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FKLNSGTNTSDLAGRVVAITGAGSGIGRELALLCAQRGADLALCDINDTAVADTAQTARGFGHDVITRRV DVSDPEQMTAFADATLGHFGGVDLLVNNAGVGLIGGFLDTSRKDWDWLVSINVMGVVHGCEAFLPAMIES GRGGHVVNLSSAAGLLANSALSAYSATKFAVLGLSEALRIELEPHRIGVTAICPGVINTAITKASPIRGA GDTEGRRQRLTVTYQRRGYTPARAARNILRAVERNKAVAPVAAEAHVMYVLSRIMPPLARWVSAQMAKAA K*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2600 | - | - | 100% (282) | short-chain dehydrogenase |
| M. marinum M | MMAR_3259 | ephD | 5e-56 | 44.23% (260) | short-chain dehydrogenase EphD |
| M. marinum M | MMAR_1932 | ephD_1 | 3e-54 | 42.97% (263) | short-chain dehydrogenase EphD_1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2237c | ephD | 4e-52 | 41.31% (259) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_2937 | - | 2e-45 | 39.77% (259) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv2214c | ephD | 4e-52 | 41.31% (259) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_00862 | ephD | 1e-51 | 38.55% (275) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4019c | - | 6e-52 | 41.54% (272) | short chain dehydrogenase |
| M. avium 104 | MAV_3670 | - | 1e-53 | 42.54% (268) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4280 | - | 7e-48 | 39.00% (259) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_4323 | - | 5e-51 | 41.31% (259) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_3160 | - | 1e-158 | 99.65% (282) | short-chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_3576 | - | 1e-45 | 38.22% (259) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2237c|M.bovis_AF2122/97 MPATQQMS--------RLVDSPDGVRIAVY--HEGNPDGPTVVLVHGFPD
Rv2214c|M.tuberculosis_H37Rv MPATQQMS--------RLVDSPDGVRIAVY--HEGNPDGPTVVLVHGFPD
MLBr_00862|M.leprae_Br4923 MPATQSIHKVP----HQFVESPDGVRLAIY--QSGQPEGPAIVLVHGFPD
TH_4323|M.thermoresistible__bu MAT------------EHFIDSSGGVRIAAY--EEGNPDGPTVVLVHGWPD
MSMEG_4280|M.smegmatis_MC2_155 MYT--------------FVTSQDGTRIAVY--QQGDPERPTLVMAHGWPD
Mflv_2937|M.gilvum_PYR-GCK MSSQ------------RFVVSRDGVRIAVY--EEGAADGPTVVLVHGHAD
Mvan_3576|M.vanbaalenii_PYR-1 MSTQ------------RFVESSDGVRIAVS--EQGNPDGPTLVLVHGLRD
MAB_4019c|M.abscessus_ATCC_199 MTLTTERDGVTNGGMTEHVVRNGDIDVAYF--MQGNPEGETILLVHGWPD
MMAR_2600|M.marinum_M --------------------------------------------------
MUL_3160|M.ulcerans_Agy99 --------------------------------------------------
MAV_3670|M.avium_104 MTVT------------STITADDGVTLAVHRYTDIDPARPTILAIHGFPD
Mb2237c|M.bovis_AF2122/97 SHVLWDGVVPLLAER-FRIVRYDNRGVGRSSVPKPISAYTMAHFADDFDA
Rv2214c|M.tuberculosis_H37Rv SHVLWDGVVPLLAER-FRIVRYDNRGVGRSSVPKPISAYTMAHFADDFDA
MLBr_00862|M.leprae_Br4923 SHVLWDGVVPLLAKR-FRIVRYDNRGVGQSSVPKPVSAYTMTRFADDFAA
TH_4323|M.thermoresistible__bu SHVVWDSVAPLLADR-FRIIRYDNRGVGRTTAPRRVADHTMARYADDFGA
MSMEG_4280|M.smegmatis_MC2_155 SHVLWDGVVGELGDR-YRIVRYDNRGAGASDVPKATSAYTMERFADDFSA
Mflv_2937|M.gilvum_PYR-GCK THEAWDAVVALLAAR-FRIVRYDTRGAGRSAAPQRTSGFRLERYADDLAA
Mvan_3576|M.vanbaalenii_PYR-1 THRVWDPVVALLADR-FRIVAYDTRGAGNSGAPKQTSAYTVDRFADDFAA
MAB_4019c|M.abscessus_ATCC_199 SHHLWDGVAPLLRDR-FRLVAIDNRGAGKSSNPKSFRDFRLTEMASDYVA
MMAR_2600|M.marinum_M --------------------------------------------------
MUL_3160|M.ulcerans_Agy99 --------------------------------------------------
MAV_3670|M.avium_104 NHHVWDGVADELTGAPYNFVAYDVRGAGESSCPATRSGYGFAQLARDMGA
Mb2237c|M.bovis_AF2122/97 VIGELSPGEPVHVLAHDWGSVGVWEYLRRPGAS-----DRVASFTSVSGP
Rv2214c|M.tuberculosis_H37Rv VIGELSPGEPVHVLAHDWGSVGVWEYLRRPGAS-----DRVASFTSVSGP
MLBr_00862|M.leprae_Br4923 VIDELSPDRPVHVLAHDWGSVGVWEYLSRSGAS-----DRVASFTSVSGP
TH_4323|M.thermoresistible__bu VIDALAPGQRVHVLAHDWGSAGVWEYLARPEAE-----DRIASFTSVSGP
MSMEG_4280|M.smegmatis_MC2_155 VIDAVSPDAPVHVLAHDWGSVGIWEYLSRQGSA-----ARMVSFTSVSGP
Mflv_2937|M.gilvum_PYR-GCK VLDAVSAEAPVHVLAHDRGSAGVWRYLARPESR-----GRLASFTSVSGP
Mvan_3576|M.vanbaalenii_PYR-1 VAAAVGGDTPVHVLAHGWGAAGVWQYLKRADAP-----ERVASLTSVSGP
MAB_4019c|M.abscessus_ATCC_199 VADAVSPDKPVHVLGHDWGSVAMWEAICDPELE-----HRFSSFTSVSGP
MMAR_2600|M.marinum_M --------------------------------------------------
MUL_3160|M.ulcerans_Agy99 --------------------------------------------------
MAV_3670|M.avium_104 VIDSLGVGR-VHLLAHDWGSIQAWAAVTDQAIMGESVMDKVASFTSISGP
Mb2237c|M.bovis_AF2122/97 SQDHLVNYVYGGLRRPWRPRTFLRAISQTLRLSYMALFSVPVVAPLLLRV
Rv2214c|M.tuberculosis_H37Rv SQDHLVNYVYGGLRRPWRPRTFLRAISQTLRLSYMALFSVPVVAPLLLRV
MLBr_00862|M.leprae_Br4923 SQDQLVDYILSGLRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWI
TH_4323|M.thermoresistible__bu SGDHLARYVLDGLAAPYRPRRFLRSLTQLLRLSYMGFFSIPVLAPLLVRG
MSMEG_4280|M.smegmatis_MC2_155 STDHYGAYVRRGLARPYRPVQFARAVNLASRFSYWIPFSIPVLAPALMR-
Mflv_2937|M.gilvum_PYR-GCK APEHVARYLRDTLARPQHPARFAGGLGHLARL------------------
Mvan_3576|M.vanbaalenii_PYR-1 SPEHVAGYVRAALTSPR---RFVRGAGQLVRL------------------
MAB_4019c|M.abscessus_ATCC_199 SAHHMSKWVRSRFGNPT-PKNLALALGQIGSLLYMFGSMTPVIPNVLLKL
MMAR_2600|M.marinum_M --------------------------------------------------
MUL_3160|M.ulcerans_Agy99 --------------------------------------------------
MAV_3670|M.avium_104 HLNYAGAFLRS----ARTPRAVARVVRQLIASGYIGFFLCPGAAELSFRA
Mb2237c|M.bovis_AF2122/97 ALSSAAVR--RNMVGDIPVDQIHHSETLARDAAHSVKTYPANYFRSFSSS
Rv2214c|M.tuberculosis_H37Rv ALSSAAVR--RNMVGDIPVDQIHHSETLARDAAHSVKTYPANYFRSFSSS
MLBr_00862|M.leprae_Br4923 ALSSATIR--RTMVDNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGR
TH_4323|M.thermoresistible__bu VLSKALRRS-LRLRDGVPADRLHHSDTFAADAARSIKVYGANFLRTLRHA
MSMEG_4280|M.smegmatis_MC2_155 --RGAARR----LQAIDTPGPKFQSENLDIDAANSLKIYRANAIRSFTHV
Mflv_2937|M.gilvum_PYR-GCK --AAAAPR------------------------AVTDKTLRAN----LFPV
Mvan_3576|M.vanbaalenii_PYR-1 --AAAAPR------------------------AATAKPYRAN----LRPA
MAB_4019c|M.abscessus_ATCC_199 TMNERRWRTGLSLAEGAPVEDIHLGSTFMSDITRTLRVYRANALPAMLHP
MMAR_2600|M.marinum_M --------------------------------------------------
MUL_3160|M.ulcerans_Agy99 --------------------------------------------------
MAV_3670|M.avium_104 GIGVKVIAALERIGHTSTRSQRRDTQRSLRDYLNGLQLYRQNMPAPMLAP
Mb2237c|M.bovis_AF2122/97 RRGRAIPIVDVPVQLIVNSQDPYVRPYGYDQTARWVPRLWRRDIKAGHFS
Rv2214c|M.tuberculosis_H37Rv RRGRAIPIVDVPVQLIVNSQDPYVRPYGYDQTARWVPRLWRRDIKAGHFS
MLBr_00862|M.leprae_Br4923 RRGKGVPVVNVPVQLIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHFS
TH_4323|M.thermoresistible__bu RTDH---FVRVPVQLIVNTRDPYVRPHVYDETDRWVSRLWRRDIKAGHWS
MSMEG_4280|M.smegmatis_MC2_155 RRDH---YVQVPVQLICNRKDPVVRGEGYRDESKWVPLLWRRDLDAGHWA
Mflv_2937|M.gilvum_PYR-GCK SSGGDAHDVDIPVQLIVGSADPYPDPHLFEDRAGRPARLWRRDVKAGHVT
Mvan_3576|M.vanbaalenii_PYR-1 APAG--VPVDVPVQLIVPDHDPHVGPHVYDGMSASVSRLWRRDIKTGDLS
MAB_4019c|M.abscessus_ATCC_199 QDRH----TRVPVQVIVGTRDPAVRQSNYDDELKWNQQTWRRVLDGGHWL
MMAR_2600|M.marinum_M --------------------------------------------------
MUL_3160|M.ulcerans_Agy99 --------------------------------------------------
MAV_3670|M.avium_104 GPRLP--ETTVPVQTLVPRRDVFVTPALQRFTGAIPQRARVIEIEGGHWV
Mb2237c|M.bovis_AF2122/97 PMSHPQVMAAAVHDFADLADGKQPSRALL--RAQVGRPRGYFGDTLVSVT
Rv2214c|M.tuberculosis_H37Rv PMSHPQVMAAAVHDFADLADGKQPSRALL--RAQVGRPRGYFGDTLVSVT
MLBr_00862|M.leprae_Br4923 PMSHPQVMAAAVHDLADLVDGKQPSRALL--RAQVGRSRDTFGDTLVSVT
TH_4323|M.thermoresistible__bu PMSHPQVLATAVTELADHLAGAPAGRALL--RAQVGRPREYFGDMLVAIT
MSMEG_4280|M.smegmatis_MC2_155 PFSHPRAIAQAVGEFVDHMEGAPPARALR--RAEVARPRKAFSDMLVSVT
Mflv_2937|M.gilvum_PYR-GCK PTSHPGILARALTQLVDHLDGAPAARELL--RAQVGRPRKAFGDTLVAVT
Mvan_3576|M.vanbaalenii_PYR-1 PGSHPQVLARAVDQLVDHLGGAPAPRELL--RAQVGRARKVFGDTLVSVT
MAB_4019c|M.abscessus_ATCC_199 PFSHPQVLAAATAELIDAVSGNQPGRGLR--RAEMGKSRRPFEDQLVVIT
MMAR_2600|M.marinum_M --------------MFKLNSG---------------TNTSDLAGRVVAIT
MUL_3160|M.ulcerans_Agy99 --------------MFKLNSG---------------TNTSDLAGRVVAIT
MAV_3670|M.avium_104 VTSRPDVIARLTTEWVDLQSAGAVAPQLTGERRELPGERREVRGRLALVT
. . . . :. :*
Mb2237c|M.bovis_AF2122/97 GAGSGIGRETALAFAREGA-EIVISDIDEATVKDTAAEIAARGGIAYPYV
Rv2214c|M.tuberculosis_H37Rv GAGSGIGRETALAFAREGA-EIVISDIDEATVKDTAAEIAARGGIAYPYV
MLBr_00862|M.leprae_Br4923 GAGSGIGRETALALARRGA-EVVVSDIDEAAAKNTAAQIVASGGVAYAYA
TH_4323|M.thermoresistible__bu GAGGGIGRETALAFAREGA-EVIVSDIDEATAKDTAAEIAARGGVAHAYQ
MSMEG_4280|M.smegmatis_MC2_155 GAASGIGRATALEFARLGA-EIVVSDIDEAGAKATATAIDEAGGVAHAYG
Mflv_2937|M.gilvum_PYR-GCK GAASGIGRATALAFAHHGA-DVVISDVNAAGLDETARLVTSAGVHAYPYT
Mvan_3576|M.vanbaalenii_PYR-1 GAASGIGRETALAFARAGA-DVVISDVDEAGLEQTARLVTAAGAAAHSYT
MAB_4019c|M.abscessus_ATCC_199 GGGSGIGRETALEFARQGA-EVVLSDVNLDGANETVSLIEQSGGVAHAYR
MMAR_2600|M.marinum_M GAGSGIGRELALLCAQRGA-DLALCDINDTAVADTAQTARGFGHDVITRR
MUL_3160|M.ulcerans_Agy99 GAGSGIGRELALLCAQRGA-DLALCDINDTAVADTAQTARGFGHDVITRR
MAV_3670|M.avium_104 GAGAGIGRATAVELARQGARKVVIVDRDRAAADQTADAVRAAGAGAAVYQ
*...**** *: *: ** .: : * : *. * .
Mb2237c|M.bovis_AF2122/97 LDVSDAEAVEAFAERVSAEHGVPDIVVNNAGIGQAGRFLDTPAEQFDRVL
Rv2214c|M.tuberculosis_H37Rv LDVSDAEAVEAFAERVSAEHGVPDIVVNNAGIGQAGRFLDTPAEQFDRVL
MLBr_00862|M.leprae_Br4923 LDVSDAAAVEAFAEQVSAKHGVPDIVVNNAGIGQAGRFLDTPPEEFDRVL
TH_4323|M.thermoresistible__bu LDVSDAAAVDRFADEVCARHGVPDIVVNNAGIGHAGRFLDTPRDQWDRVL
MSMEG_4280|M.smegmatis_MC2_155 LDVADPDAVQRFVDDVCATHGVPDIVVNNAGIGHAGNFLDTPADQYERVL
Mflv_2937|M.gilvum_PYR-GCK VDVADAAAVEAFAEQVCAEHGVPDVVVNNAGVGHAGFFLDTPAEEFDRVL
Mvan_3576|M.vanbaalenii_PYR-1 VDVADAAAVEAMAELVCAAHGVPDIVVNNAGVGHAGFFLDTPAEEFDRVL
MAB_4019c|M.abscessus_ATCC_199 LNVADEEAVNAHAEEVVKRHGVPDVLVNNAGVGAAGGFLDTPSEEFRRVI
MMAR_2600|M.marinum_M VDVSDPEQMTAFADATLGHFGGVDLLVNNAGVGLIGGFLDTSRKDWDWLV
MUL_3160|M.ulcerans_Agy99 VDVSDPEQMTAFADATLGHFGGVDLLVNNAGVGLIGGFLDTSRKDWDWLV
MAV_3670|M.avium_104 VDVSDEAAMNDLAAQVRNEHGVVDILVNNAGIGMAGRFLETSPANWDAIM
::*:* : . . .* *::*****:* * **:*. :: ::
Mb2237c|M.bovis_AF2122/97 AVNLGGVVNGCRAFGQRLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKA
Rv2214c|M.tuberculosis_H37Rv AVNLGGVVNGCRAFGQRLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKA
MLBr_00862|M.leprae_Br4923 AVNLGGVVNCCRAFGQRLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKA
TH_4323|M.thermoresistible__bu EVNLGGVVNGCRAFAPRLVERGTGGHIVNIASMASYAPLQSLNAYCTSKA
MSMEG_4280|M.smegmatis_MC2_155 EVNFGGVVNCCRAFGRRLVEQGTGGHIVNVASMAAYSPAGSMNAYATSKA
Mflv_2937|M.gilvum_PYR-GCK DINFGGVVNGCRSFGKRLADRGVGGHIVNVASMASYTPVNVMNAYCTSKA
Mvan_3576|M.vanbaalenii_PYR-1 GINFGGVVNGCRSWGRRLVDRGTGGHIVNVASMASYTPVNVMNAYCTSKA
MAB_4019c|M.abscessus_ATCC_199 ETNLFGVVNGSRAFGAKMAERGLGGHIVNLSSMAAYSPQKAFTAYSTSKS
MMAR_2600|M.marinum_M SINVMGVVHGCEAFLPAMIESGRGGHVVNLSSAAGLLANSALSAYSATKF
MUL_3160|M.ulcerans_Agy99 SINVMGVVHGCEAFLPAMIESGRGGHVVNLSSAAGLLANPALSAYSATKF
MAV_3670|M.avium_104 GVNVRGVIWGSRAFGAQMVERGQGGTIINVASAAAYLPSKSMVAYGTTKA
*. **: ..:: : : * ** ::*::* *. . : ** ::*
Mb2237c|M.bovis_AF2122/97 ATYMFSDCLRAELDAAGVGLTTICPGVIDTNIVATTGFHAPGTDEEKIDG
Rv2214c|M.tuberculosis_H37Rv ATYMFSDCLRAELDAAGVGLTTICPGVIDTNIVATTGFHAPGTDEEKIDG
MLBr_00862|M.leprae_Br4923 ATYMFSDCLRAELDAVGVGLTTICPGVIDTNIIQSTRIDTPTAKQERVRD
TH_4323|M.thermoresistible__bu AVYMFSDCLRAELDSAGIMLTTICPSTVNTNIIGSTRFNAPDGLDDVVDT
MSMEG_4280|M.smegmatis_MC2_155 AVFMFSDCLRAELAHAGIGVTTLCPGMIDTGIVDTTRFDVPAHKAGQVEA
Mflv_2937|M.gilvum_PYR-GCK AVFMFSDCLRAELDSFGIGLTTICPGFISTNIVDTTRFSLAQGRDDDVDV
Mvan_3576|M.vanbaalenii_PYR-1 AVFMFSDCLRAELDSAGIGVTTICPGVIGTNIVDTTRFSLPEARRDDAES
MAB_4019c|M.abscessus_ATCC_199 AVFMFSDCLRADLAAHNIGVTTICPGVVHTNIVATTKISGVSADEEARMQ
MMAR_2600|M.marinum_M AVLGLSEALRIELEPHRIGVTAICPGVINTAITKASPIRG----AGDTEG
MUL_3160|M.ulcerans_Agy99 AVLGLSEALRIELEPHRIGVTAICPGVINTAITKASPIRG----AGDTEG
MAV_3670|M.avium_104 AVLALSESLRADFADEGITVTAVCPGFVNTNIAKSTIYAGMS--AQQQER
*. :*:.** :: : :*::**. : * * ::
Mb2237c|M.bovis_AF2122/97 RRGQIDKMFALRSYGPDKVADAIVSAVKKKKPIRPVAPEAYALYGISRVL
Rv2214c|M.tuberculosis_H37Rv RRGQIDKMFALRSYGPDKVADAIVSAVKKKKPIRPVAPEAYALYGISRVL
MLBr_00862|M.leprae_Br4923 RRGQLDMMFRLRRYGPDKVADTILSAIKKNKPIRPVAPEAYALYGISRVL
TH_4323|M.thermoresistible__bu RREQLQKLFALRRFGPDKAAKAIVSAVKQNKPIRPVMPEAYFVYGVSRVL
MSMEG_4280|M.smegmatis_MC2_155 RRAQVKKTFQARRYGPEKVAKAVTSAVSRNQALRPVTPEAYVAYGVSRLF
Mflv_2937|M.gilvum_PYR-GCK LRGRAQKGFSARKYGPEKVADAIVDAVRTNKAIRPVAPEARFVYGVAHAL
Mvan_3576|M.vanbaalenii_PYR-1 IRRRARQGFAVRRVGPDKVAKAIVAAVQKNKPVRPVTTEAYLVYGVAHAL
MAB_4019c|M.abscessus_ATCC_199 QAG--DRAYAMRRYGPEKVARQIVGAVRKNKQVVPVTPEARLQYLNNRLA
MMAR_2600|M.marinum_M RRQRLTVTYQRRGYTPARAARNILRAVERNKAVAPVAAEAHVMYVLSRIM
MUL_3160|M.ulcerans_Agy99 RRQRLTVTYQRRGYTPARAARNILRAVERNKAVAPVAAEAHVMYVLSRIM
MAV_3670|M.avium_104 ARDRADAAYRRRNFTPEATAKAIVKAIKTGPAVVPIAAESRIGYALRRIS
: * * .* : *: : *: .*: * :
Mb2237c|M.bovis_AF2122/97 PQALRSTARLRVI-----------
Rv2214c|M.tuberculosis_H37Rv PQALRSTARLRVI-----------
MLBr_00862|M.leprae_Br4923 PQVLRSTARIRVI-----------
TH_4323|M.thermoresistible__bu PQALRSTARGRVL-----------
MSMEG_4280|M.smegmatis_MC2_155 PAALRRAARSQVL-----------
Mflv_2937|M.gilvum_PYR-GCK PQVLRSTARGGNFV----------
Mvan_3576|M.vanbaalenii_PYR-1 PQAMRSAARGGNIM----------
MAB_4019c|M.abscessus_ATCC_199 PGLTRYFATKAGMTDLIKLVPNKK
MMAR_2600|M.marinum_M PPLARWVSAQMAKAAK--------
MUL_3160|M.ulcerans_Agy99 PPLARWVSAQMAKAAK--------
MAV_3670|M.avium_104 PGAIRLLARWDIRQT---------
* * :