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QRVATLEQVTYETLDEGRIARIWLNRPDAQNAQSRTLLVQLDEAFGRAEADDEVRVVILAARGKNFSAGH DLGSEEAIAERTPGPDQHPTFTFNGGTRDAISERTYLQEWHYFFNNTSRWRDLRKITIAQVQGNAISAGL MLIWACDLIVASDDARFSDVVAVRMGMPGVEYYAHPWEFGARKAKELLLTGDAIDADEAHRLGMVSKVFP RAELEDKTLEFARRIAERPTMAALLVKDSVNAASDAMGFTEALRHAFHIHELGHAHWAAYNENRYPVGLP PNVPDWRTLGAPKLSRRDQP*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. vanbaalenii PYR-1 | Mvan_5190 | - | - | 100% (301) | enoyl-CoA hydratase |
M. vanbaalenii PYR-1 | Mvan_4005 | - | 4e-92 | 58.63% (278) | enoyl-CoA hydratase |
M. vanbaalenii PYR-1 | Mvan_4219 | - | 3e-52 | 45.56% (259) | enoyl-CoA hydratase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1970c | echA13 | 1e-97 | 60.68% (295) | enoyl-CoA hydratase |
M. gilvum PYR-GCK | Mflv_1568 | - | 1e-168 | 95.02% (301) | enoyl-CoA hydratase |
M. tuberculosis H37Rv | Rv1935c | echA13 | 1e-97 | 60.68% (295) | enoyl-CoA hydratase |
M. leprae Br4923 | MLBr_02402 | - | 6e-18 | 27.72% (267) | enoyl-CoA hydratase |
M. abscessus ATCC 19977 | MAB_2058 | - | 5e-22 | 28.99% (276) | enoyl-CoA dehydratase/isomerase |
M. marinum M | MMAR_4972 | echA13_1 | 1e-147 | 83.22% (298) | enoyl-CoA hydratase EchA13_1 |
M. avium 104 | MAV_0670 | - | 1e-150 | 87.07% (294) | enoyl-CoA hydratase |
M. smegmatis MC2 155 | MSMEG_5886 | - | 1e-149 | 86.69% (293) | enoyl-CoA hydratase |
M. thermoresistible (build 8) | TH_1273 | - | 1e-121 | 87.19% (242) | PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE |
M. ulcerans Agy99 | MUL_4429 | echA12_2 | 1e-19 | 34.01% (247) | enoyl-CoA hydratase, EchA12_2 |
CLUSTAL 2.0.9 multiple sequence alignment Mb1970c|M.bovis_AF2122/97 --MFVGRVGPVDRRSDGERSRRPREFEYIRYETIDDGRIAAITLDRPKQR Rv1935c|M.tuberculosis_H37Rv --MFVGRVGPVDRRSDGERSRRPREFEYIRYETIDDGRIAAITLDRPKQR Mvan_5190|M.vanbaalenii_PYR-1 ----MQRVATLE---------------QVTYETLDEGRIARIWLNRPDAQ Mflv_1568|M.gilvum_PYR-GCK ----MQRVADQD---------------QVTYETLDEGRIARIWLNRPDAQ MSMEG_5886|M.smegmatis_MC2_155 MPYLLMRWFDMTGSDGDGGQA-----RQIEYETLDEGRIARIWLNRPQAQ MMAR_4972|M.marinum_M ----MTLSEQADTSAEGVAPA-----ELVAYETLDEGRIARIWLNRPEAH MAV_0670|M.avium_104 ----MTLSEQAGAQPGARPAE-----ELVTYETLDEGRIARIWLNRPDAH TH_1273|M.thermoresistible__bu ----MGWSAVAKP-----DAS-----EQVTYETLDDGRIARIWLNRPEAQ MLBr_02402|M.leprae_Br4923 -------------------------MKYDTILVDGYQRVGIITLNRPQAL MUL_4429|M.ulcerans_Agy99 -------------------------------MQTLQHNIACVTLNRPTRL MAB_2058|M.abscessus_ATCC_1997 -------------------------MAEQPIRYEVVDSVAWLTINRPEAR :. : ::** Mb1970c|M.bovis_AF2122/97 NAQTRGMLVELGAAFELAEADDTVRVVILRAA-GPAFSAGHDLGSADDIR Rv1935c|M.tuberculosis_H37Rv NAQTRGMLVELGAAFELAEADDTVRVVILRAA-GPAFSAGHDLGSADDIR Mvan_5190|M.vanbaalenii_PYR-1 NAQSRTLLVQLDEAFGRAEADDEVRVVILAAR-GKNFSAGHDLGSEEAIA Mflv_1568|M.gilvum_PYR-GCK NAQSRTLLVQLDEAFGRAEADDVVRVVILAAR-GKNFSAGHDLGSEAALA MSMEG_5886|M.smegmatis_MC2_155 NAQSRTLLVQLDEAFARAEADDTVRVVILAAR-GKNFSAGHDLGSEEALA MMAR_4972|M.marinum_M NAQNRTLLVQLDEAFGRAEADDTVRVVILAAR-GKNFSAGHDLGSEAALL MAV_0670|M.avium_104 NAQSRGLLVQLDEAFVRAEADDAVRVVILAAR-GKNFSAGHDLGSELALA TH_1273|M.thermoresistible__bu NAQSRTLLVQLDEAFLRAEADDQVRVVILAAR-GRNFSAGHDLGSEEALL MLBr_02402|M.leprae_Br4923 NALNSQMMNEITNAAKELDIDPDVGAILITGS-PKVFAAGADIK------ MUL_4429|M.ulcerans_Agy99 NAIDGSLLDAMDDALDALSGG-EFRAAILTGA-GRGFCAGADLSGTGQPW MAB_2058|M.abscessus_ATCC_1997 NALNNAVRTGLIDAVLRFNDDDAAKVLVLTGVGDKAFCAGGDLK------ ** : : * . . . :: . *.** *: Mb1970c|M.bovis_AF2122/97 ERSPGPDQHPSYRCNGATFGGVESRN-RQEWHYYFENTKRWRNLRKITIA Rv1935c|M.tuberculosis_H37Rv ERSPGPDQHPSYRCNGATFGGVESRN-RQEWHYYFENTKRWRNLRKITIA Mvan_5190|M.vanbaalenii_PYR-1 ERTPGPDQHPTFTFNGGTRDAISERTYLQEWHYFFNNTSRWRDLRKITIA Mflv_1568|M.gilvum_PYR-GCK ERAPGPDQHPTFTCNGATREAVIERTYLQEWHYFFNNTSRWRDLRKITIA MSMEG_5886|M.smegmatis_MC2_155 EREPGPGQHPTFAGYGATVAGVAERTYRQEWHFYFENTKRWRDLRKITIA MMAR_4972|M.marinum_M ERKPGPAQHPTFRSHGGTRDAVMEKLYLQEWHFYFQNTCRWRDLRKITIA MAV_0670|M.avium_104 ERQPGPGQHPTFRFNGATRDPIAEKTYLQEWHYFFQNTCRWRDLRKITIA TH_1273|M.thermoresistible__bu ERQPGPDQHPTFRSHGATATGIAERTYRQEWHFYFENTCRWRDLRKITIA MLBr_02402|M.leprae_Br4923 -----EMASLTFTDAFDAD--------------FFSAWGKLAAVRTPMIA MUL_4429|M.ulcerans_Agy99 TKATPTTPPFKATYDAQVR--------------LADQLTRLYELPIPVIA MAB_2058|M.abscessus_ATCC_1997 ------EMAQNALKVPPKD--------------FAPQFGRNIDVAKPTIA . : : ** Mb1970c|M.bovis_AF2122/97 QVHGAVLSAGLMLAWCCDLIVASEDTVFADVVGTRLGMCG--VEYFGHPW Rv1935c|M.tuberculosis_H37Rv QVHGAVLSAGLMLAWCCDLIVASEDTVFADVVGTRLGMCG--VEYFGHPW Mvan_5190|M.vanbaalenii_PYR-1 QVQGNAISAGLMLIWACDLIVASDDARFSDVVAVRMGMPG--VEYYAHPW Mflv_1568|M.gilvum_PYR-GCK QVQGNAISAALMLIWACDLIVASDDAKFSDVVAVRMGMPG--VEYYAHPW MSMEG_5886|M.smegmatis_MC2_155 QVQGNAISAALMLIWACDLIVAADDARFSDVVAVRMGMPG--VEYYAHPW MMAR_4972|M.marinum_M QVQGNAISAALMLIWACDLIVAADNAKFSDVVAVRLGMPG--VEYYAHPW MAV_0670|M.avium_104 QVQGNAISAGLMLIWACDLIVAADNAKFSDVVGVRMGMPG--VEYYAHPW TH_1273|M.thermoresistible__bu QVQGNAISAALMLIWACDLIVAADDARFSDVVGVRMGMPG--VEYYAHPW MLBr_02402|M.leprae_Br4923 AVAGYALGGGCELAMMCDLLIAADTAKFGQPEIKLGVLPG-MGGSQRLTR MUL_4429|M.ulcerans_Agy99 AVNGVAVGGGLAFALHCDIRIAAEDARFGSVFIKAGFSSMDMGTSYLLPR MAB_2058|M.abscessus_ATCC_1997 AVNGVAFAGGFLLAQQCDLVVAAEHATFAVSEVKVGRGSP---WATPLSW * * ..... : **: :*:: : *. . Mb1970c|M.bovis_AF2122/97 EFGPRKTKELLLTGDCIGADEAHALGMVSKVFPADELATSTIEFARRIAK Rv1935c|M.tuberculosis_H37Rv EFGPRKTKELLLTGDCIGADEAHALGMVSKVFPADELATSTIEFARRIAK Mvan_5190|M.vanbaalenii_PYR-1 EFGARKAKELLLTGDAIDADEAHRLGMVSKVFPRAELEDKTLEFARRIAE Mflv_1568|M.gilvum_PYR-GCK EFGARKAKELLLTGDAIDADEAHRLGMVSKVFPRAELEDKTLEFARRIAE MSMEG_5886|M.smegmatis_MC2_155 EFGPRKAKELLLTGDSIDADEAYRLGMVSKVFGREELEDKTLEFARRIAE MMAR_4972|M.marinum_M EFGPRKAKELLLTGDSLDAEEAYRLGMVSKVFPADELADKTLQFARRIAE MAV_0670|M.avium_104 EFGPRKAKELLLTGDALDADEAYRLGMVSKVFPADELADKTLEFARRIAE TH_1273|M.thermoresistible__bu EFGPRKAKELLLTGDSIDADEAYRMGMVSKVFPRAELEEKTLEFARRIAE MLBr_02402|M.leprae_Br4923 AIGKAKAMDLILTGRTIDAAEAERSGLVSRVVLADDLLPEAKAVATTISQ MUL_4429|M.ulcerans_Agy99 IVGAGVARELMLTGRIIDAVEAYRIRLVHEVVVADELLTAAQKLAGSIAE MAB_2058|M.abscessus_ATCC_1997 LVPPRVAMQILLTGDPITAARAHQVGLVNEVVPADQLRERTQQLALSIAA . : :::*** : * .* :* .*. :* : .* *: Mb1970c|M.bovis_AF2122/97 VPTMAALLIKESVNQTVDAMGFS-----------AALDGCFKIHQLN--H Rv1935c|M.tuberculosis_H37Rv VPTMAALLIKESVNQTVDAMGFS-----------AALDGCFKIHQLN--H Mvan_5190|M.vanbaalenii_PYR-1 RPTMAALLVKDSVNAASDAMGFT-----------EALRHAFHIHELG--H Mflv_1568|M.gilvum_PYR-GCK RPTMAALLVKDSVNAASDAMGFT-----------EALRHAFHIHELG--H MSMEG_5886|M.smegmatis_MC2_155 RPTMAALLVKDSVNAAADSMGFA-----------EALHHAFHIHELG--H MMAR_4972|M.marinum_M RPTMAALLVKDSVNAASDAMGFT-----------EALRHAFHVHELG--H MAV_0670|M.avium_104 RPTMAALLIKDSVNAASDAMGFT-----------EALRHAFHIHELG--H TH_1273|M.thermoresistible__bu RPTMAALLIKDSGNAASDAMGXXXQPPVPAGGRLDRLRDLVLIGDVGRMG MLBr_02402|M.leprae_Br4923 MSRSATRMAKEAVNRSFES----------------TLAEGLLHERRLFHS MUL_4429|M.ulcerans_Agy99 NNAYGVWQTKIGLNAAPDAP---------------SLRHAKEIENRTEII MAB_2058|M.abscessus_ATCC_1997 NAPLSVLASKRTVYLSAQH----------------HLAAAYDLADEIWEP .. * : : * Mb1970c|M.bovis_AF2122/97 AHWGEVTG-----GKLSYGTVEYG-------------------------- Rv1935c|M.tuberculosis_H37Rv AHWGEVTG-----GKLSYGTVEYG-------------------------- Mvan_5190|M.vanbaalenii_PYR-1 AHWAAYNE-----NRYPVGLPPN--------------------------- Mflv_1568|M.gilvum_PYR-GCK AHWAAYNE-----NRYPVGLPPN--------------------------- MSMEG_5886|M.smegmatis_MC2_155 AHWAAANE-----NRWPVGMPPD--------------------------- MMAR_4972|M.marinum_M AHWAAHNE-----NRYPIGLPPD--------------------------- MAV_0670|M.avium_104 AHWAAHNE-----NRYPVGLPPD--------------------------- TH_1273|M.thermoresistible__bu AHLAARPGEFACGGGQPVGIASDDQHLATGRGDRGGHPFADTASAAGHQI MLBr_02402|M.leprae_Br4923 TFVTDDQS------------------------------------------ MUL_4429|M.ulcerans_Agy99 SGFTNNPA------------------------------------------ MAB_2058|M.abscessus_ATCC_1997 VYLSDDAQ------------------------------------------ Mb1970c|M.bovis_AF2122/97 --LEDWRAAPQIRPAIKQRP------------------------------ Rv1935c|M.tuberculosis_H37Rv --LEDWRAAPQIRPAIKQRP------------------------------ Mvan_5190|M.vanbaalenii_PYR-1 --VPDWRTLGAPKLSRRDQP------------------------------ Mflv_1568|M.gilvum_PYR-GCK --VPDWRTLGAPKLSRRDEP------------------------------ MSMEG_5886|M.smegmatis_MC2_155 --VPDWRTLGAPKLARRDTP------------------------------ MMAR_4972|M.marinum_M --VEDWRTAGPTQVARRDTP------------------------------ MAV_0670|M.avium_104 --VEDWRNAKPTRLARRDTP------------------------------ TH_1273|M.thermoresistible__bu RPVGQRQLHGHPPFRSRDITAGGLXGWHARLHGVVHCAGGSETIGPITQV MLBr_02402|M.leprae_Br4923 ---EGMAAFIEKRAPQFTHR------------------------------ MUL_4429|M.ulcerans_Agy99 ---EAARAHQEKRPPAWDSL------------------------------ MAB_2058|M.abscessus_ATCC_1997 ---EGPAAFREKRAPQWKGH------------------------------ Mb1970c|M.bovis_AF2122/97 -------------------------------------------------- Rv1935c|M.tuberculosis_H37Rv -------------------------------------------------- Mvan_5190|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_1568|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_5886|M.smegmatis_MC2_155 -------------------------------------------------- MMAR_4972|M.marinum_M -------------------------------------------------- MAV_0670|M.avium_104 -------------------------------------------------- TH_1273|M.thermoresistible__bu DSEAWRRTVDLNVNGTMYLIKHAAREMVRGGGGSFVGVSSIASSNTHRWF MLBr_02402|M.leprae_Br4923 -------------------------------------------------- MUL_4429|M.ulcerans_Agy99 -------------------------------------------------- MAB_2058|M.abscessus_ATCC_1997 -------------------------------------------------- Mb1970c|M.bovis_AF2122/97 -------------------------------------------------- Rv1935c|M.tuberculosis_H37Rv -------------------------------------------------- Mvan_5190|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_1568|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_5886|M.smegmatis_MC2_155 -------------------------------------------------- MMAR_4972|M.marinum_M -------------------------------------------------- MAV_0670|M.avium_104 -------------------------------------------------- TH_1273|M.thermoresistible__bu GAYGPSKAALDHLLMVAADELGPSWVRVNGIRPGLTKTDLVAPIMDTPAV MLBr_02402|M.leprae_Br4923 -------------------------------------------------- MUL_4429|M.ulcerans_Agy99 -------------------------------------------------- MAB_2058|M.abscessus_ATCC_1997 -------------------------------------------------- Mb1970c|M.bovis_AF2122/97 -------------------------------------------------- Rv1935c|M.tuberculosis_H37Rv -------------------------------------------------- Mvan_5190|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_1568|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_5886|M.smegmatis_MC2_155 -------------------------------------------------- MMAR_4972|M.marinum_M -------------------------------------------------- MAV_0670|M.avium_104 -------------------------------------------------- TH_1273|M.thermoresistible__bu VDDYRACTPLPRFGEVSDIANLAVFLLSDAASWITGQIINVDGGHGLRRG MLBr_02402|M.leprae_Br4923 -------------------------------------------------- MUL_4429|M.ulcerans_Agy99 -------------------------------------------------- MAB_2058|M.abscessus_ATCC_1997 -------------------------------------------------- Mb1970c|M.bovis_AF2122/97 ---------------------- Rv1935c|M.tuberculosis_H37Rv ---------------------- Mvan_5190|M.vanbaalenii_PYR-1 ---------------------- Mflv_1568|M.gilvum_PYR-GCK ---------------------- MSMEG_5886|M.smegmatis_MC2_155 ---------------------- MMAR_4972|M.marinum_M ---------------------- MAV_0670|M.avium_104 ---------------------- TH_1273|M.thermoresistible__bu PDMSGMLEPVFGADGLRGVVEG MLBr_02402|M.leprae_Br4923 ---------------------- MUL_4429|M.ulcerans_Agy99 ---------------------- MAB_2058|M.abscessus_ATCC_1997 ----------------------