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PYLLMRWFDMTGSDGDGGQARQIEYETLDEGRIARIWLNRPQAQNAQSRTLLVQLDEAFARAEADDTVRV VILAARGKNFSAGHDLGSEEALAEREPGPGQHPTFAGYGATVAGVAERTYRQEWHFYFENTKRWRDLRKI TIAQVQGNAISAALMLIWACDLIVAADDARFSDVVAVRMGMPGVEYYAHPWEFGPRKAKELLLTGDSIDA DEAYRLGMVSKVFGREELEDKTLEFARRIAERPTMAALLVKDSVNAAADSMGFAEALHHAFHIHELGHAH WAAANENRWPVGMPPDVPDWRTLGAPKLARRDTP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5886 | - | - | 100% (315) | enoyl-CoA hydratase |
| M. smegmatis MC2 155 | MSMEG_4846 | - | 5e-55 | 45.72% (269) | enoyl-CoA hydratase |
| M. smegmatis MC2 155 | MSMEG_1594 | - | 9e-23 | 34.36% (227) | enoyl-CoA hydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1970c | echA13 | 5e-98 | 60.33% (300) | enoyl-CoA hydratase |
| M. gilvum PYR-GCK | Mflv_1568 | - | 1e-149 | 87.37% (293) | enoyl-CoA hydratase |
| M. tuberculosis H37Rv | Rv1935c | echA13 | 5e-98 | 60.33% (300) | enoyl-CoA hydratase |
| M. leprae Br4923 | MLBr_02402 | - | 7e-18 | 29.05% (241) | enoyl-CoA hydratase |
| M. abscessus ATCC 19977 | MAB_0834 | - | 9e-22 | 32.70% (263) | putative enoyl-CoA hydratase/isomerase |
| M. marinum M | MMAR_4972 | echA13_1 | 1e-145 | 83.05% (295) | enoyl-CoA hydratase EchA13_1 |
| M. avium 104 | MAV_0670 | - | 1e-144 | 81.35% (311) | enoyl-CoA hydratase |
| M. thermoresistible (build 8) | TH_1273 | - | 1e-124 | 88.48% (243) | PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE |
| M. ulcerans Agy99 | MUL_0754 | echA4 | 8e-20 | 27.69% (260) | enoyl-CoA hydratase |
| M. vanbaalenii PYR-1 | Mvan_5190 | - | 1e-149 | 86.69% (293) | enoyl-CoA hydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1970c|M.bovis_AF2122/97 --MFVGRVGPVDRRSDGERSRRPREFEYIRYETIDDGRIAAITLDRPKQR
Rv1935c|M.tuberculosis_H37Rv --MFVGRVGPVDRRSDGERSRRPREFEYIRYETIDDGRIAAITLDRPKQR
Mflv_1568|M.gilvum_PYR-GCK ----MQRVADQD---------------QVTYETLDEGRIARIWLNRPDAQ
Mvan_5190|M.vanbaalenii_PYR-1 ----MQRVATLE---------------QVTYETLDEGRIARIWLNRPDAQ
MSMEG_5886|M.smegmatis_MC2_155 MPYLLMRWFDMTGSDGDGGQA-----RQIEYETLDEGRIARIWLNRPQAQ
MMAR_4972|M.marinum_M ----MTLSEQADTSAEGVAPA-----ELVAYETLDEGRIARIWLNRPEAH
MAV_0670|M.avium_104 ----MTLSEQAGAQPGARPAE-----ELVTYETLDEGRIARIWLNRPDAH
TH_1273|M.thermoresistible__bu ----MGWSAVAKP-----DAS-----EQVTYETLDDGRIARIWLNRPEAQ
MAB_0834|M.abscessus_ATCC_1997 ---------------------------MIRVEPREHG-ILVVTIDRPERR
MLBr_02402|M.leprae_Br4923 -------------------------MKYDTILVDGYQRVGIITLNRPQAL
MUL_0754|M.ulcerans_Agy99 ---MTHAIRPVDFDN------------LKTMTYEVTDRVARITFNRPEKG
: : ::**.
Mb1970c|M.bovis_AF2122/97 NAQTRGMLVELGAAFELAEADDTVRVVILRAAGPAFSAGHDLGSADDIRE
Rv1935c|M.tuberculosis_H37Rv NAQTRGMLVELGAAFELAEADDTVRVVILRAAGPAFSAGHDLGSADDIRE
Mflv_1568|M.gilvum_PYR-GCK NAQSRTLLVQLDEAFGRAEADDVVRVVILAARGKNFSAGHDLGSEAALAE
Mvan_5190|M.vanbaalenii_PYR-1 NAQSRTLLVQLDEAFGRAEADDEVRVVILAARGKNFSAGHDLGSEEAIAE
MSMEG_5886|M.smegmatis_MC2_155 NAQSRTLLVQLDEAFARAEADDTVRVVILAARGKNFSAGHDLGSEEALAE
MMAR_4972|M.marinum_M NAQNRTLLVQLDEAFGRAEADDTVRVVILAARGKNFSAGHDLGSEAALLE
MAV_0670|M.avium_104 NAQSRGLLVQLDEAFVRAEADDAVRVVILAARGKNFSAGHDLGSELALAE
TH_1273|M.thermoresistible__bu NAQSRTLLVQLDEAFLRAEADDQVRVVILAARGRNFSAGHDLGSEEALLE
MAB_0834|M.abscessus_ATCC_1997 NALDPQTVAELHAVIESIDGDPKVRVVVLTAVGASFCAGADLKS---LPS
MLBr_02402|M.leprae_Br4923 NALNSQMMNEITNAAKELDIDPDVGAILITGSPKVFAAGADIKEMASLTF
MUL_0754|M.ulcerans_Agy99 NAIVADTPLELSALVERADLDPAVQVILVSGRGEGFCAGFDLSAYAEGSS
** :: : * * .::: . *.** *:
Mb1970c|M.bovis_AF2122/97 RSPGPDQHPSYRCNGATFGGVESRN--------RQEWHYYFENTKRWRNL
Rv1935c|M.tuberculosis_H37Rv RSPGPDQHPSYRCNGATFGGVESRN--------RQEWHYYFENTKRWRNL
Mflv_1568|M.gilvum_PYR-GCK RAPGPDQHPTFTCNGATREAVIERTY-------LQEWHYFFNNTSRWRDL
Mvan_5190|M.vanbaalenii_PYR-1 RTPGPDQHPTFTFNGGTRDAISERTY-------LQEWHYFFNNTSRWRDL
MSMEG_5886|M.smegmatis_MC2_155 REPGPGQHPTFAGYGATVAGVAERTY-------RQEWHFYFENTKRWRDL
MMAR_4972|M.marinum_M RKPGPAQHPTFRSHGGTRDAVMEKLY-------LQEWHFYFQNTCRWRDL
MAV_0670|M.avium_104 RQPGPGQHPTFRFNGATRDPIAEKTY-------LQEWHYFFQNTCRWRDL
TH_1273|M.thermoresistible__bu RQPGPDQHPTFRSHGATATGIAERTY-------RQEWHFYFENTCRWRDL
MAB_0834|M.abscessus_ATCC_1997 DFTSAGVTSTAALLAATDSELVRTLA-------AQELMASLFERIHR--M
MLBr_02402|M.leprae_Br4923 TDAFD--------------------------------ADFFSAWGKLAAV
MUL_0754|M.ulcerans_Agy99 SSGAEGGYRGTVLDGKAQAVNHLPNQPWDPMIDYQMMSRFVRGFSSLTHA
.
Mb1970c|M.bovis_AF2122/97 RKITIAQVHGAVLSAGLMLAWCCDLIVASEDTVFADVVGTRLGMCGVEY-
Rv1935c|M.tuberculosis_H37Rv RKITIAQVHGAVLSAGLMLAWCCDLIVASEDTVFADVVGTRLGMCGVEY-
Mflv_1568|M.gilvum_PYR-GCK RKITIAQVQGNAISAALMLIWACDLIVASDDAKFSDVVAVRMGMPGVEY-
Mvan_5190|M.vanbaalenii_PYR-1 RKITIAQVQGNAISAGLMLIWACDLIVASDDARFSDVVAVRMGMPGVEY-
MSMEG_5886|M.smegmatis_MC2_155 RKITIAQVQGNAISAALMLIWACDLIVAADDARFSDVVAVRMGMPGVEY-
MMAR_4972|M.marinum_M RKITIAQVQGNAISAALMLIWACDLIVAADNAKFSDVVAVRLGMPGVEY-
MAV_0670|M.avium_104 RKITIAQVQGNAISAGLMLIWACDLIVAADNAKFSDVVGVRMGMPGVEY-
TH_1273|M.thermoresistible__bu RKITIAQVQGNAISAALMLIWACDLIVAADDARFSDVVGVRMGMPGVEY-
MAB_0834|M.abscessus_ATCC_1997 RQPVIAAVNGHAIGGGFALALACDIRFASPAASFG-AVFIRHGVSNCDMG
MLBr_02402|M.leprae_Br4923 RTPMIAAVAGYALGGGCELAMMCDLLIAADTAKFGQPEIKLGVLPGMGG-
MUL_0754|M.ulcerans_Agy99 DKPTVVKIHGYCVAGGTDIALHADQVIAAADAKIGYPPTRVWGVPAAGL-
:. : * :... : .* .*: : :. :
Mb1970c|M.bovis_AF2122/97 --FGHPWEFGPRKTKELLLTGDCIGADEAHALGMVSKVFPADELATSTIE
Rv1935c|M.tuberculosis_H37Rv --FGHPWEFGPRKTKELLLTGDCIGADEAHALGMVSKVFPADELATSTIE
Mflv_1568|M.gilvum_PYR-GCK --YAHPWEFGARKAKELLLTGDAIDADEAHRLGMVSKVFPRAELEDKTLE
Mvan_5190|M.vanbaalenii_PYR-1 --YAHPWEFGARKAKELLLTGDAIDADEAHRLGMVSKVFPRAELEDKTLE
MSMEG_5886|M.smegmatis_MC2_155 --YAHPWEFGPRKAKELLLTGDSIDADEAYRLGMVSKVFGREELEDKTLE
MMAR_4972|M.marinum_M --YAHPWEFGPRKAKELLLTGDSLDAEEAYRLGMVSKVFPADELADKTLQ
MAV_0670|M.avium_104 --YAHPWEFGPRKAKELLLTGDALDADEAYRLGMVSKVFPADELADKTLE
TH_1273|M.thermoresistible__bu --YAHPWEFGPRKAKELLLTGDSIDADEAYRMGMVSKVFPRAELEEKTLE
MAB_0834|M.abscessus_ATCC_1997 TSYHLPRLVGAARAAELMLTGRVFDAQEAYRMGLVFDVVPAEELLDAALS
MLBr_02402|M.leprae_Br4923 -SQRLTRAIGKAKAMDLILTGRTIDAAEAERSGLVSRVVLADDLLPEAKA
MUL_0754|M.ulcerans_Agy99 ----WAHRLGDQRAKRLLFTGDCITGAQAAEWGLAVEAPDPKDLDERTER
. .* :: *::** : . :* *:. . :* :
Mb1970c|M.bovis_AF2122/97 FARRIAKVPTMAALLIKESVNQTVDAMGFS-----------AALDGCFKI
Rv1935c|M.tuberculosis_H37Rv FARRIAKVPTMAALLIKESVNQTVDAMGFS-----------AALDGCFKI
Mflv_1568|M.gilvum_PYR-GCK FARRIAERPTMAALLVKDSVNAASDAMGFT-----------EALRHAFHI
Mvan_5190|M.vanbaalenii_PYR-1 FARRIAERPTMAALLVKDSVNAASDAMGFT-----------EALRHAFHI
MSMEG_5886|M.smegmatis_MC2_155 FARRIAERPTMAALLVKDSVNAAADSMGFA-----------EALHHAFHI
MMAR_4972|M.marinum_M FARRIAERPTMAALLVKDSVNAASDAMGFT-----------EALRHAFHV
MAV_0670|M.avium_104 FARRIAERPTMAALLIKDSVNAASDAMGFT-----------EALRHAFHI
TH_1273|M.thermoresistible__bu FARRIAERPTMAALLIKDSGNAASDAMGXXXQPPVPAGGRLDRLRDLVLI
MAB_0834|M.abscessus_ATCC_1997 KAREIAVHSPLAVWMTKETMWQTVDAPSLR---------------HALDL
MLBr_02402|M.leprae_Br4923 VATTISQMSRSATRMAKEAVNRSFESTLAEG-----------------LL
MUL_0754|M.ulcerans_Agy99 LVERIAALPVNQLIMIKLALNSALLQQGGVN------SRMLSTVFDGVAR
. *: . : * : :
Mb1970c|M.bovis_AF2122/97 HQLN--HAHWGEVTG-----GKLSYGTVEYG-------------------
Rv1935c|M.tuberculosis_H37Rv HQLN--HAHWGEVTG-----GKLSYGTVEYG-------------------
Mflv_1568|M.gilvum_PYR-GCK HELG--HAHWAAYNE-----NRYPVGLPPN--------------------
Mvan_5190|M.vanbaalenii_PYR-1 HELG--HAHWAAYNE-----NRYPVGLPPN--------------------
MSMEG_5886|M.smegmatis_MC2_155 HELG--HAHWAAANE-----NRWPVGMPPD--------------------
MMAR_4972|M.marinum_M HELG--HAHWAAHNE-----NRYPIGLPPD--------------------
MAV_0670|M.avium_104 HELG--HAHWAAHNE-----NRYPVGLPPD--------------------
TH_1273|M.thermoresistible__bu GDVGRMGAHLAARPGEFACGGGQPVGIASDDQHLATGRGDRGGHPFADTA
MAB_0834|M.abscessus_ATCC_1997 ENRT--QVMCTATG------------------------------------
MLBr_02402|M.leprae_Br4923 HERRLFHSTFVTDDQ-----------------------------------
MUL_0754|M.ulcerans_Agy99 HTPEG-HAFVADAVEHG---------------------------------
Mb1970c|M.bovis_AF2122/97 ---------LEDWRAAPQIRPAIKQRP-----------------------
Rv1935c|M.tuberculosis_H37Rv ---------LEDWRAAPQIRPAIKQRP-----------------------
Mflv_1568|M.gilvum_PYR-GCK ---------VPDWRTLGAPKLSRRDEP-----------------------
Mvan_5190|M.vanbaalenii_PYR-1 ---------VPDWRTLGAPKLSRRDQP-----------------------
MSMEG_5886|M.smegmatis_MC2_155 ---------VPDWRTLGAPKLARRDTP-----------------------
MMAR_4972|M.marinum_M ---------VEDWRTAGPTQVARRDTP-----------------------
MAV_0670|M.avium_104 ---------VEDWRNAKPTRLARRDTP-----------------------
TH_1273|M.thermoresistible__bu SAAGHQIRPVGQRQLHGHPPFRSRDITAGGLXGWHARLHGVVHCAGGSET
MAB_0834|M.abscessus_ATCC_1997 ----------ELRRSFDAFREGRG--------------------------
MLBr_02402|M.leprae_Br4923 ---------SEGMAAFIEKRAPQFTHR-----------------------
MUL_0754|M.ulcerans_Agy99 ------FRDAVNHRDEPFGDYGRRASSV----------------------
Mb1970c|M.bovis_AF2122/97 --------------------------------------------------
Rv1935c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1568|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5190|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5886|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4972|M.marinum_M --------------------------------------------------
MAV_0670|M.avium_104 --------------------------------------------------
TH_1273|M.thermoresistible__bu IGPITQVDSEAWRRTVDLNVNGTMYLIKHAAREMVRGGGGSFVGVSSIAS
MAB_0834|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02402|M.leprae_Br4923 --------------------------------------------------
MUL_0754|M.ulcerans_Agy99 --------------------------------------------------
Mb1970c|M.bovis_AF2122/97 --------------------------------------------------
Rv1935c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1568|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5190|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5886|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4972|M.marinum_M --------------------------------------------------
MAV_0670|M.avium_104 --------------------------------------------------
TH_1273|M.thermoresistible__bu SNTHRWFGAYGPSKAALDHLLMVAADELGPSWVRVNGIRPGLTKTDLVAP
MAB_0834|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02402|M.leprae_Br4923 --------------------------------------------------
MUL_0754|M.ulcerans_Agy99 --------------------------------------------------
Mb1970c|M.bovis_AF2122/97 --------------------------------------------------
Rv1935c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1568|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5190|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5886|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4972|M.marinum_M --------------------------------------------------
MAV_0670|M.avium_104 --------------------------------------------------
TH_1273|M.thermoresistible__bu IMDTPAVVDDYRACTPLPRFGEVSDIANLAVFLLSDAASWITGQIINVDG
MAB_0834|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02402|M.leprae_Br4923 --------------------------------------------------
MUL_0754|M.ulcerans_Agy99 --------------------------------------------------
Mb1970c|M.bovis_AF2122/97 -----------------------------
Rv1935c|M.tuberculosis_H37Rv -----------------------------
Mflv_1568|M.gilvum_PYR-GCK -----------------------------
Mvan_5190|M.vanbaalenii_PYR-1 -----------------------------
MSMEG_5886|M.smegmatis_MC2_155 -----------------------------
MMAR_4972|M.marinum_M -----------------------------
MAV_0670|M.avium_104 -----------------------------
TH_1273|M.thermoresistible__bu GHGLRRGPDMSGMLEPVFGADGLRGVVEG
MAB_0834|M.abscessus_ATCC_1997 -----------------------------
MLBr_02402|M.leprae_Br4923 -----------------------------
MUL_0754|M.ulcerans_Agy99 -----------------------------