For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MRRRLGTFDTVTLGLGSMIGAGIFVALAPAAAAAGTGLLVGLAVAALIAVCNAMSSARLAARYPESGGTY VYGRERLGPFWGHTAGWSFIVGKTASCAAMALTVGYYVWPAYANAVAVGSVVALTAVSYAGVQRSATLTR VIVALVLGVLAMVVVVVFGSGDVDASRLALGPDVDAYGVLQAAGLLFFAFAGYARIATLGEEVRDPARTI PRAIGLALVIALLTYAVVAVAVLAQLGSTGLATADAPLADAVRAAGLPALAPVVAVGAALAALGALLALL LGVSRTTLAMARDRHLPHPLAHVHPGHGTPQRAEVAVGVVVAVVAAVVDVRSAIGFSSFGVLLYYAVANA SAWTLTATPRARLVPAVGLIGCVVLAFTLPPVSVLAGAAVVLVGMLAYTTGGALRRGV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0187 | - | - | 100% (408) | amino acid permease-associated region |
| M. gilvum PYR-GCK | Mflv_4722 | - | 1e-37 | 26.99% (452) | amino acid permease-associated region |
| M. gilvum PYR-GCK | Mflv_4427 | - | 2e-35 | 29.18% (401) | amino acid permease-associated region |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2022c | - | 1e-152 | 71.82% (401) | integral membrane protein |
| M. tuberculosis H37Rv | Rv1999c | - | 1e-152 | 71.82% (401) | integral membrane protein |
| M. leprae Br4923 | MLBr_01974 | - | 2e-14 | 25.68% (331) | putative permease |
| M. abscessus ATCC 19977 | MAB_2598 | - | 1e-150 | 68.38% (408) | hypothetical protein MAB_2598 |
| M. marinum M | MMAR_2407 | rocE_1 | 7e-39 | 28.38% (437) | cationic amino acid transport integral membrane protein, |
| M. avium 104 | MAV_4216 | - | 1e-35 | 27.79% (457) | cationic amino acid transporter |
| M. smegmatis MC2 155 | MSMEG_0812 | - | 1e-159 | 74.12% (398) | amino acid transporter |
| M. thermoresistible (build 8) | TH_3126 | - | 1e-93 | 69.17% (253) | PUTATIVE putative amino acid permease-associated region |
| M. ulcerans Agy99 | MUL_1244 | rocE | 9e-38 | 28.80% (441) | cationic amino acid transport integral membrane protein RocE |
| M. vanbaalenii PYR-1 | Mvan_0718 | - | 0.0 | 83.25% (400) | amino acid permease-associated region |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0187|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0718|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0812|M.smegmatis_MC2_155 --------------------------------------------------
Mb2022c|M.bovis_AF2122/97 --------------------------------------------------
Rv1999c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_2598|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3126|M.thermoresistible__bu --------------------------------------------------
MMAR_2407|M.marinum_M --------------------------------------------------
MUL_1244|M.ulcerans_Agy99 --------------------------------------------------
MAV_4216|M.avium_104 --------------------------------------------------
MLBr_01974|M.leprae_Br4923 MFLSADVSCIEIVDINCSELRNDRRIPPQLALFCTNAANKAESAVTSHGQ
Mflv_0187|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0718|M.vanbaalenii_PYR-1 --------------------------------------------MSSPGG
MSMEG_0812|M.smegmatis_MC2_155 --------------------------------------------MSTPGG
Mb2022c|M.bovis_AF2122/97 --------------------------------------------MRRPLD
Rv1999c|M.tuberculosis_H37Rv --------------------------------------------MRRPLD
MAB_2598|M.abscessus_ATCC_1997 --------------------------------------------MSSQQ-
TH_3126|M.thermoresistible__bu --------------------------------------------------
MMAR_2407|M.marinum_M ---------------------------MAAPTIGLIQQMLRRRPVIGAPV
MUL_1244|M.ulcerans_Agy99 ---------------------------MPATSIRLREQMLRRRPAGGAPV
MAV_4216|M.avium_104 ----------------------------------MASRWRTKSVEQSIAD
MLBr_01974|M.leprae_Br4923 LPIMANRRWAPHTRRQSGRATSTCSSLMRFSASESRAHSRFECYTLVRWS
Mflv_0187|M.gilvum_PYR-GCK -------MRRRLGTFDTVTLGLGSMIGAGIFVALAPAAAAAG-TGLLVGL
Mvan_0718|M.vanbaalenii_PYR-1 S-----TLDRRLGVFDTVTIGLGSMIGAGIFVALAPAAAAAG-SGLLIGL
MSMEG_0812|M.smegmatis_MC2_155 -------LQRRLGTFDAVTIGLGSMIGAGIFAAIGPAAAAAG-SGLLIGL
Mb2022c|M.bovis_AF2122/97 PRDIPDELRRRLGLLDAVVIGLGSMIGAGIFAALAPAAYAAG-SGLLLGL
Rv1999c|M.tuberculosis_H37Rv PRDIPDELRRRLGLLDAVVIGLGSMIGAGIFAALAPAAYAAG-SGLLLGL
MAB_2598|M.abscessus_ATCC_1997 ----PGALRRELGTFDAVMIGLGSMIGAGIFAALAPAARSAG-SALLIGL
TH_3126|M.thermoresistible__bu -------LPRRLGTLDAVTIGLGAMIGAGIFVALGPAAAAAG-PWLLAGL
MMAR_2407|M.marinum_M AHGASDQLKRSIGTFQLTLFGVGATVGTGIFFVLSEAVPEAG-PGVVASF
MUL_1244|M.ulcerans_Agy99 AEGAAGSLKRSFGTFELTMFGVGSTVGTGIFFVLAEAVPEAG-PAVIVSF
MAV_4216|M.avium_104 TDEPDTRLRKDLTWWDLVVFGVAVVIGAGIFTVTASTTGDITGPAIWVSF
MLBr_01974|M.leprae_Br4923 IRGQGGRAISKLGFWSVVMLGINSIIGAGIFMTPGEVIKIAG-PFAPIAY
: . . :*: :*:*** . . . . .
Mflv_0187|M.gilvum_PYR-GCK AVAALIAVCNAMSSARLAARYPESGGTYVYGRERLGPFWGHTAGWSFIVG
Mvan_0718|M.vanbaalenii_PYR-1 AVAAVVAVCNAMSSARLAARYPQSGGTYVYGRERLGPFWGHAAGWSFIVG
MSMEG_0812|M.smegmatis_MC2_155 ALAAVVAYCNATSSARLAAIYPQSGGTYVYGRERLGEFWGYLAGWSFAVG
Mb2022c|M.bovis_AF2122/97 AVAAVVAYCNAISSARLAARYPASGGTYVYGRMRLGDFWGYLAGWGFVVG
Rv1999c|M.tuberculosis_H37Rv AVAAVVAYCNAISSARLAARYPASGGTYVYGRMRLGDFWGYLAGWGFVVG
MAB_2598|M.abscessus_ATCC_1997 CVAAVIAYCNATSSARLAAVYPASGGTYVYGRERLGDFWGYLAGWGFVVG
TH_3126|M.thermoresistible__bu GIAAAVAYCNATASARLAARYPQSGGTYVYGRERLGAFWGYTAGFSFVVG
MMAR_2407|M.marinum_M VIAGIAAGLAAVCYAELASAVPVSGSTYSYAYTTLGELVAMGVAACLLLE
MUL_1244|M.ulcerans_Agy99 IIAGVAAGLAAICCAELASAVPVSGSSYSYAYATLGEAVAMGVASCLLLE
MAV_4216|M.avium_104 VIAAGTCALAALCYAEFASTLPVAGSAYTFSYATFGEFLAWIIGWNLLLE
MLBr_01974|M.leprae_Br4923 TLAGIFAAVLAIVFATAAKYVKTNGSSYAYTTAAFGHRIGIYVGVTHAIT
:*. . * * * *.:* : :* . . :
Mflv_0187|M.gilvum_PYR-GCK KTASCAAMALTVG------YYVWPAYANAVAVGSVVALTAVSYA------
Mvan_0718|M.vanbaalenii_PYR-1 KTASCAAMALTVG------FYAWPEYANAVAVASVVALTAVGYA------
MSMEG_0812|M.smegmatis_MC2_155 KTASCAAMALTVG------SYAWPEHANAVAVGAVVALTAVNYV------
Mb2022c|M.bovis_AF2122/97 KTASCAAMALTVG------FYVWPAQAHAVAVAVVVALTAVNYA------
Rv1999c|M.tuberculosis_H37Rv KTASCAAMALTVG------FYVWPAQAHAVAVAVVVALTAVNYA------
MAB_2598|M.abscessus_ATCC_1997 KTASCAAMALTIG------FYAWPGHAHAVAVASVVALTAINYV------
TH_3126|M.thermoresistible__bu KTASCAAMALTIG------FYLWPGHAHAIAVAAVVALTALTYL------
MMAR_2407|M.marinum_M YGVSTAAVAVGWS------QYVNKLLDNFFGHHLPQALSAAPWG---DAS
MUL_1244|M.ulcerans_Agy99 YGVATAAVAVGLS------GYVNKLLHNVFGFQLPQALSEAPWDERPGEA
MAV_4216|M.avium_104 LAIGAAVVAKGWS------SYLGTVFG-FSGGTVKFGAAQLDWG------
MLBr_01974|M.leprae_Br4923 ASIAWGVLASSFVSTLLRVAFPEKIWADNDELISVKTLTFLVFIAVLLAI
. ..:* : : :
Mflv_0187|M.gilvum_PYR-GCK ---------------------GVQRSATLTRVIVALVLGVLAMVVVVVFG
Mvan_0718|M.vanbaalenii_PYR-1 ---------------------GVQRSAALTRIIVALVLAVLAMVVVVLLG
MSMEG_0812|M.smegmatis_MC2_155 ---------------------GVQKSAVLTRVIVAVVLAILATVVVLLLG
Mb2022c|M.bovis_AF2122/97 ---------------------GIQKSAWLTRSIVAVVLVVLTAVVVAAYG
Rv1999c|M.tuberculosis_H37Rv ---------------------GIQKSAWLTRSIVAVVLVVLTAVVVAAYG
MAB_2598|M.abscessus_ATCC_1997 ---------------------GVQKSAWLTRVIVAIVLSVLAAIVATAAG
TH_3126|M.thermoresistible__bu ---------------------GIEKSALLTRLVVAGVLGVLTAVVVLVLG
MMAR_2407|M.marinum_M PGIINLPAVVLVGLCAVLLIRGASESAKVNTIMVLIKLSVLVMFAVIALT
MUL_1244|M.ulcerans_Agy99 AGYLNLPAIILIGLCALLLIRGVSESAKVNAIMVLIKLGVLGMFVILALT
MAV_4216|M.avium_104 -------ALVIVGGVATLIALGTKLSSRFSAVITGIKVSVVVFVVVVGVF
MLBr_01974|M.leprae_Br4923 N---------IFGNLVIRWANGISALGKIFALSVFIAGGLWTIITQHVNN
* . . . . : ..
Mflv_0187|M.gilvum_PYR-GCK SGDVDASRLALG------------------------PDVDAYGVLQAAGL
Mvan_0718|M.vanbaalenii_PYR-1 FGGADTSRLALG------------------------DDVTVYGVLQAAGL
MSMEG_0812|M.smegmatis_MC2_155 SGDADPARLSLG------------------------DDVSAVGVLQAAGL
Mb2022c|M.bovis_AF2122/97 SGAADPARLDIG------------------------VDAHVWGMLQAAGL
Rv1999c|M.tuberculosis_H37Rv SGAADPARLDIG------------------------VDAHVWGMLQAAGL
MAB_2598|M.abscessus_ATCC_1997 SGSVDIAALDL-------------------------TGTSWRGVLQAAGL
TH_3126|M.thermoresistible__bu FGAPAGRVAGGG------------------------TDIGAGAVLQSAAL
MMAR_2407|M.marinum_M AFDADRFAEFAP--------------------------FGVAGIGAAAGT
MUL_1244|M.ulcerans_Agy99 AYDTNHLKDFAP--------------------------FGVAGVGAAAGT
MAV_4216|M.avium_104 YIKRANYSPFIPKPEAGGQAKGIDQSVLSLLTGAHTSHYGWYGVLAGASI
MLBr_01974|M.leprae_Br4923 YVTSRSAYQPTTYSLLG---------------VTEIGKSTAASMTLATIV
.: .:
Mflv_0187|M.gilvum_PYR-GCK LFFAFAGYARIATLGEEVRDPARTIPRAIGLALVIALLTYAVVAVAVLAQ
Mvan_0718|M.vanbaalenii_PYR-1 LFFAFAGYARIATLGEEVRDPARTIPRAVALALVIALMVYAVVAVAVVSE
MSMEG_0812|M.smegmatis_MC2_155 LFFAFAGYARIATLGEEVRDPARIIPRAIRIALGLTLVVYAVVAGAVLAV
Mb2022c|M.bovis_AF2122/97 LFFAFAGYARIATLGEEVRDPARTIPRAIPLALGITLAVYALVAVAVIAV
Rv1999c|M.tuberculosis_H37Rv LFFAFAGYARIATLGEEVRDPARTIPRAIPLALGITLAVYALVAVAVIAV
MAB_2598|M.abscessus_ATCC_1997 LFFAFAGYARIATLGEEVRDPARTIPRAIPIALGIALVVYVVVALAVLIT
TH_3126|M.thermoresistible__bu LFFAFAGYARIATLGEEVRDPARTIRRAIPLALGITLTVYGAVTAAVLVA
MMAR_2407|M.marinum_M IFFSYIGLDAVSTAGDEVKNPQKTMPLAIMAALVTVTTVYVVVTVAALGA
MUL_1244|M.ulcerans_Agy99 IFFSFIGLDAVSTAGEEVRNPQQSVPRALIAALFVVTGVYVLVAFAALGT
MAV_4216|M.avium_104 VFFAFIGFDIVATMAEETKHPQRDVPRGILASLGIVTLLYVAVAVVLSGM
MLBr_01974|M.leprae_Br4923 ALYAFTGFESIANAAEEMNTPDRTLPKAIPLTILTVGVIYILALVVAMLL
:::: * ::. .:* . * : : .: :: . * . .
Mflv_0187|M.gilvum_PYR-GCK LGSTGLATAD----APLADAVRAAGLPALAPVVAVGAALAALGALLALLL
Mvan_0718|M.vanbaalenii_PYR-1 LGVAGLASAT----APLSDAVRAAGFPGLTPVVNVGAAIAALGALLALLL
MSMEG_0812|M.smegmatis_MC2_155 LGGTDLAGAT----APLADAVAAVGAGQWQPLVRAGAAIAALGSLLALIL
Mb2022c|M.bovis_AF2122/97 LGPQRLARAA----APLSEAMRVAGVNWLIPVVQIGAAVAALGSLLALIL
Rv1999c|M.tuberculosis_H37Rv LGPQRLARAA----APLSEAMRVAGVNWLIPVVQIGAAVAALGSLLALIL
MAB_2598|M.abscessus_ATCC_1997 LGPSRLASSA----APLLDAVTAAGAGWMEPVVRIGAVVAATGSLLALIL
TH_3126|M.thermoresistible__bu LGSAGLARSP----APVADAVTAAXX---------HGRQQPFGELPG---
MMAR_2407|M.marinum_M QPWRDFEGQQ-AGLATVLDRVVSG--HYWGSVLAAGAVISIFSVTLVVLY
MUL_1244|M.ulcerans_Agy99 QPWQMFAGQEEAGLATILDNVTHS--AWASTVLAMGAVISIFTVTLVTMY
MAV_4216|M.avium_104 VSYTQLKTMPGRGQANLATAFTANGIHWASKIISIGALAGLTTVVMVLML
MLBr_01974|M.leprae_Br4923 GSDKIVATNH------TVKLAAAVGNNTFRTIIVVGALVSMFGINVAASF
. .
Mflv_0187|M.gilvum_PYR-GCK GVSRTTLAMARDRHLPHPLAHVHPGHGTPQRAEVAVGVVVAVVAAVVDVR
Mvan_0718|M.vanbaalenii_PYR-1 GVSRTTLAMARDRYLPAGLAAVHPKHGTPHHAEVAVGLVVAVVAAFVDLR
MSMEG_0812|M.smegmatis_MC2_155 GVSRTTLAMARDHHLPSALGAVHPRFGVPHRAEVTVGVVVAVLAAVADLR
Mb2022c|M.bovis_AF2122/97 GVSRTTLAMARDRHLPRWLAAVHPRFKVPFRAELVVGAVVAALAATADIR
Rv1999c|M.tuberculosis_H37Rv GVSRTTLAMARDRHLPRWLAAVHPRFKVPFRAELVVGAVVAALAATADIR
MAB_2598|M.abscessus_ATCC_1997 GVSRTTFAMARDRHLPHTLATVHPKYGVPYRAEILVGLVVSVLAATADLR
TH_3126|M.thermoresistible__bu -------AEEVDRGHPQRIPDAR---RHPGHVEHRS------SPTTCAPR
MMAR_2407|M.marinum_M GQTRILFAMGRDGLLPPVFAKVRPPNMTPVYNTIIVAVVICILAGFVPLS
MUL_1244|M.ulcerans_Agy99 GQTRILFAMGRDGLLPARFAAVHPRFQTPVSNTVVVAIAAAVLAALVPLN
MAV_4216|M.avium_104 GQCRVLFAMARDGLLPRALAKTGSR-GTPVRITVLVALVVAVTASVFPIT
MLBr_01974|M.leprae_Br4923 GAPRLWTALSDGRILPTRLSSKN-RFGVPIVAFGITAFLTLAFPLSLRFD
* . * : * .
Mflv_0187|M.gilvum_PYR-GCK SA--IGFSSFGVLLYYAVANASAWTLTATPR--AR----------LVPAV
Mvan_0718|M.vanbaalenii_PYR-1 GA--IGFSSFGVLLYYAIANASAWTLG------AR----------LIPAI
MSMEG_0812|M.smegmatis_MC2_155 GA--IGFSSFAVLLYYAIANASAATLG------GR----------LVPAV
Mb2022c|M.bovis_AF2122/97 GA--IGFSSFGVLVYYAIANASALTLGLDEGRPRR----------LIPLV
Rv1999c|M.tuberculosis_H37Rv GA--IGFSSFGVLVYYAIANASALTLGLDEGRPRR----------LIPLV
MAB_2598|M.abscessus_ATCC_1997 GA--IGFSSFAVLVYYAVANASAWTLTPSQGRPAR----------IIPAV
TH_3126|M.thermoresistible__bu -----------------------------------------------PLT
MMAR_2407|M.marinum_M YL--ADVVSIGTLVAFIVVSVGVVILRVREPDLPRGFKV--PLYPVTPVL
MUL_1244|M.ulcerans_Agy99 RL--ADMVSIGTLTAFIVVSVGVIILRVREPALPRGFWV--PGYPVTPIL
MAV_4216|M.avium_104 KL--EEMVNVGTLFAFVLVSAGVMVLRRTRPDLERGFKA--PWVPVLPIA
MLBr_01974|M.leprae_Br4923 SLNLTGLAVIARFIQFIIVPIALFALARSRTTNSVYVKRNVFTDKVLPIT
*
Mflv_0187|M.gilvum_PYR-GCK GLIGCVVLAFTLPPVSVLAG---AAVVLVGMLAYTTGGALRRGV------
Mvan_0718|M.vanbaalenii_PYR-1 GLVGCLVLAFTLPLTSVLAG---AAVVLVGMIAYTIGGTR----------
MSMEG_0812|M.smegmatis_MC2_155 GLVGCLVLAFTLPLSSVLAG---LAVVAAGAVVYGVRRIS----------
Mb2022c|M.bovis_AF2122/97 GLIGCVVLAFALPLSSVAAG---AAVLGVGVAAYGVRRIITRRARQTDSG
Rv1999c|M.tuberculosis_H37Rv GLIGCVVLAFALPLSSVAAG---AAVLGVGVAAYGVRRIITRRARQTDSG
MAB_2598|M.abscessus_ATCC_1997 GLVGCVIVSLALPLSSVAAG---TGVLAVGVIVYALRRVSGPGRRE----
TH_3126|M.thermoresistible__bu WRTTWAPMPDPQPVTTTRRP---S--------------------------
MMAR_2407|M.marinum_M SVLACGYILFSLPWYTWLAF---SIWVSVVLVFYFVWGRHHSALNDGGDG
MUL_1244|M.ulcerans_Agy99 SILACGYLLYSLHWYTWIAF---GGWVGIALIFYLFWGRHHSRLN-----
MAV_4216|M.avium_104 SIGACVWLMLNLTALTWVRF---GIWLVVGTAIYAGYGYWHSVQGRRDAG
MLBr_01974|M.leprae_Br4923 AVVVSAGLMVSFDYRSIFLTRGGPNYFSISLIAITFIGIPAVAYLHYYRT
: :
Mflv_0187|M.gilvum_PYR-GCK --------------------
Mvan_0718|M.vanbaalenii_PYR-1 --------------------
MSMEG_0812|M.smegmatis_MC2_155 --------------------
Mb2022c|M.bovis_AF2122/97 DTQRSGHPSAT---------
Rv1999c|M.tuberculosis_H37Rv DTQRSGHPSAT---------
MAB_2598|M.abscessus_ATCC_1997 --------------------
TH_3126|M.thermoresistible__bu --------------------
MMAR_2407|M.marinum_M VIGAMPADAGDSDVLAQRDH
MUL_1244|M.ulcerans_Agy99 -----APALHDNPTGEER--
MAV_4216|M.avium_104 EPDRSDALAADPNSPVP---
MLBr_01974|M.leprae_Br4923 SGIK----------------