For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
PKSEPPVDKVIRYDKDPETRIATITFDRPGHLNAPTIAARLRYADLLHRASIDDEVKVLVIRGEGEDLGS GADLEEFMEVMNSPDQGPRLAEFRIGPEEVKYPPLGSFRHGASVSQWYANPNAGIRGLQDFKKISILEVK GYCYGWHFYQAADADLVISSDDALFGHPSFRYYGWGPRMWWWAQTMGIRKFQEMVFTGRAFTAAEMQDCN FLNSVVPREELEAEVAKYALACARNRPNDTVFMQKVFFEIMKQFQGEYMGSLLSGFFESMGSGVRADTDD LMLDDAIEQGLGDAVKDNDSRFPPEWRLSKKSRAKDGTGKPAKQKKKKG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4758 | echA4_1 | - | 100% (330) | enoyl-CoA hydratase, EchA4_1 |
| M. marinum M | MMAR_1002 | echA4 | 5e-18 | 26.83% (287) | enoyl-CoA hydratase, EchA4 |
| M. marinum M | MMAR_0778 | echA2 | 1e-15 | 27.81% (302) | enoyl-CoA hydratase EchA2 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0692 | echA4 | 1e-17 | 25.35% (284) | enoyl-CoA hydratase |
| M. gilvum PYR-GCK | Mflv_2422 | - | 1e-127 | 70.25% (316) | enoyl-CoA hydratase/isomerase |
| M. tuberculosis H37Rv | Rv0673 | echA4 | 1e-17 | 25.35% (284) | enoyl-CoA hydratase |
| M. leprae Br4923 | MLBr_01241 | - | 3e-05 | 35.09% (57) | enoyl-CoA hydratase |
| M. abscessus ATCC 19977 | MAB_3859c | - | 2e-14 | 24.40% (291) | enoyl-CoA hydratase |
| M. avium 104 | MAV_2982 | - | 1e-107 | 58.58% (309) | enoyl-CoA hydratase/isomerase |
| M. smegmatis MC2 155 | MSMEG_4852 | - | 1e-129 | 72.06% (315) | enoyl-CoA hydratase, putative |
| M. thermoresistible (build 8) | TH_2025 | - | 1e-130 | 71.84% (316) | enoyl-CoA hydratase, putative |
| M. ulcerans Agy99 | MUL_0754 | echA4 | 1e-17 | 26.48% (287) | enoyl-CoA hydratase |
| M. vanbaalenii PYR-1 | Mvan_4230 | - | 1e-127 | 70.00% (320) | enoyl-CoA hydratase/isomerase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0692|M.bovis_AF2122/97 -------MTHAIRPVDFDNLKTMTYEVTGRIARITFNRPEKGNAIIADTP
Rv0673|M.tuberculosis_H37Rv -------MTHAIRPVDFDNLKTMTYEVTGRIARITFNRPEKGNAIIADTP
MUL_0754|M.ulcerans_Agy99 -------MTHAIRPVDFDNLKTMTYEVTDRVARITFNRPEKGNAIVADTP
MAB_3859c|M.abscessus_ATCC_199 ---------------MVDTLKTMTYEVTDRVARITFNRPEQGNAIIADTP
Mflv_2422|M.gilvum_PYR-GCK --MAERPSPSAAERPTPEEIILYEKDPQTKIATITFNRPEFLNAPTSMAR
Mvan_4230|M.vanbaalenii_PYR-1 --MAERPQPPAAERPAPEEIILYDKDPKTKIATITFNRPEFLNAPTSMAR
MSMEG_4852|M.smegmatis_MC2_155 ----------MAERPTPEEIILYDKDPETKIATITFNRPEFLNAPTSMAR
TH_2025|M.thermoresistible__bu ----------MADRPAPEEIILYDKDPRTKIATITFNRPEFLNAPTSAAR
MMAR_4758|M.marinum_M ---------MPKSEPPVDKVIRYDKDPETRIATITFDRPGHLNAPTIAAR
MAV_2982|M.avium_104 ----MPEYDYEELKKEAEQYIKFEKDKKNRIAYITFDRPDAQNSATLGMR
MLBr_01241|M.leprae_Br4923 MSQTDASCTIAELPYRSVTDLVVLDFPRPEVALITLNRPGRMNSMALDLM
.:* **::** *:
Mb0692|M.bovis_AF2122/97 LELSALVERADLDPGVHVILVSGRGEGFCAGFDLSAYAEGSSSTGGGGAY
Rv0673|M.tuberculosis_H37Rv LELSALVERADLDPGVHVILVSGRGEGFCAGFDLSAYAEGSSSTGGGGAY
MUL_0754|M.ulcerans_Agy99 LELSALVERADLDPAVQVILVSGRGEGFCAGFDLSAYAEGSSSSGAEGGY
MAB_3859c|M.abscessus_ATCC_199 LELAALVERADLDPQVHVILVSGRGDGFCGGFDLSAYAEANDE--GSVRY
Mflv_2422|M.gilvum_PYR-GCK LRYADVLRAANADNDVKVVIIRGVGDNLGSGADLPEFMEGNDNP--AVRL
Mvan_4230|M.vanbaalenii_PYR-1 LRYADVLRAANTDNDVKVVIIRGVGDNLGSGADLPEFMEGNDNP--AARL
MSMEG_4852|M.smegmatis_MC2_155 LRYADVLRAANADNDVKVVVIRGVGDNLGSGADLPEFMEGNDNP--AVRL
TH_2025|M.thermoresistible__bu LRYADLLRAATVDNDVKVVVIRGVGDNLGSGADLPEFMEGNDNP--ALRL
MMAR_4758|M.marinum_M LRYADLLHRASIDDEVKVLVIRGEGEDLGSGADLEEFMEVMNSPDQGPRL
MAV_2982|M.avium_104 QNYADLIHKCNVDDDVKVVVIRGEGEDFGSGGDLPEQRGMLENPG-MPLL
MLBr_01241|M.leprae_Br4923 KSLKQVLKRITYDHSVRVVVLTGAGRGFCSGADQKFTAP-----------
::. * *:*::: * * .: .* *
Mb0692|M.bovis_AF2122/97 QGTVLDGKTQAVNHLPNQP--WDPMIDYQMMSRFVRGFASLMHADKPTVV
Rv0673|M.tuberculosis_H37Rv QGTVLDGKTQAVNHLPNQP--WDPMIDYQMMSRFVRGFASLMHADKPTVV
MUL_0754|M.ulcerans_Agy99 RGTVLDGKAQAVNHLPNQP--WDPMIDYQMMSRFVRGFSSLTHADKPTVV
MAB_3859c|M.abscessus_ATCC_199 SGTALDGQVQLRNHLPNIN--WDPMLDYQMMSRFTRGFSSLLHANKPTVV
Mflv_2422|M.gilvum_PYR-GCK AELRLEDDGVGEVTYPPKGTFRNGATISAWYANSQAGNRALQDFKKISIV
Mvan_4230|M.vanbaalenii_PYR-1 AELRLEDDGVGEVTYPPKGTFRNGATISAWYANSQAGNRALQDFKKISIV
MSMEG_4852|M.smegmatis_MC2_155 AELRLEDDGVGEVTYPPRGTFRNGATISAWYANSQAGNRALQDFKKISIV
TH_2025|M.thermoresistible__bu AELRLEDDGVGEVTYPPKGTFRNGATISAWYANSQAGNRPLQELKKISIV
MMAR_4758|M.marinum_M AEFRIGPE---EVKYPPLGSFRHGASVSQWYANPNAGIRGLQDFKKISIL
MAV_2982|M.avium_104 HELAINDD---DVKYPPGGSYRYLSTVTDFYAKARAGNRPLQELRKISII
MLBr_01241|M.leprae_Br4923 --------------VPQVEGLTQPVRALRAMELLEEVILALRRLHQPVIA
* * : :
Mb0692|M.bovis_AF2122/97 KIHGYCVAGGTDIALHADQVIAAADAKIGYPPTR---VWGV-PAAGLWAH
Rv0673|M.tuberculosis_H37Rv KIHGYCVAGGTDIALHADQVIAAADAKIGYPPTR---VWGV-PAAGLWAH
MUL_0754|M.ulcerans_Agy99 KIHGYCVAGGTDIALHADQVIAAADAKIGYPPTR---VWGV-PAAGLWAH
MAB_3859c|M.abscessus_ATCC_199 KVHGYCVAGGTDIALHADQLIVAADAKIGYPPTR---VWGV-PATGLWAH
Mflv_2422|M.gilvum_PYR-GCK EAKGYCYGWHFYQCADADLVISSDDALFGHPSFR---YHGWGPRMWTWVQ
Mvan_4230|M.vanbaalenii_PYR-1 EAKGYCYGWHFYQCADADLVISSDDALFGHPSFR---YHGWGPRMWTWVQ
MSMEG_4852|M.smegmatis_MC2_155 EAKGYCYGWHFYQCADADLVISSDDALFGHPSFR---YHGWGPRMWTWVQ
TH_2025|M.thermoresistible__bu EAKGYCYGWHFYQCADADLVISSDDALFGHPSFR---YYGWGPRMWTWVQ
MMAR_4758|M.marinum_M EVKGYCYGWHFYQAADADLVISSDDALFGHPSFR---YYGWGPRMWWWAQ
MAV_2982|M.avium_104 EAKGYCYGWHFYQAGDADLVIASDDALFGHPAFR---YVGWGPRLWWWAE
MLBr_01241|M.leprae_Br4923 AINGPAIGGGLCLALAADVRVASTRAYFRAAGINNGLSASELGLSYLLPR
:* . . . ** : : * : . . . .
Mb0692|M.bovis_AF2122/97 RLGDQRAKRLLFTGDCITGAQAAEWGLAVEAPEPADLDERTERLVARIA-
Rv0673|M.tuberculosis_H37Rv RLGDQRAKRLLFTGDCITGAQAAEWGLAVEAPEPADLDERTERLVARIA-
MUL_0754|M.ulcerans_Agy99 RLGDQRAKRLLFTGDCITGAQAAEWGLAVEAPDPKDLDERTERLVERIA-
MAB_3859c|M.abscessus_ATCC_199 KLGDQRAKRLLLTGDCLSGRQAYDWGLAVEAPEPDELDERTERLVERIA-
Mflv_2422|M.gilvum_PYR-GCK MMGLRKFQEMVFTGRPFTAAEMYDCNFLNKVVERDQLEAETQKYALACAR
Mvan_4230|M.vanbaalenii_PYR-1 MMGLRKFQEMVFTGRPFTAAEMYDCNFLNKVVTRDQLEAETRKYALACAR
MSMEG_4852|M.smegmatis_MC2_155 MMGLRKFQEMVFTGRPFTAAEMYDCNFLNKVVPRDRLEAEVDKYATACAR
TH_2025|M.thermoresistible__bu MMGLRKFSEMVFTGRPFTAAEMYDCNFLNKVVPRDQLEAEVDKYARACAR
MMAR_4758|M.marinum_M TMGIRKFQEMVFTGRAFTAAEMQDCNFLNSVVPREELEAEVAKYALACAR
MAV_2982|M.avium_104 TMGLRKFSEMLFTGRPFSAKEMYDCGFVNSVVPRDKLEAETEKYALACSK
MLBr_01241|M.leprae_Br4923 AVGSSRAFEIMLSGRDVGAEEAEQIGLVSYRVSDDRLLDTCYSIAARMAT
:* : .::::* . . : : .: * . :
Mb0692|M.bovis_AF2122/97 ALPVNQLIMVKLALNSALLQ--QGVATSRMVSTVFDGAAR---HTPEGHA
Rv0673|M.tuberculosis_H37Rv ALPVNQLIMVKLALNSALLQ--QGVATSRMVSTVFDGAAR---HTPEGHA
MUL_0754|M.ulcerans_Agy99 ALPVNQLIMIKLALNSALLQ--QGGVNSRMLSTVFDGVAR---HTPEGHA
MAB_3859c|M.abscessus_ATCC_199 AMPLNQLMMIKLACNSVLIN--QGIANSAMIGTVFDGISR---HTPEAHA
Mflv_2422|M.gilvum_PYR-GCK NRPVDTVFQQKMFFEIFKQQ--QGEYMGSLLSAFFESMGNGVANDSDEDL
Mvan_4230|M.vanbaalenii_PYR-1 NRPVDTVFQQKMFFEIFKQQ--QGEYMGSLLSAFFESMGNGVANDSDDDL
MSMEG_4852|M.smegmatis_MC2_155 NRPVDTVFQQKMFFEIFKQQ--QGEYMGSLLSAFFESMGNGVANDSDDDL
TH_2025|M.thermoresistible__bu NRPVDTVFQQKIFFEVFKQH--QGEYMGSLLSAFFESMGSGAVNDDTDDL
MMAR_4758|M.marinum_M NRPNDTVFMQKVFFEIMKQF--QGEYMGSLLSGFFESMGSGVRADT-DDL
MAV_2982|M.avium_104 ARPTDTVAVQKTFLELYKQH--KGEYFGSLLTGLVEGMLPLIANDAEEVD
MLBr_01241|M.leprae_Br4923 FSRSGTELTKRALWGGLDAASLDKHMQSESLAQLFIALHT----------
. : . . : .. .
Mb0692|M.bovis_AF2122/97 FVADAVEHGFRDAVRRRDEPFGDYGRQASRV-----------------
Rv0673|M.tuberculosis_H37Rv FVADAVEHGFRDAVRRRDEPFGDYGRQASRV-----------------
MUL_0754|M.ulcerans_Agy99 FVADAVEHGFRDAVNHRDEPFGDYGRRASSV-----------------
MAB_3859c|M.abscessus_ATCC_199 FTADAIANGYRQAVRHRDEPFGDYGRKPTEL-----------------
Mflv_2422|M.gilvum_PYR-GCK DMFESIDSGLSAAVNDNDSKFPPEFRLSKRNRAKD-------------
Mvan_4230|M.vanbaalenii_PYR-1 DMFESIDSGLSAAVNDNDSKFPPEFRLSKRNRAKKD------------
MSMEG_4852|M.smegmatis_MC2_155 DMFESIDSGLSAAVNDNDSRFPPEFRLSKKNRAKP-------------
TH_2025|M.thermoresistible__bu DMHEAIDSGLADAVNDNDMRFPPEFRLSKSNRAKE-------------
MMAR_4758|M.marinum_M MLDDAIEQGLGDAVKDNDSRFPPEWRLSKKSRAKDGTGKPAKQKKKKG
MAV_2982|M.avium_104 LTAGTFEKGLNNVVKDNDLNFPPEWRLSRSGRAKP-------------
MLBr_01241|M.leprae_Br4923 ---SNFEEAAAPCTEKRPTVLVDARGCATSPG----------------
. . .. . : .