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MVINQPHADSGMQDFGYKESLDRSIGKFASFAAGVSYISILTGTFQLFYFGFGTAGPAYLWSWPLVFVGQ MAVALCFMELAAKYPVAGSVYNWSKKLASRLVGWTSGWLMLTASIVTISAVALAYQLNLPRLWSGFQIIG DGSGTYDYAANAVLLGSLLIAFTTLVNALGVRLMSRINSSGVFIELIAAVLIVFLLAINVQHSPEIFFST NGYGAGESMGFLGAFLIASLASGYVMYGFDTASSLGEETVEPRRTAPKAIARAILASFVIGGGILVFAVM AAPNLQDPQLGESSGGLQYIVQQVMWGPLGTIFLACIVIAVTVCCLAVHTAAIRLTFAMARDNALPFGEK LATVNPKTQTPIVPAVTIGIISILILVINVANVQIFTVLTSIAIIMIYLAYLMVTGPLLKKRIQGHWPPP DLKEGGYFTMGKWGMPVNIVAVIWGIGMALNLAWPRAAVYGEGWYYEWGAFIYIGVILGAGLVWYFVKGR NHIGTLKSHAAESLDG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3084 | - | - | 100% (506) | amino acid permease-associated region |
| M. gilvum PYR-GCK | Mflv_2651 | - | 3e-58 | 30.04% (496) | amino acid permease-associated region |
| M. gilvum PYR-GCK | Mflv_0800 | - | 8e-49 | 27.66% (470) | amino acid permease-associated region |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2347c | rocE | 4e-26 | 25.35% (493) | cationic amino acid transport integral membrane protein RocE |
| M. tuberculosis H37Rv | Rv2320c | rocE | 4e-26 | 25.35% (493) | cationic amino acid transport integral membrane protein RocE |
| M. leprae Br4923 | MLBr_01974 | - | 6e-06 | 20.89% (359) | putative permease |
| M. abscessus ATCC 19977 | MAB_4090 | - | 1e-124 | 49.28% (483) | putative amino-acid permease |
| M. marinum M | MMAR_3621 | rocE | 9e-28 | 26.29% (502) | cationic amino acid transport integral membrane protein RocE |
| M. avium 104 | MAV_2087 | - | 5e-29 | 29.01% (493) | amino acid transporter |
| M. smegmatis MC2 155 | MSMEG_2184 | - | 1e-122 | 45.73% (492) | amino acid permease |
| M. thermoresistible (build 8) | TH_0471 | - | 5e-22 | 24.31% (469) | POSSIBLE CATIONIC AMINO ACID TRANSPORT INTEGRAL MEMBRANE |
| M. ulcerans Agy99 | MUL_1244 | rocE | 5e-27 | 26.49% (502) | cationic amino acid transport integral membrane protein RocE |
| M. vanbaalenii PYR-1 | Mvan_1845 | - | 5e-65 | 29.96% (474) | amino acid permease-associated region |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2347c|M.bovis_AF2122/97 --------------------------------------------------
Rv2320c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3621|M.marinum_M --------------------------------------------------
MUL_1244|M.ulcerans_Agy99 --------------------------------------------------
MAV_2087|M.avium_104 --------------------------------------------------
TH_0471|M.thermoresistible__bu --------------------------------------------------
MAB_4090|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_2184|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_3084|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1845|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_01974|M.leprae_Br4923 MFLSADVSCIEIVDINCSELRNDRRIPPQLALFCTNAANKAESAVTSHGQ
Mb2347c|M.bovis_AF2122/97 -------------------MPTTSMSLRELMLRRRPVSGAPVAS------
Rv2320c|M.tuberculosis_H37Rv -------------------MPTTSMSLRELMLRRRPVSGAPVAS------
MMAR_3621|M.marinum_M -------------------MPATSIRLREQMLRRRPVGGAPVAE------
MUL_1244|M.ulcerans_Agy99 -------------------MPATSIRLREQMLRRRPAGGAPVAE------
MAV_2087|M.avium_104 -----------------------------------------MAP------
TH_0471|M.thermoresistible__bu --------------------------MTDRLRVKSVEQSIADTD------
MAB_4090|M.abscessus_ATCC_1997 ----------------MNASTATGTAAPSAAISAASDSDDLAAF------
MSMEG_2184|M.smegmatis_MC2_155 -------------------MTSSATAPGPDVADPSGDHRDLAEF------
Mflv_3084|M.gilvum_PYR-GCK -----------------------------MVINQPHADSGMQDF------
Mvan_1845|M.vanbaalenii_PYR-1 ----------MSTTQPTSDARGRNEGDGFYDFHDKDDAAHLHAL------
MLBr_01974|M.leprae_Br4923 LPIMANRRWAPHTRRQSGRATSTCSSLMRFSASESRAHSRFECYTLVRWS
Mb2347c|M.bovis_AF2122/97 --GASGNLKRSFGTFQLTMFGVG-ATIGTGIFFVLAQAVP-EAGPGVIVS
Rv2320c|M.tuberculosis_H37Rv --GASGNLKRSFGTFQLTMFGVG-ATIGTGIFFVLAQAVP-EAGPGVIVS
MMAR_3621|M.marinum_M --GAAGSLKRSFGTFELTMFGVG-STVGTGIFFVLAEAVP-EAGPAVIVS
MUL_1244|M.ulcerans_Agy99 --GAAGSLKRSFGTFELTMFGVG-STVGTGIFFVLAEAVP-EAGPAVIVS
MAV_2087|M.avium_104 --GTADHLRRGIGTFQLTMFGVG-STIGTGIFFVMSQAVP-EAGPAVIVS
TH_0471|M.thermoresistible__bu --EPDSRLRKDLSWWDLTVFGVS-VVIGAGIFTVTASTAGNITGPAISVS
MAB_4090|M.abscessus_ATCC_1997 --GYKPQLHRSLGKFASFAAGFSFVSILTTIFQLFAFGFS-FGGPAFFWT
MSMEG_2184|M.smegmatis_MC2_155 --GYDQQLHRRLGRFESFAAGFSFVSILTTIFQLFGLGFG-FGGPAFFWT
Mflv_3084|M.gilvum_PYR-GCK --GYKESLDRSIGKFASFAAGVSYISILTGTFQLFYFGFG-TAGPAYLWS
Mvan_1845|M.vanbaalenii_PYR-1 --GYKSEFKRDMSPWANFSLGFTYLSPVVGIYTLFAFALA-TGGPPMIWS
MLBr_01974|M.leprae_Br4923 IRGQGGRAISKLGFWSVVMLGIN-SIIGAGIFMTPGEVIK-IAGPFAPIA
:. : *. . : ** :
Mb2347c|M.bovis_AF2122/97 FIIAGIAAGLAAICYAELASAVPISGSAYSYAYTTLGEAVAMVVAACLLL
Rv2320c|M.tuberculosis_H37Rv FIIAGIAAGLAAICYAELASAVPISGSAYSYAYTTLGEAVAMVVAACLLL
MMAR_3621|M.marinum_M FIIAGVAAGLAAICYAELASAVPVSGSSYSYAYATLGEAVAMGVASCLLL
MUL_1244|M.ulcerans_Agy99 FIIAGVAAGLAAICCAELASAVPVSGSSYSYAYATLGEAVAMGVASCLLL
MAV_2087|M.avium_104 FLLAGVAAGLAAVCYAELASAVPVSGSSYSYAYTTLGEVVAMGVAACLLL
TH_0471|M.thermoresistible__bu FIIAAIACGLAALCYAEFASTVPVAGSAYTFSYATFGEFVAWIIGWDLIL
MAB_4090|M.abscessus_ATCC_1997 WPIVFLGQYMVALNFAELAARYPISGAIYQWARRLGGAAVGWFAGWFMII
MSMEG_2184|M.smegmatis_MC2_155 WPAVFVGQFLVALCFAELAARYPISGAIYQWSRRMGGEVIGWFGGWFMIL
Mflv_3084|M.gilvum_PYR-GCK WPLVFVGQMAVALCFMELAAKYPVAGSVYNWSKKLASRLVGWTSGWLMLT
Mvan_1845|M.vanbaalenii_PYR-1 LVIVGVGQLLVALTFSEIVAQFPVAGGVYPWARRLWGRRYAWMTGWVYLV
MLBr_01974|M.leprae_Br4923 YTLAGIFAAVLAIVFATAAKYVKTNGSSYAYTTAAFGHRIGIYVGVTHAI
. : *: . *. * :: . . .
Mb2347c|M.bovis_AF2122/97 EYGVATAAVAVGWSGYVNKLLSNLFGFQMPHVLSAAPWDTHPG----WVN
Rv2320c|M.tuberculosis_H37Rv EYGVATAAVAVGWSGYVNKLLSNLFGFQMPHVLSAAPWDTHPG----WVN
MMAR_3621|M.marinum_M EYGVATAAVAVGWSGYVNKLLHNVFGFQLPQALSEAPWDERPGEAAGYLN
MUL_1244|M.ulcerans_Agy99 EYGVATAAVAVGLSGYVNKLLHNVFGFQLPQALSEAPWDERPGEAAGYLN
MAV_2087|M.avium_104 EYGVATAAVSVNWSGYLNKLLSNVVGFQLPHALSAAPWDAQPG----YVN
TH_0471|M.thermoresistible__bu EFSVAAAVVAKGWSSYLG----EVFEFAG-ATTRLGPITLDWG-------
MAB_4090|M.abscessus_ATCC_1997 AQIVTASAAAIALQVVLPTVWSGFQLIGTDSSLTSVSGASNAV-------
MSMEG_2184|M.smegmatis_MC2_155 AQIVTASAAAIALQVVLPTIWPGFQIIGDDPALTSASGATNAV-------
Mflv_3084|M.gilvum_PYR-GCK ASIVTISAVALAYQLNLPRLWSGFQIIGDGS--GTYDYAANAV-------
Mvan_1845|M.vanbaalenii_PYR-1 ALLVTIASVAYGSGPFIAATFGIDATVNNVIA-----FS-----------
MLBr_01974|M.leprae_Br4923 TASIAWGVLASSFVSTLLRVAFPEKIWADNDELISVKTLTFLVF---IAV
:: . : :
Mb2347c|M.bovis_AF2122/97 LPAVILIGLCALLLIRGASESARVNAIMVLIKLGVLGMFMIIAFSAYSAD
Rv2320c|M.tuberculosis_H37Rv LPAVILIGLCALLLIRGASESARVNAIMVLIKLGVLGMFMIIAFSAYSAD
MMAR_3621|M.marinum_M LPAIILIGLCALLLIRGVSESAKVNAIMVLIKLGVLGMFVILALTAYDTN
MUL_1244|M.ulcerans_Agy99 LPAIILIGLCALLLIRGVSESAKVNAIMVLIKLGVLGMFVILALTAYDTN
MAV_2087|M.avium_104 LPAVMLIGMCALLLIRGASESAKVNAIMVMVKLGVLVVFGILAFTAFDMH
TH_0471|M.thermoresistible__bu --ALLIIGFVTVLLATGTKLSANVSLAITVIKVGVVLLVVIVGAFFIKAA
MAB_4090|M.abscessus_ATCC_1997 LLGSLLLVATTAINAVGVNWMSRINSIGVTCEIVGVVAVVGMLFGHAERG
MSMEG_2184|M.smegmatis_MC2_155 LLGTVLLVVTTTINCLGVKWMSRVNSAGVVCEIVGVIAVIGVFFTHAQRG
Mflv_3084|M.gilvum_PYR-GCK LLGSLLIAFTTLVNALGVRLMSRINSSGVFIELIAAVLIVFLLAINVQHS
Mvan_1845|M.vanbaalenii_PYR-1 ---LLLLAVATAINFMGTKVLAKAAIIGFSAEIIGALVVGGWLLIAHREH
MLBr_01974|M.leprae_Br4923 LLAINIFGNLVIRWANGISALGKIFALSVFIAGGLWTIITQHVNNYVTSR
:: . * .. .
Mb2347c|M.bovis_AF2122/97 HL-KDFVP---------------------------FGVAGIGSAAGTIFF
Rv2320c|M.tuberculosis_H37Rv HL-KDFVP---------------------------FGVAGIGSAAGTIFF
MMAR_3621|M.marinum_M HL-KDFAP---------------------------FGVAGVGAAAGTIFF
MUL_1244|M.ulcerans_Agy99 HL-KDFAP---------------------------FGVAGVGAAAGTIFF
MAV_2087|M.avium_104 HL-DDFAP---------------------------FGVAGVGTAAGTIFF
TH_0471|M.thermoresistible__bu NY-TPFIPPAEAGGEAGRSLDQSLFSLITGAEGSSYGWYGLLAGASIVFF
MAB_4090|M.abscessus_ATCC_1997 PS-VVLHTG--------------------DAG--SGYPWAFLAAGLMAAY
MSMEG_2184|M.smegmatis_MC2_155 PQ-VVFDTG--------------------HAGGQPGYIWAWIVSGLMAAY
Mflv_3084|M.gilvum_PYR-GCK PE-IFFSTNG------------------YGAGESMGFLGAFLIASLASGY
Mvan_1845|M.vanbaalenii_PYR-1 NIGIIFDSFG--------------------AGGDGDYMWAFAAAALIGLY
MLBr_01974|M.leprae_Br4923 SAYQPTTYSLLG-----------------VTEIGKSTAASMTLATIVALY
. . :
Mb2347c|M.bovis_AF2122/97 SYIGLDAVSTAGDEVKDPQKTMPRALIAALVVVTGVYVLVALAALGTQPW
Rv2320c|M.tuberculosis_H37Rv SYIGLDAVSTAGDEVKDPQKTMPRALIAALVVVTGVYVLVALAALGTQPW
MMAR_3621|M.marinum_M SFIGLDAVSTAGEEVRNPQQSVPRALIAALFVVTGVYVLVAFAALGTQPW
MUL_1244|M.ulcerans_Agy99 SFIGLDAVSTAGEEVRNPQQSVPRALIAALFVVTGVYVLVAFAALGTQPW
MAV_2087|M.avium_104 SYIGLDAVSTAGDEVTNPQKTMPRALIAALLTVTGVYVFVALAALGTQPW
TH_0471|M.thermoresistible__bu AFIGFDIIATTAEETKNPQRDVARGIMATLGIVTVLYVAVSLVLTGMVHY
MAB_4090|M.abscessus_ATCC_1997 VLVGFGSASELAEETRNPRRVAPRTILSAIVVSAIGGALMILGALMAAPS
MSMEG_2184|M.smegmatis_MC2_155 VMVGFGSAGELAEETRNPRRVAPRTIRLALSVSALGGGLMILGALMAAPS
Mflv_3084|M.gilvum_PYR-GCK VMYGFDTASSLGEETVEPRRTAPKAIARAILASFVIGGGILVFAVMAAPN
Mvan_1845|M.vanbaalenii_PYR-1 QYYGFEACGDVAEEVPDPGRLIPKAMRRTIYIGGAAATFVCLSLILAVAD
MLBr_01974|M.leprae_Br4923 AFTGFESIANAAEEMNTPDRTLPKAIPLTILTVGVIYILALVVAMLLGSD
*: . .:* * : .: : :: .
Mb2347c|M.bovis_AF2122/97 QDFAEQ--ETAGLAIILDNVTHGEWASTILAAGAVVSIFTVTLVTMYGQT
Rv2320c|M.tuberculosis_H37Rv QDFAEQ--ETAGLAIILDNVTHGEWASTILAAGAVVSIFTVTLVTMYGQT
MMAR_3621|M.marinum_M QMFAGQ--EEAGLATILDNVTHSAWASTVLAMGAVISIFTVTLVTMYGQT
MUL_1244|M.ulcerans_Agy99 QMFAGQ--EEAGLATILDNVTHSAWASTVLAMGAVISIFTVTLVTMYGQT
MAV_2087|M.avium_104 QDFGGQ--QEAGLATILDHVTHGSWASTILAAGAVISIFSVTLVTMYGIT
TH_0471|M.thermoresistible__bu TELRAAG-ENANLATAFA-ANGIDWAAKVISIGALAGLTTVVIVLVLGQT
MAB_4090|M.abscessus_ATCC_1997 LTDGQL--ATGGLPYVLDSKLASPFG-TLLLIDVAIAVFVCTLAIQTAAS
MSMEG_2184|M.smegmatis_MC2_155 LTDGRL--ATEGLPYVLDTVLSSPWG-TVLLIDVCIAITICTLAIQTAAS
Mflv_3084|M.gilvum_PYR-GCK LQDPQLGESSGGLQYIVQQVMWGPLG-TIFLACIVIAVTVCCLAVHTAAI
Mvan_1845|M.vanbaalenii_PYR-1 IPAVIAGEDTDPVSTVLG-EAFGPVGSKIILVIVLISFLSCAMSLQAAAS
MLBr_01974|M.leprae_Br4923 KIVATN------HTVKLAAAVGNNTFRTIIVVGALVSMFGINVAASFGAP
. .:: .. : .
Mb2347c|M.bovis_AF2122/97 RILFAMGRDGLLPA--RFAKVNPRTMTPVHNTVIVAIFASTLAAFIP---
Rv2320c|M.tuberculosis_H37Rv RILFAMGRDGLLPA--RFAKVNPRTMTPVHNTVIVAIFASTLAAFIP---
MMAR_3621|M.marinum_M RILFAMGRDGLLPA--RFAAVHPRFQTPVSNTVVVAIAAAVLAALVP---
MUL_1244|M.ulcerans_Agy99 RILFAMGRDGLLPA--RFAAVHPRFQTPVSNTVVVAIAAAVLAALVP---
MAV_2087|M.avium_104 RILFAMGRDGLLPP--RFARVNPRTMTPVNNTVIVAVAAATLAAFIP---
TH_0471|M.thermoresistible__bu RVLFAMSRDGLLPR--PLSKTGPR-GTPVRITVLVGALVAIAASVFP---
MAB_4090|M.abscessus_ATCC_1997 RLMFSMARDGKLPFSAVLSHVNPRTGTPIAPAVVVGVCCVLILAVNFGNA
MSMEG_2184|M.smegmatis_MC2_155 RLMFSMARDGRLPASAILAKVNGRTGTPIWPSVLIGVLCIAVLLVNVGNS
Mflv_3084|M.gilvum_PYR-GCK RLTFAMARDNALPFGEKLATVNPKTQTPIVPAVTIGIISILILVINVANV
Mvan_1845|M.vanbaalenii_PYR-1 RLAYSYGRDEMIMGSSLLKKFSPTRHVPPYALLLAAVVPAVIIVGSKFST
MLBr_01974|M.leprae_Br4923 RLWTALSDGRILPTR---LSSKNRFGVPIVAFGITAFLTLAFPLSLR---
*: : . . : .* .
Mb2347c|M.bovis_AF2122/97 --LDSLADMVSIGTLTAFSVVAVGVIVLRVRE-----------PDLPRGF
Rv2320c|M.tuberculosis_H37Rv --LDSLADMVSIGTLTAFSVVAVGVIVLRVRE-----------PDLPRGF
MMAR_3621|M.marinum_M --LNRLADMVSIGTLTAFIVVSVGVIILRVRE-----------PALPRGF
MUL_1244|M.ulcerans_Agy99 --LNRLADMVSIGTLTAFIVVSVGVIILRVRE-----------PALPRGF
MAV_2087|M.avium_104 --LQNLADMVSIGTLTAFVVVSVGVIVLRVRE-----------PDLPRGF
TH_0471|M.thermoresistible__bu --VGNLEEMVNIGTLFAFALVSAGVIVLRRTR-----------PDLKRGF
MAB_4090|M.abscessus_ATCC_1997 ALFTSLCSVCIALIYLAYLMVTTPLLLRRLGIGGSTWDANLGQTDADGRK
MSMEG_2184|M.smegmatis_MC2_155 AIFATLASVCIILIYLAYLMVTAPLLYRRFKG----WPAQRNQVDAEGLP
Mflv_3084|M.gilvum_PYR-GCK QIFTVLTSIAIIMIYLAYLMVTGPLLKKRIQG---HWPPP----DLKEGG
Mvan_1845|M.vanbaalenii_PYR-1 DAITKIISFAALGIYIGFQMVVLAALRARLKG-------------WVPSG
MLBr_01974|M.leprae_Br4923 FDSLNLTGLAVIARFIQFIIVPIALFALARSR------------TTNSVY
: . : :* :
Mb2347c|M.bovis_AF2122/97 KVPGYPVTPVLSVLACGYILASLHWYTWLAFSGWVAVAVIFYLMWGRHHS
Rv2320c|M.tuberculosis_H37Rv KVPGYPVTPVLSVLACGYILASLHWYTWLAFSGWVAVAVIFYLMWGRHHS
MMAR_3621|M.marinum_M WVPGYPVTPILSILACGYLLYSLHWYTWIAFGGWVGIALIFYLFWGRHHS
MUL_1244|M.ulcerans_Agy99 WVPGYPVTPILSILACGYLLYSLHWYTWIAFGGWVGIALIFYLFWGRHHS
MAV_2087|M.avium_104 RVPGYPVTPVLSIMACGYILASLHWYTWIAFSGWVLLALIFYFVWGRHHS
TH_0471|M.thermoresistible__bu RVPFVPWLPLAAIAACLWLMLNLTGLTWVRFLGWMALGLVLYFFYGRHHS
MAB_4090|M.abscessus_ATCC_1997 LFSLGRCGLPINILAVGYGAFMILNLSWPRPAVFDPTGEHPYLVWMAPIC
MSMEG_2184|M.smegmatis_MC2_155 LFSLGRFGIVVNVLAVLYGAVMIVNLGWPRAEIFNPTGEYPVLQWAGPLS
Mflv_3084|M.gilvum_PYR-GCK YFTMGKWGMPVNIVAVIWGIGMALNLAWPRAAVY---GEGWYYEWGAFIY
Mvan_1845|M.vanbaalenii_PYR-1 KYSLGKWGLAVNIAALVYGVTAMINMAWPR-----TPDAPWYDNWIVALS
MLBr_01974|M.leprae_Br4923 VKRNVFTDKVLPITAVVVSAGLMVSFDYRSIFLTRGGPNYFSISLIAITF
: * :
Mb2347c|M.bovis_AF2122/97 ALNEEVP--------------------------
Rv2320c|M.tuberculosis_H37Rv ALNEEVP--------------------------
MMAR_3621|M.marinum_M RLNAPALHDNPTGEER-----------------
MUL_1244|M.ulcerans_Agy99 RLNAPALHDNPTGEER-----------------
MAV_2087|M.avium_104 ALNDAAVD--PSGQER-----------------
TH_0471|M.thermoresistible__bu MLGRGMTDISARRTG------------------
MAB_4090|M.abscessus_ATCC_1997 IIAVLLAGLVAYPRHT-------ASTTEETVR-
MSMEG_2184|M.smegmatis_MC2_155 IAATVLLGALCFPRGK-------THPKPVTIGA
Mflv_3084|M.gilvum_PYR-GCK IGVILGAGLVWYFVKGRNHIGTLKSHAAESLDG
Mvan_1845|M.vanbaalenii_PYR-1 AAVVIGIGLVYMVVHPLHDKSTAPYADAIPTK-
MLBr_01974|M.leprae_Br4923 IGIPAVAYLHYYRTSGIK---------------