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MTELAGKVAVVTGGASGIGRGIAARFAAEGAAVVIADVRDDLGEALVRELNESGAKTVYRHTDVGDQAQV ADLVSSTVETFGALNVMVNNAGISSPLRKGLFHEDLEEFDRVMRVNLLGVMAGTRDAARHMADHGGGSVI NLGSIGGIQAGGGVSTYRASKAAIIHFTKCAAIELAHYEVRVNCLAPGNIPTPILASSATDEDRERLEKF EARIRQQMRDDRPLKREGTADDVAEAALYLATDRSRYVTGTVLPIDGGTVAGKVIVRKPKDQQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2415 | - | - | 100% (273) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_4369 | fabG | 3e-41 | 40.00% (255) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. gilvum PYR-GCK | Mflv_3281 | - | 4e-39 | 38.61% (259) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1385 | fabG | 1e-40 | 40.00% (255) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. tuberculosis H37Rv | Rv1350 | fabG | 1e-40 | 40.00% (255) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. leprae Br4923 | MLBr_02565 | fabG | 4e-24 | 33.84% (263) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. abscessus ATCC 19977 | MAB_4680c | - | 2e-39 | 37.79% (262) | putative short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_4765 | - | 1e-100 | 68.68% (265) | short chain dehydrogenase |
| M. avium 104 | MAV_0886 | - | 1e-102 | 71.27% (268) | short-chain dehydrogenase/reductase SDR |
| M. smegmatis MC2 155 | MSMEG_4859 | - | 1e-102 | 70.37% (270) | oxidoreductase, short chain dehydrogenase/reductase family |
| M. thermoresistible (build 8) | TH_3420 | - | 1e-101 | 71.43% (266) | PUTATIVE oxidoreductase, short chain dehydrogenase/reductase |
| M. ulcerans Agy99 | MUL_0336 | - | 4e-99 | 67.92% (265) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4237 | - | 1e-138 | 90.71% (269) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1385|M.bovis_AF2122/97 --------------------------------------------------
Rv1350|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2415|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4237|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4859|M.smegmatis_MC2_155 --------------------------------------------------
TH_3420|M.thermoresistible__bu --------------------------------------------------
MMAR_4765|M.marinum_M --------------------------------------------------
MUL_0336|M.ulcerans_Agy99 --------------------------------------------------
MAV_0886|M.avium_104 --------------------------------------------------
MAB_4680c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 MAPKCSSDLFSQIVSSGPGSFVAKQLGVPRPETLRRYRPSDAPLCGSLLI
Mb1385|M.bovis_AF2122/97 --------------------------------------------------
Rv1350|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2415|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4237|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4859|M.smegmatis_MC2_155 --------------------------------------------------
TH_3420|M.thermoresistible__bu --------------------------------------------------
MMAR_4765|M.marinum_M --------------------------------------------------
MUL_0336|M.ulcerans_Agy99 --------------------------------------------------
MAV_0886|M.avium_104 --------------------------------------------------
MAB_4680c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 GGDGRLVEPLRATLEKDYDLVSNNLGGRWTDSFGGLVFDATGITAPAELK
Mb1385|M.bovis_AF2122/97 --------------------------------------------------
Rv1350|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2415|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4237|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4859|M.smegmatis_MC2_155 --------------------------------------------------
TH_3420|M.thermoresistible__bu --------------------------------------------------
MMAR_4765|M.marinum_M --------------------------------------------------
MUL_0336|M.ulcerans_Agy99 --------------------------------------------------
MAV_0886|M.avium_104 --------------------------------------------------
MAB_4680c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 GLHNFFTPLLRNLGRCARVVVIGTTPDATTSTDERIAQRALEGFSRSLGK
Mb1385|M.bovis_AF2122/97 --------------------------------------------------
Rv1350|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2415|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4237|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4859|M.smegmatis_MC2_155 --------------------------------------------------
TH_3420|M.thermoresistible__bu --------------------------------------------------
MMAR_4765|M.marinum_M --------------------------------------------------
MUL_0336|M.ulcerans_Agy99 --------------------------------------------------
MAV_0886|M.avium_104 --------------------------------------------------
MAB_4680c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 ELRRGATVALVYLSPDAKPAATGLESTMRFILSAKSAYVNGQVFYVGAAD
Mb1385|M.bovis_AF2122/97 ------MASLLNARTAVITGGAQGLGLAIGQRFVAEGARVVLGDVNLEAT
Rv1350|M.tuberculosis_H37Rv ------MASLLNARTAVITGGAQGLGLAIGQRFVAEGARVVLGDVNLEAT
Mflv_2415|M.gilvum_PYR-GCK -------MTELAGKVAVVTGGASGIGRGIAARFAAEGAAVVIADVRDDLG
Mvan_4237|M.vanbaalenii_PYR-1 -------MTELVGKVAIVTGGASGIGRGIAERFAAEGARVVIADVRDDLG
MSMEG_4859|M.smegmatis_MC2_155 -------MSELAGRVAVVTGGASGLGEGLVRRFVAEGAQVMIGDVDKDRG
TH_3420|M.thermoresistible__bu ---VTERAGELAGKVAVVTGGAAGLGAGLARRFVAEGAKVLIGDVDTGNG
MMAR_4765|M.marinum_M ------MVDELAGKIAIVTGGASGIGRATVARFIAEGARVVIADVEEERG
MUL_0336|M.ulcerans_Agy99 ------MVDELAGKIAIVTGGASGIGRATVARFIAEGARVVIADVEEERG
MAV_0886|M.avium_104 ------MVNELAGKVAIVTGGASGIGRGIVERFVAEGARVVIADIETERG
MAB_4680c|M.abscessus_ATCC_199 ---MNGNSALLQGKNVIVTGGARGLGAAFSRHIVSQGGRVVIADVLDGDG
MLBr_02565|M.leprae_Br4923 STPPTNWDRPLENKVAIVTGAARGIGAAIAEVVARDGARVVAIDVESAAE
* : .::**.* *:* . . :*. *: *:
Mb1385|M.bovis_AF2122/97 EVAAKRLG-GDDVALAVRCDVTQADDVDILIRTAVERFG-GLDVMVNNAG
Rv1350|M.tuberculosis_H37Rv EVAAKRLG-GDDVALAVRCDVTQADDVDILIRTAVERFG-GLDVMVNNAG
Mflv_2415|M.gilvum_PYR-GCK EALVRELNESGAKTVYRHTDVGDQAQVADLVSSTVETFG-ALNVMVNNAG
Mvan_4237|M.vanbaalenii_PYR-1 EPLAAELNSRGAKTVYRHTDVGDQRQVAELVAAAVDTFG-GLDVMVNNAG
MSMEG_4859|M.smegmatis_MC2_155 TALAEEL---GAHTEFLTTDVADQEQVAALVSAGVERFG-GLHVMVNNAG
TH_3420|M.thermoresistible__bu AKLAAEL---GADAEFVEADVADLDQVSGLVSTAVERFG-GLHVMVNNAG
MMAR_4765|M.marinum_M ESLAAAL---GADAMFCRTDVSQPEQVAAVVAAAVENFG-GLHVMVNNAG
MUL_0336|M.ulcerans_Agy99 ESLAAAL---GADAMFCRTDVSQPEQVAAVVAAAVDNFG-GLHVMVNNAG
MAV_0886|M.avium_104 ERLAAEL---GGEAVFRRTDVSDIEQVGALVAAAVEKFG-GLHVMVNNAG
MAB_4680c|M.abscessus_ATCC_199 RQLAAEL---GDAARFTHLDVTDAEQWRELIDTTLAGFG-TITGLVNNAG
MLBr_02565|M.leprae_Br4923 ALDETAN---RVGGTTLSLDVTADDAVDKITEHLHDYQGGHADILVNNAG
** : * :*****
Mb1385|M.bovis_AF2122/97 ITRDATMRTMTE--EQFDQVIAVHLKGTWNGTRLAAAIMRERKRGAIVNM
Rv1350|M.tuberculosis_H37Rv ITRDATMRTMTE--EQFDQVIAVHLKGTWNGTRLAAAIMRERKRGAIVNM
Mflv_2415|M.gilvum_PYR-GCK ISSPLRKGLFHEDLEEFDRVMRVNLLGVMAGTRDAARHMADHGGGSVINL
Mvan_4237|M.vanbaalenii_PYR-1 ISSPLRKGLFHEDLEEFDRVMRVNLLGVMAGTRDAGRYMADHGGGSIINL
MSMEG_4859|M.smegmatis_MC2_155 VSGTMHRRFLDDDLADFHKVMGVNVLGVMAGTREAARYMADNGGGSILNL
TH_3420|M.thermoresistible__bu ISGTMHRSLLDDDLADFDRVMRINVRAVMAGTRDAARHMAEHGGGSIINL
MMAR_4765|M.marinum_M VSGVMHRRFLDDDLADFHRVMAVNVLGVMAGTRDAARHMAAHGGGSIVNL
MUL_0336|M.ulcerans_Agy99 VSGAMHRRFLDDDLADFHRVMAVNVLGVMAGTRDAARHMAAHGGGSIVNL
MAV_0886|M.avium_104 ISSPLRR-LLDDDLADFHRVMGVNVLGVMAGTRDAARHMADNGGGAIINL
MAB_4680c|M.abscessus_ATCC_199 ISS--AAMVADEPLEHFRKVIEINLVGVFIGMQAVIPAMRAHGCGSIVNI
MLBr_02565|M.leprae_Br4923 ITRDKLLANMDD--CRWDAVLEVNLLAPQRLTEGLVGNGSISKGGRVIVL
:: : : *: ::: . . * :: :
Mb1385|M.bovis_AF2122/97 SSVSGKVGMVGQTNYSAAKAGIVGMTKAAAKELAHLGIRVNAIAPGLIRS
Rv1350|M.tuberculosis_H37Rv SSVSGKVGMVGQTNYSAAKAGIVGMTKAAAKELAHLGIRVNAIAPGLIRS
Mflv_2415|M.gilvum_PYR-GCK GSIGGIQAGGGVSTYRASKAAIIHFTKCAAIELAHYEVRVNCLAPGNIPT
Mvan_4237|M.vanbaalenii_PYR-1 GSIGGIQAGGGVSTYRASKAAIIHFTKCAAIELAHYEVRVNCLAPGNIPT
MSMEG_4859|M.smegmatis_MC2_155 TSIGGIQAGGGVMTYRASKAAVIQFTKSAAIELAHHEIRVNAIAPGNIRT
TH_3420|M.thermoresistible__bu TSIGGIQAGGGVQTYRASKAAVIQFTKSAAIELAHHEIRVNALAPGNIRT
MMAR_4765|M.marinum_M TSIGGIQAGGGVMTYRASKAAVIQFTKSAAIELAHYEIRVNAIAPGNIPT
MUL_0336|M.ulcerans_Agy99 TSIGGIQAGGGVMTYRASKGAVIQFTKSAAIELAHYEIRVNAIAPGNIPT
MAV_0886|M.avium_104 TSIGGIQAGGGVMTYRASKAAVIQFTKAAAIELARYDIRVNAIAPGNIPT
MAB_4680c|M.abscessus_ATCC_199 SSAAGLVGLALTSGYGASKWGVRGLSKVAAIELGRERIRVNSVHPGVIYT
MLBr_02565|M.leprae_Br4923 SSMAGIAGNRGQTNYATAKAGVIGLTQALAPGLAEKGITINAVAPGFIET
* .* . * ::* .: ::: * *.. : :*.: ** * :
Mb1385|M.bovis_AF2122/97 AMTEAMPQR------------IWDQKLAEVPMGRAGEPSEVASVAVFLAS
Rv1350|M.tuberculosis_H37Rv AMTEAMPQR------------IWDQKLAEVPMGRAGEPSEVASVAVFLAS
Mflv_2415|M.gilvum_PYR-GCK PILASSATDEDRERLEKFEARIRQQMRDDRPLKREGTADDVAEAALYLAT
Mvan_4237|M.vanbaalenii_PYR-1 PILASSATDEDRERLERFEARIRRQMRDDRPLKREGTAEDVAEAALYLAT
MSMEG_4859|M.smegmatis_MC2_155 AIVAKSASEEDRQRIEEFEANIRAQMRADRPLKREGTVEDVAEAALYFAT
TH_3420|M.thermoresistible__bu AIVRKSATGADLERLERFEARIRQQMRDDRPLKREGTVEDVAEAALYFAG
MMAR_4765|M.marinum_M PLLASSAAGMDQEQVERFTAQIRQTMREDRPLKREGTPEDIAEAALYFAG
MUL_0336|M.ulcerans_Agy99 PLLASSAAGLDQEQVERFTAQIRQTMREDRPLKREGTPEDIAEAALYFAG
MAV_0886|M.avium_104 PILGKSAGDMDPEQRERFEARIREGMREDRPLKREGTPDDVAEAALYFAT
MAB_4680c|M.abscessus_ATCC_199 PMTAKEGFREGEGNMP------IAAMG------RVGNADEVAGAVAYLLS
MLBr_02565|M.leprae_Br4923 QMTAAIPLAT------------REVGRRLNSLLQGGLPVDVAETIAYFAI
: : * ::* . ::
Mb1385|M.bovis_AF2122/97 DLSSYMTGTVLDVTG----GRFI-----------
Rv1350|M.tuberculosis_H37Rv DLSSYMTGTVLDVTG----GRFI-----------
Mflv_2415|M.gilvum_PYR-GCK DRSRYVTGTVLPIDGGTVAGKVIVRKPKDQQ---
Mvan_4237|M.vanbaalenii_PYR-1 DRSRYITGTVLPVDGGTVAGKVIVRKPPPAEAAT
MSMEG_4859|M.smegmatis_MC2_155 DRSRYVTGTVLPIDGGTVAGKVIVRKEKR-----
TH_3420|M.thermoresistible__bu DRSRYVTGTVLPIDGGTVAGKVIARKSHAE----
MMAR_4765|M.marinum_M ERSRYVTGTVLPVDGGTVAGKVIRRSR-------
MUL_0336|M.ulcerans_Agy99 ERSRYVTGTVLPVDGGTVAGKVIRRSR-------
MAV_0886|M.avium_104 ERSRYVTGTVLPVDGGTSAGKAMRSKRQG-----
MAB_4680c|M.abscessus_ATCC_199 DAASYVTGAELAVDGGWTAGPTLTTITGQ-----
MLBr_02565|M.leprae_Br4923 PASNAVTGNVIRVCGQAMLGA-------------
: :** : : * *