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MAERPSPSAAERPTPEEIILYEKDPQTKIATITFNRPEFLNAPTSMARLRYADVLRAANADNDVKVVIIR GVGDNLGSGADLPEFMEGNDNPAVRLAELRLEDDGVGEVTYPPKGTFRNGATISAWYANSQAGNRALQDF KKISIVEAKGYCYGWHFYQCADADLVISSDDALFGHPSFRYHGWGPRMWTWVQMMGLRKFQEMVFTGRPF TAAEMYDCNFLNKVVERDQLEAETQKYALACARNRPVDTVFQQKMFFEIFKQQQGEYMGSLLSAFFESMG NGVANDSDEDLDMFESIDSGLSAAVNDNDSKFPPEFRLSKRNRAKD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2422 | - | - | 100% (326) | enoyl-CoA hydratase/isomerase |
| M. gilvum PYR-GCK | Mflv_2433 | - | 1e-16 | 30.97% (226) | enoyl-CoA hydratase |
| M. gilvum PYR-GCK | Mflv_1568 | - | 3e-13 | 27.02% (248) | enoyl-CoA hydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0464c | echA2 | 7e-18 | 27.30% (315) | enoyl-CoA hydratase |
| M. tuberculosis H37Rv | Rv0456c | echA2 | 8e-18 | 27.30% (315) | enoyl-CoA hydratase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3859c | - | 6e-17 | 23.37% (291) | enoyl-CoA hydratase |
| M. marinum M | MMAR_4758 | echA4_1 | 1e-127 | 70.25% (316) | enoyl-CoA hydratase, EchA4_1 |
| M. avium 104 | MAV_2982 | - | 1e-101 | 56.91% (311) | enoyl-CoA hydratase/isomerase |
| M. smegmatis MC2 155 | MSMEG_4852 | - | 0.0 | 96.20% (316) | enoyl-CoA hydratase, putative |
| M. thermoresistible (build 8) | TH_2025 | - | 1e-170 | 88.64% (317) | enoyl-CoA hydratase, putative |
| M. ulcerans Agy99 | MUL_0754 | echA4 | 5e-17 | 25.77% (291) | enoyl-CoA hydratase |
| M. vanbaalenii PYR-1 | Mvan_4230 | - | 0.0 | 96.92% (325) | enoyl-CoA hydratase/isomerase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2422|M.gilvum_PYR-GCK MAERPSPSAAERPTPEEIILYEKDPQTKIATITFNRPEFLNAPTSMARLR
Mvan_4230|M.vanbaalenii_PYR-1 MAERPQPPAAERPAPEEIILYDKDPKTKIATITFNRPEFLNAPTSMARLR
MSMEG_4852|M.smegmatis_MC2_155 --------MAERPTPEEIILYDKDPETKIATITFNRPEFLNAPTSMARLR
TH_2025|M.thermoresistible__bu --------MADRPAPEEIILYDKDPRTKIATITFNRPEFLNAPTSAARLR
MMAR_4758|M.marinum_M -------MPKSEPPVDKVIRYDKDPETRIATITFDRPGHLNAPTIAARLR
MAV_2982|M.avium_104 --MPEYDYEELKKEAEQYIKFEKDKKNRIAYITFDRPDAQNSATLGMRQN
Mb0464c|M.bovis_AF2122/97 ------------MPTPDFQTLLYTTAGPVATITLNRPEQLNTIVPPMPDE
Rv0456c|M.tuberculosis_H37Rv ------------MPTPDFQTLLYTTAGPVATITLNRPEQLNTIVPPMPDE
MAB_3859c|M.abscessus_ATCC_199 -------------MVDTLKTMTYEVTDRVARITFNRPEQGNAIIADTPLE
MUL_0754|M.ulcerans_Agy99 -----MTHAIRPVDFDNLKTMTYEVTDRVARITFNRPEKGNAIVADTPLE
:* **::** *: .
Mflv_2422|M.gilvum_PYR-GCK YADVLRAANADNDVKVVIIRGVGDNLGSGADLPEFMEGNDNP--AVRLAE
Mvan_4230|M.vanbaalenii_PYR-1 YADVLRAANTDNDVKVVIIRGVGDNLGSGADLPEFMEGNDNP--AARLAE
MSMEG_4852|M.smegmatis_MC2_155 YADVLRAANADNDVKVVVIRGVGDNLGSGADLPEFMEGNDNP--AVRLAE
TH_2025|M.thermoresistible__bu YADLLRAATVDNDVKVVVIRGVGDNLGSGADLPEFMEGNDNP--ALRLAE
MMAR_4758|M.marinum_M YADLLHRASIDDEVKVLVIRGEGEDLGSGADLEEFMEVMNSPDQGPRLAE
MAV_2982|M.avium_104 YADLIHKCNVDDDVKVVVIRGEGEDFGSGGDLPEQRGMLENPG-MPLLHE
Mb0464c|M.bovis_AF2122/97 IEAAIGLAERDQDIKVIVLRGAGRAFSGGYDFGGGFQHWG----------
Rv0456c|M.tuberculosis_H37Rv IEAAIGLAERDQDIKVIVLRGAGRAFSGGYDFGGGFQHWG----------
MAB_3859c|M.abscessus_ATCC_199 LAALVERADLDPQVHVILVSGRGDGFCGGFDLSAYAEANDEGSVR--YSG
MUL_0754|M.ulcerans_Agy99 LSALVERADLDPAVQVILVSGRGEGFCAGFDLSAYAEGSSSSGAEGGYRG
: . * ::*::: * * : .* *:
Mflv_2422|M.gilvum_PYR-GCK LRLEDDGVGEVTYPPK--GTFRNGATISAWYANSQAGNRALQDFKKISIV
Mvan_4230|M.vanbaalenii_PYR-1 LRLEDDGVGEVTYPPK--GTFRNGATISAWYANSQAGNRALQDFKKISIV
MSMEG_4852|M.smegmatis_MC2_155 LRLEDDGVGEVTYPPR--GTFRNGATISAWYANSQAGNRALQDFKKISIV
TH_2025|M.thermoresistible__bu LRLEDDGVGEVTYPPK--GTFRNGATISAWYANSQAGNRPLQELKKISIV
MMAR_4758|M.marinum_M FRIGPE---EVKYPPL--GSFRHGASVSQWYANPNAGIRGLQDFKKISIL
MAV_2982|M.avium_104 LAINDD---DVKYPPG--GSYRYLSTVTDFYAKARAGNRPLQELRKISII
Mb0464c|M.bovis_AF2122/97 ---------DAMMTDGRWDPGKDFAMVTARETGPTQKFMAIWRASKPVIA
Rv0456c|M.tuberculosis_H37Rv ---------DAMMTDGRWDPGKDFAMVTARETGPTQKFMAIWRASKPVIA
MAB_3859c|M.abscessus_ATCC_199 TALDGQVQLRNHLPNINWDPMLDYQMMSRFTRG----FSSLLHANKPTVV
MUL_0754|M.ulcerans_Agy99 TVLDGKAQAVNHLPNQPWDPMIDYQMMSRFVRG----FSSLTHADKPTVV
. .. :: : * :
Mflv_2422|M.gilvum_PYR-GCK EAKGYCYGWHFYQCADADLVISSDDALFGHPSFRYHGWGPRMWTWVQMMG
Mvan_4230|M.vanbaalenii_PYR-1 EAKGYCYGWHFYQCADADLVISSDDALFGHPSFRYHGWGPRMWTWVQMMG
MSMEG_4852|M.smegmatis_MC2_155 EAKGYCYGWHFYQCADADLVISSDDALFGHPSFRYHGWGPRMWTWVQMMG
TH_2025|M.thermoresistible__bu EAKGYCYGWHFYQCADADLVISSDDALFGHPSFRYYGWGPRMWTWVQMMG
MMAR_4758|M.marinum_M EVKGYCYGWHFYQAADADLVISSDDALFGHPSFRYYGWGPRMWWWAQTMG
MAV_2982|M.avium_104 EAKGYCYGWHFYQAGDADLVIASDDALFGHPAFRYVGWGPRLWWWAETMG
Mb0464c|M.bovis_AF2122/97 QVHGWCVGGASDYALCADIVIASEDAVIGTPYSRMWG-AYLTGMWLYRLS
Rv0456c|M.tuberculosis_H37Rv QVHGWCVGGASDYALCADIVIASEDAVIGTPYSRMWG-AYLTGMWLYRLS
MAB_3859c|M.abscessus_ATCC_199 KVHGYCVAGGTDIALHADQLIVAADAKIGYPPTRVWG-VPATGLWAHKLG
MUL_0754|M.ulcerans_Agy99 KIHGYCVAGGTDIALHADQVIAAADAKIGYPPTRVWG-VPAAGLWAHRLG
: :*:* . . ** :* : ** :* * * * * :.
Mflv_2422|M.gilvum_PYR-GCK LRKFQEMVFTGRPFTAAEMYDCNFLNKVVERDQLEAETQKYALACARNRP
Mvan_4230|M.vanbaalenii_PYR-1 LRKFQEMVFTGRPFTAAEMYDCNFLNKVVTRDQLEAETRKYALACARNRP
MSMEG_4852|M.smegmatis_MC2_155 LRKFQEMVFTGRPFTAAEMYDCNFLNKVVPRDRLEAEVDKYATACARNRP
TH_2025|M.thermoresistible__bu LRKFSEMVFTGRPFTAAEMYDCNFLNKVVPRDQLEAEVDKYARACARNRP
MMAR_4758|M.marinum_M IRKFQEMVFTGRAFTAAEMQDCNFLNSVVPREELEAEVAKYALACARNRP
MAV_2982|M.avium_104 LRKFSEMLFTGRPFSAKEMYDCGFVNSVVPRDKLEAETEKYALACSKARP
Mb0464c|M.bovis_AF2122/97 LAKVKWHSLTGRPLTGVQAAEAELINEAVPFERLEARVAEIATELAR-IP
Rv0456c|M.tuberculosis_H37Rv LAKVKWHSLTGRPLTGVQAAEAELINEAVPFERLEARVAEIATELAR-IP
MAB_3859c|M.abscessus_ATCC_199 DQRAKRLLLTGDCLSGRQAYDWGLAVEAPEPDELDERTERLVERIAA-MP
MUL_0754|M.ulcerans_Agy99 DQRAKRLLFTGDCITGAQAAEWGLAVEAPDPKDLDERTERLVERIAA-LP
: . :** ::. : : : .. . *: .. . . : *
Mflv_2422|M.gilvum_PYR-GCK VDTVFQQKMFFEIFKQQQGEYMGSLLSAFFESMGNGVANDSDEDLDMFES
Mvan_4230|M.vanbaalenii_PYR-1 VDTVFQQKMFFEIFKQQQGEYMGSLLSAFFESMGNGVANDSDDDLDMFES
MSMEG_4852|M.smegmatis_MC2_155 VDTVFQQKMFFEIFKQQQGEYMGSLLSAFFESMGNGVANDSDDDLDMFES
TH_2025|M.thermoresistible__bu VDTVFQQKIFFEVFKQHQGEYMGSLLSAFFESMGSGAVNDDTDDLDMHEA
MMAR_4758|M.marinum_M NDTVFMQKVFFEIMKQFQGEYMGSLLSGFFESMGSGVRADT-DDLMLDDA
MAV_2982|M.avium_104 TDTVAVQKTFLELYKQHKGEYFGSLLTGLVEGMLPLIANDAEEVDLTAGT
Mb0464c|M.bovis_AF2122/97 LSQLQAQKLIVNQAYENMGLASTQLLGGILDGLMR---NTPDALEFIRTA
Rv0456c|M.tuberculosis_H37Rv LSQLQAQKLIVNQAYENMGLASTQLLGGILDGLMR---NTPDALEFIRTA
MAB_3859c|M.abscessus_ATCC_199 LNQLMMIKLACNSVLINQGIANSAMIGTVFDGISR---HTPEAHAFTADA
MUL_0754|M.ulcerans_Agy99 VNQLIMIKLALNSALLQQGGVNSRMLSTVFDGVAR---HTPEGHAFVADA
. : * : * :: ..:.: :
Mflv_2422|M.gilvum_PYR-GCK IDSGLSAAVNDNDSKFPPEFRLSKRNRAKD-------------
Mvan_4230|M.vanbaalenii_PYR-1 IDSGLSAAVNDNDSKFPPEFRLSKRNRAKKD------------
MSMEG_4852|M.smegmatis_MC2_155 IDSGLSAAVNDNDSRFPPEFRLSKKNRAKP-------------
TH_2025|M.thermoresistible__bu IDSGLADAVNDNDMRFPPEFRLSKSNRAKE-------------
MMAR_4758|M.marinum_M IEQGLGDAVKDNDSRFPPEWRLSKKSRAKDGTGKPAKQKKKKG
MAV_2982|M.avium_104 FEKGLNNVVKDNDLNFPPEWRLSRSGRAKP-------------
Mb0464c|M.bovis_AF2122/97 QTQGVRAAVERRDGPFGDYSQAPPELRPDPTHVITPDGSM---
Rv0456c|M.tuberculosis_H37Rv QTQGVRAAVERRDGPFGDYSQAPPELRPDPTHVITPDGSM---
MAB_3859c|M.abscessus_ATCC_199 IANGYRQAVRHRDEPFGDYGRKPTEL-----------------
MUL_0754|M.ulcerans_Agy99 VEHGFRDAVNHRDEPFGDYGRRASSV-----------------
* .*. .* * : .