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SSTADFAGKQALLTGGGSGIGAALCRALDRAGAHVVCTDIDELAAERVVSTLSSRARAARLDVTDSAAVQ AAVDDVEARAGRLDLMFNNAGIVFGGETELLTLDQWNAIIDVNIRGVVHGVAAAYPLMLRQGHGHIVNTA SMAGLAAAGHLTSYVATKHAVVGLSLALRSEALSRGIGVLAVCPAAVETPILDKGAVGSFGGRDFFLRAQ GGKAYDADRLAREVLDAITRNKAVLVKPRVAHAQWLLNRLAPTGLNRLASRFLAAQQSSRVNSG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2070 | - | - | 100% (275) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_3370 | - | 8e-57 | 46.24% (279) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_4505 | - | 3e-30 | 41.36% (191) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1976 | - | 5e-31 | 36.57% (216) | short-chain type dehydrogenase/reductase |
| M. tuberculosis H37Rv | Rv1941 | - | 5e-31 | 36.57% (216) | short-chain type dehydrogenase/reductase |
| M. leprae Br4923 | MLBr_00862 | ephD | 8e-31 | 33.20% (259) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0090c | - | 6e-33 | 34.51% (255) | oxidoreductase EphD |
| M. marinum M | MMAR_2600 | - | 1e-37 | 35.74% (277) | short-chain dehydrogenase |
| M. avium 104 | MAV_1384 | - | 1e-32 | 35.47% (265) | short chain alcohol dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5235 | - | 1e-107 | 74.26% (272) | short chain dehydrogenase family protein |
| M. thermoresistible (build 8) | TH_2445 | - | 1e-106 | 74.44% (266) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_3160 | - | 2e-37 | 35.74% (277) | short-chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4644 | - | 1e-117 | 78.28% (267) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2070|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4644|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5235|M.smegmatis_MC2_155 --------------------------------------------------
TH_2445|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 MPATQSIHKVPHQFVESPDGVRLAIYQSGQPEGPAIVLVHGFPDSHVLWD
MAB_0090c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_2600|M.marinum_M --------------------------------------------------
MUL_3160|M.ulcerans_Agy99 --------------------------------------------------
MAV_1384|M.avium_104 --------------------------------------------------
Mb1976|M.bovis_AF2122/97 --------------------------------------------------
Rv1941|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2070|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4644|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5235|M.smegmatis_MC2_155 --------------------------------------------------
TH_2445|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 GVVPLLAKRFRIVRYDNRGVGQSSVPKPVSAYTMTRFADDFAAVIDELSP
MAB_0090c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_2600|M.marinum_M --------------------------------------------------
MUL_3160|M.ulcerans_Agy99 --------------------------------------------------
MAV_1384|M.avium_104 --------------------------------------------------
Mb1976|M.bovis_AF2122/97 --------------------------------------------------
Rv1941|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2070|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4644|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5235|M.smegmatis_MC2_155 --------------------------------------------------
TH_2445|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSVSGPSQDQLVDYILSG
MAB_0090c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_2600|M.marinum_M --------------------------------------------------
MUL_3160|M.ulcerans_Agy99 --------------------------------------------------
MAV_1384|M.avium_104 --------------------------------------------------
Mb1976|M.bovis_AF2122/97 --------------------------------------------------
Rv1941|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2070|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4644|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5235|M.smegmatis_MC2_155 --------------------------------------------------
TH_2445|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWIALSSATIRRTMV
MAB_0090c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_2600|M.marinum_M --------------------------------------------------
MUL_3160|M.ulcerans_Agy99 --------------------------------------------------
MAV_1384|M.avium_104 --------------------------------------------------
Mb1976|M.bovis_AF2122/97 --------------------------------------------------
Rv1941|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2070|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4644|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5235|M.smegmatis_MC2_155 --------------------------------------------------
TH_2445|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRRGKGVPVVNVPVQ
MAB_0090c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_2600|M.marinum_M --------------------------------------------------
MUL_3160|M.ulcerans_Agy99 --------------------------------------------------
MAV_1384|M.avium_104 --------------------------------------------------
Mb1976|M.bovis_AF2122/97 --------------------------------------------------
Rv1941|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2070|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4644|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5235|M.smegmatis_MC2_155 --------------------------------------------------
TH_2445|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHD
MAB_0090c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_2600|M.marinum_M --------------------------------------------------
MUL_3160|M.ulcerans_Agy99 --------------------------------------------------
MAV_1384|M.avium_104 --------------------------------------------------
Mb1976|M.bovis_AF2122/97 --------------------------------------------------
Rv1941|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2070|M.gilvum_PYR-GCK ------------MSSTADFAG-------KQALLTGGGSGIGAALCRALDR
Mvan_4644|M.vanbaalenii_PYR-1 ----------------MRFTG-------KHAIITGGGSGIGAALCRALDR
MSMEG_5235|M.smegmatis_MC2_155 ----------------MSFTG-------KTAIVTGAGSGIGATLCRALVD
TH_2445|M.thermoresistible__bu ----------------MTFAG-------KHALVTGAGSGIGAALCRALAA
MLBr_00862|M.leprae_Br4923 LADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTGAGSGIGRETALALAR
MAB_0090c|M.abscessus_ATCC_199 ---MTSG--------SAQR--------NSLVVVTGAGSGIGRETSLAFAR
MMAR_2600|M.marinum_M MFKLNSGTN------TSDLAG-------RVVAITGAGSGIGRELALLCAQ
MUL_3160|M.ulcerans_Agy99 MFKLNSGTN------TSDLAG-------RVVAITGAGSGIGRELALLCAQ
MAV_1384|M.avium_104 ---------------MQGFAG-------KVAVVTGAGSGIGQALAVELAR
Mb1976|M.bovis_AF2122/97 -------------MNHPDLAG-------KVAIVTGAGAGIGLAVARRLAD
Rv1941|M.tuberculosis_H37Rv -------------MNHPDLAG-------KVAIVTGAGAGIGLAVARRLAD
. :**.*:*** .
Mflv_2070|M.gilvum_PYR-GCK AGAHVVCTDIDE-----LAAERVVSTLSSRARAARLDVTDSAAVQAAVDD
Mvan_4644|M.vanbaalenii_PYR-1 AGAQVVCTDIDE-----AAAGAVVSTLSPRARAARLDVTDAAAVQGVVDD
MSMEG_5235|M.smegmatis_MC2_155 AGADVLCTDVDADAAARTAAARTAAALG--ARSARLDVTDAAAVQTTVDD
TH_2445|M.thermoresistible__bu AGAEVMCTDIDG-----AAAERTAQSIG--GRWAALDVTDAAAVQAAVDG
MLBr_00862|M.leprae_Br4923 RGAEVVVSDIDEAA--AKNTAAQIVASGGVAYAYALDVSDAAAVEAFAEQ
MAB_0090c|M.abscessus_ATCC_199 QGARVVVADINHDT--ANETVGLIEKLGGSAYPYALDVSDEAAVTAFADD
MMAR_2600|M.marinum_M RGADLALCDINDTA--VADTAQTARGFGHDVITRRVDVSDPEQMTAFADA
MUL_3160|M.ulcerans_Agy99 RGADLALCDINDTA--VADTAQTARGFGHDVITRRVDVSDPEQMTAFADA
MAV_1384|M.avium_104 SGAKVAISDVDLEG--LAHTEEQLKAIGAQYKADRLDVTEREAFLAYADA
Mb1976|M.bovis_AF2122/97 EGCHVLCADIDG-----DAADAAATKIGCGAAACRVDVSDEQQIIAMVDA
Rv1941|M.tuberculosis_H37Rv EGCHVLCADIDG-----DAADAAATKIGCGAAACRVDVSDEQQIIAMVDA
*. : *:: : . :**:: . .:
Mflv_2070|M.gilvum_PYR-GCK VEARAGRLDLMFNNAGIVFGGETELLTLDQWNAIIDVNIRGVVHGVAAAY
Mvan_4644|M.vanbaalenii_PYR-1 VVARTGRLDLIFNNAGIVWGGDTELLTLDQWNAIIDINLRGVVHGVAAAY
MSMEG_5235|M.smegmatis_MC2_155 VVARAGRLDLMFNNAGIVWGGDTELLTLDQWNAIIDVNIRGVVHGVAAAY
TH_2445|M.thermoresistible__bu VVDRAGRLDLLFNNAGIVWGGDTELLTLDQWNAIIDVNIRGVVHGVAAAY
MLBr_00862|M.leprae_Br4923 VSAKHGVPDIVVNNAGIGQAGRFLDTPPEEFDRVLAVNLGGVVNCCRAFG
MAB_0090c|M.abscessus_ATCC_199 VCAKHGVPDVLINNAGVGHGGRFFETSSTDFQRVLNINLGGVVHGCRAFG
MMAR_2600|M.marinum_M TLGHFGGVDLLVNNAGVGLIGGFLDTSRKDWDWLVSINVMGVVHGCEAFL
MUL_3160|M.ulcerans_Agy99 TLGHFGGVDLLVNNAGVGLIGGFLDTSRKDWDWLVSINVMGVVHGCEAFL
MAV_1384|M.avium_104 VKEHFGKVNQIYNNAGIAFTGDVEVSQFKDIERVMDVDFWGVVNGTKAFL
Mb1976|M.bovis_AF2122/97 CVAAFGGVDKLVANAGVVHLASLIDTTVEDFDRVIAINLRGAWLCTKHAA
Rv1941|M.tuberculosis_H37Rv CVAAFGGVDKLVANAGVVHLASLIDTTVEDFDRVIAINLRGAWLCTKHAA
* : : ***: . : : :: ::. *.
Mflv_2070|M.gilvum_PYR-GCK PLMLRQGHG-HIVNTASMAGLAAAGHLTSYVATKHAVVGLSLALRSEALS
Mvan_4644|M.vanbaalenii_PYR-1 PQMLRQGHG-HIVNTASMAGLTAAGQVTSYVATKHAVVGLSMALRSEAVP
MSMEG_5235|M.smegmatis_MC2_155 PQMIRQGHG-HIVNTASMAGLAAAGQLTSYVMSKHAVVGLSLALRSEAAA
TH_2445|M.thermoresistible__bu PLMVRQGHG-HIVNTASMAGLAAAGQLTSYVMTKHAVVGLSLALRSEAAA
MLBr_00862|M.leprae_Br4923 QRLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRAELDA
MAB_0090c|M.abscessus_ATCC_199 PRMAERKSG-HIVNISSAAAYTPIPEMGAYATSKAAVFMFSDVLRGELAR
MMAR_2600|M.marinum_M PAMIESGRGGHVVNLSSAAGLLANSALSAYSATKFAVLGLSEALRIELEP
MUL_3160|M.ulcerans_Agy99 PAMIESGRGGHVVNLSSAAGLLANPALSAYSATKFAVLGLSEALRIELEP
MAV_1384|M.avium_104 PHLIASGDG-HVVNVSSVFGLFSVPGQAAYNSAKFAVRGFTEALRQEMAA
Mb1976|M.bovis_AF2122/97 PRMIERGGG-AIVNLSSLAGQVAVGGTGAYGMSKAGIIQLSRITAAELRS
Rv1941|M.tuberculosis_H37Rv PRMIERGGG-AIVNLSSLAGQVAVGGTGAYGMSKAGIIQLSRITAAELRS
: * :** :* . . :* :* . :: *
Mflv_2070|M.gilvum_PYR-GCK RG--IGVLAVCPAAVETPILDKGAVGSFGGRDFFLRAQGGK--------A
Mvan_4644|M.vanbaalenii_PYR-1 RG--VGVLVVCPAAVETPILDKGAVGGFVGRDYFLQTQGGR--------A
MSMEG_5235|M.smegmatis_MC2_155 HG--VGVLAVCPAAVETPILDKGAVGGFVGRDYFLRGQGMKT-------A
TH_2445|M.thermoresistible__bu HG--VGVLAVCPAAVETPLLDKGAVGGFLGRDYFIRGQGVRS-------A
MLBr_00862|M.leprae_Br4923 VG--VGLTTICPGVIDTNIIQSTRIDTPTAKQERVRDRRGQLDMMFRLRR
MAB_0090c|M.abscessus_ATCC_199 DK--VKVSTICPGIVNTNIIRTTQFSGLSPEDEAKRQQQG--AGLYAKRG
MMAR_2600|M.marinum_M HR--IGVTAICPGVINTAITKASPIRGAG-DTEGRRQRLT---VTYQRRG
MUL_3160|M.ulcerans_Agy99 HR--IGVTAICPGVINTAITKASPIRGAG-DTEGRRQRLT---VTYQRRG
MAV_1384|M.avium_104 AGHPVAVTTVHPGGIKTAIARNATAAEGLDQAELAKLFDK------RLAK
Mb1976|M.bovis_AF2122/97 SG--IRSNTLLPAFVDTPMQQTAMA------------------------M
Rv1941|M.tuberculosis_H37Rv SG--IRSNTLLPAFVDTPMQQTAMA------------------------M
: .: *. :.* :
Mflv_2070|M.gilvum_PYR-GCK YDADRLAREVLDAITRNKAVLVKPRVAHAQWLLNRLAPTGLNRLASRFLA
Mvan_4644|M.vanbaalenii_PYR-1 YDADRLARDTLRAVERNKAILVKPTVAQAQWWFARLAPGLMNRMAMRFVT
MSMEG_5235|M.smegmatis_MC2_155 YDPDRLAADTLRAIERNKALLVKPRRAHASWLLARLAPGLMQRLSVRFVA
TH_2445|M.thermoresistible__bu YDPDRLASDTLRAVQRNKALLVKPRVAHAGWLFARLAPGLMQRASIRFVE
MLBr_00862|M.leprae_Br4923 YGPDKVADTILSAIKKNKPIRPVAPEAYALYGISRVLPQ-VLRSTARIRV
MAB_0090c|M.abscessus_ATCC_199 YGPEKVAKEIVNAVAKGKSVVPVTPEAHVQYHFSRLAPA-LNRFFWGLSD
MMAR_2600|M.marinum_M YTPARAARNILRAVERNKAVAPVAAEAHVMYVLSRIMPP-LARWVSAQMA
MUL_3160|M.ulcerans_Agy99 YTPARAARNILRAVERNKAVAPVAAEAHVMYVLSRIMPP-LARWVSAQMA
MAV_1384|M.avium_104 TTPQRAAQIILDAVRKKKARVLVGSDAKALDILVRLTGSGYQRLFGPVMS
Mb1976|M.bovis_AF2122/97 FDGALGAGGARSMIARLQGRMAAPEEMAGIVVFLLSDDASMITGTTQIAD
Rv1941|M.tuberculosis_H37Rv FDGALGAGGARSMIARLQGRMAAPEEMAGIVVFLLSDDASMITGTTQIAD
* : : : :
Mflv_2070|M.gilvum_PYR-GCK AQQSSRVN--------SG-
Mvan_4644|M.vanbaalenii_PYR-1 GQRTRQVDRYPSSAADTG-
MSMEG_5235|M.smegmatis_MC2_155 AQRASQAR------TANH-
TH_2445|M.thermoresistible__bu RQRAGQRA------AQVGR
MLBr_00862|M.leprae_Br4923 I------------------
MAB_0090c|M.abscessus_ATCC_199 KISR---------------
MMAR_2600|M.marinum_M KAAK---------------
MUL_3160|M.ulcerans_Agy99 KAAK---------------
MAV_1384|M.avium_104 RLLPN--------------
Mb1976|M.bovis_AF2122/97 GGTIAALW-----------
Rv1941|M.tuberculosis_H37Rv GGTIAALW-----------