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VQRVADQDQVTYETLDEGRIARIWLNRPDAQNAQSRTLLVQLDEAFGRAEADDVVRVVILAARGKNFSAG HDLGSEAALAERAPGPDQHPTFTCNGATREAVIERTYLQEWHYFFNNTSRWRDLRKITIAQVQGNAISAA LMLIWACDLIVASDDAKFSDVVAVRMGMPGVEYYAHPWEFGARKAKELLLTGDAIDADEAHRLGMVSKVF PRAELEDKTLEFARRIAERPTMAALLVKDSVNAASDAMGFTEALRHAFHIHELGHAHWAAYNENRYPVGL PPNVPDWRTLGAPKLSRRDEP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1568 | - | - | 100% (301) | enoyl-CoA hydratase |
| M. gilvum PYR-GCK | Mflv_2433 | - | 7e-54 | 46.90% (258) | enoyl-CoA hydratase |
| M. gilvum PYR-GCK | Mflv_4596 | - | 1e-25 | 32.62% (279) | enoyl-CoA hydratase/isomerase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1970c | echA13 | 1e-97 | 60.68% (295) | enoyl-CoA hydratase |
| M. tuberculosis H37Rv | Rv1935c | echA13 | 1e-97 | 60.68% (295) | enoyl-CoA hydratase |
| M. leprae Br4923 | MLBr_02402 | - | 3e-17 | 27.34% (267) | enoyl-CoA hydratase |
| M. abscessus ATCC 19977 | MAB_2058 | - | 4e-22 | 29.64% (280) | enoyl-CoA dehydratase/isomerase |
| M. marinum M | MMAR_4972 | echA13_1 | 1e-148 | 83.89% (298) | enoyl-CoA hydratase EchA13_1 |
| M. avium 104 | MAV_0670 | - | 1e-148 | 86.10% (295) | enoyl-CoA hydratase |
| M. smegmatis MC2 155 | MSMEG_5886 | - | 1e-149 | 87.37% (293) | enoyl-CoA hydratase |
| M. thermoresistible (build 8) | TH_1273 | - | 1e-120 | 86.78% (242) | PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE |
| M. ulcerans Agy99 | MUL_0210 | echA8 | 4e-19 | 29.10% (244) | enoyl-CoA hydratase |
| M. vanbaalenii PYR-1 | Mvan_5190 | - | 1e-168 | 95.02% (301) | enoyl-CoA hydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1970c|M.bovis_AF2122/97 --MFVGRVGPVDRRSDGERSRRPREFEYIRYETIDDGRIAAITLDRPKQR
Rv1935c|M.tuberculosis_H37Rv --MFVGRVGPVDRRSDGERSRRPREFEYIRYETIDDGRIAAITLDRPKQR
Mflv_1568|M.gilvum_PYR-GCK ----MQRVADQD---------------QVTYETLDEGRIARIWLNRPDAQ
Mvan_5190|M.vanbaalenii_PYR-1 ----MQRVATLE---------------QVTYETLDEGRIARIWLNRPDAQ
MSMEG_5886|M.smegmatis_MC2_155 MPYLLMRWFDMTGSDGDGGQA-----RQIEYETLDEGRIARIWLNRPQAQ
MMAR_4972|M.marinum_M ----MTLSEQADTSAEGVAPA-----ELVAYETLDEGRIARIWLNRPEAH
MAV_0670|M.avium_104 ----MTLSEQAGAQPGARPAE-----ELVTYETLDEGRIARIWLNRPDAH
TH_1273|M.thermoresistible__bu ----MGWSAVAKP-----DAS-----EQVTYETLDDGRIARIWLNRPEAQ
MLBr_02402|M.leprae_Br4923 -------------------------MKYDTILVDGYQRVGIITLNRPQAL
MUL_0210|M.ulcerans_Agy99 -------------------------MSYETILVERDQRVGIITLNRPQAL
MAB_2058|M.abscessus_ATCC_1997 -------------------------MAEQPIRYEVVDSVAWLTINRPEAR
:. : ::**.
Mb1970c|M.bovis_AF2122/97 NAQTRGMLVELGAAFELAEADDTVRVVILRAA-GPAFSAGHDLGSADDIR
Rv1935c|M.tuberculosis_H37Rv NAQTRGMLVELGAAFELAEADDTVRVVILRAA-GPAFSAGHDLGSADDIR
Mflv_1568|M.gilvum_PYR-GCK NAQSRTLLVQLDEAFGRAEADDVVRVVILAAR-GKNFSAGHDLGSEAALA
Mvan_5190|M.vanbaalenii_PYR-1 NAQSRTLLVQLDEAFGRAEADDEVRVVILAAR-GKNFSAGHDLGSEEAIA
MSMEG_5886|M.smegmatis_MC2_155 NAQSRTLLVQLDEAFARAEADDTVRVVILAAR-GKNFSAGHDLGSEEALA
MMAR_4972|M.marinum_M NAQNRTLLVQLDEAFGRAEADDTVRVVILAAR-GKNFSAGHDLGSEAALL
MAV_0670|M.avium_104 NAQSRGLLVQLDEAFVRAEADDAVRVVILAAR-GKNFSAGHDLGSELALA
TH_1273|M.thermoresistible__bu NAQSRTLLVQLDEAFLRAEADDQVRVVILAAR-GRNFSAGHDLGSEEALL
MLBr_02402|M.leprae_Br4923 NALNSQMMNEITNAAKELDIDPDVGAILITGS-PKVFAAGADIKEMASLT
MUL_0210|M.ulcerans_Agy99 NALNSQVMNEVTSAAAELDNDPGIGAIIITGS-AKAFAAGADIKEMADLT
MAB_2058|M.abscessus_ATCC_1997 NALNNAVRTGLIDAVLRFNDDDAAKVLVLTGVGDKAFCAGGDLKEMAQNA
** . : : * : * .::: . *.** *: .
Mb1970c|M.bovis_AF2122/97 ERSPGPDQHPSYRCNGATFGGVESRN-RQEWHYYFENTKRWRNLRKITIA
Rv1935c|M.tuberculosis_H37Rv ERSPGPDQHPSYRCNGATFGGVESRN-RQEWHYYFENTKRWRNLRKITIA
Mflv_1568|M.gilvum_PYR-GCK ERAPGPDQHPTFTCNGATREAVIERTYLQEWHYFFNNTSRWRDLRKITIA
Mvan_5190|M.vanbaalenii_PYR-1 ERTPGPDQHPTFTFNGGTRDAISERTYLQEWHYFFNNTSRWRDLRKITIA
MSMEG_5886|M.smegmatis_MC2_155 EREPGPGQHPTFAGYGATVAGVAERTYRQEWHFYFENTKRWRDLRKITIA
MMAR_4972|M.marinum_M ERKPGPAQHPTFRSHGGTRDAVMEKLYLQEWHFYFQNTCRWRDLRKITIA
MAV_0670|M.avium_104 ERQPGPGQHPTFRFNGATRDPIAEKTYLQEWHYFFQNTCRWRDLRKITIA
TH_1273|M.thermoresistible__bu ERQPGPDQHPTFRSHGATATGIAERTYRQEWHFYFENTCRWRDLRKITIA
MLBr_02402|M.leprae_Br4923 FTDAFD-------------------------ADFFSAWGKLAAVRTPMIA
MUL_0210|M.ulcerans_Agy99 FSEAFD-------------------------ADFFAAWGKLAAVRTPTIA
MAB_2058|M.abscessus_ATCC_1997 LKVPP--------------------------KDFAPQFGRNIDVAKPTIA
. : : : . **
Mb1970c|M.bovis_AF2122/97 QVHGAVLSAGLMLAWCCDLIVASEDTVFADVVGTRLGMCGVEYFGHP-WE
Rv1935c|M.tuberculosis_H37Rv QVHGAVLSAGLMLAWCCDLIVASEDTVFADVVGTRLGMCGVEYFGHP-WE
Mflv_1568|M.gilvum_PYR-GCK QVQGNAISAALMLIWACDLIVASDDAKFSDVVAVRMGMPGVEYYAHP-WE
Mvan_5190|M.vanbaalenii_PYR-1 QVQGNAISAGLMLIWACDLIVASDDARFSDVVAVRMGMPGVEYYAHP-WE
MSMEG_5886|M.smegmatis_MC2_155 QVQGNAISAALMLIWACDLIVAADDARFSDVVAVRMGMPGVEYYAHP-WE
MMAR_4972|M.marinum_M QVQGNAISAALMLIWACDLIVAADNAKFSDVVAVRLGMPGVEYYAHP-WE
MAV_0670|M.avium_104 QVQGNAISAGLMLIWACDLIVAADNAKFSDVVGVRMGMPGVEYYAHP-WE
TH_1273|M.thermoresistible__bu QVQGNAISAALMLIWACDLIVAADDARFSDVVGVRMGMPGVEYYAHP-WE
MLBr_02402|M.leprae_Br4923 AVAGYALGGGCELAMMCDLLIAADTAKFGQPEIKLGVLPGMGGSQRLTRA
MUL_0210|M.ulcerans_Agy99 AVAGYALGGGCEVAMMCDLIIAADTAKFGQPEIKLGVLPGMGGSQRLTRA
MAB_2058|M.abscessus_ATCC_1997 AVNGVAFAGGFLLAQQCDLVVAAEHATFAVSEVKVG--RGSPWATPLSWL
* * .:... : ***::*:: : *. *
Mb1970c|M.bovis_AF2122/97 FGPRKTKELLLTGDCIGADEAHALGMVSKVFPADELATSTIEFARRIAKV
Rv1935c|M.tuberculosis_H37Rv FGPRKTKELLLTGDCIGADEAHALGMVSKVFPADELATSTIEFARRIAKV
Mflv_1568|M.gilvum_PYR-GCK FGARKAKELLLTGDAIDADEAHRLGMVSKVFPRAELEDKTLEFARRIAER
Mvan_5190|M.vanbaalenii_PYR-1 FGARKAKELLLTGDAIDADEAHRLGMVSKVFPRAELEDKTLEFARRIAER
MSMEG_5886|M.smegmatis_MC2_155 FGPRKAKELLLTGDSIDADEAYRLGMVSKVFGREELEDKTLEFARRIAER
MMAR_4972|M.marinum_M FGPRKAKELLLTGDSLDAEEAYRLGMVSKVFPADELADKTLQFARRIAER
MAV_0670|M.avium_104 FGPRKAKELLLTGDALDADEAYRLGMVSKVFPADELADKTLEFARRIAER
TH_1273|M.thermoresistible__bu FGPRKAKELLLTGDSIDADEAYRMGMVSKVFPRAELEEKTLEFARRIAER
MLBr_02402|M.leprae_Br4923 IGKAKAMDLILTGRTIDAAEAERSGLVSRVVLADDLLPEAKAVATTISQM
MUL_0210|M.ulcerans_Agy99 IGKAKAMDLILTGRTIDAAEAERSGLVSRVVPADDLLTEAKAVATTISQM
MAB_2058|M.abscessus_ATCC_1997 VPPRVAMQILLTGDPITAARAHQVGLVNEVVPADQLRERTQQLALSIAAN
. : :::*** : * .* *:*..*. :* : .* *:
Mb1970c|M.bovis_AF2122/97 PTMAALLIKESVNQTVDAMGFS-----------AALDGCFKIHQLN--HA
Rv1935c|M.tuberculosis_H37Rv PTMAALLIKESVNQTVDAMGFS-----------AALDGCFKIHQLN--HA
Mflv_1568|M.gilvum_PYR-GCK PTMAALLVKDSVNAASDAMGFT-----------EALRHAFHIHELG--HA
Mvan_5190|M.vanbaalenii_PYR-1 PTMAALLVKDSVNAASDAMGFT-----------EALRHAFHIHELG--HA
MSMEG_5886|M.smegmatis_MC2_155 PTMAALLVKDSVNAAADSMGFA-----------EALHHAFHIHELG--HA
MMAR_4972|M.marinum_M PTMAALLVKDSVNAASDAMGFT-----------EALRHAFHVHELG--HA
MAV_0670|M.avium_104 PTMAALLIKDSVNAASDAMGFT-----------EALRHAFHIHELG--HA
TH_1273|M.thermoresistible__bu PTMAALLIKDSGNAASDAMGXXXQPPVPAGGRLDRLRDLVLIGDVGRMGA
MLBr_02402|M.leprae_Br4923 SRSATRMAKEAVNRSFESTLAEG-----------------LLHERRLFHS
MUL_0210|M.ulcerans_Agy99 SRSAARMAKEAVNRTFEATLAEG-----------------LLYERRLIHS
MAB_2058|M.abscessus_ATCC_1997 APLSVLASKRTVYLSAQHHLAAA-----------------YDLADEIWEP
. :. * : : : .
Mb1970c|M.bovis_AF2122/97 HWGEVTG-----GKLSYGTVEYG---------------------------
Rv1935c|M.tuberculosis_H37Rv HWGEVTG-----GKLSYGTVEYG---------------------------
Mflv_1568|M.gilvum_PYR-GCK HWAAYNE-----NRYPVGLPPN----------------------------
Mvan_5190|M.vanbaalenii_PYR-1 HWAAYNE-----NRYPVGLPPN----------------------------
MSMEG_5886|M.smegmatis_MC2_155 HWAAANE-----NRWPVGMPPD----------------------------
MMAR_4972|M.marinum_M HWAAHNE-----NRYPIGLPPD----------------------------
MAV_0670|M.avium_104 HWAAHNE-----NRYPVGLPPD----------------------------
TH_1273|M.thermoresistible__bu HLAARPGEFACGGGQPVGIASDDQHLATGRGDRGGHPFADTASAAGHQIR
MLBr_02402|M.leprae_Br4923 TFVTDDQ--------SEGMAAFI---------------------------
MUL_0210|M.ulcerans_Agy99 AFATADQ--------SEGMAAFI---------------------------
MAB_2058|M.abscessus_ATCC_1997 VYLSDDA--------QEGPAAFR---------------------------
*
Mb1970c|M.bovis_AF2122/97 -LEDWRAAPQIRPAIKQRP-------------------------------
Rv1935c|M.tuberculosis_H37Rv -LEDWRAAPQIRPAIKQRP-------------------------------
Mflv_1568|M.gilvum_PYR-GCK -VPDWRTLGAPKLSRRDEP-------------------------------
Mvan_5190|M.vanbaalenii_PYR-1 -VPDWRTLGAPKLSRRDQP-------------------------------
MSMEG_5886|M.smegmatis_MC2_155 -VPDWRTLGAPKLARRDTP-------------------------------
MMAR_4972|M.marinum_M -VEDWRTAGPTQVARRDTP-------------------------------
MAV_0670|M.avium_104 -VEDWRNAKPTRLARRDTP-------------------------------
TH_1273|M.thermoresistible__bu PVGQRQLHGHPPFRSRDITAGGLXGWHARLHGVVHCAGGSETIGPITQVD
MLBr_02402|M.leprae_Br4923 ------EKRAPQFTHR----------------------------------
MUL_0210|M.ulcerans_Agy99 ------EKRPPNFTHR----------------------------------
MAB_2058|M.abscessus_ATCC_1997 ------EKRAPQWKGH----------------------------------
:
Mb1970c|M.bovis_AF2122/97 --------------------------------------------------
Rv1935c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1568|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5190|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5886|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4972|M.marinum_M --------------------------------------------------
MAV_0670|M.avium_104 --------------------------------------------------
TH_1273|M.thermoresistible__bu SEAWRRTVDLNVNGTMYLIKHAAREMVRGGGGSFVGVSSIASSNTHRWFG
MLBr_02402|M.leprae_Br4923 --------------------------------------------------
MUL_0210|M.ulcerans_Agy99 --------------------------------------------------
MAB_2058|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1970c|M.bovis_AF2122/97 --------------------------------------------------
Rv1935c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1568|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5190|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5886|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4972|M.marinum_M --------------------------------------------------
MAV_0670|M.avium_104 --------------------------------------------------
TH_1273|M.thermoresistible__bu AYGPSKAALDHLLMVAADELGPSWVRVNGIRPGLTKTDLVAPIMDTPAVV
MLBr_02402|M.leprae_Br4923 --------------------------------------------------
MUL_0210|M.ulcerans_Agy99 --------------------------------------------------
MAB_2058|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1970c|M.bovis_AF2122/97 --------------------------------------------------
Rv1935c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1568|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5190|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5886|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4972|M.marinum_M --------------------------------------------------
MAV_0670|M.avium_104 --------------------------------------------------
TH_1273|M.thermoresistible__bu DDYRACTPLPRFGEVSDIANLAVFLLSDAASWITGQIINVDGGHGLRRGP
MLBr_02402|M.leprae_Br4923 --------------------------------------------------
MUL_0210|M.ulcerans_Agy99 --------------------------------------------------
MAB_2058|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1970c|M.bovis_AF2122/97 ---------------------
Rv1935c|M.tuberculosis_H37Rv ---------------------
Mflv_1568|M.gilvum_PYR-GCK ---------------------
Mvan_5190|M.vanbaalenii_PYR-1 ---------------------
MSMEG_5886|M.smegmatis_MC2_155 ---------------------
MMAR_4972|M.marinum_M ---------------------
MAV_0670|M.avium_104 ---------------------
TH_1273|M.thermoresistible__bu DMSGMLEPVFGADGLRGVVEG
MLBr_02402|M.leprae_Br4923 ---------------------
MUL_0210|M.ulcerans_Agy99 ---------------------
MAB_2058|M.abscessus_ATCC_1997 ---------------------