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M. gilvum PYR-GCK Mflv_2172 (-)

annotation: aldehyde dehydrogenase
coordinates: 2248080 - 2251502
length: 1140

MTRIGGDEHLVSEVETLVRRWLDDAAGHRVAPAARRLADVLRDPGGLDFTVGFVDRVIRPDDPRVAAANL
RELARTAPGFLPWHLRLLIRLGAAVSVVLPGVVIPIASRALREMVGHLLADATDARLGRSIERIRRRGVN
LNVNLLGEAVLGRREARRRLTGTERLLARPDVDYVSIKVSASVPPHSVWAFDEAVDHIEQSLLPLFTQAA
TAATPKFINLDMEEYRDLELTMAVFTRLLDRPELRALEAGIVLQAYLPDALGAMIRLQDWARDRRQRGGA
GIKVRLVKGANLPMEHVEASLHGWPVATWPTKQDTDTNYKRVLNYALQPDRIANVRIGVAGHNLFDVAYA
WILAGRRGVRDGVEFEMLLGMADAQAEAVRATVGSLLLYVPVVHPEDFDVAIAYLVRRLEEGSSHQNFMS
AVFELHSDDMLFQRERERFVASLAAVDDDVPLPNRRQDRRADDPAAAVRAEFSNVADTDPALPGNRAWGR
AVTGRIAGSTAGRSAVDEHTVTTVDGLEAVISRGVDAGARWAALSGAERAAVLRRAAATLEARRATLLEV
MAAETGKTLDQGDPEVSEAIDFANYYASLAEKLDRVDGAIARPVGLTVVTPPWNFPVAIPAGSTLAALAA
GSAVVIKPTTQARRCGSVMVEALWDAGIGRDTLQLVHLDEGELGARLISDARVDRVILTGAFDTAALFRS
FRPDLVLLAETSGKNAIVVTPHADVDLAVKDLVYSAFGHAGQKCSAASLGILVGSVARSARFRDQLVDAV
TSLNVGYPTDPTVQMGPVIEPADGKLLRALTTLGPGEKWLVAPRQLDDSGRLWSPGVRTGVRRGSEFHLT
EYFGPVLGLMEARDLDEAIAMQNQVDYGLTAGLHSLDRHEVERWIDRVEAGNAYVNRSTVGAVVARQPFG
GWKKSAVGAGAKAGGPNYLIGLTDWESAPAQQAGRLSPAMREFLSAAGRLDLSAEDREFLGRSARSDALA
WEQEFGIARDVAGLTAEKNVLRYRPVPVTVRAEDGHTASLLRVVAAGLLAGAAITVSTPAPPASAVADLL
HMRGVTLRVDDAEHWRKLLRGNAPARVRLIGGSREAFAGAGEGRADVALYAQPVVEAGRIELLTFLREQA
VAVTAHRFGSPTTLADGLFA
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. gilvum PYR-GCKMflv_2172--100% (1140)aldehyde dehydrogenase
M. gilvum PYR-GCKMflv_4799-1e-3930.36% (494) aldehyde dehydrogenase
M. gilvum PYR-GCKMflv_4063-5e-3627.69% (437) betaine-aldehyde dehydrogenase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2883caldC2e-3829.83% (419) aldehyde dehydrogenase
M. tuberculosis H37RvRv2858caldC2e-3829.83% (419) aldehyde dehydrogenase
M. leprae Br4923MLBr_02573gabD15e-3325.87% (429) succinic semialdehyde dehydrogenase
M. abscessus ATCC 19977MAB_0823-3e-4432.13% (445) aldehyde dehydrogenase
M. marinum MMMAR_1240pcd6e-4232.03% (434) piperideine-6-carboxilic acid dehydrogenase Pcd
M. avium 104MAV_2521mmsA1e-3827.87% (427) methylmalonate-semialdehyde dehydrogenase
M. smegmatis MC2 155MSMEG_6687-2e-4530.68% (453) aldehyde dehydrogenase, thermostable
M. thermoresistible (build 8)TH_2909-5e-3827.61% (431) PUTATIVE methylmalonate-semialdehyde dehydrogenase [acylating)
M. ulcerans Agy99MUL_2647pcd6e-4232.03% (434) piperideine-6-carboxilic acid dehydrogenase Pcd
M. vanbaalenii PYR-1Mvan_1856-1e-4330.68% (440) aldehyde dehydrogenase

CLUSTAL 2.0.9 multiple sequence alignment


MSMEG_6687|M.smegmatis_MC2_155      --------------------------------------------------
Mvan_1856|M.vanbaalenii_PYR-1       --------------------------------------------------
MAB_0823|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_2521|M.avium_104                --------------------------------------------------
TH_2909|M.thermoresistible__bu      --------------------------------------------------
Mb2883c|M.bovis_AF2122/97           --------------------------------------------------
Rv2858c|M.tuberculosis_H37Rv        --------------------------------------------------
MLBr_02573|M.leprae_Br4923          --------------------------------------------------
MMAR_1240|M.marinum_M               --------------------------------------------------
MUL_2647|M.ulcerans_Agy99           --------------------------------------------------
Mflv_2172|M.gilvum_PYR-GCK          MTRIGGDEHLVSEVETLVRRWLDDAAGHRVAPAARRLADVLRDPGGLDFT
                                                                                      

MSMEG_6687|M.smegmatis_MC2_155      --------------------------------------------------
Mvan_1856|M.vanbaalenii_PYR-1       --------------------------------------------------
MAB_0823|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_2521|M.avium_104                --------------------------------------------------
TH_2909|M.thermoresistible__bu      --------------------------------------------------
Mb2883c|M.bovis_AF2122/97           --------------------------------------------------
Rv2858c|M.tuberculosis_H37Rv        --------------------------------------------------
MLBr_02573|M.leprae_Br4923          --------------------------------------------------
MMAR_1240|M.marinum_M               --------------------------------------------------
MUL_2647|M.ulcerans_Agy99           --------------------------------------------------
Mflv_2172|M.gilvum_PYR-GCK          VGFVDRVIRPDDPRVAAANLRELARTAPGFLPWHLRLLIRLGAAVSVVLP
                                                                                      

MSMEG_6687|M.smegmatis_MC2_155      --------------------------------------------------
Mvan_1856|M.vanbaalenii_PYR-1       --------------------------------------------------
MAB_0823|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_2521|M.avium_104                --------------------------------------------------
TH_2909|M.thermoresistible__bu      --------------------------------------------------
Mb2883c|M.bovis_AF2122/97           --------------------------------------------------
Rv2858c|M.tuberculosis_H37Rv        --------------------------------------------------
MLBr_02573|M.leprae_Br4923          --------------------------------------------------
MMAR_1240|M.marinum_M               --------------------------------------------------
MUL_2647|M.ulcerans_Agy99           --------------------------------------------------
Mflv_2172|M.gilvum_PYR-GCK          GVVIPIASRALREMVGHLLADATDARLGRSIERIRRRGVNLNVNLLGEAV
                                                                                      

MSMEG_6687|M.smegmatis_MC2_155      --------------------------------------------------
Mvan_1856|M.vanbaalenii_PYR-1       --------------------------------------------------
MAB_0823|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_2521|M.avium_104                --------------------------------------------------
TH_2909|M.thermoresistible__bu      --------------------------------------------------
Mb2883c|M.bovis_AF2122/97           --------------------------------------------------
Rv2858c|M.tuberculosis_H37Rv        --------------------------------------------------
MLBr_02573|M.leprae_Br4923          --------------------------------------------------
MMAR_1240|M.marinum_M               --------------------------------------------------
MUL_2647|M.ulcerans_Agy99           --------------------------------------------------
Mflv_2172|M.gilvum_PYR-GCK          LGRREARRRLTGTERLLARPDVDYVSIKVSASVPPHSVWAFDEAVDHIEQ
                                                                                      

MSMEG_6687|M.smegmatis_MC2_155      --------------------------------------------------
Mvan_1856|M.vanbaalenii_PYR-1       --------------------------------------------------
MAB_0823|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_2521|M.avium_104                --------------------------------------------------
TH_2909|M.thermoresistible__bu      --------------------------------------------------
Mb2883c|M.bovis_AF2122/97           --------------------------------------------------
Rv2858c|M.tuberculosis_H37Rv        --------------------------------------------------
MLBr_02573|M.leprae_Br4923          --------------------------------------------------
MMAR_1240|M.marinum_M               --------------------------------------------------
MUL_2647|M.ulcerans_Agy99           --------------------------------------------------
Mflv_2172|M.gilvum_PYR-GCK          SLLPLFTQAATAATPKFINLDMEEYRDLELTMAVFTRLLDRPELRALEAG
                                                                                      

MSMEG_6687|M.smegmatis_MC2_155      --------------------------------------------------
Mvan_1856|M.vanbaalenii_PYR-1       --------------------------------------------------
MAB_0823|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_2521|M.avium_104                --------------------------------------------------
TH_2909|M.thermoresistible__bu      --------------------------------------------------
Mb2883c|M.bovis_AF2122/97           --------------------------------------------------
Rv2858c|M.tuberculosis_H37Rv        --------------------------------------------------
MLBr_02573|M.leprae_Br4923          --------------------------------------------------
MMAR_1240|M.marinum_M               --------------------------------------------------
MUL_2647|M.ulcerans_Agy99           --------------------------------------------------
Mflv_2172|M.gilvum_PYR-GCK          IVLQAYLPDALGAMIRLQDWARDRRQRGGAGIKVRLVKGANLPMEHVEAS
                                                                                      

MSMEG_6687|M.smegmatis_MC2_155      --------------------------------------------------
Mvan_1856|M.vanbaalenii_PYR-1       --------------------------------------------------
MAB_0823|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_2521|M.avium_104                --------------------------------------------------
TH_2909|M.thermoresistible__bu      --------------------------------------------------
Mb2883c|M.bovis_AF2122/97           --------------------------------------------------
Rv2858c|M.tuberculosis_H37Rv        --------------------------------------------------
MLBr_02573|M.leprae_Br4923          --------------------------------------------------
MMAR_1240|M.marinum_M               --------------------------------------------------
MUL_2647|M.ulcerans_Agy99           --------------------------------------------------
Mflv_2172|M.gilvum_PYR-GCK          LHGWPVATWPTKQDTDTNYKRVLNYALQPDRIANVRIGVAGHNLFDVAYA
                                                                                      

MSMEG_6687|M.smegmatis_MC2_155      --------------------------------------------------
Mvan_1856|M.vanbaalenii_PYR-1       --------------------------------------------------
MAB_0823|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_2521|M.avium_104                --------------------------------------------------
TH_2909|M.thermoresistible__bu      --------------------------------------------------
Mb2883c|M.bovis_AF2122/97           --------------------------------------------------
Rv2858c|M.tuberculosis_H37Rv        --------------------------------------------------
MLBr_02573|M.leprae_Br4923          --------------------------------------------------
MMAR_1240|M.marinum_M               --------------------------------------------------
MUL_2647|M.ulcerans_Agy99           --------------------------------------------------
Mflv_2172|M.gilvum_PYR-GCK          WILAGRRGVRDGVEFEMLLGMADAQAEAVRATVGSLLLYVPVVHPEDFDV
                                                                                      

MSMEG_6687|M.smegmatis_MC2_155      --------------------------------------------------
Mvan_1856|M.vanbaalenii_PYR-1       --------------------------------------------------
MAB_0823|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_2521|M.avium_104                --------------------------------------------------
TH_2909|M.thermoresistible__bu      --------------------------------------------------
Mb2883c|M.bovis_AF2122/97           --------------------------------------------------
Rv2858c|M.tuberculosis_H37Rv        --------------------------------------------------
MLBr_02573|M.leprae_Br4923          --------------------------------------------------
MMAR_1240|M.marinum_M               --------------------------------------------------
MUL_2647|M.ulcerans_Agy99           --------------------------------------------------
Mflv_2172|M.gilvum_PYR-GCK          AIAYLVRRLEEGSSHQNFMSAVFELHSDDMLFQRERERFVASLAAVDDDV
                                                                                      

MSMEG_6687|M.smegmatis_MC2_155      ---------------------MT-PVTINHLVAGDWVAGAGDVVVSVNPA
Mvan_1856|M.vanbaalenii_PYR-1       ---------------------MTGPASVRHLIDGEWLPGGGDALVSVNPA
MAB_0823|M.abscessus_ATCC_1997      ----------------------MHINEIQSFVGGRWISGGGQAVISVCPA
MAV_2521|M.avium_104                --------------------MTAHTTLIPHFIDGRRSAGQSGRSADVFDP
TH_2909|M.thermoresistible__bu      -----------------------MTRQIHHFINGQHTAGQSTRTADVMNP
Mb2883c|M.bovis_AF2122/97           -----------------------------------------MSTTQLINP
Rv2858c|M.tuberculosis_H37Rv        -----------------------------------------MSTTQLINP
MLBr_02573|M.leprae_Br4923          ------------------------------------------MSIATINP
MMAR_1240|M.marinum_M               -------------MTHSDELRNRVRKAFEAIGVTASLDEPGGHGMPSSTP
MUL_2647|M.ulcerans_Agy99           -------------MTHSDELRNRVRKAFEAIGVTASLDEPGGHGMPSSTP
Mflv_2172|M.gilvum_PYR-GCK          PLPNRRQDRRADDPAAAVRAEFSNVADTDPALPGNRAWGRAVTGRIAGST
                                                                                     .

MSMEG_6687|M.smegmatis_MC2_155      RPGDIVAEGHNATTAQVDTAVAAAAEAFRAWAATPTHQRGAVLLAAAQIV
Mvan_1856|M.vanbaalenii_PYR-1       RPTVVVAEGSCAVASDVDAAVGAAAAAAPSWAATGMHQRGARLLAAAEIV
MAB_0823|M.abscessus_ATCC_1997      FPDRVIAEGLAAGPAEFDEAAAAARAAQPGWAAMSLHARGAMLSHAAAVV
MAV_2521|M.avium_104                STGGVQATVPMAGQADIDAAVASAVEAQKGWAATNPQRRARVMMRFVELV
TH_2909|M.thermoresistible__bu      STGKVQAKVVMGTAADIDAAVAGAAEAQKEWAAWNPQRRARVLMKFIDLV
Mb2883c|M.bovis_AF2122/97           ATEEVLASVDHTDANAVDDAVQRARAAQRRWARLAPAQRAAGLRAFAAAV
Rv2858c|M.tuberculosis_H37Rv        ATEEVLASVDHTDANAVDDAVQRARAAQRRWARLAPAQRAAGLRAFAAAV
MLBr_02573|M.leprae_Br4923          ATGETVKTFTPTTQDEVEDAIARAYARFDNYRHTTFTQRAKWANATADLL
MMAR_1240|M.marinum_M               ITCKTLFTLTATTAEQTERSIADAQAAFTQWRSTPAPVRGALVARLGELI
MUL_2647|M.ulcerans_Agy99           ITCETLFTLTATTAEQTERSIADAQAAFTQWRSTPAPVRGALVARLGELI
Mflv_2172|M.gilvum_PYR-GCK          AGRSAVDEHTVTTVDGLEAVISRGVDAGARWAALSGAERAAVLRRAAATL
                                                     :     .      :       *.         :

MSMEG_6687|M.smegmatis_MC2_155      DRNAEAWGLELATEEGKTKAEGIGEVRRAAQILRYYGNEGDRQAGE--IF
Mvan_1856|M.vanbaalenii_PYR-1       ERNAERWGLELATEEGKTRAEGVGEVRRAAQILRYYGNEGDRQAGE--IY
MAB_0823|M.abscessus_ATCC_1997      DRNADAWGLELAAEEGKTKAEGIAEVRRAAQILRYYGNEGDRQTGE--IF
MAV_2521|M.avium_104                NEHNDELAELLSREHGKTLADAKGDIQRGIEVIEFCVGIPHLLKGE--YS
TH_2909|M.thermoresistible__bu      NQNVDELAELLSLEHGKTLADAKGDIQRGIEVIEFSIGIPHLQKGE--YT
Mb2883c|M.bovis_AF2122/97           QAHLDELAALEVANSGHPIVSAEWEAGHVRDVLAFYAASPERLSG----R
Rv2858c|M.tuberculosis_H37Rv        QAHLDELAALEVANSGHPIVSAEWEAGHVRDVLAFYAASPERLSG----R
MLBr_02573|M.leprae_Br4923          EAEANQSAALMTLEMGKTLQSAKDEAMKCAKGFRYYAEKAETLLAD--EP
MMAR_1240|M.marinum_M               SAHKHDLAELVTIEVGKTGSEALGEVQEMIDICEFAVGLSRQLYGL--TI
MUL_2647|M.ulcerans_Agy99           SAHKHDLAELVTIEVGKTGSEALGEVQEMIDICEFAVGLSRQLYGL--TI
Mflv_2172|M.gilvum_PYR-GCK          EARRATLLEVMAAETGKTLDQGDPEVSEAIDFANYYASLAEKLDRVDG--
                                    . .          : *:.  ..  :  .  .   :               

MSMEG_6687|M.smegmatis_MC2_155      SSPRAG--EQILVTRKPLGVVGVITPFNFPIAIPAWKIAPALVYGNTVVW
Mvan_1856|M.vanbaalenii_PYR-1       SSPRPG--EQILVTRKPLGVVGVVTPFNFPIAIPAWKIAPALVYGNTVVW
MAB_0823|M.abscessus_ATCC_1997      SSPRRG--EHILVTRKPLGVVGVITPFNFPIAIPAWKIAPALVYGNAVLW
MAV_2521|M.avium_104                EGAGPG--IDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVL
TH_2909|M.thermoresistible__bu      EGAGPG--IDVYSMRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFIL
Mb2883c|M.bovis_AF2122/97           QIPVAG--GVDVTFNEPMGVVGVITPWNFPMVIASWAIAPALAAGNAVLV
Rv2858c|M.tuberculosis_H37Rv        QIPVAG--GVDVTFNEPMGVVGVITPWNFPMVIASWAIAPALAAGNAVLV
MLBr_02573|M.leprae_Br4923          AEAAAVGASKALARYQPLGVVLAVMPWNFPLWQTVRFAAPALMAGNVGLL
MMAR_1240|M.marinum_M               ASERPG--HRLMETWHPLGVVGVITAFNFPVAVWAWNTAVALVCGDTVLW
MUL_2647|M.ulcerans_Agy99           ASERPG--HRLMETWHPLGVVGVITAFNFPVAVWAWNTAVALVCGDTVLW
Mflv_2172|M.gilvum_PYR-GCK          ------------AIARPVGLTVVTPPWNFPVAIPAGSTLAALAAGSAVVI
                                                   .*:*:.    .:***          **  *.. : 

MSMEG_6687|M.smegmatis_MC2_155      KPASTVPVLAIR----FAQALTEAGLPAGALNLVIG-DSETGTAIVDHPR
Mvan_1856|M.vanbaalenii_PYR-1       KPASTVPLLALR----FAEALTDAGLPPGVLNLVVG-GADIGDAIVNHPG
MAB_0823|M.abscessus_ATCC_1997      KPASTVPLLAMR----LAQAFDAAGLPPGVLNLVVG-DTGVGDAMVNDSR
MAV_2521|M.avium_104                KPSERDPSVPVR----LAELFVEAGLPPGVFQVVHG-DKEAVDAILNHPD
TH_2909|M.thermoresistible__bu      KPSERDPSVPVR----LAELFLQAGLPSGLFQVVHG-DKEAVDAILEHPT
Mb2883c|M.bovis_AF2122/97           KPAELTPLTTMR----LGELAVEAGLDEDLLQVLPGKGTVVGERFVTHPD
Rv2858c|M.tuberculosis_H37Rv        KPAELTPLTTMR----LGELAVEAGLDEDLLQVLPGKGTVVGERFVTHPD
MLBr_02573|M.leprae_Br4923          KHASNVPQCALY----LADVIARGGFPEDCFQTLLI-SANGVEAILRDPR
MMAR_1240|M.marinum_M               KPSELAPLTALACQALLTRAAADVGAPPSVGAVVLG-GAELGEQLVDDPR
MUL_2647|M.ulcerans_Agy99           KPSELAPLTALACQALLTRAAADVGAPPSVGAVVLG-GAELGEQLVDDPR
Mflv_2172|M.gilvum_PYR-GCK          KPTTQARRCGSV----MVEALWDAGIGRDTLQLVHLDEGELGARLISDAR
                                    * :             :       *   .    :          :: .. 

MSMEG_6687|M.smegmatis_MC2_155      IDGLTFTGSTAVGRRLASVAATCGIPMQAEMGGKNAAVVLDDADLDVAVE
Mvan_1856|M.vanbaalenii_PYR-1       IDGITFTGSTGVGRRIAAAAAARGVPAQAEMGGKNAAVVLDDADLDLAVE
MAB_0823|M.abscessus_ATCC_1997      VDALTFTGSTGVGRRIAAAGAARGIPVQAEMGGKNAAVVLDDADVDLAVE
MAV_2521|M.avium_104                IQAVGFVGSSDIAQYIYAGAAATGKRAQCFGGAKNHMIVMPDADLDQAVD
TH_2909|M.thermoresistible__bu      IQAVGFVGSSDIAQYIYAGATAHGKRAQCFGGAKNHMIVMPDADLDQAVD
Mb2883c|M.bovis_AF2122/97           IRKIVFTGSTEVGKRVMAGAAAQVKRVTLELGGKSANIVFHDCDLERAAT
Rv2858c|M.tuberculosis_H37Rv        IRKIVFTGSTEVGKRVMAGAAAQVKRVTLELGGKSANIVFHDCDLERAAT
MLBr_02573|M.leprae_Br4923          VAAATLTGSEPAGQAVGAIAGNEIKPTVLELGGSDPFIVMPSADLDAAVA
MMAR_1240|M.marinum_M               IALLSATGSVRMGQQVGPRVARRFGRVLLELGGNNAVIVTPSADLDLAVR
MUL_2647|M.ulcerans_Agy99           IALLSATGSVRMGQQVGPRVARRFGRVLLELGGNNAVIVTPSADLDLAVR
Mflv_2172|M.gilvum_PYR-GCK          VDRVILTG--AFDTAALFRSFRPDLVLLAETSGKNAIVVTPHADVDLAVK
                                    :     .*                       ....  :*   .*:: *. 

MSMEG_6687|M.smegmatis_MC2_155      QVMLGAFRSTGQKCTATSRLIVT--DGIADKFTEALVERARALRVGDPTD
Mvan_1856|M.vanbaalenii_PYR-1       QVMLGAFRSTGQKCTATSRLIVT--AGIADAFSEALLAQARALRVGDPVD
MAB_0823|M.abscessus_ATCC_1997      QVLLGAFRSTGQKCTATSRLVLT--EGIADAFLSLLKDRADALVVGDPTA
MAV_2521|M.avium_104                ALIGAGYGSAGERCMAISVAVPVG-DQTADRLRARLIERVNNLRVGHSLD
TH_2909|M.thermoresistible__bu      ALIGAGYGSAGERCMAISVAVPVG-DEIADRLRARLIERVANLRVGHSLD
Mb2883c|M.bovis_AF2122/97           TAPAGVFDNAGQDCCARSRILVQ--RSVYDRFMELLEPAVHSIVVGDPGS
Rv2858c|M.tuberculosis_H37Rv        TAPAGVFDNAGQDCCARSRILVQ--RSVYDRFMELLEPAVHSIVVGDPGS
MLBr_02573|M.leprae_Br4923          TAVTGRVQNNGQSCIAAKRFIAH--ADIYDEFVEKFVARMETLRVGDPTD
MMAR_1240|M.marinum_M               GIVFAAAGTAGQRCTSLRRLIVH--SSVADDVVARVVAACRTLPVGDPCD
MUL_2647|M.ulcerans_Agy99           GIVFAAAGTAGQRCTSLRRLIVH--SSVADDVVARVVAACRTLPVGDPCD
Mflv_2172|M.gilvum_PYR-GCK          DLVYSAFGHAGQKCSAASLGILVGSVARSARFRDQLVDAVTSLNVGYPTD
                                        .     *: * :    :          .   .      : ** .  

MSMEG_6687|M.smegmatis_MC2_155      DATEMGPVITDTSRASILAGIDTAVAQGATVLAGGR-------PYTEGPL
Mvan_1856|M.vanbaalenii_PYR-1       DATQMGPVVSDSAQQSITAGIDTAVTQGATVLTGGR-------PYQDGAL
MAB_0823|M.abscessus_ATCC_1997      DDTQMGPVVSESAFGTITAGIGGAVAQGAVTLAGGH-------GYGDGPL
MAV_2521|M.avium_104                PKADYGPLVTEAALARVRDYIAQGVDAGAELVIDGRERASDDLAFGDANL
TH_2909|M.thermoresistible__bu      PKADYGPLVTEAALQRVRDYIGQGVEAGAELLVDGRERGSDDLQFGDDSL
Mb2883c|M.bovis_AF2122/97           RATEMGPLVSRAHRDKVAGYVPDDAPVAFR---------------GTAPA
Rv2858c|M.tuberculosis_H37Rv        RATEMGPLVSRAHRDKVAGYVPDDAPVAFR---------------GTAPA
MLBr_02573|M.leprae_Br4923          PDTDVGPLATESGRAQVEQQVDAAAAAGAVIRCGGK-----------RPD
MMAR_1240|M.marinum_M               PATLIGPLIHETAYRDMLGALDQARAEGGEVIDPNP---------RRDGP
MUL_2647|M.ulcerans_Agy99           PATLIGPLIHETAYRDMLGALDQARAEGGEVIDPNP---------RRDGP
Mflv_2172|M.gilvum_PYR-GCK          PTVQMGPVIEPADGKLLRALTTLGPGEKWLVAPRQLD-------------
                                      .  **:   :    :                                 

MSMEG_6687|M.smegmatis_MC2_155      AEGYFIAPTVLELDGSPAKVWSEELFGPVLAVRRAADADEAFELANDSEF
Mvan_1856|M.vanbaalenii_PYR-1       AEGYFVAPTVVELGAAPVDVWTDELFGPVLAIRRATDAEEAFALANDSEF
MAB_0823|M.abscessus_ATCC_1997      AAGYFIAPTIMELGMGAVDLWTEELFGPVLAVRRAADTEEAFRLANDSEY
MAV_2521|M.avium_104                EGGFFIGPTLFDHVTPDMSIYTDEIFGPVLCIVRAHDYEEALALPSQHEY
TH_2909|M.thermoresistible__bu      EGGYFIGPTLFDRVTTDMSIYRDEIFGPVLCMVRAKNYEEALALPSEHEY
Mb2883c|M.bovis_AF2122/97           GRGFWFPPTVLTPKRGDR-TVTDEIFGPVVVVLTFDDEADAISLANDTAY
Rv2858c|M.tuberculosis_H37Rv        GRGFWFPPTVLTPKRGDR-TVTDEIFGPVVVVLTFDDEADAISLANDTAY
MLBr_02573|M.leprae_Br4923          RPGWFYPPTVITDITKDMALYTDEVFGPVASVYCATNIDDAIEIANATPF
MMAR_1240|M.marinum_M               AGGYYVAPAVVR-MPAQTAIVATETFAPILYVLTYDDLDDAIALNNAVPQ
MUL_2647|M.ulcerans_Agy99           AGGYYVAPAVVR-MPAQTAIVATETFAPILYVLTYDDLDDAIALNNAVPQ
Mflv_2172|M.gilvum_PYR-GCK          DSGRLWSPGVRTGVRRGSEFHLTEYFGPVLGLMEARDLDEAIAMQNQVDY
                                      *    * :             * *.*:  :    :  :*: : .    

MSMEG_6687|M.smegmatis_MC2_155      GLSAAIFTQDVTRVLQAMEQIDVGVLHVNSESAGADPHVP-FGGDKKSGL
Mvan_1856|M.vanbaalenii_PYR-1       GLSAAVFTQDMTRALQAVERIDVGVLHVNSESAGADPHVP-FGGAKKSGL
MAB_0823|M.abscessus_ATCC_1997      GLSAAIFTKDLTRALSAVDHVDVGILHVNSESAGADPHVP-FGGAKKSGL
MAV_2521|M.avium_104                GNGVAVFTGDGDAARDFVSRVQVGMVGVNVPIPVPVAYHT-FGGWKRSGF
TH_2909|M.thermoresistible__bu      GNGVAIFTRDGDTARDFVSRVQCGMVGVNVPIPVPVAYHT-FGGWKRSGF
Mb2883c|M.bovis_AF2122/97           GLSGSIWTDDLSRALRVARAVESGNLSVNSHSS-VRFNTP-FGGFKQSGV
Rv2858c|M.tuberculosis_H37Rv        GLSGSIWTDDLSRALRVARAVESGNLSVNSHSS-VRFNTP-FGGFKQSGV
MLBr_02573|M.leprae_Br4923          GLGSNAWTQNESEQRHFIDNIVAGQVFIN-GMTVSYPELP-FGGIKRSGY
MMAR_1240|M.marinum_M               GLSSAIFTNDLREAERFLAASDCGIANVNIGTSGAEIGGA-FGGEKQTGG
MUL_2647|M.ulcerans_Agy99           GLSSAFFTNDLREAERFLAASDCGIANVNIGTSGAEIGGA-FGGEKQTGG
Mflv_2172|M.gilvum_PYR-GCK          GLTAGLHSLDRHEVERWIDRVEAGNAYVNRSTVGAVVARQPFGGWKKSAV
                                    *      : :             *   :*            *** *::. 

MSMEG_6687|M.smegmatis_MC2_155      GPK------------------------EQGAAARDFFTHTTTVYLRGGRP
Mvan_1856|M.vanbaalenii_PYR-1       GPK------------------------EQGGAAREFFTHTTTVYLRGGRA
MAB_0823|M.abscessus_ATCC_1997      GPK------------------------EQGRAAREFFTHTTTVYLRGEEA
MAV_2521|M.avium_104                GDLN-----------------------QHGPASITFYTKTKTVTQRWPSG
TH_2909|M.thermoresistible__bu      GDLN-----------------------QHGPHSILFYTKTKTVTQRWPSG
Mb2883c|M.bovis_AF2122/97           GRE-------------------------LGPDAPLQFTETKNVFIAVGEE
Rv2858c|M.tuberculosis_H37Rv        GRE-------------------------LGPDAPLQFTETKNVFIAVGEE
MLBr_02573|M.leprae_Br4923          GRE-------------------------LSTHGIREFCNIKTVWIA----
MMAR_1240|M.marinum_M               GRE-------------------------SGSDAWKAYMRRATNTINYSTE
MUL_2647|M.ulcerans_Agy99           GRE-------------------------SGSDAWKAYMRRATNTINYSTE
Mflv_2172|M.gilvum_PYR-GCK          GAGAKAGGPNYLIGLTDWESAPAQQAGRLSPAMREFLSAAGRLDLSAEDR
                                    *                            .                    

MSMEG_6687|M.smegmatis_MC2_155      GV------------------------------------------------
Mvan_1856|M.vanbaalenii_PYR-1       GS------------------------------------------------
MAB_0823|M.abscessus_ATCC_1997      M-------------------------------------------------
MAV_2521|M.avium_104                IKDGAEFSIPTMI-------------------------------------
TH_2909|M.thermoresistible__bu      IKDGAEFSIPTMK-------------------------------------
Mb2883c|M.bovis_AF2122/97           M-------------------------------------------------
Rv2858c|M.tuberculosis_H37Rv        M-------------------------------------------------
MLBr_02573|M.leprae_Br4923          --------------------------------------------------
MMAR_1240|M.marinum_M               LPLAQGVQFG----------------------------------------
MUL_2647|M.ulcerans_Agy99           LPLAQSVQFG----------------------------------------
Mflv_2172|M.gilvum_PYR-GCK          EFLGRSARSDALAWEQEFGIARDVAGLTAEKNVLRYRPVPVTVRAEDGHT
                                                                                      

MSMEG_6687|M.smegmatis_MC2_155      --------------------------------------------------
Mvan_1856|M.vanbaalenii_PYR-1       --------------------------------------------------
MAB_0823|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_2521|M.avium_104                --------------------------------------------------
TH_2909|M.thermoresistible__bu      --------------------------------------------------
Mb2883c|M.bovis_AF2122/97           --------------------------------------------------
Rv2858c|M.tuberculosis_H37Rv        --------------------------------------------------
MLBr_02573|M.leprae_Br4923          --------------------------------------------------
MMAR_1240|M.marinum_M               --------------------------------------------------
MUL_2647|M.ulcerans_Agy99           --------------------------------------------------
Mflv_2172|M.gilvum_PYR-GCK          ASLLRVVAAGLLAGAAITVSTPAPPASAVADLLHMRGVTLRVDDAEHWRK
                                                                                      

MSMEG_6687|M.smegmatis_MC2_155      --------------------------------------------------
Mvan_1856|M.vanbaalenii_PYR-1       --------------------------------------------------
MAB_0823|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_2521|M.avium_104                --------------------------------------------------
TH_2909|M.thermoresistible__bu      --------------------------------------------------
Mb2883c|M.bovis_AF2122/97           --------------------------------------------------
Rv2858c|M.tuberculosis_H37Rv        --------------------------------------------------
MLBr_02573|M.leprae_Br4923          --------------------------------------------------
MMAR_1240|M.marinum_M               --------------------------------------------------
MUL_2647|M.ulcerans_Agy99           --------------------------------------------------
Mflv_2172|M.gilvum_PYR-GCK          LLRGNAPARVRLIGGSREAFAGAGEGRADVALYAQPVVEAGRIELLTFLR
                                                                                      

MSMEG_6687|M.smegmatis_MC2_155      -----------------------
Mvan_1856|M.vanbaalenii_PYR-1       -----------------------
MAB_0823|M.abscessus_ATCC_1997      -----------------------
MAV_2521|M.avium_104                -----------------------
TH_2909|M.thermoresistible__bu      -----------------------
Mb2883c|M.bovis_AF2122/97           -----------------------
Rv2858c|M.tuberculosis_H37Rv        -----------------------
MLBr_02573|M.leprae_Br4923          -----------------------
MMAR_1240|M.marinum_M               -----------------------
MUL_2647|M.ulcerans_Agy99           -----------------------
Mflv_2172|M.gilvum_PYR-GCK          EQAVAVTAHRFGSPTTLADGLFA