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M. thermoresistible (build 8) TH_2445 (-)

annotation: short-chain dehydrogenase/reductase SDR
coordinates: 1202735 - 1203556
length: 274

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_2445--100% (274)short-chain dehydrogenase/reductase SDR
M. thermoresistible (build 8)TH_4323-2e-3137.61% (234) PUTATIVE short-chain dehydrogenase/reductase SDR
M. thermoresistible (build 8)TH_1828-2e-3034.08% (267) PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3083c-6e-3334.66% (277) short chain dehydrogenase
M. gilvum PYR-GCKMflv_2070-1e-10674.44% (266) short-chain dehydrogenase/reductase SDR
M. tuberculosis H37RvRv3057c-7e-3334.66% (277) short chain dehydrogenase
M. leprae Br4923MLBr_00862ephD3e-3235.29% (272) short chain dehydrogenase
M. abscessus ATCC 19977MAB_1526-2e-3336.12% (263) short chain dehydrogenase
M. marinum MMMAR_2600-2e-3836.47% (266) short-chain dehydrogenase
M. avium 104MAV_1384-3e-3236.68% (259) short chain alcohol dehydrogenase
M. smegmatis MC2 155MSMEG_5235-1e-12581.92% (271) short chain dehydrogenase family protein
M. ulcerans Agy99MUL_3160-2e-3836.47% (266) short-chain dehydrogenase
M. vanbaalenii PYR-1Mvan_4644-1e-11175.46% (273) short-chain dehydrogenase/reductase SDR

CLUSTAL 2.0.9 multiple sequence alignment


TH_2445|M.thermoresistible__bu      --------------------------------------------------
MSMEG_5235|M.smegmatis_MC2_155      --------------------------------------------------
Mflv_2070|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_4644|M.vanbaalenii_PYR-1       --------------------------------------------------
MMAR_2600|M.marinum_M               --------------------------------------------------
MUL_3160|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00862|M.leprae_Br4923          MPATQSIHKVPHQFVESPDGVRLAIYQSGQPEGPAIVLVHGFPDSHVLWD
MAV_1384|M.avium_104                --------------------------------------------------
Mb3083c|M.bovis_AF2122/97           --------------------------------------------------
Rv3057c|M.tuberculosis_H37Rv        --------------------------------------------------
MAB_1526|M.abscessus_ATCC_1997      --------------------------------------------------
                                                                                      

TH_2445|M.thermoresistible__bu      --------------------------------------------------
MSMEG_5235|M.smegmatis_MC2_155      --------------------------------------------------
Mflv_2070|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_4644|M.vanbaalenii_PYR-1       --------------------------------------------------
MMAR_2600|M.marinum_M               --------------------------------------------------
MUL_3160|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00862|M.leprae_Br4923          GVVPLLAKRFRIVRYDNRGVGQSSVPKPVSAYTMTRFADDFAAVIDELSP
MAV_1384|M.avium_104                --------------------------------------------------
Mb3083c|M.bovis_AF2122/97           --------------------------------------------------
Rv3057c|M.tuberculosis_H37Rv        --------------------------------------------------
MAB_1526|M.abscessus_ATCC_1997      --------------------------------------------------
                                                                                      

TH_2445|M.thermoresistible__bu      --------------------------------------------------
MSMEG_5235|M.smegmatis_MC2_155      --------------------------------------------------
Mflv_2070|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_4644|M.vanbaalenii_PYR-1       --------------------------------------------------
MMAR_2600|M.marinum_M               --------------------------------------------------
MUL_3160|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00862|M.leprae_Br4923          DRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSVSGPSQDQLVDYILSG
MAV_1384|M.avium_104                --------------------------------------------------
Mb3083c|M.bovis_AF2122/97           --------------------------------------------------
Rv3057c|M.tuberculosis_H37Rv        --------------------------------------------------
MAB_1526|M.abscessus_ATCC_1997      --------------------------------------------------
                                                                                      

TH_2445|M.thermoresistible__bu      --------------------------------------------------
MSMEG_5235|M.smegmatis_MC2_155      --------------------------------------------------
Mflv_2070|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_4644|M.vanbaalenii_PYR-1       --------------------------------------------------
MMAR_2600|M.marinum_M               --------------------------------------------------
MUL_3160|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00862|M.leprae_Br4923          LRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWIALSSATIRRTMV
MAV_1384|M.avium_104                --------------------------------------------------
Mb3083c|M.bovis_AF2122/97           --------------------------------------------------
Rv3057c|M.tuberculosis_H37Rv        --------------------------------------------------
MAB_1526|M.abscessus_ATCC_1997      --------------------------------------------------
                                                                                      

TH_2445|M.thermoresistible__bu      --------------------------------------------------
MSMEG_5235|M.smegmatis_MC2_155      --------------------------------------------------
Mflv_2070|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_4644|M.vanbaalenii_PYR-1       --------------------------------------------------
MMAR_2600|M.marinum_M               --------------------------------------------------
MUL_3160|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00862|M.leprae_Br4923          DNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRRGKGVPVVNVPVQ
MAV_1384|M.avium_104                --------------------------------------------------
Mb3083c|M.bovis_AF2122/97           --------------------------------------------------
Rv3057c|M.tuberculosis_H37Rv        --------------------------------------------------
MAB_1526|M.abscessus_ATCC_1997      --------------------------------------------------
                                                                                      

TH_2445|M.thermoresistible__bu      --------------------------------------------------
MSMEG_5235|M.smegmatis_MC2_155      --------------------------------------------------
Mflv_2070|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_4644|M.vanbaalenii_PYR-1       --------------------------------------------------
MMAR_2600|M.marinum_M               --------------------------------------------------
MUL_3160|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00862|M.leprae_Br4923          LIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHD
MAV_1384|M.avium_104                --------------------------------------------------
Mb3083c|M.bovis_AF2122/97           --------------------------------------------------
Rv3057c|M.tuberculosis_H37Rv        --------------------------------------------------
MAB_1526|M.abscessus_ATCC_1997      --------------------------------------------------
                                                                                      

TH_2445|M.thermoresistible__bu      -----------------------MTFAGKHALVTGAGSGIGAALCRALAA
MSMEG_5235|M.smegmatis_MC2_155      -----------------------MSFTGKTAIVTGAGSGIGATLCRALVD
Mflv_2070|M.gilvum_PYR-GCK          -------------------MSSTADFAGKQALLTGGGSGIGAALCRALDR
Mvan_4644|M.vanbaalenii_PYR-1       -----------------------MRFTGKHAIITGGGSGIGAALCRALDR
MMAR_2600|M.marinum_M               -------------MFKLNSGTNTSDLAGRVVAITGAGSGIGRELALLCAQ
MUL_3160|M.ulcerans_Agy99           -------------MFKLNSGTNTSDLAGRVVAITGAGSGIGRELALLCAQ
MLBr_00862|M.leprae_Br4923          LADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTGAGSGIGRETALALAR
MAV_1384|M.avium_104                ----------------------MQGFAGKVAVVTGAGSGIGQALAVELAR
Mb3083c|M.bovis_AF2122/97           ----------------MLQRGAGQYFAGKRCFVTGAASGIGRATALRLAA
Rv3057c|M.tuberculosis_H37Rv        ----------------MLQRGAGQYFAGKRCFVTGAASGIGRATALRLAA
MAB_1526|M.abscessus_ATCC_1997      -----------------MSRYPKIELAGAVVVITGGARGIGAATARLFAD
                                                             : .    :**.. ***   .     

TH_2445|M.thermoresistible__bu      AGAEVMCTDIDG-----AAAERTAQSIG--GRWAALDVTDAAAVQAAVDG
MSMEG_5235|M.smegmatis_MC2_155      AGADVLCTDVDADAAARTAAARTAAALG--ARSARLDVTDAAAVQTTVDD
Mflv_2070|M.gilvum_PYR-GCK          AGAHVVCTDIDE-----LAAERVVSTLSSRARAARLDVTDSAAVQAAVDD
Mvan_4644|M.vanbaalenii_PYR-1       AGAQVVCTDIDE-----AAAGAVVSTLSPRARAARLDVTDAAAVQGVVDD
MMAR_2600|M.marinum_M               RGADLALCDINDTA-VADTAQTARGFGHDVITR-RVDVSDPEQMTAFADA
MUL_3160|M.ulcerans_Agy99           RGADLALCDINDTA-VADTAQTARGFGHDVITR-RVDVSDPEQMTAFADA
MLBr_00862|M.leprae_Br4923          RGAEVVVSDIDEAA-AKNTAAQIVASGGVAYAY-ALDVSDAAAVEAFAEQ
MAV_1384|M.avium_104                SGAKVAISDVDLEG-LAHTEEQLKAIGAQYKAD-RLDVTEREAFLAYADA
Mb3083c|M.bovis_AF2122/97           QGAELYLTDRDRDG-LAQTVCDARALGAQVPEHRVLDVSDYQDVAAFAAD
Rv3057c|M.tuberculosis_H37Rv        QGAELYLTDRDRDG-LAQTVCDARALGAQVPEHRVLDVSDYQDVAAFAAD
MAB_1526|M.abscessus_ATCC_1997      RGADVWIGDVDD------VVAKETANGIPNAHSGALDVTKPESWAGFLDQ
                                     **.:   * :       .                :**:.          

TH_2445|M.thermoresistible__bu      VVDRAGRLDLLFNNAGIVWGGDTELLTLDQWNAIIDVNIRGVVHGVAAAY
MSMEG_5235|M.smegmatis_MC2_155      VVARAGRLDLMFNNAGIVWGGDTELLTLDQWNAIIDVNIRGVVHGVAAAY
Mflv_2070|M.gilvum_PYR-GCK          VEARAGRLDLMFNNAGIVFGGETELLTLDQWNAIIDVNIRGVVHGVAAAY
Mvan_4644|M.vanbaalenii_PYR-1       VVARTGRLDLIFNNAGIVWGGDTELLTLDQWNAIIDINLRGVVHGVAAAY
MMAR_2600|M.marinum_M               TLGHFGGVDLLVNNAGVGLIGGFLDTSRKDWDWLVSINVMGVVHGCEAFL
MUL_3160|M.ulcerans_Agy99           TLGHFGGVDLLVNNAGVGLIGGFLDTSRKDWDWLVSINVMGVVHGCEAFL
MLBr_00862|M.leprae_Br4923          VSAKHGVPDIVVNNAGIGQAGRFLDTPPEEFDRVLAVNLGGVVNCCRAFG
MAV_1384|M.avium_104                VKEHFGKVNQIYNNAGIAFTGDVEVSQFKDIERVMDVDFWGVVNGTKAFL
Mb3083c|M.bovis_AF2122/97           IHARHPSMDVVLNIAGVSAWGTVDQLTHDQWSRMVAINLMGPIHVIETLV
Rv3057c|M.tuberculosis_H37Rv        IHARHPSMDVVLNIAGVSAWGTVDQLTHDQWSRMVAINLMGPIHVIETLV
MAB_1526|M.abscessus_ATCC_1997      VRAESGPVDILINNAGVMPLGGFIEENERTTDLILDVNVRGPLNGARAVL
                                       .    : : * **:   *          . :: ::. * ::   :  

TH_2445|M.thermoresistible__bu      PLMVRQG-HGHIVNTASMAGLAAAGQLTSYVMTKHAVVGLSLALRSEAAA
MSMEG_5235|M.smegmatis_MC2_155      PQMIRQG-HGHIVNTASMAGLAAAGQLTSYVMSKHAVVGLSLALRSEAAA
Mflv_2070|M.gilvum_PYR-GCK          PLMLRQG-HGHIVNTASMAGLAAAGHLTSYVATKHAVVGLSLALRSEALS
Mvan_4644|M.vanbaalenii_PYR-1       PQMLRQG-HGHIVNTASMAGLTAAGQVTSYVATKHAVVGLSMALRSEAVP
MMAR_2600|M.marinum_M               PAMIESGRGGHVVNLSSAAGLLANSALSAYSATKFAVLGLSEALRIELEP
MUL_3160|M.ulcerans_Agy99           PAMIESGRGGHVVNLSSAAGLLANPALSAYSATKFAVLGLSEALRIELEP
MLBr_00862|M.leprae_Br4923          QRLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRAELDA
MAV_1384|M.avium_104                PHLIASG-DGHVVNVSSVFGLFSVPGQAAYNSAKFAVRGFTEALRQEMAA
Mb3083c|M.bovis_AF2122/97           PPMVAAGRGGHLVNVSSAAGLVGLPWHAAYSASKYGLRGLSEVLRFDLAR
Rv3057c|M.tuberculosis_H37Rv        PPMVAAGRGGHLVNVSSAAGLVGLPWHAAYSASKYGLRGLSEVLRFDLAR
MAB_1526|M.abscessus_ATCC_1997      PQMVARG-RGHVVNVASMAGKLAVPGMVTYNASKFGAVGLSVALRKEYGN
                                      ::  *  **:** :*  .        :*  :* .   ::  ** :   

TH_2445|M.thermoresistible__bu      HG--VGVLAVCPAAVETPLLDKGAVGGFLGRD-------YFIRGQGVRSA
MSMEG_5235|M.smegmatis_MC2_155      HG--VGVLAVCPAAVETPILDKGAVGGFVGRD-------YFLRGQGMKTA
Mflv_2070|M.gilvum_PYR-GCK          RG--IGVLAVCPAAVETPILDKGAVGSFGGRD-------FFLRAQGGK-A
Mvan_4644|M.vanbaalenii_PYR-1       RG--VGVLVVCPAAVETPILDKGAVGGFVGRD-------YFLQTQGGR-A
MMAR_2600|M.marinum_M               HR--IGVTAICPGVINTAITKASPIRGAGDTE----GRRQRLTVTYQRRG
MUL_3160|M.ulcerans_Agy99           HR--IGVTAICPGVINTAITKASPIRGAGDTE----GRRQRLTVTYQRRG
MLBr_00862|M.leprae_Br4923          VG--VGLTTICPGVIDTNIIQSTRIDTPTAKQERVRDRRGQLDMMFRLRR
MAV_1384|M.avium_104                AGHPVAVTTVHPGGIKTAIARNATAAEGLDQA------ELAKLFDKRLAK
Mb3083c|M.bovis_AF2122/97           HG--IGVSVVVPGAVKTPLVNTVEIAGVDRDD----PRVNRWVERFSGHA
Rv3057c|M.tuberculosis_H37Rv        HG--IGVSVVVPGAVKTPLVNTVEIAGVDRDD----PRVNRWVERFSGHA
MAB_1526|M.abscessus_ATCC_1997      TG--VSVSCVLPSAVRTELASGAPLGKGMPTVD------PEDVAAAIVRS
                                        :.:  : *. : * :                               

TH_2445|M.thermoresistible__bu      YDPDRLASDTLRAVQRNKALLVKPRVAHAGWLFARLAPGLMQRASIRFVE
MSMEG_5235|M.smegmatis_MC2_155      YDPDRLAADTLRAIERNKALLVKPRRAHASWLLARLAPGLMQRLSVRFVA
Mflv_2070|M.gilvum_PYR-GCK          YDADRLAREVLDAITRNKAVLVKPRVAHAQWLLNRLAPTGLNRLASRFLA
Mvan_4644|M.vanbaalenii_PYR-1       YDADRLARDTLRAVERNKAILVKPTVAQAQWWFARLAPGLMNRMAMRFVT
MMAR_2600|M.marinum_M               YTPARAARNILRAVERNKAVAPVAAEAHVMYVLSRIMPPLARWVSAQMAK
MUL_3160|M.ulcerans_Agy99           YTPARAARNILRAVERNKAVAPVAAEAHVMYVLSRIMPPLARWVSAQMAK
MLBr_00862|M.leprae_Br4923          YGPDKVADTILSAIKKNKPIRPVAPEAYALYGISRVLPQVLRSTARIRVI
MAV_1384|M.avium_104                TTPQRAAQIILDAVRKKKARVLVGSDAKALDILVRLTGSGYQRLFGPVMS
Mb3083c|M.bovis_AF2122/97           VTPEKAADKILAGVTRNRYLVYTSADIRALYAFKRYAWWPYTLVMRRVNV
Rv3057c|M.tuberculosis_H37Rv        VTPEKAADKILAGVTRNRYLVYTSADIRALYAFKRYAWWPYTLVMRRVNV
MAB_1526|M.abscessus_ATCC_1997      VDTRRAQISVPGWLAFGWGLVDLFVPEPVERLARRLIDDRRALTSLDLNA
                                      . :        :              .     *               

TH_2445|M.thermoresistible__bu      RQRAGQRAAQVGR-----
MSMEG_5235|M.smegmatis_MC2_155      AQRASQARTANH------
Mflv_2070|M.gilvum_PYR-GCK          AQQSSRVN--------SG
Mvan_4644|M.vanbaalenii_PYR-1       GQRTRQVDRYPSSAADTG
MMAR_2600|M.marinum_M               AAK---------------
MUL_3160|M.ulcerans_Agy99           AAK---------------
MLBr_00862|M.leprae_Br4923          ------------------
MAV_1384|M.avium_104                RLLPN-------------
Mb3083c|M.bovis_AF2122/97           FFTRALRPGP--------
Rv3057c|M.tuberculosis_H37Rv        FFTRALRPGP--------
MAB_1526|M.abscessus_ATCC_1997      RGAYIERIERQSKEHQK-