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MSEEAITYEVVDGVAWLTINRPEARNALNGAVRQGLFHSVHRFNADDSAKVLVLTGAGDKAFCAGGDLKE MAETALTVPPPDFAPQFGRNIQVAKPTIAAVNGVAFAGGFLLAQQCDLVIAAEHARFAVSEVKVGRGSPW AVPLSWLLPPRIALQILMTGDPITAERAREVGMVNEVVPAAELRVRVQEIALRIASNAPLSVLAAKKTVY LSAAHHLTEAYAHADQIWEPVYLSADALEGPAAFREKRTPVWKGR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4596 | - | - | 100% (255) | enoyl-CoA hydratase/isomerase |
| M. gilvum PYR-GCK | Mflv_2117 | - | 2e-39 | 37.60% (250) | enoyl-CoA hydratase/isomerase |
| M. gilvum PYR-GCK | Mflv_1542 | - | 3e-36 | 40.08% (247) | enoyl-CoA hydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3545 | echA19 | 4e-32 | 37.01% (254) | enoyl-CoA hydratase |
| M. tuberculosis H37Rv | Rv0222 | echA1 | 3e-36 | 36.92% (260) | enoyl-CoA hydratase |
| M. leprae Br4923 | MLBr_02402 | - | 5e-31 | 34.13% (252) | enoyl-CoA hydratase |
| M. abscessus ATCC 19977 | MAB_2058 | - | 1e-116 | 79.92% (254) | enoyl-CoA dehydratase/isomerase |
| M. marinum M | MMAR_4317 | echA1_1 | 8e-40 | 40.00% (250) | enoyl-CoA hydratase, EchA1_1 |
| M. avium 104 | MAV_2597 | - | 1e-41 | 40.30% (263) | carnitinyl-CoA dehydratase |
| M. smegmatis MC2 155 | MSMEG_0335 | - | 8e-95 | 66.93% (251) | enoyl-CoA hydratase/isomerase |
| M. thermoresistible (build 8) | TH_4462 | - | 1e-38 | 36.89% (244) | PUTATIVE putative enoyl-CoA hydratase |
| M. ulcerans Agy99 | MUL_0972 | echA1_1 | 2e-39 | 40.00% (250) | enoyl-CoA hydratase, EchA1_1 |
| M. vanbaalenii PYR-1 | Mvan_0344 | - | 5e-90 | 62.40% (250) | enoyl-CoA hydratase/isomerase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0222|M.tuberculosis_H37Rv MSSESDAANTEPEVLVEQRDRILIITINRPKAKNAVNAAVSRGLADAMDQ
TH_4462|M.thermoresistible__bu MTAPTTARQATDPVLVSADSHVLTITLNRPDVHNAVNLDMAQRISDALDR
Mb3545|M.bovis_AF2122/97 -------MESGPDALVERRGHTLIVTMNRPAARNALSTEMMRIMVQAWDR
Mflv_4596|M.gilvum_PYR-GCK --------MSEEAITYEVVDGVAWLTINRPEARNALNGAVRQGLFHSVHR
MAB_2058|M.abscessus_ATCC_1997 --------MAEQPIRYEVVDSVAWLTINRPEARNALNNAVRTGLIDAVLR
MSMEG_0335|M.smegmatis_MC2_155 -----------MSVDYEVRNGVAWLTINRPEARNSLNKAVRDGLFDGVRR
Mvan_0344|M.vanbaalenii_PYR-1 -----------MSVTYTVRNGVAWLTIDRPDARNSLNKAVRDGLFDGVRR
MMAR_4317|M.marinum_M -MTDAGDDQP--AGLVEHRGNVMVITINRPEARNAINGAVSVAVGDALES
MUL_0972|M.ulcerans_Agy99 -MTDAGDDQP--AGLVEHRGNVMVITINRPEARNAINGAVSVAVGGALES
MAV_2597|M.avium_104 -MAETLTEVTRQAAVVERRGNVALITIDRPDARNAVNGAVSTAVGDALEE
MLBr_02402|M.leprae_Br4923 --------MKYDTILVDGYQRVGIITLNRPQALNALNSQMMNEITNAAKE
:*::** . *::. : : .
Rv0222|M.tuberculosis_H37Rv LDGDAGLSVAILTGGG-GSFCAGMDLKAFAR---GENVVV----EGRGLG
TH_4462|M.thermoresistible__bu LDDDPDLRVGIIAANG-RSFCAGMDLKAFAR---GEVPRP----EPRGFA
Mb3545|M.bovis_AF2122/97 VDNDPDIRCCILTGAG-GYFCAGMDLKAATQKPPGDSFKDGSYDPSRIDA
Mflv_4596|M.gilvum_PYR-GCK FNADDSAKVLVLTGAGDKAFCAGGDLKEMAE----TALTVPPPDFAPQFG
MAB_2058|M.abscessus_ATCC_1997 FNDDDAAKVLVLTGVGDKAFCAGGDLKEMAQ----NALKVPPKDFAPQFG
MSMEG_0335|M.smegmatis_MC2_155 FNNDAQAKVLVLTGAGDKAFCAGGDLKEMSD----DQLTVPPIDFVPQFG
Mvan_0344|M.vanbaalenii_PYR-1 FNADTAAKVLVLTGAGDKAFCAGGDLKEMSA----DGLTIPPVDFVPQFG
MMAR_4317|M.marinum_M AQNDPEVRAVVITGAGDKSFCAGADLLAISR----RENIYHPDHNEWGFA
MUL_0972|M.ulcerans_Agy99 AQNDAEVRAVVITGAGDKSFCAGADLLAISR----RENIYHPDHNEWGFA
MAV_2597|M.avium_104 AQRDPEVWAVVITGAGDKSFCAGADLKAISR----GENLYHAEHPEWGFA
MLBr_02402|M.leprae_Br4923 LDIDPDVGAILITGSP-KVFAAGADIKEMAS-----LTFTDAFDADFFSA
: * :::. *.** *: : .
Rv0222|M.tuberculosis_H37Rv -FTERPPTKPLIAAVEGYALAGGTELALAADLIVAARDSAFGIPEVKRGL
TH_4462|M.thermoresistible__bu GIVKQPPAKPLVAAVEGAAVGGGFEIVLACDLIVASESARFSLPEVTRGL
Mb3545|M.bovis_AF2122/97 LLKGRRLTKPLIAAVEGPAIAGGTEILQGTDIRVAGESAKFGISEAKWSL
Mflv_4596|M.gilvum_PYR-GCK RNIQ--VAKPTIAAVNGVAFAGGFLLAQQCDLVIAAEHARFAVSEVKVG-
MAB_2058|M.abscessus_ATCC_1997 RNID--VAKPTIAAVNGVAFAGGFLLAQQCDLVVAAEHATFAVSEVKVG-
MSMEG_0335|M.smegmatis_MC2_155 RNIT--VDKPTIAAVNGVAFAGGFLLAQTCDLCVASTTAKFAITEAKVG-
Mvan_0344|M.vanbaalenii_PYR-1 RNIK--VDKPTIAAVNGAAFAGGFLLAQTCDLCVASTTATFGITEVKVG-
MMAR_4317|M.marinum_M GYVHHFIDKPTIAAVNGTALGGGTELALASDLVVADERAKFGLPEVKRGL
MUL_0972|M.ulcerans_Agy99 GYVHHFIDKPTIAAVNGTALCGGTELALASDLVVADERAKFGLPEAKRGF
MAV_2597|M.avium_104 GYVHHFIDKPTIAAVNGTALGGGSELALASDLVIACESASFGLPEVKRGL
MLBr_02402|M.leprae_Br4923 WGKLAAVRTPMIAAVAGYALGGGCELAMMCDLLIAADTAKFGQPEIKLGV
.* :*** * *. ** : *: :* : *. .* . .
Rv0222|M.tuberculosis_H37Rv VAGGGGLLRLPERIPYAIAMELALTGDNLPAERAHELGLVNVLAEPGTAL
TH_4462|M.thermoresistible__bu TPNGGGLLRLPRRIPHHLAMELILTGRPVTAARAAELGLLNRLTPPGSAL
Mb3545|M.bovis_AF2122/97 YPMGGSAVRLVRQIPYTLACDLLLTGRHITAAEAKEMGLIGHVVPDGQAL
Mflv_4596|M.gilvum_PYR-GCK -RGSPWAVPLSWLLPPRIALQILMTGDPITAERAREVGMVNEVVPAAELR
MAB_2058|M.abscessus_ATCC_1997 -RGSPWATPLSWLVPPRVAMQILLTGDPITAARAHQVGLVNEVVPADQLR
MSMEG_0335|M.smegmatis_MC2_155 -RGSPWAAPLPLMIPRRIAMELVLTGAPISAARAHEIGFVNRLAEPADLH
Mvan_0344|M.vanbaalenii_PYR-1 -RGSPWAAPLPLMIPRRVVMELVLTGAPMSARRAHEIGFVNRLAEPSDLV
MMAR_4317|M.marinum_M IAAAGGVFRIVNQLPRKVAMEMLLTGEPITASDAYEWGLINQVVKQGAVL
MUL_0972|M.ulcerans_Agy99 IAAAGGVFRIVNQLPRKVAMEMLLTGEPITASDAYEWGLINQVVKQGAVL
MAV_2597|M.avium_104 IAGAGGVFRIVEQLPRKVALELVLTGEPMTASDALRWGLINEVVPDGTVV
MLBr_02402|M.leprae_Br4923 LPGMGGSQRLTRAIGKAKAMDLILTGRTIDAAEAERSGLVSRVVLADDLL
: : . :: :** : * * . *::. :.
Rv0222|M.tuberculosis_H37Rv DAAIALAEKITANGPLAVVATKRIITESRGWSPDTM---FAEQMKILVPV
TH_4462|M.thermoresistible__bu STARELAAVIAANGPLAIRAAKRVVEESPDWPRTEM---FTRQEDIVAPV
Mb3545|M.bovis_AF2122/97 TKALELADAISANGPLAVQAILRSIRETECMPENEA---FKIDTQIGIKV
Mflv_4596|M.gilvum_PYR-GCK VRVQEIALRIASNAPLSVLAAKKTVYLSAAHHLTEA---YAHADQIWEPV
MAB_2058|M.abscessus_ATCC_1997 ERTQQLALSIAANAPLSVLASKRTVYLSAQHHLAAA---YDLADEIWEPV
MSMEG_0335|M.smegmatis_MC2_155 AVAQKLAEQIAANAPLSVAAGKRTATLTAEHPLSEA---FDIAESIWEPV
Mvan_0344|M.vanbaalenii_PYR-1 DSTQALAEQIAANAPLSVAAGKATAVLTAEYPLSEA---YDHAERLWQEV
MMAR_4317|M.marinum_M DAALALAARVTVNAPLSVRASKRIAYGVDDGVVADEERGWERTMREMRSL
MUL_0972|M.ulcerans_Agy99 DAALALAARVTVNAPLSVRASKRIAYGVDDGVVADEERGWERTMREMRSL
MAV_2597|M.avium_104 EAALALAERITCNAPLSVQASKRVAYGADDGIIGAEEPKWERTIREFTEL
MLBr_02402|M.leprae_Br4923 PEAKAVATTISQMSRSATRMAKEAVNRSFESTLAEG---LLHERRLFHST
. :* :: . :
Rv0222|M.tuberculosis_H37Rv FTSNDAKEGAIAFAERRRPRWTGT
TH_4462|M.thermoresistible__bu RSSADAAEGARAFAEKRMPLWRNR
Mb3545|M.bovis_AF2122/97 FLSDDAKEGPRAFAEKRAPNFQNR
Mflv_4596|M.gilvum_PYR-GCK YLSADALEGPAAFREKRTPVWKGR
MAB_2058|M.abscessus_ATCC_1997 YLSDDAQEGPAAFREKRAPQWKGH
MSMEG_0335|M.smegmatis_MC2_155 YLSGDAQEGMAAFKEKRSPVWKGR
Mvan_0344|M.vanbaalenii_PYR-1 YLSSDAQEGMQAFKDKRAPVWKGI
MMAR_4317|M.marinum_M IRSEDAKEGPLAFAQKREPVWKAR
MUL_0972|M.ulcerans_Agy99 IRSEDAKEGPLAFAEKREPVWKTR
MAV_2597|M.avium_104 LKSEDAKEGPLAFAEKRQPVWKAR
MLBr_02402|M.leprae_Br4923 FVTDDQSEGMAAFIEKRAPQFTHR
: * ** ** ::* * :