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ARDEADVLIVGAGISGLIAARTVLAAGLTPLVVEADTRVGGRVLTEELAGLPMELGAQWIGDTHHRMFAL AAELGVETYPQYDDGETSYELAGTGVLRGNDFHERFAGELAELEKVLRRLDELAAEVCAATPWTAPHAAE WDAITAGAWYDAQGLSPVARTLLEICTVGILAVPTVEVSFLHLLFTIQTCGVTAELFAESEGGAQTTRFV GGTAEIPKRLAALISEHIVLDSPVQLIEHRADSVTLHCRGGRTAQGRRVIVAVSPTLAGRIMYDPPLSGY RDQLTQRMPNSAAMKAFFVYDEPFWRADGLNGQLISDIGPARMSNDTCIQGDDHGVILLFLEGEQARTHG HWSEEERREALTAELVRHFGDRAARPSHYIDGEWGSRQWTRGCYNANCGPLVWTTYGAALAEPIGVIHWA STDTAVEWSAYMEGAVEAGERAAREVIDALVSQRDR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1230 | - | - | 100% (457) | amine oxidase (flavin-containing) |
| M. gilvum PYR-GCK | Mflv_4501 | - | 3e-67 | 35.07% (442) | amine oxidase |
| M. gilvum PYR-GCK | Mflv_2278 | - | 6e-17 | 24.29% (457) | amine oxidase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3195 | aofH | 8e-69 | 35.37% (441) | flavin-containing monoamine oxidase |
| M. tuberculosis H37Rv | Rv3170 | aofH | 8e-69 | 35.37% (441) | flavin-containing monoamine oxidase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2659 | - | 2e-64 | 34.44% (450) | putative flavin-containing monoamine oxidase AofH |
| M. marinum M | MMAR_1389 | aofH | 8e-71 | 35.60% (441) | flavin-containing monoamine oxidase AofH (amine oxidase) |
| M. avium 104 | MAV_4062 | - | 3e-69 | 35.97% (442) | putative flavin-containing monoamine oxidase AofH |
| M. smegmatis MC2 155 | MSMEG_2035 | - | 7e-70 | 35.19% (449) | amine oxidase |
| M. thermoresistible (build 8) | TH_2921 | - | 7e-95 | 43.48% (460) | PUTATIVE putative flavin-containing monoamine oxidase AofH_1 |
| M. ulcerans Agy99 | MUL_2487 | aofH | 6e-70 | 35.37% (441) | flavin-containing monoamine oxidase AofH (amine oxidase) |
| M. vanbaalenii PYR-1 | Mvan_5578 | - | 0.0 | 89.58% (451) | amine oxidase (flavin-containing) |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3195|M.bovis_AF2122/97 MT------NPPWTVDVVVVGAGFAGLAAARELTRQGHEVLVFEGRDRVGG
Rv3170|M.tuberculosis_H37Rv MT------NPPWTVDVVVVGAGFAGLAAARELTRQGHEVLVFEGRDRVGG
MAV_4062|M.avium_104 MS------GPPRIVDVVVVGAGFAGLAAARELNRQGHDVVVFEGRDRVGG
MMAR_1389|M.marinum_M MT------NPSWIVDVVIVGAGFAGLAAARDLARQGHDVLVLEGRDRVGG
MUL_2487|M.ulcerans_Agy99 MT------NPSWIVDVVIVGAGFAGLAAARDLARQGHDVLVLEGRDRVGG
MSMEG_2035|M.smegmatis_MC2_155 MS------IPT-SADVVVVGAGFAGLTAARRLVQLGYDVVVLEGRDRVGG
MAB_2659|M.abscessus_ATCC_1997 MSRSVDNAVEAASVDVVIVGAGFAGLSAADRLVNMGVSVLVIDARERVGG
Mflv_1230|M.gilvum_PYR-GCK --------MARDEADVLIVGAGISGLIAARTVLAAGLTPLVVEADTRVGG
Mvan_5578|M.vanbaalenii_PYR-1 MSG-----MTGHEADVVVVGAGLSGLIAARTLLGAGLTPLILEADTRVGG
TH_2921|M.thermoresistible__bu ---------------VVVVGAGLAGLTAARTLRRAGVDVVVLEARDRVGG
*::****::** ** : * ::.:. ****
Mb3195|M.bovis_AF2122/97 RSLTGRVAGVP-------ADMGGSFIGPTQDAVLALATELGIPTTPTHRD
Rv3170|M.tuberculosis_H37Rv RSLTGRVAGVP-------ADMGGSFIGPTQDAVLALATELGIPTTPTHRD
MAV_4062|M.avium_104 RSFTGSVAGLP-------ADLGGTFVGPTQDAVLALAAELEVPTTPTHHE
MMAR_1389|M.marinum_M RSFTGSIAGLP-------ADMGGSFVGPTQDAVLALAAELGVPTVPTFHD
MUL_2487|M.ulcerans_Agy99 RSFTGSIAGLP-------ADMGGSFVGPSQDAVLALAAELGVPTVPTFHD
MSMEG_2035|M.smegmatis_MC2_155 RSSTATIAGVP-------VDLGGTFVGPTQDAVLGLAAELGCATVPTYNR
MAB_2659|M.abscessus_ATCC_1997 RSFTGEVAGVK-------VDLGATWVAKRHTAIRDLMDRLGCSLTPQYDE
Mflv_1230|M.gilvum_PYR-GCK RVLTEELAGLP-------MELGAQWIGDTHHRMFALAAELGVETYPQYDD
Mvan_5578|M.vanbaalenii_PYR-1 RILTEDLGGLP-------MELGAQWIGDTHHRMFALAAELGVETYPQFDD
TH_2921|M.thermoresistible__bu RTLNHFLEHGPDPENDAVVELGGQWIGPGHQRIRALIDELGLSTFDTYDR
* . : ::*. ::. : : * .* .
Mb3195|M.bovis_AF2122/97 GRNVIQWRGSARSYRGTIPKLSLTGLIDIGRLRWQFERIARGVPVAAPWD
Rv3170|M.tuberculosis_H37Rv GRNVIQWRGSARSYRGTIPKLSLTGLIDIGRLRWQFERIARGVPVAAPWD
MAV_4062|M.avium_104 GKNLIHWRGWTHAYHGTIPKLSLTGLLDIGRLRWQFDRIARSIPLAAPWE
MMAR_1389|M.marinum_M GKNVIRWRGGVRPYSGTIPRLSLTGLLDIARLRWQFERLARSIPISAPWA
MUL_2487|M.ulcerans_Agy99 GKNVIRWRGGVRPYSGTIPRLSLTGLLDIARLRWQFERLARSIPISAPWA
MSMEG_2035|M.smegmatis_MC2_155 GKNLIRWHGRVRSYRSTIPRLSIIELLDVSRIQWRFERLFRHVDVAEPWN
MAB_2659|M.abscessus_ATCC_1997 GVNLLWMAGKRKTWTGTLPTVDPVDLEDLGRITIEMGKLLETINVDAAWK
Mflv_1230|M.gilvum_PYR-GCK GETSYELAGTGVLRGNDFHERFAGELAELEKVLRRLDELAAEVCAATPWT
Mvan_5578|M.vanbaalenii_PYR-1 GETTYELAGTGVLRGNEFHDRFAGELAELEKVLRRLDGLATEVDPATPWT
TH_2921|M.thermoresistible__bu GAKLWEHNGRVRRYTGEIPRANPLHLADLQIALTRLERMARRIDPAAPWA
* . * . : * :: .: : : .*
Mb3195|M.bovis_AF2122/97 ARRARELDDVSLGEWLRLVRATSSSRNLMAIMTRVTWGCEPDDVSMLHAA
Rv3170|M.tuberculosis_H37Rv ARRARELDDVSLGEWLRLVRATSSSRNLMAIMTRVTWGCEPDDVSMLHAA
MAV_4062|M.avium_104 ARRAAELDGLSLGGWLRSVRATASSHALLAMVARVTWGCEPDEVSMLHAA
MMAR_1389|M.marinum_M ANRAADLDGVSLRQWLRSVRASASSHDLMAIMTRVTWGCEPDDVSMLHAA
MUL_2487|M.ulcerans_Agy99 ANRAADLDGVSLRQWLRSVRASASSHDLMAIMTRVTWECEPDDVSMLHAA
MSMEG_2035|M.smegmatis_MC2_155 GSLAHKLDQYSMERWLRYVHANASTRNLMAIMSRVTWGAEPDQVSMLHAV
MAB_2659|M.abscessus_ATCC_1997 SPNADQLDSISFGEWLSQQQAVTSTNALMYIVTRVQWGCSPLDVSLLHVL
Mflv_1230|M.gilvum_PYR-GCK APHAAEWDAITAGAWYDAQGLSPVARTLLEICTVGILAVPTVEVSFLHLL
Mvan_5578|M.vanbaalenii_PYR-1 APHAAEWDAITAGAWYDAQGLSPVARTLLEICTVGILAVPTVEVSFLHLL
TH_2921|M.thermoresistible__bu APRAAQWDRQTVAGWIDRHVRTAVGRAFIELVCEAVWAADAADLSLLHLL
. * . * : * . . :: : . ::*:**
Mb3195|M.bovis_AF2122/97 RYVRAAGGLDRLLD-VKNGAQQDRVPGGTQQIAQAAAAQLGARVLLNAAV
Rv3170|M.tuberculosis_H37Rv RYVRAAGGLDRLLD-VKNGAQQDRVPGGTQQIAQAAAAQLGARVLLNAAV
MAV_4062|M.avium_104 RYAHAAGGLDRLLD-VEDGAQQDRFPGGTQQIAAAAAAELGARVVLGAPV
MMAR_1389|M.marinum_M RYVRAAGGLDRLLD-VENGAQQELIPGGTQQIAELAAAELGTHVVLDAPV
MUL_2487|M.ulcerans_Agy99 RSVRAAGGLDRLLD-VENGAQQELIPGGTQQIAELAAAELGIHVVLDAPV
MSMEG_2035|M.smegmatis_MC2_155 RYVKAAGGLTRLLD-VEGGAQQDRLVEGTQQIALRMADELGQRIALDAPV
MAB_2659|M.abscessus_ATCC_1997 RYVQAVGGLDHMLA-VEHGQQEYRVTETTQEIAKRLAAQIGDQIVLNTRV
Mflv_1230|M.gilvum_PYR-GCK FTIQTCGVTAELFAESEGGAQTTRFVGGTAEIPKRLAALISEHIVLDSPV
Mvan_5578|M.vanbaalenii_PYR-1 FTIQTCGVTSELFAESEGGAQTTRFVGGTAEIPKRLAAMLTEHLVLDAPV
TH_2921|M.thermoresistible__bu TYTSSNQGLSQLIT-TRGGAQQSRIIGGAQQISTAMADELGDAVRLGAPV
: .:: . * * . : :*. * : : *.: *
Mb3195|M.bovis_AF2122/97 RRIDRHGAG-VTVTSDQGQAEAGFVIVAIPPAHRVAIEFDPPLPPEYQQL
Rv3170|M.tuberculosis_H37Rv RRIDRHGAG-VTVTSDQGQAEAGFVIVAIPPAHRVAIEFDPPLPPEYQQL
MAV_4062|M.avium_104 RRIERHGAG-VTVRTDLGDTEAGFVIVAIPPAHRAAIEFAPPLPAEYEQL
MMAR_1389|M.marinum_M RRIDRHGAG-VTVTSDQGQAEAGFVIVAIPPAHRAAIEFNPPLPTGYQEL
MUL_2487|M.ulcerans_Agy99 RRIDRHGAG-VTVTSDQGQAEAGFVIVAIPPAHRAAIEFNPPLPTGYQEL
MSMEG_2035|M.smegmatis_MC2_155 QRIERHSGGDIGVTFTTGHVRARAVVIAIAPQHRGDIEFDPPLPPEYTEL
MAB_2659|M.abscessus_ATCC_1997 RQISQDDNG-VTVSTDSGVINAKYAIVTAAPEHRAYIEYQPALPAKIEGL
Mflv_1230|M.gilvum_PYR-GCK QLIEHRADSVTLHCRGGRTAQGRRVIVAVSPTLAGRIMYDPPLSGYRDQL
Mvan_5578|M.vanbaalenii_PYR-1 QLIEHGSDSVTVHCRGGRTARGRRIIVAVSPMLAGRIMYDPPLSGYRDQL
TH_2921|M.thermoresistible__bu REIRTR-DGVQVVADT-ATVRAERVVVAMSPTLAGRLHYDEPLPADRDQL
: * . .. ::: .* : : .*. *
Mb3195|M.bovis_AF2122/97 AHHWPQGRLSKAYAAYSTPFWRASGYSGQALSDEAPVFITFDVSPHADGP
Rv3170|M.tuberculosis_H37Rv AHHWPQGRLSKAYAAYSTPFWRASGYSGQALSDEAPVFITFDVSPHADGP
MAV_4062|M.avium_104 ARHWPQGRLSKAYAAYSTPFWRADGFSGQALSDEGPVFITFDVSPHPDGP
MMAR_1389|M.marinum_M ADNWPQGRLSKAYAAYSTPFWRINGFTGQSLSDIGPVFITFDASPHDDGP
MUL_2487|M.ulcerans_Agy99 ADNWPQGRLSKAYAAYSTPFWRINGFTGQSLSDMGPVFITFDASPHDDAP
MSMEG_2035|M.smegmatis_MC2_155 AARWPQGRLSKAYAAYDRPFWRANGCSGEALSDEGPVFITFDVSPGDEGP
MAB_2659|M.abscessus_ATCC_1997 TTSFPMGALSKAFVAYDKPFWRAEGLSGEALTDTAPVFITFDVSPSDDGP
Mflv_1230|M.gilvum_PYR-GCK TQRMPNSAAMKAFFVYDEPFWRADGLNGQLISDIGPARMSNDTCIQGDDH
Mvan_5578|M.vanbaalenii_PYR-1 TQRMPNSAAMKAFFVYDEPFWRADGLNGQLISDVGPARMSNDTCIRGDDR
TH_2921|M.thermoresistible__bu TQRMPNGSVVKCMAIYDEPFWRADGLSGQGVGFTGPVKVFFDNSPPSGRP
: * . *. *. **** .* .*: : .*. : * .
Mb3195|M.bovis_AF2122/97 GILMGFVD---ARGFDSLPIEERRRDALRCFASLFGDEALDPLDYVDYRW
Rv3170|M.tuberculosis_H37Rv GILMGFVD---ARGFDSLPIEERRRDALRCFASLFGDEALDPLDYVDYRW
MAV_4062|M.avium_104 GILMGFVD---ARAFDSLPADQRRRDALRCFATLFGDDALKPLDYVDHRW
MMAR_1389|M.marinum_M GILMGFVD---AREFDSLSADQRRDRTLRCFASLFGDDALEPLDYVDYCW
MUL_2487|M.ulcerans_Agy99 GILMGFVD---AREFDSLSADQRRDRTLRCFASLFGDDALEPLDYADYCW
MSMEG_2035|M.smegmatis_MC2_155 GILLGFTD---ARTFDALPPEQRRQRALGGFATFFGDAARDPIDYLDHCW
MAB_2659|M.abscessus_ATCC_1997 GILMVFCT---ARVYDGFGPEVRRKLVLKQLVDLYGEQANTPIDYIDHCW
Mflv_1230|M.gilvum_PYR-GCK GVILLFLEGEQARTHGHWSEEERREALTAELVRHFGDRAARPSHYIDGEW
Mvan_5578|M.vanbaalenii_PYR-1 GVILLFLEGEQARTHGHWSEEERRAALTAELVRHFGERAAHPQLYVDGEW
TH_2921|M.thermoresistible__bu GVLLGFLEGSQARELGRADTRTRREAVIGCFARMFGPRAARPVDYVEKVW
*::: * ** . ** :. :* * * * : *
Mb3195|M.bovis_AF2122/97 GTEEFAPGGPTAAVPPGSWTKYGHWLREPVGPIHWASTETADEWTGYFDG
Rv3170|M.tuberculosis_H37Rv GTEEFAPGGPTAAVPPGSWTKYGHWLREPVGPIHWASTETADEWTGYFDG
MAV_4062|M.avium_104 GAEEFAPGGPTAAVPPGSWTRFGRWLREPVGPIHWAGTETADEWTGFLDG
MMAR_1389|M.marinum_M GTEQFAPGGPTAAVPPGSWTRYGQLLRKPVGPIHWAGTETADEWTGYFDG
MUL_2487|M.ulcerans_Agy99 GTEQFAPGGPTAAVPPGSWTRYGQLLRKPVGPIHWAGTETADEWTGYFDG
MSMEG_2035|M.smegmatis_MC2_155 GTEAFAPGGPTAAVPPEAWTAYGPWLRKPIDGIHWAGTETADVWTGFLDG
MAB_2659|M.abscessus_ATCC_1997 GTEPFAAGGPHPAAPPFASVNYGEALREPHGRIHWAGTETAGEWVGTMNG
Mflv_1230|M.gilvum_PYR-GCK GSRQWTRGCYNANCGPLVWTTYGAALAEPIGVIHWASTDTAVEWSAYMEG
Mvan_5578|M.vanbaalenii_PYR-1 GSRQWTRGCYNANCGPLVWTTYGAALAEPIGPIHWASTDTATEWSAYMEG
TH_2921|M.thermoresistible__bu AADQWTRGCYGAFLPPNTWTQVGPALRRAVGPIHWAGAETAVRSMGYMDG
.: :: * . * . * * .. . ****.::** . ::*
Mb3195|M.bovis_AF2122/97 AVRSGQRAAAEVAALL--------
Rv3170|M.tuberculosis_H37Rv AVRSGQRAAAEVAALL--------
MAV_4062|M.avium_104 AIRSGRRAAAEVTALL--------
MMAR_1389|M.marinum_M AVRSGQRAAAEVAALL--------
MUL_2487|M.ulcerans_Agy99 AVRAGQRAAAEVAALL--------
MSMEG_2035|M.smegmatis_MC2_155 AVRSGQRAATEVAEALKSSAAAG-
MAB_2659|M.abscessus_ATCC_1997 AILMGLHTADQIAQQLGVTGEVSK
Mflv_1230|M.gilvum_PYR-GCK AVEAGERAAREVIDALVSQRDR--
Mvan_5578|M.vanbaalenii_PYR-1 AVQAGERAAAEVIEALTK------
TH_2921|M.thermoresistible__bu AVASGERAAAEVLTALGSGA----
*: * ::* :: *