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AKIPDYVKALDLDSGRRYEVRPEVTGPDGKRKQQRKRFKTLKEATDFYTRIAGDRSRGVHVAPSELTVEA AVDAWLAAQRVRTKAMTGYVTALRPLVDHLGGKAVQAVTKADIEKVVAALRGGTSKMGTWNAPEKIKGKQ VRAKWGPSGTNHFIRRSRAVFEDLVQQGVLGRNPAALVQPVPMARAELNTLTAAQAERLLAATRNDVFAA AWRLALMGLRRGEILGLSWDSVDLDAGLLTVRANRAPVPGGVEVGSPKTAAGLRTLPMPAELTVAMKQAR KQQRERRLALGSKWVESGLVVVGEDGAPPHPDTLSHVWAETIAAHKLPAVRLHDARHTCATLMHQDGVPL AVISAWLGHTNAAFTLATYGHSSDDSLAAAAQRLDALTGGKATPAEAK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0253 | - | - | 100% (399) | site-specific recombinase, phage integrase family protein |
| M. avium 104 | MAV_0698 | - | 2e-69 | 41.33% (375) | site-specific recombinase, phage integrase family protein |
| M. avium 104 | MAV_2217 | - | 8e-16 | 23.02% (378) | traSA:integrase fusion protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2335c | - | 9e-05 | 42.86% (49) | hypothetical protein Mb2335c |
| M. gilvum PYR-GCK | Mflv_2786 | - | 1e-51 | 32.54% (418) | phage integrase family protein |
| M. tuberculosis H37Rv | Rv2659c | - | 2e-10 | 27.78% (234) | phiRv2 prophage integrase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1723 | - | 4e-23 | 27.32% (388) | putative phage integrase |
| M. marinum M | MMAR_4848 | - | 2e-17 | 24.27% (379) | prophage integrase |
| M. smegmatis MC2 155 | MSMEG_5754 | - | 1e-138 | 60.50% (400) | gp41 protein |
| M. thermoresistible (build 8) | TH_0846 | xerC | 2e-07 | 29.82% (228) | PROBABLE INTEGRASE/RECOMBINASE XERC |
| M. ulcerans Agy99 | MUL_0529 | - | 2e-20 | 25.58% (391) | prophage integrase |
| M. vanbaalenii PYR-1 | Mvan_3747 | - | 1e-51 | 32.54% (418) | phage integrase family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_0253|M.avium_104 ---------------------------------MAKIPDYVKALDLDSGR
MSMEG_5754|M.smegmatis_MC2_155 -----------------------------MLQRMARIPDYVKVIDLDSGR
Mflv_2786|M.gilvum_PYR-GCK ---------MQATTVQTPAGAWMTTTDKPPPKRTRRTEPITRRNAKNGAV
Mvan_3747|M.vanbaalenii_PYR-1 ---------MQATTVQTPAGAWMTTTDKPPPKRTRRTEPIMRRNAKNGAV
MMAR_4848|M.marinum_M -------------------------------MAGSVPRGIRKRTNSAGQA
MUL_0529|M.ulcerans_Agy99 -------------------------------MAGNTPRGIRKRLNAAGEP
Mb2335c|M.bovis_AF2122/97 --------------------------------------------------
Rv2659c|M.tuberculosis_H37Rv ---------------------------------MTQTGKRQRRKFGRIRQ
MAB_1723|M.abscessus_ATCC_1997 MEQTERVKKRPACKCKHVYFAHPNEGPCNQCGDCPKYRERERRERGEGGL
TH_0846|M.thermoresistible__bu --------------------------------------------------
MAV_0253|M.avium_104 RYEVR----PEV--TGPDGKRKQQRKRFKTLKEATDFYTRIAGDRS----
MSMEG_5754|M.smegmatis_MC2_155 RYEVR----PEV--TGADGKRRQKRERFKTLKEAVDHYTAIAGDRG----
Mflv_2786|M.gilvum_PYR-GCK SYTFQ----VDVG-THADGTRDRQRFTFSTFAEARREYRKISTEVA----
Mvan_3747|M.vanbaalenii_PYR-1 SYTFQ----VDVG-THADGTRDRQRFTFSTFAEARREYRKISTEVA----
MMAR_4848|M.marinum_M RYQVR----YLVRDPNSPSGWVETSSTFATMREARAFKADRDGEAA----
MUL_0529|M.ulcerans_Agy99 RYQVR----YLIRDPDAPSGWVETSATFPTLREAKAFKSERDNEAA----
Mb2335c|M.bovis_AF2122/97 --------------------------------------------------
Rv2659c|M.tuberculosis_H37Rv FNSGR----WQASYTGPDGRVYIAPKTFNAKIDAEAWLTDRRREIDRQLW
MAB_1723|M.abscessus_ATCC_1997 FQRADGMWVGSVEVPSEDGLRRRQTVSAKDKGVALDKLRDLRSAIR----
TH_0846|M.thermoresistible__bu -------------------------MSVDTVLDEFADYLALQRGRS----
MAV_0253|M.avium_104 --RGVHVAPSELTVEAAVDAWLA----AQR-VRTKAMTGYVTALRP-LVD
MSMEG_5754|M.smegmatis_MC2_155 --RGVHVAPSELTVEDAVDSWLL----GQR-IRPKTMSAYITSLRP-IVD
Mflv_2786|M.gilvum_PYR-GCK --AGTFVKRDLTTVAEYLARWLD----GRRDVRVNTLAGYRHSLKP-VID
Mvan_3747|M.vanbaalenii_PYR-1 --AGTFVKRDLTTVAEYLGRWLD----GRRDVRVNTLAGYRHSLKP-VID
MMAR_4848|M.marinum_M --IGARRFDPRLGRASLSAIWTQYSASKQPAVSPKTWSGYAQHWELRISP
MUL_0529|M.ulcerans_Agy99 --LGARRFDPRLGRTPLSRIWTQFSDSKKPAVSPKTWSGYNQHWELRIKP
Mb2335c|M.bovis_AF2122/97 --------------------------------------------------
Rv2659c|M.tuberculosis_H37Rv SPASGQEDRPGAPFGEYAEGWLK-----QRGIKDRTRAHYRKLLDNHILA
MAB_1723|M.abscessus_ATCC_1997 --SGKSPTSSKVHLEQWLNHWLET--IQKPRVRPTTYKYYETTVRLYILP
TH_0846|M.thermoresistible__bu ----PHTCRAYLGDLRSLFDFVE----------QRSPGSGLGGLSLPVLR
MAV_0253|M.avium_104 HLG-GKAVQAVTKADIEKVVAALRGGT-----------------------
MSMEG_5754|M.smegmatis_MC2_155 HLG-KRTVQSITKDDLEQVVQALRAGT-----------------------
Mflv_2786|M.gilvum_PYR-GCK NLG-GLGLQQLRTSDIDALVTLRLNGTPISQRERRGRRAAEVLAYLRSRS
Mvan_3747|M.vanbaalenii_PYR-1 NLG-GLGLQQLRTSDIDALVTLRLNGTPISQRERRGRRAAEVLAYLRSRS
MMAR_4848|M.marinum_M RFG-HVPVDEISRKDVQQFIGGLTVGP-----------------------
MUL_0529|M.ulcerans_Agy99 RFG-HVPVDEITRADVRAFVDGLTVGP-----------------------
Mb2335c|M.bovis_AF2122/97 --------------------------------------------------
Rv2659c|M.tuberculosis_H37Rv TFA-DTDLRDITPAAVRRWYATTAVGTP----------------------
MAB_1723|M.abscessus_ATCC_1997 FIDGRTQLGKLTPAQVRKMIAKNGTRN-----------------------
TH_0846|M.thermoresistible__bu AWLAAQAADGSARTTLARRTSAVKTFT-----------------------
MAV_0253|M.avium_104 -------------------------------SKMGTWNAPEKIK--GKQV
MSMEG_5754|M.smegmatis_MC2_155 -------------------------------SKMGTWNAPTKLTKAAKKV
Mflv_2786|M.gilvum_PYR-GCK GGAQYADVRDELGNPGVKALDRLVASGEVIRPSRGRYVAVRDSDPVQSKI
Mvan_3747|M.vanbaalenii_PYR-1 GGAQYADVRDELGNPGVKALDRLVASGEVIRPSRGRYVAVRDSDPVQSKI
MMAR_4848|M.marinum_M --------------------------------------------------
MUL_0529|M.ulcerans_Agy99 --------------------------------------------------
Mb2335c|M.bovis_AF2122/97 --------------------------------------------------
Rv2659c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1723|M.abscessus_ATCC_1997 --------------------------------------------------
TH_0846|M.thermoresistible__bu --------------------------------------------------
MAV_0253|M.avium_104 RAKWGPSGTNHFIRRSRAVFEDLVQQGVLGRNPAALVQPVP-MARAELNT
MSMEG_5754|M.smegmatis_MC2_155 RSPWAASSINPMLARTRSIFEDLVNQGVVVRNVAALVKPLATDTEKTMNT
Mflv_2786|M.gilvum_PYR-GCK PGNVSSRTVVTMLVVLSSALDDAMREGLVARNVARLVKRPA-VEHHEMAT
Mvan_3747|M.vanbaalenii_PYR-1 PGNVSSRTVVTMLVVLSSALDDAMREGLVARNVARLVKRPA-VEHHEMAT
MMAR_4848|M.marinum_M ------WAKLATLRLLRSILDMAREDGRIHINPAQGVSSGR-IPARERHR
MUL_0529|M.ulcerans_Agy99 ------WAKVSTLRLLRSILDVAHQDGRIHRNPALGVSAGR-IPERERHR
Mb2335c|M.bovis_AF2122/97 --------------------------------------------------
Rv2659c|M.tuberculosis_H37Rv ------TMRAHSYSLLRAIMQTALADDLIDSNPCRISGASTARRVHKIRP
MAB_1723|M.abscessus_ATCC_1997 --------AQKAHQTLVKALGDAMDEGMLDKNVAAVVDKPK-HVAIERQP
TH_0846|M.thermoresistible__bu -------AWAVRQGLLSTDPALRLQVPKARRTLPAVLRRDQALAAMAAAD
MAV_0253|M.avium_104 LTAAQAERLLAATR---NDVFAAAWRLALMGLRRGEILGLSWDSVDLDAG
MSMEG_5754|M.smegmatis_MC2_155 LNAEQVTQLLAVTD---SHCYGIAWRLAVLGLRRGEILALRWDAVDFDAG
Mflv_2786|M.gilvum_PYR-GCK WTAEQAVRFREHVR---GDRLAACWLLTLAGLRRSEVLGLRWSDVDLDGG
Mvan_3747|M.vanbaalenii_PYR-1 WTAEQAVRFREHVR---GDRLAACWLLTLAGLRRSEVLGLRWSDVDLDGG
MMAR_4848|M.marinum_M YLSATEVAALAHAC---GDQGDIVTILAFTGLRWSELVGLRVGDIDLKAR
MUL_0529|M.ulcerans_Agy99 YLTAQEVRMLATAC---GDQGDVVTILAYTGLRWSEPVGLRVKDIDLTAR
Mb2335c|M.bovis_AF2122/97 --------------------------------------------------
Rv2659c|M.tuberculosis_H37Rv ATLDELETITKAMP---DPYQAFVLMAAWLAMRYGELTELRRKDIDLHGE
MAB_1723|M.abscessus_ATCC_1997 FTFDEARQIIATAIKRNDPWATMWAAMFFTGARQGEIIGMEWDRCDLEKG
TH_0846|M.thermoresistible__bu SGAQQKDPIALRDR-------LIVEMLYATGIRVSELCGLDIDDVDTDR-
MAV_0253|M.avium_104 LLTVRANRAPVPG-------------GVEVGSPKTAAGLRTLPMPAELTV
MSMEG_5754|M.smegmatis_MC2_155 TLAISAARLATAG-------------GATTGAPKTKTSVRTLPMPEDLTA
Mflv_2786|M.gilvum_PYR-GCK TVTIAQGRVVAEGQ------------GTITGDPKSKRSRRALPMPAEVLA
Mvan_3747|M.vanbaalenii_PYR-1 TVTIAQGRVVAEGQ------------GTITGDPKSKRSRRALPMPAEVLA
MMAR_4848|M.marinum_M RLYVRQAAPDVEG-------------RIIVGPPKTRAAVRTVPLPRIVID
MUL_0529|M.ulcerans_Agy99 RLYVRRAAPEVEG-------------HIVIGPPKTRAGIRTVPLPQVVVD
Mb2335c|M.bovis_AF2122/97 ----------MTGA------------GIVETTTN---RVRHVPVPEPVSE
Rv2659c|M.tuberculosis_H37Rv VARVRR-AVVRVGE------------GFKVTTPKSDAGVRDISIPPHLIP
MAB_1723|M.abscessus_ATCC_1997 LFDFSWQLQQLPPELPRGFKHRPCHLSLAWTKPKTKAGARVAPMTKPLQA
TH_0846|M.thermoresistible__bu ---------------------------HLARVLGKGGRQRTVPFGEPARG
* ..
MAV_0253|M.avium_104 AMKQARKQQRERRLALGSKWVESGLVVVGEDGAPPHPDTLSHVWAETIAA
MSMEG_5754|M.smegmatis_MC2_155 ALRRVRKRQKEYRLKLGSKWTDSGYVVVDEFGVAPYPDTLTAAWRKTLAN
Mflv_2786|M.gilvum_PYR-GCK ALRAFRLRQSEERLAIGSEYPDTGLVAVNVIGLPIRPETYSGEFMRHAKD
Mvan_3747|M.vanbaalenii_PYR-1 ALRVFRLRQSEERLAIGSEYPDTGLVAVNVIGLPIRPETYSGEFMRHAKD
MMAR_4848|M.marinum_M ALKPRIENRSTKEQAITS--PNGGFLRSNNWRRHTH-------WNKALKK
MUL_0529|M.ulcerans_Agy99 IFKGRITGQAPDQPAVTS--TNGAMLRSNNWRRHTH-------WNKALKS
Mb2335c|M.bovis_AF2122/97 RLRDELPTEPN---ALVFPSYRGGHLPIEEYRRAFD---------KGCKA
Rv2659c|M.tuberculosis_H37Rv AIEDHLHKHVN------PGRESLLFPSVNDPNRHLAPSALYRMFYKARKA
MAB_1723|M.abscessus_ATCC_1997 IMEAYAKTDTGP--------NPHGLVWRHPDGHPISPTDASDAWRALVKA
TH_0846|M.thermoresistible__bu ALTDWLTDGRP---ALATAESGPALLLGVRGRRLDPRQARTVVHQTVAAV
:
MAV_0253|M.avium_104 HKLPAVRLHDARHTCATLMHQDGVPLAVISAWLGHTNAAFTLATYGHSSD
MSMEG_5754|M.smegmatis_MC2_155 AGLPHVRLHDARHSCATLMHLSGVPTVVIAAWLGHQDPGFTLRTYAHSNH
Mflv_2786|M.gilvum_PYR-GCK AGVPLIRLHDVRHTAATMLLDRGTTPSATAKWLGH-DPAITLRVYGHVYD
Mvan_3747|M.vanbaalenii_PYR-1 AGVPLIRLHDVRHTAATMLLDRGTTPSATAKWLGH-DPAITLRVYGHVYD
MMAR_4848|M.marinum_M TGLAPLTIHDLRHTYASLARKSGADLRYVQKTMGHSTPTVTANIYSDLYS
MUL_0529|M.ulcerans_Agy99 TDLAPLTIHDLRHTYASLARKSGADLRYVQKTMGHSTPTVTANIYSDLYA
Mb2335c|M.bovis_AF2122/97 VGIADLVPHGLRHTTASLAISAGANVKVVQRLLGHATAAMTLDRHGHLLS
Rv2659c|M.tuberculosis_H37Rv AGRPDLRVHDLRHSGAVLAASTGATLAELMQRLGHSTAGAALR-YQHAAK
MAB_1723|M.abscessus_ATCC_1997 ADVPYRSMHSARHTTATLLNNAGVSQETRMKVVGH-SSAVAQQIYVHVDH
TH_0846|M.thermoresistible__bu AGAPDIGPHGLRHSAATHLLEGGADLRIVQELLGH-TSLATTQLYTHVTV
. *. **: * *. :** . : : .
MAV_0253|M.avium_104 DSLAAAAQRLDALTGGKATPAEAK--------------
MSMEG_5754|M.smegmatis_MC2_155 DALADAAAMLGSITTGKKK--EAK--------------
Mflv_2786|M.gilvum_PYR-GCK GALAAAGDTLLRGH------------------------
Mvan_3747|M.vanbaalenii_PYR-1 GALAAAGDTLLRGH------------------------
MMAR_4848|M.marinum_M DELDHVATNLDRLNDVAKDQAN-GQEPDTPKHP-----
MUL_0529|M.ulcerans_Agy99 DELDQVATNLDQLHATEIQTPTTGQEPDEPNQPSSA--
Mb2335c|M.bovis_AF2122/97 DDLAGVAGLLVQAIKSAAASLRYSDPDSVAVENISAAS
Rv2659c|M.tuberculosis_H37Rv GRDREIAALLSKLAENQEM-------------------
MAB_1723|M.abscessus_ATCC_1997 EPARAALSNLNELLS-----------------------
TH_0846|M.thermoresistible__bu ERLRAVHDQAHPRA------------------------