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VTSAGEEPAWKQRAVERSIKTAKLRAAQRVQRFLDAAQAIIIEKGSTDFTVQEVVDRSRQSLRSFYLQFD GKHELLLALFEDALSRSADQIRAATASHSDPLERLKVAIQLLFESSRPDPAAKRPLFTDFAPRLLVSHPS EVKVAHAPLLALLTELMEEAGEAGLLREGINPKRMAAMTMQTVMFVAQSSGGADESTPNPITADEVWDFV AHGFSADPPA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4847 | - | - | 100% (220) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_2995 | - | 5e-21 | 33.65% (208) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_6480 | - | 1e-05 | 24.29% (140) | putative transcriptional regulatory protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0140c | - | 6e-06 | 26.92% (130) | transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_2432 | - | 1e-106 | 89.81% (216) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0135c | - | 7e-06 | 26.92% (130) | transcriptional regulatory protein |
| M. leprae Br4923 | MLBr_01070 | - | 3e-06 | 29.29% (99) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_4479 | - | 3e-08 | 34.95% (103) | TetR family transcriptional regulator |
| M. marinum M | MMAR_4752 | - | 1e-103 | 86.11% (216) | transcriptional regulatory protein |
| M. avium 104 | MAV_1626 | - | 2e-21 | 35.87% (184) | hypothetical protein MAV_1626 |
| M. thermoresistible (build 8) | TH_2023 | - | 1e-107 | 90.78% (217) | transcriptional regulator, TetR family protein |
| M. ulcerans Agy99 | MUL_0323 | - | 1e-103 | 85.65% (216) | transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_4220 | - | 1e-108 | 91.67% (216) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0140c|M.bovis_AF2122/97 ---------------------------------MTAVAAGALVVETDSFR
Rv0135c|M.tuberculosis_H37Rv ---------------------------------MTAVAAGALVVETDSFR
Mflv_2432|M.gilvum_PYR-GCK MARRSPVQSVHVFPSRAASEPPVTTPSEEPAWKQRAVERSIKTAKLRAAQ
Mvan_4220|M.vanbaalenii_PYR-1 MARRSPVQSVRVLPNRPASEPPVTSPSEEPAWKQRAVERSIKTAKLRAAQ
MSMEG_4847|M.smegmatis_MC2_155 ----------------------MTSAGEEPAWKQRAVERSIKTAKLRAAQ
TH_2023|M.thermoresistible__bu ----------------------VTTPSEEPAWKQRAVERSIKTAKLRAAQ
MMAR_4752|M.marinum_M ----------------------MTNPSEEPAWKQRAVERSIKTAKLRAAQ
MUL_0323|M.ulcerans_Agy99 ----------------------MTNPSEEPAWKQRAVERSIKTAKLRAAQ
MAV_1626|M.avium_104 ---------------------------------------MAEPNEDVEIT
MAB_4479|M.abscessus_ATCC_1997 -------------------------------MAASPGLWGGRTAAQRRAE
MLBr_01070|M.leprae_Br4923 ----------------------MIVVGNFTQSNYVPASRGRRSSQLSGDD
Mb0140c|M.bovis_AF2122/97 --LRLLDGLVASIGERGYRATTVSDIVRHARTSKRTFYDRFTSKEQCFLE
Rv0135c|M.tuberculosis_H37Rv --LRLLDGLVASIGERGYRATTVSDIVRHARTSKRTFYDRFTSKEQCFLE
Mflv_2432|M.gilvum_PYR-GCK RVQRFLDAAQAIIIEKGSTDFTVQEVVDRSRQSLRSFYLQFDGKHELLLA
Mvan_4220|M.vanbaalenii_PYR-1 RVQRFLDAAQAIIIEKGSTDFTVQEVVDRSRQSLRSFYLQFDGKHELLLA
MSMEG_4847|M.smegmatis_MC2_155 RVQRFLDAAQAIIIEKGSTDFTVQEVVDRSRQSLRSFYLQFDGKHELLLA
TH_2023|M.thermoresistible__bu RVQRFLDAAQAIIIEKGSTDFTVQEVVDRSRQSLRSFYLQFDGKHELLLA
MMAR_4752|M.marinum_M RVQRFLDAAQAIIIEKGSTDFTVQEVVDRSRQSLRSFYLQFDGKHELLLA
MUL_0323|M.ulcerans_Agy99 RVQRFLDAAQAIIIEKGSTDFTVQEVVDRSRQSLRSFYLQFDGKHELLLA
MAV_1626|M.avium_104 RGDRFIKTAVAILGETGRTDFTVQEVVARSKTSLRAFYQHFSSKDELLLA
MAB_4479|M.abscessus_ATCC_1997 RRERLVGAAQEIWIEQGWAAVTMRGVCARTSLNDRYFYEDFADREDLLAA
MLBr_01070|M.leprae_Br4923 REQAILAVAERLLAERPLGDFSVDELAKGAGISRPTFYFYFPSKNAVLLS
:: * :: : : . ** * .:. :
Mb0140c|M.bovis_AF2122/97 LLLADNETLGNSIRAAVDPN--ADWHDQIRQAVEAYVTHIESRPAVTLS-
Rv0135c|M.tuberculosis_H37Rv LLLADNETLGNSIRAAVDPN--ADWHDQIRQAVEAYVTHIESRPAVTLS-
Mflv_2432|M.gilvum_PYR-GCK LFEDALSRSAEQIRAATSGQ--ESPIDRLKVAIQLLFESSRPDPSAKRP-
Mvan_4220|M.vanbaalenii_PYR-1 LFEDALSRSADQIRAATGGH--EEPIERLKVAIQLLFESSRPDPAAKRP-
MSMEG_4847|M.smegmatis_MC2_155 LFEDALSRSADQIRAATASH--SDPLERLKVAIQLLFESSRPDPAAKRP-
TH_2023|M.thermoresistible__bu LFEDALSRSADQIRAATAGK--TDPLERLKTAIELLFESSRPDPNAKRP-
MMAR_4752|M.marinum_M LFEDALSRSADQIRAATETH--ADPLERLKVAVELLYEASRPDPTAKRP-
MUL_0323|M.ulcerans_Agy99 LFEDALSRSADQIRAATETH--ADPLERLKVAVELLYEASRPDPTAKRP-
MAV_1626|M.avium_104 LFDRTIAQSAQTWRAETAG---LDSTAALKLVIDRVSQQPESSTQDSLNR
MAB_4479|M.abscessus_ATCC_1997 VWDGVRDELIAQISAIVAEDPDRPPLDTLRKTITLVVERVSGDPGWADII
MLBr_01070|M.leprae_Br4923 LLDDLNMKSRSAVEALAEQLP-ADPAAVWRSAITAFFEVCGTHRAVAVA-
: * . : .:
Mb0140c|M.bovis_AF2122/97 WIREFPSLGAAAYP----VQRRGMEQLTSLLIELSASPGFRRANLPPLNV
Rv0135c|M.tuberculosis_H37Rv WIREFPSLGAAAYP----VQRRGMEQLTSLLIELSASPGFRRANLPPLNV
Mflv_2432|M.gilvum_PYR-GCK LFTDFAPRLLVSHPSEVKVAHAPLLALLTELMEEASEAGQLREGINPKRM
Mvan_4220|M.vanbaalenii_PYR-1 LFTDFAPRLLVSHPSEVKVAHAPLLALLTELMEEASAAGQLRDGINPKRM
MSMEG_4847|M.smegmatis_MC2_155 LFTDFAPRLLVSHPSEVKVAHAPLLALLTELMEEAGEAGLLREGINPKRM
TH_2023|M.thermoresistible__bu LFTDFAPRLLVSHPEEVKVAHAPLLALLTELMEEAAAAGKLREGINPKRM
MMAR_4752|M.marinum_M LFTDFAPRLLVSHPAEVKVAHAPLVALLTELMEAAAEAGELREDLNPRRI
MUL_0323|M.ulcerans_Agy99 LFTDFAPRLLVSHPTEVKVAHAPLVTLLTELMEAAAEAGELREDLNPRRI
MAV_1626|M.avium_104 ALTLYNQHLAETRPREYARVLSPLHRLIRDIVGQGITEGVFNPGLDVGAA
MAB_4479|M.abscessus_ATCC_1997 FVRHVGSAVLEQRR---IDLLHQATAVLIAAAEPYLVKNIDRTGFRMDTL
MLBr_01070|M.leprae_Br4923 --GAAAKATSPEVRRLWSTVMQQWIDYNTAAIQAERKCGVAPDTIPAEDL
. :
Mb0140c|M.bovis_AF2122/97 PLAVILLGGLRELTALTVED-GQPIRNIVEPAVDASIALLGPRS------
Rv0135c|M.tuberculosis_H37Rv PLAVILLGGLRELTALTVED-GQPIRNIVEPAVDASIALLGPRS------
Mflv_2432|M.gilvum_PYR-GCK AAMTMQTVMFVAQSSGEYDE-NAAHPITADEVWDFCAHGFAAG-------
Mvan_4220|M.vanbaalenii_PYR-1 AAMTMQTVMFVAQSSGDVDE-NAANPITADEVWDFCAHGFAAV-------
MSMEG_4847|M.smegmatis_MC2_155 AAMTMQTVMFVAQSSGGADE-STPNPITADEVWDFVAHGFSADPPA----
TH_2023|M.thermoresistible__bu AAMTMQTVMFVAQSSGGTGD-GTVHPITADEVWDFVAHGFAADD------
MMAR_4752|M.marinum_M AAMTMQTVMFIAQSSGGTDD-ATTHPITADEVWDFCSRGFAAS-------
MUL_0323|M.ulcerans_Agy99 AAMTMQTVMFIAQSSGGTDD-ATTHPITADEVWDFCSRGFAAS-------
MAV_1626|M.avium_104 AAIVMQTMMGAQRLHWLGAE-LNGTPVDAGQLYDFCSRALGIRDTDEDAG
MAB_4479|M.abscessus_ATCC_1997 VGIGGFSELVNAWRSGLLDV-SADELIEHSTRIGATLASRYLAAG-----
MLBr_01070|M.leprae_Br4923 AVALQLMTERVMAATFSDEKPLIPDKKVIDTLVHIWLASIYGS-------
Mb0140c|M.bovis_AF2122/97 --------------------------------------------------
Rv0135c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2432|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4220|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4847|M.smegmatis_MC2_155 --------------------------------------------------
TH_2023|M.thermoresistible__bu --------------------------------------------------
MMAR_4752|M.marinum_M --------------------------------------------------
MUL_0323|M.ulcerans_Agy99 --------------------------------------------------
MAV_1626|M.avium_104 APSLAELFGQIGMRPGTRNGQFAMTMPVSPAVVNTSGALQGGLIATLVDV
MAB_4479|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01070|M.leprae_Br4923 --------------------------------------------------
Mb0140c|M.bovis_AF2122/97 --------------------------------------------------
Rv0135c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2432|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4220|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4847|M.smegmatis_MC2_155 --------------------------------------------------
TH_2023|M.thermoresistible__bu --------------------------------------------------
MMAR_4752|M.marinum_M --------------------------------------------------
MUL_0323|M.ulcerans_Agy99 --------------------------------------------------
MAV_1626|M.avium_104 AGGQFGLDYLRPGTTMTTADLFVRYLRPVRQGSAFAVPRMLRSGRRAMVM
MAB_4479|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01070|M.leprae_Br4923 --------------------------------------------------
Mb0140c|M.bovis_AF2122/97 ------------------------------------
Rv0135c|M.tuberculosis_H37Rv ------------------------------------
Mflv_2432|M.gilvum_PYR-GCK ------------------------------------
Mvan_4220|M.vanbaalenii_PYR-1 ------------------------------------
MSMEG_4847|M.smegmatis_MC2_155 ------------------------------------
TH_2023|M.thermoresistible__bu ------------------------------------
MMAR_4752|M.marinum_M ------------------------------------
MUL_0323|M.ulcerans_Agy99 ------------------------------------
MAV_1626|M.avium_104 QVDIFGDGDDELLATATVNFAIINGDTPSSGLPPAE
MAB_4479|M.abscessus_ATCC_1997 ------------------------------------
MLBr_01070|M.leprae_Br4923 ------------------------------------