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M. vanbaalenii PYR-1 Mvan_5190 (-)

annotation: enoyl-CoA hydratase
coordinates: 5556159 - 5557064
length: 301

QRVATLEQVTYETLDEGRIARIWLNRPDAQNAQSRTLLVQLDEAFGRAEADDEVRVVILAARGKNFSAGH
DLGSEEAIAERTPGPDQHPTFTFNGGTRDAISERTYLQEWHYFFNNTSRWRDLRKITIAQVQGNAISAGL
MLIWACDLIVASDDARFSDVVAVRMGMPGVEYYAHPWEFGARKAKELLLTGDAIDADEAHRLGMVSKVFP
RAELEDKTLEFARRIAERPTMAALLVKDSVNAASDAMGFTEALRHAFHIHELGHAHWAAYNENRYPVGLP
PNVPDWRTLGAPKLSRRDQP*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. vanbaalenii PYR-1Mvan_5190--100% (301)enoyl-CoA hydratase
M. vanbaalenii PYR-1Mvan_4005-4e-9258.63% (278) enoyl-CoA hydratase
M. vanbaalenii PYR-1Mvan_4219-3e-5245.56% (259) enoyl-CoA hydratase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1970cechA131e-9760.68% (295) enoyl-CoA hydratase
M. gilvum PYR-GCKMflv_1568-1e-16895.02% (301) enoyl-CoA hydratase
M. tuberculosis H37RvRv1935cechA131e-9760.68% (295) enoyl-CoA hydratase
M. leprae Br4923MLBr_02402-6e-1827.72% (267) enoyl-CoA hydratase
M. abscessus ATCC 19977MAB_2058-5e-2228.99% (276) enoyl-CoA dehydratase/isomerase
M. marinum MMMAR_4972echA13_11e-14783.22% (298) enoyl-CoA hydratase EchA13_1
M. avium 104MAV_0670-1e-15087.07% (294) enoyl-CoA hydratase
M. smegmatis MC2 155MSMEG_5886-1e-14986.69% (293) enoyl-CoA hydratase
M. thermoresistible (build 8)TH_1273-1e-12187.19% (242) PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE
M. ulcerans Agy99MUL_4429echA12_21e-1934.01% (247) enoyl-CoA hydratase, EchA12_2

CLUSTAL 2.0.9 multiple sequence alignment


Mb1970c|M.bovis_AF2122/97           --MFVGRVGPVDRRSDGERSRRPREFEYIRYETIDDGRIAAITLDRPKQR
Rv1935c|M.tuberculosis_H37Rv        --MFVGRVGPVDRRSDGERSRRPREFEYIRYETIDDGRIAAITLDRPKQR
Mvan_5190|M.vanbaalenii_PYR-1       ----MQRVATLE---------------QVTYETLDEGRIARIWLNRPDAQ
Mflv_1568|M.gilvum_PYR-GCK          ----MQRVADQD---------------QVTYETLDEGRIARIWLNRPDAQ
MSMEG_5886|M.smegmatis_MC2_155      MPYLLMRWFDMTGSDGDGGQA-----RQIEYETLDEGRIARIWLNRPQAQ
MMAR_4972|M.marinum_M               ----MTLSEQADTSAEGVAPA-----ELVAYETLDEGRIARIWLNRPEAH
MAV_0670|M.avium_104                ----MTLSEQAGAQPGARPAE-----ELVTYETLDEGRIARIWLNRPDAH
TH_1273|M.thermoresistible__bu      ----MGWSAVAKP-----DAS-----EQVTYETLDDGRIARIWLNRPEAQ
MLBr_02402|M.leprae_Br4923          -------------------------MKYDTILVDGYQRVGIITLNRPQAL
MUL_4429|M.ulcerans_Agy99           -------------------------------MQTLQHNIACVTLNRPTRL
MAB_2058|M.abscessus_ATCC_1997      -------------------------MAEQPIRYEVVDSVAWLTINRPEAR
                                                                          :. : ::**   

Mb1970c|M.bovis_AF2122/97           NAQTRGMLVELGAAFELAEADDTVRVVILRAA-GPAFSAGHDLGSADDIR
Rv1935c|M.tuberculosis_H37Rv        NAQTRGMLVELGAAFELAEADDTVRVVILRAA-GPAFSAGHDLGSADDIR
Mvan_5190|M.vanbaalenii_PYR-1       NAQSRTLLVQLDEAFGRAEADDEVRVVILAAR-GKNFSAGHDLGSEEAIA
Mflv_1568|M.gilvum_PYR-GCK          NAQSRTLLVQLDEAFGRAEADDVVRVVILAAR-GKNFSAGHDLGSEAALA
MSMEG_5886|M.smegmatis_MC2_155      NAQSRTLLVQLDEAFARAEADDTVRVVILAAR-GKNFSAGHDLGSEEALA
MMAR_4972|M.marinum_M               NAQNRTLLVQLDEAFGRAEADDTVRVVILAAR-GKNFSAGHDLGSEAALL
MAV_0670|M.avium_104                NAQSRGLLVQLDEAFVRAEADDAVRVVILAAR-GKNFSAGHDLGSELALA
TH_1273|M.thermoresistible__bu      NAQSRTLLVQLDEAFLRAEADDQVRVVILAAR-GRNFSAGHDLGSEEALL
MLBr_02402|M.leprae_Br4923          NALNSQMMNEITNAAKELDIDPDVGAILITGS-PKVFAAGADIK------
MUL_4429|M.ulcerans_Agy99           NAIDGSLLDAMDDALDALSGG-EFRAAILTGA-GRGFCAGADLSGTGQPW
MAB_2058|M.abscessus_ATCC_1997      NALNNAVRTGLIDAVLRFNDDDAAKVLVLTGVGDKAFCAGGDLK------
                                    **    :   :  *    . .    . :: .     *.** *:       

Mb1970c|M.bovis_AF2122/97           ERSPGPDQHPSYRCNGATFGGVESRN-RQEWHYYFENTKRWRNLRKITIA
Rv1935c|M.tuberculosis_H37Rv        ERSPGPDQHPSYRCNGATFGGVESRN-RQEWHYYFENTKRWRNLRKITIA
Mvan_5190|M.vanbaalenii_PYR-1       ERTPGPDQHPTFTFNGGTRDAISERTYLQEWHYFFNNTSRWRDLRKITIA
Mflv_1568|M.gilvum_PYR-GCK          ERAPGPDQHPTFTCNGATREAVIERTYLQEWHYFFNNTSRWRDLRKITIA
MSMEG_5886|M.smegmatis_MC2_155      EREPGPGQHPTFAGYGATVAGVAERTYRQEWHFYFENTKRWRDLRKITIA
MMAR_4972|M.marinum_M               ERKPGPAQHPTFRSHGGTRDAVMEKLYLQEWHFYFQNTCRWRDLRKITIA
MAV_0670|M.avium_104                ERQPGPGQHPTFRFNGATRDPIAEKTYLQEWHYFFQNTCRWRDLRKITIA
TH_1273|M.thermoresistible__bu      ERQPGPDQHPTFRSHGATATGIAERTYRQEWHFYFENTCRWRDLRKITIA
MLBr_02402|M.leprae_Br4923          -----EMASLTFTDAFDAD--------------FFSAWGKLAAVRTPMIA
MUL_4429|M.ulcerans_Agy99           TKATPTTPPFKATYDAQVR--------------LADQLTRLYELPIPVIA
MAB_2058|M.abscessus_ATCC_1997      ------EMAQNALKVPPKD--------------FAPQFGRNIDVAKPTIA
                                              .                            :   :    **

Mb1970c|M.bovis_AF2122/97           QVHGAVLSAGLMLAWCCDLIVASEDTVFADVVGTRLGMCG--VEYFGHPW
Rv1935c|M.tuberculosis_H37Rv        QVHGAVLSAGLMLAWCCDLIVASEDTVFADVVGTRLGMCG--VEYFGHPW
Mvan_5190|M.vanbaalenii_PYR-1       QVQGNAISAGLMLIWACDLIVASDDARFSDVVAVRMGMPG--VEYYAHPW
Mflv_1568|M.gilvum_PYR-GCK          QVQGNAISAALMLIWACDLIVASDDAKFSDVVAVRMGMPG--VEYYAHPW
MSMEG_5886|M.smegmatis_MC2_155      QVQGNAISAALMLIWACDLIVAADDARFSDVVAVRMGMPG--VEYYAHPW
MMAR_4972|M.marinum_M               QVQGNAISAALMLIWACDLIVAADNAKFSDVVAVRLGMPG--VEYYAHPW
MAV_0670|M.avium_104                QVQGNAISAGLMLIWACDLIVAADNAKFSDVVGVRMGMPG--VEYYAHPW
TH_1273|M.thermoresistible__bu      QVQGNAISAALMLIWACDLIVAADDARFSDVVGVRMGMPG--VEYYAHPW
MLBr_02402|M.leprae_Br4923          AVAGYALGGGCELAMMCDLLIAADTAKFGQPEIKLGVLPG-MGGSQRLTR
MUL_4429|M.ulcerans_Agy99           AVNGVAVGGGLAFALHCDIRIAAEDARFGSVFIKAGFSSMDMGTSYLLPR
MAB_2058|M.abscessus_ATCC_1997      AVNGVAFAGGFLLAQQCDLVVAAEHATFAVSEVKVGRGSP---WATPLSW
                                     * * .....  :   **: :*:: : *.                   . 

Mb1970c|M.bovis_AF2122/97           EFGPRKTKELLLTGDCIGADEAHALGMVSKVFPADELATSTIEFARRIAK
Rv1935c|M.tuberculosis_H37Rv        EFGPRKTKELLLTGDCIGADEAHALGMVSKVFPADELATSTIEFARRIAK
Mvan_5190|M.vanbaalenii_PYR-1       EFGARKAKELLLTGDAIDADEAHRLGMVSKVFPRAELEDKTLEFARRIAE
Mflv_1568|M.gilvum_PYR-GCK          EFGARKAKELLLTGDAIDADEAHRLGMVSKVFPRAELEDKTLEFARRIAE
MSMEG_5886|M.smegmatis_MC2_155      EFGPRKAKELLLTGDSIDADEAYRLGMVSKVFGREELEDKTLEFARRIAE
MMAR_4972|M.marinum_M               EFGPRKAKELLLTGDSLDAEEAYRLGMVSKVFPADELADKTLQFARRIAE
MAV_0670|M.avium_104                EFGPRKAKELLLTGDALDADEAYRLGMVSKVFPADELADKTLEFARRIAE
TH_1273|M.thermoresistible__bu      EFGPRKAKELLLTGDSIDADEAYRMGMVSKVFPRAELEEKTLEFARRIAE
MLBr_02402|M.leprae_Br4923          AIGKAKAMDLILTGRTIDAAEAERSGLVSRVVLADDLLPEAKAVATTISQ
MUL_4429|M.ulcerans_Agy99           IVGAGVARELMLTGRIIDAVEAYRIRLVHEVVVADELLTAAQKLAGSIAE
MAB_2058|M.abscessus_ATCC_1997      LVPPRVAMQILLTGDPITAARAHQVGLVNEVVPADQLRERTQQLALSIAA
                                     .    : :::***  : * .*    :* .*.   :*   :  .*  *: 

Mb1970c|M.bovis_AF2122/97           VPTMAALLIKESVNQTVDAMGFS-----------AALDGCFKIHQLN--H
Rv1935c|M.tuberculosis_H37Rv        VPTMAALLIKESVNQTVDAMGFS-----------AALDGCFKIHQLN--H
Mvan_5190|M.vanbaalenii_PYR-1       RPTMAALLVKDSVNAASDAMGFT-----------EALRHAFHIHELG--H
Mflv_1568|M.gilvum_PYR-GCK          RPTMAALLVKDSVNAASDAMGFT-----------EALRHAFHIHELG--H
MSMEG_5886|M.smegmatis_MC2_155      RPTMAALLVKDSVNAAADSMGFA-----------EALHHAFHIHELG--H
MMAR_4972|M.marinum_M               RPTMAALLVKDSVNAASDAMGFT-----------EALRHAFHVHELG--H
MAV_0670|M.avium_104                RPTMAALLIKDSVNAASDAMGFT-----------EALRHAFHIHELG--H
TH_1273|M.thermoresistible__bu      RPTMAALLIKDSGNAASDAMGXXXQPPVPAGGRLDRLRDLVLIGDVGRMG
MLBr_02402|M.leprae_Br4923          MSRSATRMAKEAVNRSFES----------------TLAEGLLHERRLFHS
MUL_4429|M.ulcerans_Agy99           NNAYGVWQTKIGLNAAPDAP---------------SLRHAKEIENRTEII
MAB_2058|M.abscessus_ATCC_1997      NAPLSVLASKRTVYLSAQH----------------HLAAAYDLADEIWEP
                                        ..   *     : :                  *             

Mb1970c|M.bovis_AF2122/97           AHWGEVTG-----GKLSYGTVEYG--------------------------
Rv1935c|M.tuberculosis_H37Rv        AHWGEVTG-----GKLSYGTVEYG--------------------------
Mvan_5190|M.vanbaalenii_PYR-1       AHWAAYNE-----NRYPVGLPPN---------------------------
Mflv_1568|M.gilvum_PYR-GCK          AHWAAYNE-----NRYPVGLPPN---------------------------
MSMEG_5886|M.smegmatis_MC2_155      AHWAAANE-----NRWPVGMPPD---------------------------
MMAR_4972|M.marinum_M               AHWAAHNE-----NRYPIGLPPD---------------------------
MAV_0670|M.avium_104                AHWAAHNE-----NRYPVGLPPD---------------------------
TH_1273|M.thermoresistible__bu      AHLAARPGEFACGGGQPVGIASDDQHLATGRGDRGGHPFADTASAAGHQI
MLBr_02402|M.leprae_Br4923          TFVTDDQS------------------------------------------
MUL_4429|M.ulcerans_Agy99           SGFTNNPA------------------------------------------
MAB_2058|M.abscessus_ATCC_1997      VYLSDDAQ------------------------------------------
                                                                                      

Mb1970c|M.bovis_AF2122/97           --LEDWRAAPQIRPAIKQRP------------------------------
Rv1935c|M.tuberculosis_H37Rv        --LEDWRAAPQIRPAIKQRP------------------------------
Mvan_5190|M.vanbaalenii_PYR-1       --VPDWRTLGAPKLSRRDQP------------------------------
Mflv_1568|M.gilvum_PYR-GCK          --VPDWRTLGAPKLSRRDEP------------------------------
MSMEG_5886|M.smegmatis_MC2_155      --VPDWRTLGAPKLARRDTP------------------------------
MMAR_4972|M.marinum_M               --VEDWRTAGPTQVARRDTP------------------------------
MAV_0670|M.avium_104                --VEDWRNAKPTRLARRDTP------------------------------
TH_1273|M.thermoresistible__bu      RPVGQRQLHGHPPFRSRDITAGGLXGWHARLHGVVHCAGGSETIGPITQV
MLBr_02402|M.leprae_Br4923          ---EGMAAFIEKRAPQFTHR------------------------------
MUL_4429|M.ulcerans_Agy99           ---EAARAHQEKRPPAWDSL------------------------------
MAB_2058|M.abscessus_ATCC_1997      ---EGPAAFREKRAPQWKGH------------------------------
                                                                                      

Mb1970c|M.bovis_AF2122/97           --------------------------------------------------
Rv1935c|M.tuberculosis_H37Rv        --------------------------------------------------
Mvan_5190|M.vanbaalenii_PYR-1       --------------------------------------------------
Mflv_1568|M.gilvum_PYR-GCK          --------------------------------------------------
MSMEG_5886|M.smegmatis_MC2_155      --------------------------------------------------
MMAR_4972|M.marinum_M               --------------------------------------------------
MAV_0670|M.avium_104                --------------------------------------------------
TH_1273|M.thermoresistible__bu      DSEAWRRTVDLNVNGTMYLIKHAAREMVRGGGGSFVGVSSIASSNTHRWF
MLBr_02402|M.leprae_Br4923          --------------------------------------------------
MUL_4429|M.ulcerans_Agy99           --------------------------------------------------
MAB_2058|M.abscessus_ATCC_1997      --------------------------------------------------
                                                                                      

Mb1970c|M.bovis_AF2122/97           --------------------------------------------------
Rv1935c|M.tuberculosis_H37Rv        --------------------------------------------------
Mvan_5190|M.vanbaalenii_PYR-1       --------------------------------------------------
Mflv_1568|M.gilvum_PYR-GCK          --------------------------------------------------
MSMEG_5886|M.smegmatis_MC2_155      --------------------------------------------------
MMAR_4972|M.marinum_M               --------------------------------------------------
MAV_0670|M.avium_104                --------------------------------------------------
TH_1273|M.thermoresistible__bu      GAYGPSKAALDHLLMVAADELGPSWVRVNGIRPGLTKTDLVAPIMDTPAV
MLBr_02402|M.leprae_Br4923          --------------------------------------------------
MUL_4429|M.ulcerans_Agy99           --------------------------------------------------
MAB_2058|M.abscessus_ATCC_1997      --------------------------------------------------
                                                                                      

Mb1970c|M.bovis_AF2122/97           --------------------------------------------------
Rv1935c|M.tuberculosis_H37Rv        --------------------------------------------------
Mvan_5190|M.vanbaalenii_PYR-1       --------------------------------------------------
Mflv_1568|M.gilvum_PYR-GCK          --------------------------------------------------
MSMEG_5886|M.smegmatis_MC2_155      --------------------------------------------------
MMAR_4972|M.marinum_M               --------------------------------------------------
MAV_0670|M.avium_104                --------------------------------------------------
TH_1273|M.thermoresistible__bu      VDDYRACTPLPRFGEVSDIANLAVFLLSDAASWITGQIINVDGGHGLRRG
MLBr_02402|M.leprae_Br4923          --------------------------------------------------
MUL_4429|M.ulcerans_Agy99           --------------------------------------------------
MAB_2058|M.abscessus_ATCC_1997      --------------------------------------------------
                                                                                      

Mb1970c|M.bovis_AF2122/97           ----------------------
Rv1935c|M.tuberculosis_H37Rv        ----------------------
Mvan_5190|M.vanbaalenii_PYR-1       ----------------------
Mflv_1568|M.gilvum_PYR-GCK          ----------------------
MSMEG_5886|M.smegmatis_MC2_155      ----------------------
MMAR_4972|M.marinum_M               ----------------------
MAV_0670|M.avium_104                ----------------------
TH_1273|M.thermoresistible__bu      PDMSGMLEPVFGADGLRGVVEG
MLBr_02402|M.leprae_Br4923          ----------------------
MUL_4429|M.ulcerans_Agy99           ----------------------
MAB_2058|M.abscessus_ATCC_1997      ----------------------