .:
Mflv_2786|M.gilvum_PYR-GCK ALRAFRLRQSEERLAIGSEYPDTGLVAVNVIGLPIRPETYSGEFMRHAKD
Mvan_3747|M.vanbaalenii_PYR-1 ALRVFRLRQSEERLAIGSEYPDTGLVAVNVIGLPIRPETYSGEFMRHAKD
MAV_0253|M.avium_104 AMKQARKQQRERRLALGSKWVESGLVVVGEDGAPPHPDTLSHVWAETIAA
MSMEG_5754|M.smegmatis_MC2_155 ALRRVRKRQKEYRLKLGSKWTDSGYVVVDEFGVAPYPDTLTAAWRKTLAN
MMAR_4848|M.marinum_M ALKPRIENRSTKEQAITS--PNGGFLRSNNWRRHTH-------WNKALKK
MUL_0529|M.ulcerans_Agy99 IFKGRITGQAPDQPAVTS--TNGAMLRSNNWRRHTH-------WNKALKS
Mb1727|M.bovis_AF2122/97 ALDAYLVRGRPDLARRGRG---TAAIFLNARGGRLSRQSAWQVLQDAAER
TH_1542|M.thermoresistible__bu ALDAYLVRGRPELVRRGRG---TPAIFLNARGGRLSRQSAWQVLQDAAER
MLBr_01365|M.leprae_Br4923 ALDAYLVRGRSDLARRGPGMLATPAIFLNARGGRLSRQSAWQVLQDAAEH
Rv2659c|M.tuberculosis_H37Rv AIEDHLHKHVNPGR------ESLLFPSVNDPNRHLAPSALYRMFYKARKA
MAB_1723|M.abscessus_ATCC_1997 IMEAYAKTDTGPNP--------HGLVWRHPDGHPISPTDASDAWRALVKA
:
Mflv_2786|M.gilvum_PYR-GCK AGVPL-IRLHDVRHTAATMLLDRGTTPSATAKWLGH-DPAITLRVYGHVY
Mvan_3747|M.vanbaalenii_PYR-1 AGVPL-IRLHDVRHTAATMLLDRGTTPSATAKWLGH-DPAITLRVYGHVY
MAV_0253|M.avium_104 HKLPA-VRLHDARHTCATLMHQDGVPLAVISAWLGHTNAAFTLATYGHSS
MSMEG_5754|M.smegmatis_MC2_155 AGLPH-VRLHDARHSCATLMHLSGVPTVVIAAWLGHQDPGFTLRTYAHSN
MMAR_4848|M.marinum_M TGLAP-LTIHDLRHTYASLARKSGADLRYVQKTMGHSTPTVTANIYSDLY
MUL_0529|M.ulcerans_Agy99 TDLAP-LTIHDLRHTYASLARKSGADLRYVQKTMGHSTPTVTANIYSDLY
Mb1727|M.bovis_AF2122/97 AGITAGVSPHMLRHSFATHLLEGGADVRVVQELLGH-ASVTTTQIYTLVT
TH_1542|M.thermoresistible__bu AGIKAGVSPHTLRHSFATHLLDGGADVRVVQELLGH-ASVTTTQIYTMVT
MLBr_01365|M.leprae_Br4923 AGITSGVSPHMLRHSFATHLLEGGADIRVVQELMGH-ASVTTTQIYTLVT
Rv2659c|M.tuberculosis_H37Rv AGRPD-LRVHDLRHSGAVLAASTGATLAELMQRLGHSTAGAALR-YQHAA
MAB_1723|M.abscessus_ATCC_1997 ADVPY-RSMHSARHTTATLLNNAGVSQETRMKVVGH-SSAVAQQIYVHVD
* **: * *. :** . : *
Mflv_2786|M.gilvum_PYR-GCK DGALAAAGDTLLRGH----------------------
Mvan_3747|M.vanbaalenii_PYR-1 DGALAAAGDTLLRGH----------------------
MAV_0253|M.avium_104 DDSLAAAAQRLDALTGGKATPAEAK------------
MSMEG_5754|M.smegmatis_MC2_155 HDALADAAAMLGSITTGKKK--EAK------------
MMAR_4848|M.marinum_M SDELDHVATNLDRLNDVAKDQAN-GQEPDTPKHP---
MUL_0529|M.ulcerans_Agy99 ADELDQVATNLDQLHATEIQTPTTGQEPDEPNQPSSA
Mb1727|M.bovis_AF2122/97 VHALREVWAGAHPRAR---------------------
TH_1542|M.thermoresistible__bu VHALREVWAGAHPRAR---------------------
MLBr_01365|M.leprae_Br4923 VQALREVWAGAHPRAK---------------------
Rv2659c|M.tuberculosis_H37Rv KGRDREIAALLSKLAENQEM-----------------
MAB_1723|M.abscessus_ATCC_1997 HEPARAALSNLNELLS---------------------