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MFKLNSGTNTSDLAGRVVAITGAGSGIGRELALLCAQRGADLALCDINDTAVADTAQTARGFGHDVITRR VDVSDPEQMTAFADATLGHFGGVDLLVNNAGVGLIGGFLDTSRKDWDWLVSINVMGVVHGCEAFLPAMIE SGRGGHVVNLSSAAGLLANPALSAYSATKFAVLGLSEALRIELEPHRIGVTAICPGVINTAITKASPIRG AGDTEGRRQRLTVTYQRRGYTPARAARNILRAVERNKAVAPVAAEAHVMYVLSRIMPPLARWVSAQMAKA AK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_3160 | - | - | 100% (282) | short-chain dehydrogenase |
| M. ulcerans Agy99 | MUL_3574 | ephD | 6e-56 | 44.23% (260) | short chain dehydrogenase |
| M. ulcerans Agy99 | MUL_3400 | - | 4e-46 | 38.34% (253) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2237c | ephD | 5e-52 | 41.31% (259) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_2937 | - | 3e-45 | 39.77% (259) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv2214c | ephD | 5e-52 | 41.31% (259) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_00862 | ephD | 2e-51 | 38.55% (275) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0090c | - | 2e-52 | 41.95% (267) | oxidoreductase EphD |
| M. marinum M | MMAR_2600 | - | 1e-158 | 99.65% (282) | short-chain dehydrogenase |
| M. avium 104 | MAV_3670 | - | 2e-53 | 42.54% (268) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4280 | - | 1e-47 | 39.00% (259) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_4323 | - | 7e-51 | 41.31% (259) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_3576 | - | 3e-45 | 38.22% (259) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2237c|M.bovis_AF2122/97 MPATQQMS----RLVDSPDGVRIAVY--HEGNPDGPTVVLVHGFPDSHVL
Rv2214c|M.tuberculosis_H37Rv MPATQQMS----RLVDSPDGVRIAVY--HEGNPDGPTVVLVHGFPDSHVL
MLBr_00862|M.leprae_Br4923 MPATQSIHKVPHQFVESPDGVRLAIY--QSGQPEGPAIVLVHGFPDSHVL
TH_4323|M.thermoresistible__bu MAT--------EHFIDSSGGVRIAAY--EEGNPDGPTVVLVHGWPDSHVV
MSMEG_4280|M.smegmatis_MC2_155 MYT----------FVTSQDGTRIAVY--QQGDPERPTLVMAHGWPDSHVL
Mflv_2937|M.gilvum_PYR-GCK MSSQ--------RFVVSRDGVRIAVY--EEGAADGPTVVLVHGHADTHEA
Mvan_3576|M.vanbaalenii_PYR-1 MSTQ--------RFVESSDGVRIAVS--EQGNPDGPTLVLVHGLRDTHRV
MAB_0090c|M.abscessus_ATCC_199 --------------------------------------------------
MUL_3160|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2600|M.marinum_M --------------------------------------------------
MAV_3670|M.avium_104 MTVT--------STITADDGVTLAVHRYTDIDPARPTILAIHGFPDNHHV
Mb2237c|M.bovis_AF2122/97 WDGVVPLLAER-FRIVRYDNRGVGRSSVPKPISAYTMAHFADDFDAVIGE
Rv2214c|M.tuberculosis_H37Rv WDGVVPLLAER-FRIVRYDNRGVGRSSVPKPISAYTMAHFADDFDAVIGE
MLBr_00862|M.leprae_Br4923 WDGVVPLLAKR-FRIVRYDNRGVGQSSVPKPVSAYTMTRFADDFAAVIDE
TH_4323|M.thermoresistible__bu WDSVAPLLADR-FRIIRYDNRGVGRTTAPRRVADHTMARYADDFGAVIDA
MSMEG_4280|M.smegmatis_MC2_155 WDGVVGELGDR-YRIVRYDNRGAGASDVPKATSAYTMERFADDFSAVIDA
Mflv_2937|M.gilvum_PYR-GCK WDAVVALLAAR-FRIVRYDTRGAGRSAAPQRTSGFRLERYADDLAAVLDA
Mvan_3576|M.vanbaalenii_PYR-1 WDPVVALLADR-FRIVAYDTRGAGNSGAPKQTSAYTVDRFADDFAAVAAA
MAB_0090c|M.abscessus_ATCC_199 --------------------------------------------------
MUL_3160|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2600|M.marinum_M --------------------------------------------------
MAV_3670|M.avium_104 WDGVADELTGAPYNFVAYDVRGAGESSCPATRSGYGFAQLARDMGAVIDS
Mb2237c|M.bovis_AF2122/97 LSPGEPVHVLAHDWGSVGVWEYLRRPGAS-----DRVASFTSVSGPSQDH
Rv2214c|M.tuberculosis_H37Rv LSPGEPVHVLAHDWGSVGVWEYLRRPGAS-----DRVASFTSVSGPSQDH
MLBr_00862|M.leprae_Br4923 LSPDRPVHVLAHDWGSVGVWEYLSRSGAS-----DRVASFTSVSGPSQDQ
TH_4323|M.thermoresistible__bu LAPGQRVHVLAHDWGSAGVWEYLARPEAE-----DRIASFTSVSGPSGDH
MSMEG_4280|M.smegmatis_MC2_155 VSPDAPVHVLAHDWGSVGIWEYLSRQGSA-----ARMVSFTSVSGPSTDH
Mflv_2937|M.gilvum_PYR-GCK VSAEAPVHVLAHDRGSAGVWRYLARPESR-----GRLASFTSVSGPAPEH
Mvan_3576|M.vanbaalenii_PYR-1 VGGDTPVHVLAHGWGAAGVWQYLKRADAP-----ERVASLTSVSGPSPEH
MAB_0090c|M.abscessus_ATCC_199 --------------------------------------------------
MUL_3160|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2600|M.marinum_M --------------------------------------------------
MAV_3670|M.avium_104 LGVG-RVHLLAHDWGSIQAWAAVTDQAIMGESVMDKVASFTSISGPHLNY
Mb2237c|M.bovis_AF2122/97 LVNYVYGGLRRPWRPRTFLRAISQTLRLSYMALFSVPVVAPLLLRVALSS
Rv2214c|M.tuberculosis_H37Rv LVNYVYGGLRRPWRPRTFLRAISQTLRLSYMALFSVPVVAPLLLRVALSS
MLBr_00862|M.leprae_Br4923 LVDYILSGLRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWIALSS
TH_4323|M.thermoresistible__bu LARYVLDGLAAPYRPRRFLRSLTQLLRLSYMGFFSIPVLAPLLVRGVLSK
MSMEG_4280|M.smegmatis_MC2_155 YGAYVRRGLARPYRPVQFARAVNLASRFSYWIPFSIPVLAPALMR---RG
Mflv_2937|M.gilvum_PYR-GCK VARYLRDTLARPQHPARFAGGLGHLARL--------------------AA
Mvan_3576|M.vanbaalenii_PYR-1 VAGYVRAALTSPR---RFVRGAGQLVRL--------------------AA
MAB_0090c|M.abscessus_ATCC_199 --------------------------------------------------
MUL_3160|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2600|M.marinum_M --------------------------------------------------
MAV_3670|M.avium_104 AGAFLRS----ARTPRAVARVVRQLIASGYIGFFLCPGAAELSFRAGIGV
Mb2237c|M.bovis_AF2122/97 AAVR--RNMVGDIPVDQIHHSETLARDAAHSVKTYPANYFRSFSSSRRGR
Rv2214c|M.tuberculosis_H37Rv AAVR--RNMVGDIPVDQIHHSETLARDAAHSVKTYPANYFRSFSSSRRGR
MLBr_00862|M.leprae_Br4923 ATIR--RTMVDNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRRGK
TH_4323|M.thermoresistible__bu ALRRS-LRLRDGVPADRLHHSDTFAADAARSIKVYGANFLRTLRHARTDH
MSMEG_4280|M.smegmatis_MC2_155 AARR----LQAIDTPGPKFQSENLDIDAANSLKIYRANAIRSFTHVRRDH
Mflv_2937|M.gilvum_PYR-GCK AAPR------------------------AVTDKTLRAN----LFPVSSGG
Mvan_3576|M.vanbaalenii_PYR-1 AAPR------------------------AATAKPYRAN----LRPAAPAG
MAB_0090c|M.abscessus_ATCC_199 --------------------------------------------------
MUL_3160|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2600|M.marinum_M --------------------------------------------------
MAV_3670|M.avium_104 KVIAALERIGHTSTRSQRRDTQRSLRDYLNGLQLYRQN--MPAPMLAPGP
Mb2237c|M.bovis_AF2122/97 AIPIVDVPVQLIVNSQDPYVRPYGYDQTARWVPRLWRRDIKAGHFSPMSH
Rv2214c|M.tuberculosis_H37Rv AIPIVDVPVQLIVNSQDPYVRPYGYDQTARWVPRLWRRDIKAGHFSPMSH
MLBr_00862|M.leprae_Br4923 GVPVVNVPVQLIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHFSPMSH
TH_4323|M.thermoresistible__bu ---FVRVPVQLIVNTRDPYVRPHVYDETDRWVSRLWRRDIKAGHWSPMSH
MSMEG_4280|M.smegmatis_MC2_155 ---YVQVPVQLICNRKDPVVRGEGYRDESKWVPLLWRRDLDAGHWAPFSH
Mflv_2937|M.gilvum_PYR-GCK DAHDVDIPVQLIVGSADPYPDPHLFEDRAGRPARLWRRDVKAGHVTPTSH
Mvan_3576|M.vanbaalenii_PYR-1 --VPVDVPVQLIVPDHDPHVGPHVYDGMSASVSRLWRRDIKTGDLSPGSH
MAB_0090c|M.abscessus_ATCC_199 --------------------------------------------------
MUL_3160|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2600|M.marinum_M --------------------------------------------------
MAV_3670|M.avium_104 RLPETTVPVQTLVPRRDVFVTPALQRFTGAIPQRARVIEIEGGHWVVTSR
Mb2237c|M.bovis_AF2122/97 PQVMAAAVHDFADLADGKQPSRALLR--AQVGRPRGYFGDTLVSVTGAGS
Rv2214c|M.tuberculosis_H37Rv PQVMAAAVHDFADLADGKQPSRALLR--AQVGRPRGYFGDTLVSVTGAGS
MLBr_00862|M.leprae_Br4923 PQVMAAAVHDLADLVDGKQPSRALLR--AQVGRSRDTFGDTLVSVTGAGS
TH_4323|M.thermoresistible__bu PQVLATAVTELADHLAGAPAGRALLR--AQVGRPREYFGDMLVAITGAGG
MSMEG_4280|M.smegmatis_MC2_155 PRAIAQAVGEFVDHMEGAPPARALRR--AEVARPRKAFSDMLVSVTGAAS
Mflv_2937|M.gilvum_PYR-GCK PGILARALTQLVDHLDGAPAARELLR--AQVGRPRKAFGDTLVAVTGAAS
Mvan_3576|M.vanbaalenii_PYR-1 PQVLARAVDQLVDHLGGAPAPRELLR--AQVGRARKVFGDTLVSVTGAAS
MAB_0090c|M.abscessus_ATCC_199 -----------------------MTS--GSAQR------NSLVVVTGAGS
MUL_3160|M.ulcerans_Agy99 ----------MFKLNSG---------------TNTSDLAGRVVAITGAGS
MMAR_2600|M.marinum_M ----------MFKLNSG---------------TNTSDLAGRVVAITGAGS
MAV_3670|M.avium_104 PDVIARLTTEWVDLQSAGAVAPQLTGERRELPGERREVRGRLALVTGAGA
. :. :***..
Mb2237c|M.bovis_AF2122/97 GIGRETALAFAREGA-EIVISDIDEATVKDTAAEIAARGGIAYPYVLDVS
Rv2214c|M.tuberculosis_H37Rv GIGRETALAFAREGA-EIVISDIDEATVKDTAAEIAARGGIAYPYVLDVS
MLBr_00862|M.leprae_Br4923 GIGRETALALARRGA-EVVVSDIDEAAAKNTAAQIVASGGVAYAYALDVS
TH_4323|M.thermoresistible__bu GIGRETALAFAREGA-EVIVSDIDEATAKDTAAEIAARGGVAHAYQLDVS
MSMEG_4280|M.smegmatis_MC2_155 GIGRATALEFARLGA-EIVVSDIDEAGAKATATAIDEAGGVAHAYGLDVA
Mflv_2937|M.gilvum_PYR-GCK GIGRATALAFAHHGA-DVVISDVNAAGLDETARLVTSAGVHAYPYTVDVA
Mvan_3576|M.vanbaalenii_PYR-1 GIGRETALAFARAGA-DVVISDVDEAGLEQTARLVTAAGAAAHSYTVDVA
MAB_0090c|M.abscessus_ATCC_199 GIGRETSLAFARQGA-RVVVADINHDTANETVGLIEKLGGSAYPYALDVS
MUL_3160|M.ulcerans_Agy99 GIGRELALLCAQRGA-DLALCDINDTAVADTAQTARGFGHDVITRRVDVS
MMAR_2600|M.marinum_M GIGRELALLCAQRGA-DLALCDINDTAVADTAQTARGFGHDVITRRVDVS
MAV_3670|M.avium_104 GIGRATAVELARQGARKVVIVDRDRAAADQTADAVRAAGAGAAVYQVDVS
**** :: *: ** : : * : *. * . :**:
Mb2237c|M.bovis_AF2122/97 DAEAVEAFAERVSAEHGVPDIVVNNAGIGQAGRFLDTPAEQFDRVLAVNL
Rv2214c|M.tuberculosis_H37Rv DAEAVEAFAERVSAEHGVPDIVVNNAGIGQAGRFLDTPAEQFDRVLAVNL
MLBr_00862|M.leprae_Br4923 DAAAVEAFAEQVSAKHGVPDIVVNNAGIGQAGRFLDTPPEEFDRVLAVNL
TH_4323|M.thermoresistible__bu DAAAVDRFADEVCARHGVPDIVVNNAGIGHAGRFLDTPRDQWDRVLEVNL
MSMEG_4280|M.smegmatis_MC2_155 DPDAVQRFVDDVCATHGVPDIVVNNAGIGHAGNFLDTPADQYERVLEVNF
Mflv_2937|M.gilvum_PYR-GCK DAAAVEAFAEQVCAEHGVPDVVVNNAGVGHAGFFLDTPAEEFDRVLDINF
Mvan_3576|M.vanbaalenii_PYR-1 DAAAVEAMAELVCAAHGVPDIVVNNAGVGHAGFFLDTPAEEFDRVLGINF
MAB_0090c|M.abscessus_ATCC_199 DEAAVTAFADDVCAKHGVPDVLINNAGVGHGGRFFETSSTDFQRVLNINL
MUL_3160|M.ulcerans_Agy99 DPEQMTAFADATLGHFGGVDLLVNNAGVGLIGGFLDTSRKDWDWLVSINV
MMAR_2600|M.marinum_M DPEQMTAFADATLGHFGGVDLLVNNAGVGLIGGFLDTSRKDWDWLVSINV
MAV_3670|M.avium_104 DEAAMNDLAAQVRNEHGVVDILVNNAGIGMAGRFLETSPANWDAIMGVNV
* : :. . .* *:::****:* * *::*. ::: :: :*.
Mb2237c|M.bovis_AF2122/97 GGVVNGCRAFGQRLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYM
Rv2214c|M.tuberculosis_H37Rv GGVVNGCRAFGQRLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYM
MLBr_00862|M.leprae_Br4923 GGVVNCCRAFGQRLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYM
TH_4323|M.thermoresistible__bu GGVVNGCRAFAPRLVERGTGGHIVNIASMASYAPLQSLNAYCTSKAAVYM
MSMEG_4280|M.smegmatis_MC2_155 GGVVNCCRAFGRRLVEQGTGGHIVNVASMAAYSPAGSMNAYATSKAAVFM
Mflv_2937|M.gilvum_PYR-GCK GGVVNGCRSFGKRLADRGVGGHIVNVASMASYTPVNVMNAYCTSKAAVFM
Mvan_3576|M.vanbaalenii_PYR-1 GGVVNGCRSWGRRLVDRGTGGHIVNVASMASYTPVNVMNAYCTSKAAVFM
MAB_0090c|M.abscessus_ATCC_199 GGVVHGCRAFGPRMAERKSG-HIVNISSAAAYTPIPEMGAYATSKAAVFM
MUL_3160|M.ulcerans_Agy99 MGVVHGCEAFLPAMIESGRGGHVVNLSSAAGLLANPALSAYSATKFAVLG
MMAR_2600|M.marinum_M MGVVHGCEAFLPAMIESGRGGHVVNLSSAAGLLANSALSAYSATKFAVLG
MAV_3670|M.avium_104 RGVIWGSRAFGAQMVERGQGGTIINVASAAAYLPSKSMVAYGTTKAAVLA
**: ..:: : : * ::*::* *. . : ** ::* *.
Mb2237c|M.bovis_AF2122/97 FSDCLRAELDAAGVGLTTICPGVIDTNIVATTGFHAPGTDEEKIDGRRGQ
Rv2214c|M.tuberculosis_H37Rv FSDCLRAELDAAGVGLTTICPGVIDTNIVATTGFHAPGTDEEKIDGRRGQ
MLBr_00862|M.leprae_Br4923 FSDCLRAELDAVGVGLTTICPGVIDTNIIQSTRIDTPTAKQERVRDRRGQ
TH_4323|M.thermoresistible__bu FSDCLRAELDSAGIMLTTICPSTVNTNIIGSTRFNAPDGLDDVVDTRREQ
MSMEG_4280|M.smegmatis_MC2_155 FSDCLRAELAHAGIGVTTLCPGMIDTGIVDTTRFDVPAHKAGQVEARRAQ
Mflv_2937|M.gilvum_PYR-GCK FSDCLRAELDSFGIGLTTICPGFISTNIVDTTRFSLAQGRDDDVDVLRGR
Mvan_3576|M.vanbaalenii_PYR-1 FSDCLRAELDSAGIGVTTICPGVIGTNIVDTTRFSLPEARRDDAESIRRR
MAB_0090c|M.abscessus_ATCC_199 FSDVLRGELARDKVKVSTICPGIVNTNIIRTTQFSGLSPEDE--AKRQQQ
MUL_3160|M.ulcerans_Agy99 LSEALRIELEPHRIGVTAICPGVINTAITKASPIRG----AGDTEGRRQR
MMAR_2600|M.marinum_M LSEALRIELEPHRIGVTAICPGVINTAITKASPIRG----AGDTEGRRQR
MAV_3670|M.avium_104 LSESLRADFADEGITVTAVCPGFVNTNIAKSTIYAGMS--AQQQERARDR
:*: ** :: : ::::**. :.* * :: : :
Mb2237c|M.bovis_AF2122/97 IDKMFALRSYGPDKVADAIVSAVKKKKPIRPVAPEAYALYGISRVLPQAL
Rv2214c|M.tuberculosis_H37Rv IDKMFALRSYGPDKVADAIVSAVKKKKPIRPVAPEAYALYGISRVLPQAL
MLBr_00862|M.leprae_Br4923 LDMMFRLRRYGPDKVADTILSAIKKNKPIRPVAPEAYALYGISRVLPQVL
TH_4323|M.thermoresistible__bu LQKLFALRRFGPDKAAKAIVSAVKQNKPIRPVMPEAYFVYGVSRVLPQAL
MSMEG_4280|M.smegmatis_MC2_155 VKKTFQARRYGPEKVAKAVTSAVSRNQALRPVTPEAYVAYGVSRLFPAAL
Mflv_2937|M.gilvum_PYR-GCK AQKGFSARKYGPEKVADAIVDAVRTNKAIRPVAPEARFVYGVAHALPQVL
Mvan_3576|M.vanbaalenii_PYR-1 ARQGFAVRRVGPDKVAKAIVAAVQKNKPVRPVTTEAYLVYGVAHALPQAM
MAB_0090c|M.abscessus_ATCC_199 GAGLYAKRGYGPEKVAKEIVNAVAKGKSVVPVTPEAHVQYHFSRLAPALN
MUL_3160|M.ulcerans_Agy99 LTVTYQRRGYTPARAARNILRAVERNKAVAPVAAEAHVMYVLSRIMPPLA
MMAR_2600|M.marinum_M LTVTYQRRGYTPARAARNILRAVERNKAVAPVAAEAHVMYVLSRIMPPLA
MAV_3670|M.avium_104 ADAAYRRRNFTPEATAKAIVKAIKTGPAVVPIAAESRIGYALRRISPGAI
: * * .* : *: .: *: .*: * . : *
Mb2237c|M.bovis_AF2122/97 RSTARLRVI---
Rv2214c|M.tuberculosis_H37Rv RSTARLRVI---
MLBr_00862|M.leprae_Br4923 RSTARIRVI---
TH_4323|M.thermoresistible__bu RSTARGRVL---
MSMEG_4280|M.smegmatis_MC2_155 RRAARSQVL---
Mflv_2937|M.gilvum_PYR-GCK RSTARGGNFV--
Mvan_3576|M.vanbaalenii_PYR-1 RSAARGGNIM--
MAB_0090c|M.abscessus_ATCC_199 RFFWGLSDKISR
MUL_3160|M.ulcerans_Agy99 RWVSAQMAKAAK
MMAR_2600|M.marinum_M RWVSAQMAKAAK
MAV_3670|M.avium_104 RLLARWDIRQT-
*