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TSGSAQRNSLVVVTGAGSGIGRETSLAFARQGARVVVADINHDTANETVGLIEKLGGSAYPYALDVSDEA AVTAFADDVCAKHGVPDVLINNAGVGHGGRFFETSSTDFQRVLNINLGGVVHGCRAFGPRMAERKSGHIV NISSAAAYTPIPEMGAYATSKAAVFMFSDVLRGELARDKVKVSTICPGIVNTNIIRTTQFSGLSPEDEAK RQQQGAGLYAKRGYGPEKVAKEIVNAVAKGKSVVPVTPEAHVQYHFSRLAPALNRFFWGLSDKISR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0090c | - | - | 100% (277) | oxidoreductase EphD |
| M. abscessus ATCC 19977 | MAB_4019c | - | 2e-86 | 61.30% (261) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4023c | - | 3e-59 | 48.85% (262) | oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2237c | ephD | 5e-76 | 55.25% (257) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_2937 | - | 4e-73 | 53.41% (264) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv2214c | ephD | 5e-76 | 55.25% (257) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_00862 | ephD | 2e-74 | 54.02% (261) | short chain dehydrogenase |
| M. marinum M | MMAR_3259 | ephD | 6e-78 | 56.59% (258) | short-chain dehydrogenase EphD |
| M. avium 104 | MAV_2275 | - | 2e-69 | 51.55% (258) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4280 | - | 6e-73 | 53.85% (260) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_4323 | - | 4e-76 | 55.29% (255) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_3574 | ephD | 5e-78 | 56.59% (258) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_3576 | - | 4e-70 | 53.01% (266) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_00862|M.leprae_Br4923 MPATQSIHKVPHQFVESPDGVRLAIYQSGQPEGPAIVLVHGFPDSHVLWD
MAV_2275|M.avium_104 MPAPQ---HSPQHFVHSADGTRIAVYDEGNPEGPTVVLVHGFPDSHVLWD
Mb2237c|M.bovis_AF2122/97 MPATQ---QMSR-LVDSPDGVRIAVYHEGNPDGPTVVLVHGFPDSHVLWD
Rv2214c|M.tuberculosis_H37Rv MPATQ---QMSR-LVDSPDGVRIAVYHEGNPDGPTVVLVHGFPDSHVLWD
MMAR_3259|M.marinum_M MSATR---QAPQQFVDSAGGVRIAVYEEGNPDGPTVVLVHGFPDSHVLWD
MUL_3574|M.ulcerans_Agy99 MPATK---QAPQQFVDSAGGVRIAVYEEGNPDSPTVVLVHGFPDSHVLWD
TH_4323|M.thermoresistible__bu --------MATEHFIDSSGGVRIAAYEEGNPDGPTVVLVHGWPDSHVVWD
MSMEG_4280|M.smegmatis_MC2_155 ----------MYTFVTSQDGTRIAVYQQGDPERPTLVMAHGWPDSHVLWD
Mflv_2937|M.gilvum_PYR-GCK --------MSSQRFVVSRDGVRIAVYEEGAADGPTVVLVHGHADTHEAWD
Mvan_3576|M.vanbaalenii_PYR-1 --------MSTQRFVESSDGVRIAVSEQGNPDGPTLVLVHGLRDTHRVWD
MAB_0090c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 GVVPLLAKRFRIVRYDNRGVGQSSVPKPVSAYTMTRFADDFAAVIDELSP
MAV_2275|M.avium_104 GVVPLLAERFRILRYDNRGVGASSAPKPVSAYRMDRFADDFAAVIGELSP
Mb2237c|M.bovis_AF2122/97 GVVPLLAERFRIVRYDNRGVGRSSVPKPISAYTMAHFADDFDAVIGELSP
Rv2214c|M.tuberculosis_H37Rv GVVPLLAERFRIVRYDNRGVGRSSVPKPISAYTMAHFADDFDAVIGELSP
MMAR_3259|M.marinum_M GVVPRLAERFRILRYDNRGVGLSSAPKAVSAYTTACLADDFAAVIEALSP
MUL_3574|M.ulcerans_Agy99 GVVPRLAERFRILRYDNRGVGLSSAPKAVSAYTTACLADDFAAVIEALSP
TH_4323|M.thermoresistible__bu SVAPLLADRFRIIRYDNRGVGRTTAPRRVADHTMARYADDFGAVIDALAP
MSMEG_4280|M.smegmatis_MC2_155 GVVGELGDRYRIVRYDNRGAGASDVPKATSAYTMERFADDFSAVIDAVSP
Mflv_2937|M.gilvum_PYR-GCK AVVALLAARFRIVRYDTRGAGRSAAPQRTSGFRLERYADDLAAVLDAVSA
Mvan_3576|M.vanbaalenii_PYR-1 PVVALLADRFRIVAYDTRGAGNSGAPKQTSAYTVDRFADDFAAVAAAVGG
MAB_0090c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSVSGPSQDQLVDYILSG
MAV_2275|M.avium_104 GGPVHVLAHDWGSVGVWHYLKRPGANDRVATFTSVSGPSQDQLVDYIFSG
Mb2237c|M.bovis_AF2122/97 GEPVHVLAHDWGSVGVWEYLRRPGASDRVASFTSVSGPSQDHLVNYVYGG
Rv2214c|M.tuberculosis_H37Rv GEPVHVLAHDWGSVGVWEYLRRPGASDRVASFTSVSGPSQDHLVNYVYGG
MMAR_3259|M.marinum_M GQPVHVLGHDWGSVAIWEYLTRSGAADRVASFTSVSGPSQDQLVNYIFGG
MUL_3574|M.ulcerans_Agy99 GQPVHVLGHDWGSVAIWDYLTRSGAADRVASFTSVSGPSQDQLVNYIFGG
TH_4323|M.thermoresistible__bu GQRVHVLAHDWGSAGVWEYLARPEAEDRIASFTSVSGPSGDHLARYVLDG
MSMEG_4280|M.smegmatis_MC2_155 DAPVHVLAHDWGSVGIWEYLSRQGSAARMVSFTSVSGPSTDHYGAYVRRG
Mflv_2937|M.gilvum_PYR-GCK EAPVHVLAHDRGSAGVWRYLARPESRGRLASFTSVSGPAPEHVARYLRDT
Mvan_3576|M.vanbaalenii_PYR-1 DTPVHVLAHGWGAAGVWQYLKRADAPERVASLTSVSGPSPEHVAGYVRAA
MAB_0090c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWIALSSATIR-RTM
MAV_2275|M.avium_104 LRAPWRPRAFARALGQALRLSYMILLSIPVLAPLALRLTLSIPALR-RNA
Mb2237c|M.bovis_AF2122/97 LRRPWRPRTFLRAISQTLRLSYMALFSVPVVAPLLLRVALSSAAVR-RNM
Rv2214c|M.tuberculosis_H37Rv LRRPWRPRTFLRAISQTLRLSYMALFSVPVVAPLLLRVALSSAAVR-RNM
MMAR_3259|M.marinum_M LRQPWRPKTFARALTQALRLSYMALFSVPVLAPLVLRATLSRASVR-RNM
MUL_3574|M.ulcerans_Agy99 LRQPWRPKTFARALTQALRLSYMALFSVPVLAPLVLRATLSRASVR-RNM
TH_4323|M.thermoresistible__bu LAAPYRPRRFLRSLTQLLRLSYMGFFSIPVLAPLLVRGVLSKALRRSLRL
MSMEG_4280|M.smegmatis_MC2_155 LARPYRPVQFARAVNLASRFSYWIPFSIPVLAPALMR---RGAARR-LQA
Mflv_2937|M.gilvum_PYR-GCK LARPQHPARFAGGLGHLARL--------------------AAAAPR----
Mvan_3576|M.vanbaalenii_PYR-1 LTSPR---RFVRGAGQLVRL--------------------AAAAPR----
MAB_0090c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 VDNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRRGKGVPVVNVPV
MAV_2275|M.avium_104 VDNIPIEQIHHSDRLAADAARSVKTYPANYFRSFAIRK--QGVAVIDVPV
Mb2237c|M.bovis_AF2122/97 VGDIPVDQIHHSETLARDAAHSVKTYPANYFRSFSSSRRGRAIPIVDVPV
Rv2214c|M.tuberculosis_H37Rv VGDIPVDQIHHSETLARDAAHSVKTYPANYFRSFSSSRRGRAIPIVDVPV
MMAR_3259|M.marinum_M VDNLPLDRIHHSDNLASDAANSVKTYPANYFRAFSRQSRTRGVPVIDVPV
MUL_3574|M.ulcerans_Agy99 VDNLPLDQIHHSDNLASDAANSVKTYPANYFRAFSRQSRTRGVPVIDVPV
TH_4323|M.thermoresistible__bu RDGVPADRLHHSDTFAADAARSIKVYGANFLRTL---RHARTDHFVRVPV
MSMEG_4280|M.smegmatis_MC2_155 IDTP--GPKFQSENLDIDAANSLKIYRANAIRSFTHVRR---DHYVQVPV
Mflv_2937|M.gilvum_PYR-GCK -------------------AVTDKTLRANLFPVSSGGDA----HDVDIPV
Mvan_3576|M.vanbaalenii_PYR-1 -------------------AATAKPYRANLRPAAPAG------VPVDVPV
MAB_0090c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 QLIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHFSPMSHPQVMAAAVH
MAV_2275|M.avium_104 QLIVNTEDRYVRPYGYDHTPRFVPRLWRRDIRAGHFSPMSHPQVMAAAVH
Mb2237c|M.bovis_AF2122/97 QLIVNSQDPYVRPYGYDQTARWVPRLWRRDIKAGHFSPMSHPQVMAAAVH
Rv2214c|M.tuberculosis_H37Rv QLIVNSQDPYVRPYGYDQTARWVPRLWRRDIKAGHFSPMSHPQVMAAAVH
MMAR_3259|M.marinum_M QLIVNTKDPYVRPYGYDETARWVPRLWRRDIKAGHFSPMSHPQVMAAAVH
MUL_3574|M.ulcerans_Agy99 QLIVNTKDPYVRPYGYDETARWVPRLWRRDIKAGHFSPMSHPQVMAAAVH
TH_4323|M.thermoresistible__bu QLIVNTRDPYVRPHVYDETDRWVSRLWRRDIKAGHWSPMSHPQVLATAVT
MSMEG_4280|M.smegmatis_MC2_155 QLICNRKDPVVRGEGYRDESKWVPLLWRRDLDAGHWAPFSHPRAIAQAVG
Mflv_2937|M.gilvum_PYR-GCK QLIVGSADPYPDPHLFEDRAGRPARLWRRDVKAGHVTPTSHPGILARALT
Mvan_3576|M.vanbaalenii_PYR-1 QLIVPDHDPHVGPHVYDGMSASVSRLWRRDIKTGDLSPGSHPQVLARAVD
MAB_0090c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DLADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTGAGSGIGRETALALA
MAV_2275|M.avium_104 DFADMAEGKPASRALLRAQVGRPRKAFGDTLVSVTGAGSGIGRATAFAFA
Mb2237c|M.bovis_AF2122/97 DFADLADGKQPSRALLRAQVGRPRGYFGDTLVSVTGAGSGIGRETALAFA
Rv2214c|M.tuberculosis_H37Rv DFADLADGKQPSRALLRAQVGRPRGYFGDTLVSVTGAGSGIGRETALAFA
MMAR_3259|M.marinum_M DFADLVDGKPPSRALLRAQVGRPRKYFGDTLVAVTGAGSGIGRETALAFA
MUL_3574|M.ulcerans_Agy99 DFADLVDGKPPSRALLRAQVGRPRKYFGDTLVAVTGAGSGIGRETALAFA
TH_4323|M.thermoresistible__bu ELADHLAGAPAGRALLRAQVGRPREYFGDMLVAITGAGGGIGRETALAFA
MSMEG_4280|M.smegmatis_MC2_155 EFVDHMEGAPPARALRRAEVARPRKAFSDMLVSVTGAASGIGRATALEFA
Mflv_2937|M.gilvum_PYR-GCK QLVDHLDGAPAARELLRAQVGRPRKAFGDTLVAVTGAASGIGRATALAFA
Mvan_3576|M.vanbaalenii_PYR-1 QLVDHLGGAPAPRELLRAQVGRARKVFGDTLVSVTGAASGIGRETALAFA
MAB_0090c|M.abscessus_ATCC_199 --------------MTSGSAQR------NSLVVVTGAGSGIGRETSLAFA
: ... * : ** :***..**** *:: :*
MLBr_00862|M.leprae_Br4923 RRGAEVVVSDIDEAAAKNTAAQIVASGGVAYAYALDVSDAAAVEAFAEQV
MAV_2275|M.avium_104 REGAELIVSDIDEAAVKATAAEIAGRGGVAHAYVLDVSDAQAVEEFAERV
Mb2237c|M.bovis_AF2122/97 REGAEIVISDIDEATVKDTAAEIAARGGIAYPYVLDVSDAEAVEAFAERV
Rv2214c|M.tuberculosis_H37Rv REGAEIVISDIDEATVKDTAAEIAARGGIAYPYVLDVSDAEAVEAFAERV
MMAR_3259|M.marinum_M REGAEVVLSDIDEATVKDTAAEIAARGGVAHPYVLDVSDTEAVEAFADQV
MUL_3574|M.ulcerans_Agy99 REGAEVVLSDIDEATVKDTAAEIAARGGVAHPYVLDVSDTEAVEAFADQV
TH_4323|M.thermoresistible__bu REGAEVIVSDIDEATAKDTAAEIAARGGVAHAYQLDVSDAAAVDRFADEV
MSMEG_4280|M.smegmatis_MC2_155 RLGAEIVVSDIDEAGAKATATAIDEAGGVAHAYGLDVADPDAVQRFVDDV
Mflv_2937|M.gilvum_PYR-GCK HHGADVVISDVNAAGLDETARLVTSAGVHAYPYTVDVADAAAVEAFAEQV
Mvan_3576|M.vanbaalenii_PYR-1 RAGADVVISDVDEAGLEQTARLVTAAGAAAHSYTVDVADAAAVEAMAELV
MAB_0090c|M.abscessus_ATCC_199 RQGARVVVADINHDTANETVGLIEKLGGSAYPYALDVSDEAAVTAFADDV
: ** ::::*:: . *. : * *:.* :**:* ** :.: *
MLBr_00862|M.leprae_Br4923 SAKHGVPDIVVNNAGIGQAGRFLDTPPEEFDRVLAVNLGGVVNCCRAFGQ
MAV_2275|M.avium_104 SAAHGVPDIVVNNAGIGQAGGFLDTPAEEFDRVLAVNLGGVVNGCRSFAR
Mb2237c|M.bovis_AF2122/97 SAEHGVPDIVVNNAGIGQAGRFLDTPAEQFDRVLAVNLGGVVNGCRAFGQ
Rv2214c|M.tuberculosis_H37Rv SAEHGVPDIVVNNAGIGQAGRFLDTPAEQFDRVLAVNLGGVVNGCRAFGQ
MMAR_3259|M.marinum_M SATHGLPDIVVNNAGVGQAGRFLDTPAEQFDRVLDVNLGGVVNGCRAFGQ
MUL_3574|M.ulcerans_Agy99 SATHGLPDIVVNNAGVGQAGRFLDTPAEQFDRVLDVNLGGVVNGCRAFGQ
TH_4323|M.thermoresistible__bu CARHGVPDIVVNNAGIGHAGRFLDTPRDQWDRVLEVNLGGVVNGCRAFAP
MSMEG_4280|M.smegmatis_MC2_155 CATHGVPDIVVNNAGIGHAGNFLDTPADQYERVLEVNFGGVVNCCRAFGR
Mflv_2937|M.gilvum_PYR-GCK CAEHGVPDVVVNNAGVGHAGFFLDTPAEEFDRVLDINFGGVVNGCRSFGK
Mvan_3576|M.vanbaalenii_PYR-1 CAAHGVPDIVVNNAGVGHAGFFLDTPAEEFDRVLGINFGGVVNGCRSWGR
MAB_0090c|M.abscessus_ATCC_199 CAKHGVPDVLINNAGVGHGGRFFETSSTDFQRVLNINLGGVVHGCRAFGP
.* **:**:::****:*:.* *::*. :::*** :*:****: **::.
MLBr_00862|M.leprae_Br4923 RLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRAELDAV
MAV_2275|M.avium_104 RMVQRGTGGHLVNVSSMAAYAPLQSLSAYCTSKAATFMFSDCLRAELDAA
Mb2237c|M.bovis_AF2122/97 RLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRAELDAA
Rv2214c|M.tuberculosis_H37Rv RLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRAELDAA
MMAR_3259|M.marinum_M RLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATFMFSDCLRAELDAA
MUL_3574|M.ulcerans_Agy99 RLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATFMFSDCLRAELDAA
TH_4323|M.thermoresistible__bu RLVERGTGGHIVNIASMASYAPLQSLNAYCTSKAAVYMFSDCLRAELDSA
MSMEG_4280|M.smegmatis_MC2_155 RLVEQGTGGHIVNVASMAAYSPAGSMNAYATSKAAVFMFSDCLRAELAHA
Mflv_2937|M.gilvum_PYR-GCK RLADRGVGGHIVNVASMASYTPVNVMNAYCTSKAAVFMFSDCLRAELDSF
Mvan_3576|M.vanbaalenii_PYR-1 RLVDRGTGGHIVNVASMASYTPVNVMNAYCTSKAAVFMFSDCLRAELDSA
MAB_0090c|M.abscessus_ATCC_199 RMAERKSG-HIVNISSAAAYTPIPEMGAYATSKAAVFMFSDVLRGELARD
*:.:: * *:**::* *:*:* :.**.*****.:**** **.**
MLBr_00862|M.leprae_Br4923 GVGLTTICPGVIDTNIIQSTRIDTPT-AKQERVRDRRGQLDMMFRLRRYG
MAV_2275|M.avium_104 GVGLTTICPGLIDTNIINTTRFDAPAGARAERVDDRRGQLGKMFALRHYG
Mb2237c|M.bovis_AF2122/97 GVGLTTICPGVIDTNIVATTGFHAP-GTDEEKIDGRRGQIDKMFALRSYG
Rv2214c|M.tuberculosis_H37Rv GVGLTTICPGVIDTNIVATTGFHAP-GTDEEKIDGRRGQIDKMFALRSYG
MMAR_3259|M.marinum_M DVGLTTICPGVINTNIVNTTRFDAPPGKGGDQVDGRRGQIDKMFALRSYG
MUL_3574|M.ulcerans_Agy99 DVGLTTICPGVINTNIVNTTRFDAPPGKGGDQLDGRRGQIDKMFALRSYG
TH_4323|M.thermoresistible__bu GIMLTTICPSTVNTNIIGSTRFNAP-DGLDDVVDTRREQLQKLFALRRFG
MSMEG_4280|M.smegmatis_MC2_155 GIGVTTLCPGMIDTGIVDTTRFDVP-AHKAGQVEARRAQVKKTFQARRYG
Mflv_2937|M.gilvum_PYR-GCK GIGLTTICPGFISTNIVDTTRFSLAQGRDDD-VDVLRGRAQKGFSARKYG
Mvan_3576|M.vanbaalenii_PYR-1 GIGVTTICPGVIGTNIVDTTRFSLPEARRDD-AESIRRRARQGFAVRRVG
MAB_0090c|M.abscessus_ATCC_199 KVKVSTICPGIVNTNIIRTTQFSGL---SPEDEAKRQQQGAGLYAKRGYG
: ::*:**. :.*.*: :* : : : : * *
MLBr_00862|M.leprae_Br4923 PDKVADTILSAIKKNKPIRPVAPEAYALYGISRVLPQVLRSTARIRVI--
MAV_2275|M.avium_104 PDKVADAILSSVQKKKPIRPVAPEAYALYGLSRVMPQGLRNAARLRVI--
Mb2237c|M.bovis_AF2122/97 PDKVADAIVSAVKKKKPIRPVAPEAYALYGISRVLPQALRSTARLRVI--
Rv2214c|M.tuberculosis_H37Rv PDKVADAIVSAVKKKKPIRPVAPEAYALYGISRVLPQALRSTARLRVI--
MMAR_3259|M.marinum_M PDKVAKAIVSAVKKNKPIRPVAPEAYALYGISRVLPPALRSTARMRVI--
MUL_3574|M.ulcerans_Agy99 PDKVAKAIVSAVKKNKPIRPVAPEAYALYGISRVLPPALRSTARMRVI--
TH_4323|M.thermoresistible__bu PDKAAKAIVSAVKQNKPIRPVMPEAYFVYGVSRVLPQALRSTARGRVL--
MSMEG_4280|M.smegmatis_MC2_155 PEKVAKAVTSAVSRNQALRPVTPEAYVAYGVSRLFPAALRRAARSQVL--
Mflv_2937|M.gilvum_PYR-GCK PEKVADAIVDAVRTNKAIRPVAPEARFVYGVAHALPQVLRSTARGGNFV-
Mvan_3576|M.vanbaalenii_PYR-1 PDKVAKAIVAAVQKNKPVRPVTTEAYLVYGVAHALPQAMRSAARGGNIM-
MAB_0090c|M.abscessus_ATCC_199 PEKVAKEIVNAVAKGKSVVPVTPEAHVQYHFSRLAPALNRFFWGLSDKIS
*:*.*. : :: :.: ** .** * .:: * *
MLBr_00862|M.leprae_Br4923 -
MAV_2275|M.avium_104 -
Mb2237c|M.bovis_AF2122/97 -
Rv2214c|M.tuberculosis_H37Rv -
MMAR_3259|M.marinum_M -
MUL_3574|M.ulcerans_Agy99 -
TH_4323|M.thermoresistible__bu -
MSMEG_4280|M.smegmatis_MC2_155 -
Mflv_2937|M.gilvum_PYR-GCK -
Mvan_3576|M.vanbaalenii_PYR-1 -
MAB_0090c|M.abscessus_ATCC_199 R