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MTHAIRPVDFDNLKTMTYEVTDRVARITFNRPEKGNAIVADTPLELSALVERADLDPAVQVILVSGRGEG FCAGFDLSAYAEGSSSSGAEGGYRGTVLDGKAQAVNHLPNQPWDPMIDYQMMSRFVRGFSSLTHADKPTV VKIHGYCVAGGTDIALHADQVIAAADAKIGYPPTRVWGVPAAGLWAHRLGDQRAKRLLFTGDCITGAQAA EWGLAVEAPDPKDLDERTERLVERIAALPVNQLIMIKLALNSALLQQGGVNSRMLSTVFDGVARHTPEGH AFVADAVEHGFRDAVNHRDEPFGDYGRRASSV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_0754 | echA4 | - | 100% (312) | enoyl-CoA hydratase |
| M. ulcerans Agy99 | MUL_1414 | echA2 | 2e-44 | 35.23% (298) | enoyl-CoA hydratase |
| M. ulcerans Agy99 | MUL_3885 | echA4_2 | 4e-21 | 27.93% (290) | enoyl-CoA hydratase, EchA4_2 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0692 | echA4 | 1e-168 | 91.67% (312) | enoyl-CoA hydratase |
| M. gilvum PYR-GCK | Mflv_2433 | - | 2e-21 | 30.08% (266) | enoyl-CoA hydratase |
| M. tuberculosis H37Rv | Rv0673 | echA4 | 1e-168 | 91.67% (312) | enoyl-CoA hydratase |
| M. leprae Br4923 | MLBr_02402 | - | 2e-14 | 24.12% (257) | enoyl-CoA hydratase |
| M. abscessus ATCC 19977 | MAB_3859c | - | 1e-138 | 76.49% (302) | enoyl-CoA hydratase |
| M. marinum M | MMAR_1002 | echA4 | 1e-179 | 98.72% (312) | enoyl-CoA hydratase, EchA4 |
| M. avium 104 | MAV_4499 | - | 1e-166 | 90.71% (312) | enoyl-CoA hydratase |
| M. smegmatis MC2 155 | MSMEG_1388 | - | 1e-160 | 87.50% (312) | enoyl-CoA hydratase |
| M. thermoresistible (build 8) | TH_2027 | echA13 | 9e-23 | 30.16% (252) | POSSIBLE ENOYL-CoA HYDRATASE ECHA13 (ENOYL HYDRASE) |
| M. vanbaalenii PYR-1 | Mvan_1270 | - | 1e-148 | 84.44% (302) | enoyl-CoA hydratase |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_0754|M.ulcerans_Agy99 MTHAIRPVDFDNLKTMTYEVTD--RVARITFNRPEKGNAIVADTPLELSA
MMAR_1002|M.marinum_M MTHAIRPVDFDNLKTMTYEVTD--RVARITFNRPEKGNAIVADTPLELSA
Mb0692|M.bovis_AF2122/97 MTHAIRPVDFDNLKTMTYEVTG--RIARITFNRPEKGNAIIADTPLELSA
Rv0673|M.tuberculosis_H37Rv MTHAIRPVDFDNLKTMTYEVTG--RIARITFNRPEKGNAIIADTPLELSA
MAV_4499|M.avium_104 MTHAIRPVDFDNLKTMTYEVTD--RVARITFNRPEKGNAIVADTPLELSA
MSMEG_1388|M.smegmatis_MC2_155 MTHAIRPVDFDNLKTMTYEVTD--RVARITFNRPEKGNAIVADTPLELSA
Mvan_1270|M.vanbaalenii_PYR-1 MT--------ETLKTMTYEVTG--RVARITFNRPETGNAIIADTPLELAA
MAB_3859c|M.abscessus_ATCC_199 --------MVDTLKTMTYEVTD--RVARITFNRPEQGNAIIADTPLELAA
Mflv_2433|M.gilvum_PYR-GCK -------------MYIDYEVSD--RIATITLNRPEAANAQNPELLDELDA
TH_2027|M.thermoresistible__bu --MQMTERTGAEYSYVTYEVLDEGRIARIMMNRPRQRNAQNRGLLVELDD
MLBr_02402|M.leprae_Br4923 ------------MKYDTILVDGYQRVGIITLNRPQALNALNSQMMNEITN
* . *:. * :***. ** *:
MUL_0754|M.ulcerans_Agy99 LVERADLDPAVQVILVSGRGEGFCAGFDLSAYAEGSSSSGAEGGYRGTVL
MMAR_1002|M.marinum_M LVERADLDPAVHVILVSGRGEGFCAGFDLSAYAEGSSSSGAEGGYRGTVL
Mb0692|M.bovis_AF2122/97 LVERADLDPGVHVILVSGRGEGFCAGFDLSAYAEGSSSTGGGGAYQGTVL
Rv0673|M.tuberculosis_H37Rv LVERADLDPGVHVILVSGRGEGFCAGFDLSAYAEGSSSTGGGGAYQGTVL
MAV_4499|M.avium_104 LVERADLDPNVHVILVSGRGAGFCAGFDLSAYADRTGSAGGTGAYAGTVL
MSMEG_1388|M.smegmatis_MC2_155 LVERADLDPDVHVILVSGRGEGFCAGFDLSAYAEGSSSAGGGSPYEGTVL
Mvan_1270|M.vanbaalenii_PYR-1 LVERADLDPSVHVILVSGRGEGFCAGFDLGAYAEGSSTAGTDR--RGTVL
MAB_3859c|M.abscessus_ATCC_199 LVERADLDPQVHVILVSGRGDGFCGGFDLSAYAEANDE--GSVRYSGTAL
Mflv_2433|M.gilvum_PYR-GCK AWTRAAEDNDVSVIVLRANGKHFSAGHDL--------RGGGPVPD-----
TH_2027|M.thermoresistible__bu AFMRAERDDDVRVVILGGIGPMFSSGHDLGSSDDRAERSGGPAGHPTYLF
MLBr_02402|M.leprae_Br4923 AAKELDIDPDVGAILITGSPKVFAAGADIK--------------------
. * * .::: . *..* *:
MUL_0754|M.ulcerans_Agy99 DG-KAQAVNHLPNQPWDPMIDY---QMMSRFVRGFSSLTHADKPTVVKIH
MMAR_1002|M.marinum_M DG-KAQAVNHLPNQPWDPMIDY---QMMSRFVRGFSSLMHADKPTVVKIH
Mb0692|M.bovis_AF2122/97 DG-KTQAVNHLPNQPWDPMIDY---QMMSRFVRGFASLMHADKPTVVKIH
Rv0673|M.tuberculosis_H37Rv DG-KTQAVNHLPNQPWDPMIDY---QMMSRFVRGFASLMHADKPTVVKIH
MAV_4499|M.avium_104 DG-KTQAVNHLPDQPWDPMIDY---QMMSRFVRGFSSLMHADKPTVVKIH
MSMEG_1388|M.smegmatis_MC2_155 SG-KTQALNHLPDEPWDPMVDY---QMMSRFVRGFASLMHCDKPTVVKIH
Mvan_1270|M.vanbaalenii_PYR-1 DG-KTQAINHRADQPWDPMIDY---QMMSRFVRGFSSLMRCDKPTVVKIH
MAB_3859c|M.abscessus_ATCC_199 DG-QVQLRNHLPNINWDPMLDY---QMMSRFTRGFSSLLHANKPTVVKVH
Mflv_2433|M.gilvum_PYR-GCK ----KITLEFIIQHEAKRYLEY---TLRWRNVP---------KPSIAAVQ
TH_2027|M.thermoresistible__bu NGGSRQGTEQRMLQEWHYYFEN---ARRWRNLK---------KITIAETH
MLBr_02402|M.leprae_Br4923 ---EMASLTFTDAFDADFFSAWGKLAAVRT-------------PMIAAVA
. :.
MUL_0754|M.ulcerans_Agy99 GYCVAGGTDIALHADQVIAAADAKIGYPPTRVWGVPAAGLWAH---RLGD
MMAR_1002|M.marinum_M GYCVAGGTDIALHADQVIAAADAKIGYPPTRVWGVPAAGLWAH---RLGD
Mb0692|M.bovis_AF2122/97 GYCVAGGTDIALHADQVIAAADAKIGYPPTRVWGVPAAGLWAH---RLGD
Rv0673|M.tuberculosis_H37Rv GYCVAGGTDIALHADQVIAAADAKIGYPPTRVWGVPAAGLWAH---RLGD
MAV_4499|M.avium_104 GYCVAGGTDIALHADQVIAAADAKIGYPPTRVWGVPAAGLWAH---RLGD
MSMEG_1388|M.smegmatis_MC2_155 GYCVAGGTDIALHADQVIAAADAKIGYPPMRVWGVPAAGLWAH---RLGD
Mvan_1270|M.vanbaalenii_PYR-1 GYCVAGGTDIALHADQVIAAADAKIGYPPTRVWGVPAAGMWAH---RLGD
MAB_3859c|M.abscessus_ATCC_199 GYCVAGGTDIALHADQLIVAADAKIGYPPTRVWGVPATGLWAH---KLGD
Mflv_2433|M.gilvum_PYR-GCK GRCISGGLLLCWPCDLIVAADDAQFSDPV-VLMGIGGVEYHGHTW-ELGP
TH_2027|M.thermoresistible__bu GPVLAAGLMIAWTCDLIVATPTTTFADVVGTRIGMCGVEYFAHPW-ELGP
MLBr_02402|M.leprae_Br4923 GYALGGGCELAMMCDLLIAADTAKFGQPEIKLGVLPGMGGSQRLTRAIGK
* :..* :. .* ::.: : :. : . : :*
MUL_0754|M.ulcerans_Agy99 QRAKRLLFTGDCITGAQAAEWGLAVEAPDPKDLDERTERLVERIAALPVN
MMAR_1002|M.marinum_M QRAKRLLFTGDCITGAQAAEWGLAVEAPDPKDLDERTERLVERIAALPVN
Mb0692|M.bovis_AF2122/97 QRAKRLLFTGDCITGAQAAEWGLAVEAPEPADLDERTERLVARIAALPVN
Rv0673|M.tuberculosis_H37Rv QRAKRLLFTGDCITGAQAAEWGLAVEAPEPADLDERTERLVARIAALPVN
MAV_4499|M.avium_104 QRAKRLLFTGDCITGAQAAEWGLAVEAPDPADLDERTERLVQRIAAVPVN
MSMEG_1388|M.smegmatis_MC2_155 QRAKRLLFTGDCITGAQAAEWGLAVEAPDPADLDARTERLVERIAAMPVN
Mvan_1270|M.vanbaalenii_PYR-1 QRAKRLLLTGDCLTGAQAAEWGLAVEAPDPADLDERTERLVERIAAVPVN
MAB_3859c|M.abscessus_ATCC_199 QRAKRLLLTGDCLSGRQAYDWGLAVEAPEPDELDERTERLVERIAAMPLN
Mflv_2433|M.gilvum_PYR-GCK RKAKEILFTGRAMTADEVAATGMVNKVVPRAELDAETRALAEQIAKMPPF
TH_2027|M.thermoresistible__bu RRAKELLLTGDSLDAHTAHQWGMVSRIFPDDELQKRTMELAQRIAGLPTV
MLBr_02402|M.leprae_Br4923 AKAMDLILTGRTIDAAEAERSGLVSRVVLADDLLPEAKAVATTISQMSRS
:* :::** : . . *:. . :* .: :. *: :.
MUL_0754|M.ulcerans_Agy99 QLIMIKLALNSALLQQGGVNSRMLSTVFDGVARHTPEGHAFVADAVEHGF
MMAR_1002|M.marinum_M QLIMIKLALNSALLQQGVVNSRMLSTVFDGVARHTPEGHAFVADAVEHGF
Mb0692|M.bovis_AF2122/97 QLIMVKLALNSALLQQGVATSRMVSTVFDGAARHTPEGHAFVADAVEHGF
Rv0673|M.tuberculosis_H37Rv QLIMVKLALNSALLQQGVATSRMVSTVFDGAARHTPEGHAFVADAVEHGF
MAV_4499|M.avium_104 QLIMVKLALNSALLQQGVATSRMVSTVFDGVARHTPEGHAFVADAVKHGF
MSMEG_1388|M.smegmatis_MC2_155 QLIMAKLACNTALLNQGVATSQMVSTVFDGIARHTPEGHAFVATAREHGF
Mvan_1270|M.vanbaalenii_PYR-1 QLIMVKLAMNSALYNQGVATSAMISTVFDGIARHTPEGHAFVAQAREHGF
MAB_3859c|M.abscessus_ATCC_199 QLMMIKLACNSVLINQGIANSAMIGTVFDGISRHTPEAHAFTADAIANGY
Mflv_2433|M.gilvum_PYR-GCK ALRQAKRAVNQTLDVQG--FYAAIQSVFDVHQTGHGNALSVGGWPVLVNL
TH_2027|M.thermoresistible__bu TALLIKEAVNQSVDNMG--FYNALNACFSLHQINHAHWAEVTGGESHLGT
MLBr_02402|M.leprae_Br4923 ATRMAKEAVNRSFESTLAEGLLHERRLFHSTFVTDDQSEGMAAFIEKRAP
* * * . * . . .
MUL_0754|M.ulcerans_Agy99 RDAVNHRDEPFGDYGRRASSV-
MMAR_1002|M.marinum_M RDAVKHRDEPFGDYGRRASSV-
Mb0692|M.bovis_AF2122/97 RDAVRRRDEPFGDYGRQASRV-
Rv0673|M.tuberculosis_H37Rv RDAVRRRDEPFGDYGRQASRV-
MAV_4499|M.avium_104 REAVRHRDEPFGDHGRQASQV-
MSMEG_1388|M.smegmatis_MC2_155 REAVRRRDEPMGDHGRRASDV-
Mvan_1270|M.vanbaalenii_PYR-1 REAVRGRDEPFGDYGRTTSGV-
MAB_3859c|M.abscessus_ATCC_199 RQAVRHRDEPFGDYGRKPTEL-
Mflv_2433|M.gilvum_PYR-GCK EEMKAN-------IK-------
TH_2027|M.thermoresistible__bu PEFGVPRWQDAGPILPRPMSEA
MLBr_02402|M.leprae_Br4923 QFTHR-----------------