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AERPQPPAAERPAPEEIILYDKDPKTKIATITFNRPEFLNAPTSMARLRYADVLRAANTDNDVKVVIIRG VGDNLGSGADLPEFMEGNDNPAARLAELRLEDDGVGEVTYPPKGTFRNGATISAWYANSQAGNRALQDFK KISIVEAKGYCYGWHFYQCADADLVISSDDALFGHPSFRYHGWGPRMWTWVQMMGLRKFQEMVFTGRPFT AAEMYDCNFLNKVVTRDQLEAETRKYALACARNRPVDTVFQQKMFFEIFKQQQGEYMGSLLSAFFESMGN GVANDSDDDLDMFESIDSGLSAAVNDNDSKFPPEFRLSKRNRAKKD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4230 | - | - | 100% (327) | enoyl-CoA hydratase/isomerase |
| M. vanbaalenii PYR-1 | Mvan_4219 | - | 3e-18 | 31.06% (235) | enoyl-CoA hydratase |
| M. vanbaalenii PYR-1 | Mvan_0780 | - | 2e-16 | 28.66% (314) | enoyl-CoA hydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0464c | echA2 | 4e-18 | 27.52% (298) | enoyl-CoA hydratase |
| M. gilvum PYR-GCK | Mflv_2422 | - | 0.0 | 96.92% (325) | enoyl-CoA hydratase/isomerase |
| M. tuberculosis H37Rv | Rv0456c | echA2 | 4e-18 | 27.52% (298) | enoyl-CoA hydratase |
| M. leprae Br4923 | MLBr_01241 | - | 7e-05 | 30.23% (86) | enoyl-CoA hydratase |
| M. abscessus ATCC 19977 | MAB_3859c | - | 2e-15 | 22.68% (291) | enoyl-CoA hydratase |
| M. marinum M | MMAR_4758 | echA4_1 | 1e-127 | 70.00% (320) | enoyl-CoA hydratase, EchA4_1 |
| M. avium 104 | MAV_2982 | - | 1e-101 | 56.59% (311) | enoyl-CoA hydratase/isomerase |
| M. smegmatis MC2 155 | MSMEG_4852 | - | 0.0 | 95.89% (316) | enoyl-CoA hydratase, putative |
| M. thermoresistible (build 8) | TH_2025 | - | 1e-171 | 89.59% (317) | enoyl-CoA hydratase, putative |
| M. ulcerans Agy99 | MUL_1414 | echA2 | 6e-17 | 26.43% (314) | enoyl-CoA hydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0464c|M.bovis_AF2122/97 --------------MPTPDFQTLLYTTAGPVATITLNRPEQLNTIVPPMP
Rv0456c|M.tuberculosis_H37Rv --------------MPTPDFQTLLYTTAGPVATITLNRPEQLNTIVPPMP
MUL_1414|M.ulcerans_Agy99 --------------MPTPEFQTLLYSTAGPVATITLNRPEHLNTIVPPMP
MAB_3859c|M.abscessus_ATCC_199 ---------------MVDTLKTMTYEVTDRVARITFNRPEQGNAIIADTP
Mvan_4230|M.vanbaalenii_PYR-1 --MAERPQPPAAERPAPEEIILYDKDPKTKIATITFNRPEFLNAPTSMAR
Mflv_2422|M.gilvum_PYR-GCK --MAERPSPSAAERPTPEEIILYEKDPQTKIATITFNRPEFLNAPTSMAR
MSMEG_4852|M.smegmatis_MC2_155 ----------MAERPTPEEIILYDKDPETKIATITFNRPEFLNAPTSMAR
TH_2025|M.thermoresistible__bu ----------MADRPAPEEIILYDKDPRTKIATITFNRPEFLNAPTSAAR
MMAR_4758|M.marinum_M ---------MPKSEPPVDKVIRYDKDPETRIATITFDRPGHLNAPTIAAR
MAV_2982|M.avium_104 ----MPEYDYEELKKEAEQYIKFEKDKKNRIAYITFDRPDAQNSATLGMR
MLBr_01241|M.leprae_Br4923 MSQTDASCTIAELPYRSVTDLVVLDFPRPEVALITLNRPGRMNSMALDLM
:* **::** *:
Mb0464c|M.bovis_AF2122/97 DEIEAAIGLAERDQDIKVIVLRGAGRAFSGGYDFG--------GGFQHWG
Rv0456c|M.tuberculosis_H37Rv DEIEAAIGLAERDQDIKVIVLRGAGRAFSGGYDFG--------GGFQHWG
MUL_1414|M.ulcerans_Agy99 DEIEAAVGLAERDQGIKVIVLRGAGRAFSGGYDFG--------GGFQHWG
MAB_3859c|M.abscessus_ATCC_199 LELAALVERADLDPQVHVILVSGRGDGFCGGFDLSAYAEANDEGSVRYSG
Mvan_4230|M.vanbaalenii_PYR-1 LRYADVLRAANTDNDVKVVIIRGVGDNLGSGADLPEFMEGNDNP--AARL
Mflv_2422|M.gilvum_PYR-GCK LRYADVLRAANADNDVKVVIIRGVGDNLGSGADLPEFMEGNDNP--AVRL
MSMEG_4852|M.smegmatis_MC2_155 LRYADVLRAANADNDVKVVVIRGVGDNLGSGADLPEFMEGNDNP--AVRL
TH_2025|M.thermoresistible__bu LRYADLLRAATVDNDVKVVVIRGVGDNLGSGADLPEFMEGNDNP--ALRL
MMAR_4758|M.marinum_M LRYADLLHRASIDDEVKVLVIRGEGEDLGSGADLEEFMEVMNSPDQGPRL
MAV_2982|M.avium_104 QNYADLIHKCNVDDDVKVVVIRGEGEDFGSGGDLPEQRGMLENPG-MPLL
MLBr_01241|M.leprae_Br4923 KSLKQVLKRITYDHSVRVVVLTGAGRGFCSGADQKFT-------------
: * ::*::: * * : .* *
Mb0464c|M.bovis_AF2122/97 DAM---------MTDGRWDPGKDFAMVTARETGPTQKFMAIWRASKPVIA
Rv0456c|M.tuberculosis_H37Rv DAM---------MTDGRWDPGKDFAMVTARETGPTQKFMAIWRASKPVIA
MUL_1414|M.ulcerans_Agy99 ETM---------MTDGQWDPGKDFAMVTARETAPTQKFMAIWRASKPVIA
MAB_3859c|M.abscessus_ATCC_199 TALDGQVQLRNHLPNINWDPMLDYQMMSR----FTRGFSSLLHANKPTVV
Mvan_4230|M.vanbaalenii_PYR-1 AELRLEDDGVGEVTYPPKGTFRNGATISAWYANSQAGNRALQDFKKISIV
Mflv_2422|M.gilvum_PYR-GCK AELRLEDDGVGEVTYPPKGTFRNGATISAWYANSQAGNRALQDFKKISIV
MSMEG_4852|M.smegmatis_MC2_155 AELRLEDDGVGEVTYPPRGTFRNGATISAWYANSQAGNRALQDFKKISIV
TH_2025|M.thermoresistible__bu AELRLEDDGVGEVTYPPKGTFRNGATISAWYANSQAGNRPLQELKKISIV
MMAR_4758|M.marinum_M AEFRIGPE---EVKYPPLGSFRHGASVSQWYANPNAGIRGLQDFKKISIL
MAV_2982|M.avium_104 HELAINDD---DVKYPPGGSYRYLSTVTDFYAKARAGNRPLQELRKISII
MLBr_01241|M.leprae_Br4923 ------------APVPQVEGLTQPVRALRAMELLEEVILALRRLHQPVIA
: : :
Mb0464c|M.bovis_AF2122/97 QVHGWCVGGASDYALCADIVIASEDAVIGTPYSR---MWG-AYLTGMWLY
Rv0456c|M.tuberculosis_H37Rv QVHGWCVGGASDYALCADIVIASEDAVIGTPYSR---MWG-AYLTGMWLY
MUL_1414|M.ulcerans_Agy99 QIHGWCVGGASDYALCADIVIASDDAVIGTPYSR---MWG-AYLSGMWLY
MAB_3859c|M.abscessus_ATCC_199 KVHGYCVAGGTDIALHADQLIVAADAKIGYPPTR---VWG-VPATGLWAH
Mvan_4230|M.vanbaalenii_PYR-1 EAKGYCYGWHFYQCADADLVISSDDALFGHPSFR---YHGWGPRMWTWVQ
Mflv_2422|M.gilvum_PYR-GCK EAKGYCYGWHFYQCADADLVISSDDALFGHPSFR---YHGWGPRMWTWVQ
MSMEG_4852|M.smegmatis_MC2_155 EAKGYCYGWHFYQCADADLVISSDDALFGHPSFR---YHGWGPRMWTWVQ
TH_2025|M.thermoresistible__bu EAKGYCYGWHFYQCADADLVISSDDALFGHPSFR---YYGWGPRMWTWVQ
MMAR_4758|M.marinum_M EVKGYCYGWHFYQAADADLVISSDDALFGHPSFR---YYGWGPRMWWWAQ
MAV_2982|M.avium_104 EAKGYCYGWHFYQAGDADLVIASDDALFGHPAFR---YVGWGPRLWWWAE
MLBr_01241|M.leprae_Br4923 AINGPAIGGGLCLALAADVRVASTRAYFRAAGINNGLSASELGLSYLLPR
:* . . . ** : : * : . . .
Mb0464c|M.bovis_AF2122/97 RLSLAKVKWHSLTGRPLTGVQAAEAELINEAVPFERLEARVAEIATELAR
Rv0456c|M.tuberculosis_H37Rv RLSLAKVKWHSLTGRPLTGVQAAEAELINEAVPFERLEARVAEIATELAR
MUL_1414|M.ulcerans_Agy99 RLSFAKAKWHSLTGRPLSGVQAAQIELINEAVPFERLEARVAEVAAELAQ
MAB_3859c|M.abscessus_ATCC_199 KLGDQRAKRLLLTGDCLSGRQAYDWGLAVEAPEPDELDERTERLVERIAA
Mvan_4230|M.vanbaalenii_PYR-1 MMGLRKFQEMVFTGRPFTAAEMYDCNFLNKVVTRDQLEAETRKYALACAR
Mflv_2422|M.gilvum_PYR-GCK MMGLRKFQEMVFTGRPFTAAEMYDCNFLNKVVERDQLEAETQKYALACAR
MSMEG_4852|M.smegmatis_MC2_155 MMGLRKFQEMVFTGRPFTAAEMYDCNFLNKVVPRDRLEAEVDKYATACAR
TH_2025|M.thermoresistible__bu MMGLRKFSEMVFTGRPFTAAEMYDCNFLNKVVPRDQLEAEVDKYARACAR
MMAR_4758|M.marinum_M TMGIRKFQEMVFTGRAFTAAEMQDCNFLNSVVPREELEAEVAKYALACAR
MAV_2982|M.avium_104 TMGLRKFSEMLFTGRPFSAKEMYDCGFVNSVVPRDKLEAETEKYALACSK
MLBr_01241|M.leprae_Br4923 AVGSSRAFEIMLSGRDVGAEEAEQIGLVSYRVSDDRLLDTCYSIAARMAT
:. : ::* . . : : : :.* . :
Mb0464c|M.bovis_AF2122/97 -IPLSQLQAQKLIVNQAYENMGLASTQLLGGILDGLMR---NTPDALEFI
Rv0456c|M.tuberculosis_H37Rv -IPLSQLQAQKLIVNQAYENMGLASTQLLGGILDGLMR---NTPDALEFI
MUL_1414|M.ulcerans_Agy99 -IPLSQLQAQKLIVNQAYENMGLASTQTLGGILDGLMR---NTPDALDFI
MAB_3859c|M.abscessus_ATCC_199 -MPLNQLMMIKLACNSVLINQGIANSAMIGTVFDGISR---HTPEAHAFT
Mvan_4230|M.vanbaalenii_PYR-1 NRPVDTVFQQKMFFEIFKQQQGEYMGSLLSAFFESMGNGVANDSDDDLDM
Mflv_2422|M.gilvum_PYR-GCK NRPVDTVFQQKMFFEIFKQQQGEYMGSLLSAFFESMGNGVANDSDEDLDM
MSMEG_4852|M.smegmatis_MC2_155 NRPVDTVFQQKMFFEIFKQQQGEYMGSLLSAFFESMGNGVANDSDDDLDM
TH_2025|M.thermoresistible__bu NRPVDTVFQQKIFFEVFKQHQGEYMGSLLSAFFESMGSGAVNDDTDDLDM
MMAR_4758|M.marinum_M NRPNDTVFMQKVFFEIMKQFQGEYMGSLLSGFFESMGSGVRADT-DDLML
MAV_2982|M.avium_104 ARPTDTVAVQKTFLELYKQHKGEYFGSLLTGLVEGMLPLIANDAEEVDLT
MLBr_01241|M.leprae_Br4923 FSRSGTELTKRALWG-----------GLDAASLDKHMQSESLAQLFIALH
. : .:
Mb0464c|M.bovis_AF2122/97 RTAQTQGVRAAVERRDGPFGDYSQAPPELRPDPTHVITPDGSM---
Rv0456c|M.tuberculosis_H37Rv RTAQTQGVRAAVERRDGPFGDYSQAPPELRPDPTHVITPDGSM---
MUL_1414|M.ulcerans_Agy99 KTAENQGVRAAVERRDGPFGDYSQAPPELRPNPNHVIVPDRDR---
MAB_3859c|M.abscessus_ATCC_199 ADAIANGYRQAVRHRDEPFGDYGRKPTEL-----------------
Mvan_4230|M.vanbaalenii_PYR-1 FESIDSGLSAAVNDNDSKFPPEFRLSKRNRAKKD------------
Mflv_2422|M.gilvum_PYR-GCK FESIDSGLSAAVNDNDSKFPPEFRLSKRNRAKD-------------
MSMEG_4852|M.smegmatis_MC2_155 FESIDSGLSAAVNDNDSRFPPEFRLSKKNRAKP-------------
TH_2025|M.thermoresistible__bu HEAIDSGLADAVNDNDMRFPPEFRLSKSNRAKE-------------
MMAR_4758|M.marinum_M DDAIEQGLGDAVKDNDSRFPPEWRLSKKSRAKDGTGKPAKQKKKKG
MAV_2982|M.avium_104 AGTFEKGLNNVVKDNDLNFPPEWRLSRSGRAKP-------------
MLBr_01241|M.leprae_Br4923 TSNFEEAAAPCTEKRPTVLVDARGCATSPG----------------
.. .. . : .